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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...
Aliases for MIR29B2 Gene
RNA type for MIR29B2 Gene
miRNA
Aliases for MIR29B2 Gene
- Mir-29b-2 (NCBI Entrez Gene)
- MI0000107 (miRBase)
- MIRN29B2 (NCBI Entrez Gene)
- MiR-29b (NCBI Entrez Gene)
- MIR29B2 (Ensembl)
- RF00074 (Rfam)
External Ids for MIR29B2 Gene
- HGNC: 31620
- NCBI Entrez Gene: 407025
- Ensembl: ENSG00000284203
- OMIM®: 619035
- miRBase: hsa-mir-29b-2
Previous HGNC Symbols for MIR29B2 Gene
- MIRN29B2
Previous GeneCards Identifiers for MIR29B2 Gene
- GC01M206044
- GC01M207976
- GC01M207977
- GC01M207984
- GC01M207803
- GC01M207809
- GC01M207810
- GC01M207808
- GC01M207807
- GC01M207804
- GC01M207805
Summaries for MIR29B2 Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR29B2 Gene
MIR29B2 (MicroRNA 29b-2) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR29B2 include Rhabdomyosarcoma and Leukemia, Chronic Lymphocytic. Among its related pathways are MicroRNAs in cancer and Metastatic brain tumor.
Rfam classification for MIR29B2 Gene
-
mir-29 microRNA precursor
Additional gene information for MIR29B2 Gene
- HGNC (31620)
- NCBI Entrez Gene (407025)
- Ensembl (ENSG00000284203)
- OMIM® (619035)
- Open Targets Platform(ENSG00000284203)
- Alliance of Genome Resources
- Search for MIR29B2 at DataMed
- Search for MIR29B2 at HumanCyc
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR29B2 Gene
Genomics for MIR29B2 Gene
Genomic Locations for MIR29B2 Gene
Latest Assembly
- chr1:207,802,443-207,802,523
- (GRCh38/hg38)
- Size:
- 81 bases
- Orientation:
- Minus strand
Previous Assembly
- chr1:207,975,788-207,975,868
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 81 bases
- Orientation:
- Minus strand
Genomic View for MIR29B2 Gene
Genes around MIR29B2 on UCSC Golden Path with GeneCards custom track
MIR29B2 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path
- Cytogenetic band:
-
- 1q32.2 by HGNC
- 1q32.2 by Entrez Gene
- 1q32.2 by Ensembl
MIR29B2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR29B2 Gene
No data available for GeneHancer (GH) Regulatory Elements for MIR29B2 Gene
Proteins for MIR29B2 Gene
Post-translational modifications for MIR29B2 Gene
No Post-translational modifications
No data available for DME Specific Peptides for MIR29B2 Gene
Domains & Families for MIR29B2 Gene
Gene Families for MIR29B2 Gene
- HGNC:
No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR29B2 Gene
Function for MIR29B2 Gene
Phenotypes From GWAS Catalog for MIR29B2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003730 | mRNA 3'-UTR binding | IDA | -- |
| GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IMP | -- |
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MIR29B2 - Starting at $85 >
- * MIR29B2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
miRNA products for research
Inhibitory RNAs for research
Clone products for research
- Applied Biological Materials (abm): Clones for MIR29B2 - Starting at $45 >
- * MIR29B2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
Cell Lines for research
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR29B2 Gene
Localization for MIR29B2 Gene
| Compartment | Confidence |
|---|---|
| extracellular | 1 |
| cytoskeleton | 1 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | HDA | -- |
| GO:0005634 | nucleus | IDA | -- |
| GO:0005737 | cytoplasm | IDA | -- |
| GO:0005739 | mitochondrion | IEA | -- |
| GO:0070062 | extracellular exosome | IDA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR29B2 Gene
Pathways & Interactions for MIR29B2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | MicroRNAs in cancer | ||
| 2 | Metastatic brain tumor | ||
Pathways by source for MIR29B2 Gene
1 BioSystems pathway for MIR29B2 Gene
1 KEGG pathway for MIR29B2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001960 | negative regulation of cytokine-mediated signaling pathway | IDA | -- |
| GO:0008285 | negative regulation of cell proliferation | IDA | -- |
| GO:0010628 | positive regulation of gene expression | IGI | -- |
| GO:0010629 | negative regulation of gene expression | IMP | -- |
| GO:0010719 | negative regulation of epithelial to mesenchymal transition | IDA | -- |
No data available for Interacting Proteins and SIGNOR curated interactions for MIR29B2 Gene
Transcripts for MIR29B2 Gene
Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR29B2 Gene
| RNAcentral Transcript ID | RNA Type | Length (nts) | # of Sources | Source Identifiers and Annotations |
|---|---|---|---|---|
| URS000024463E_9606 | miRNA | 23 | 6 |
LncBase: hsa-miR-29b-3p, miRBase: MIMAT0000100, MirGeneDB: Hsa-Mir-29-P2a_3p, Hsa-Mir-29-P2b-v1_3p, TarBase: hsa-miR-29b-3p, ENA: EU154353.1:35774..35796:ncRNA, LM378787.1:1..23:ncRNA, LM608190.1:51..73:ncRNA, LM608191.1:52..74:ncRNA, |
| URS0000403C02_9606 | miRNA | 22 | 5 |
RefSeq: NR_029518, LncBase: hsa-miR-29b-2-5p, miRBase: MIMAT0004515, TarBase: hsa-miR-29b-2-5p, ENA: EU154351.1:1071..1092:ncRNA, EU154352.1:1256..1277:ncRNA, LM380194.1:1..22:ncRNA, LM608191.1:11..32:ncRNA, |
| URS00001E96DA_9606 | pre_miRNA | 81 | 4 |
RefSeq: NR_029518, Ensembl: ENST00000385055 (view in UCSC) , miRBase: MI0000107, ENA: AF480543.1:1..81:misc_RNA, LM608191.1:1..81:precursor_RNA, |
| URS00003266AE_9606 | pre_miRNA | 72 | 1 |
Rfam: RF00074, |
| URS0001BC7081_9606 | pre_miRNA | 72 | 1 |
Rfam: RF00074, |
MIR29B2 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path
Additional transcripts not in RNAcentral for MIR29B2 Gene
- 3 NCBI additional mRNA sequence :
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MIR29B2 - Starting at $85 >
- * MIR29B2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
miRNA products for research
Inhibitory RNAs for research
Clone products for research
- Applied Biological Materials (abm): Clones for MIR29B2 - Starting at $45 >
- * MIR29B2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
Relevant External Links for MIR29B2 Gene
- GeneLoc Exon Structure for
- MIR29B2
Expression for MIR29B2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR29B2
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR29B2 Gene
Orthologs for MIR29B2 Gene
Evolution for MIR29B2 Gene
- ENSEMBL:
- Gene Tree for MIR29B2 (if available)
- TreeFam:
- Gene Tree for MIR29B2 (if available)
- Alliance of Genome Resources:
- Additional Orthologs for MIR29B2
No data available for Orthologs for MIR29B2 Gene
Paralogs for MIR29B2 Gene
No data available for Paralogs for MIR29B2 Gene
Variants for MIR29B2 Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Additional Variant Information for MIR29B2 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR29B2 Gene
Disorders for MIR29B2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| rhabdomyosarcoma |
|
|
| leukemia, chronic lymphocytic |
|
|
| pancreatic cancer |
|
|
| prostate cancer |
|
|
| lung cancer |
|
Search MIR29B2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MIR29B2
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for MIR29B2 Gene
Publications for MIR29B2 Gene
- Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 40
- Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J … Zhao H (International journal of cancer 2009) 3 40
- [Expressions and neural function prognostic evaluation of serum microRNA-24 and microRNA-29b in elderly patients with acute ischemic stroke]. (PMID: 32148236) Guo C … Ou Y (Zhonghua wei zhong bing ji jiu yi xue 2020) 3
- Sex-Specific Regulation of miR-29b in the Myocardium Under Pressure Overload is Associated with Differential Molecular, Structural and Functional Remodeling Patterns in Mice and Patients with Aortic Stenosis. (PMID: 32235655) García R … Nistal JF (Cells 2020) 3
- miR‑29 mediates exercise‑induced skeletal muscle angiogenesis by targeting VEGFA, COL4A1 and COL4A2 via the PI3K/Akt signaling pathway. (PMID: 32467996) Chen L … Li Y (Molecular medicine reports 2020) 3
ExternalLinks
Products for MIR29B2 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR29B2
- Origene Custom Protein Services for MIR29B2
- Browse OriGene Inhibitory RNA Products For MIR29B2
- Browse OriGene qPCR primer pairs and template standards
- Browse CRISPR knockouts for MIR29B2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MIR29B2
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for MIR29B2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for MIR29B2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MIR29B2
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for MIR29B2
Sources for MIR29B2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources