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MIR29B2 Gene(RNA Gene)

MicroRNA 29b-2

GCID:
GC01M207806
GIFtS:
15
Genes Participants
UDN Logo

Aliases for MIR29B2 Gene

Subcategory (RNA class) for MIR29B2 Gene

miRNA

Quality Score for this RNA gene is

14.2

Aliases for MIR29B2 Gene

  • MicroRNA 29b-2 2 3 5
  • Hsa-Mir-29b-2 3
  • Mir-29b-2 3
  • MIRN29B2 3
  • MiR-29b 3

External Ids for MIR29B2 Gene

ORGUL Members for MIR29B2 Gene

Previous HGNC Symbols for MIR29B2 Gene

  • MIRN29B2

Previous GeneCards Identifiers for MIR29B2 Gene

  • GC01M206044
  • GC01M207976
  • GC01M207977
  • GC01M207984
  • GC01M207803
  • GC01M207804
  • GC01M207805

Summaries for MIR29B2 Gene

Entrez Gene Summary for MIR29B2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR29B2 Gene

MIR29B2 (MicroRNA 29b-2) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer and Metastatic brain tumor.

fRNAdb sequence ontologies for MIR29B2 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

Additional gene information for MIR29B2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR29B2 Gene

Genomics for MIR29B2 Gene

Products:

  1. Regulatory Element

Genomic Locations for MIR29B2 Gene

Genomic Locations for MIR29B2 Gene
chr1:207,802,443-207,802,523
(GRCh38/hg38)
Size:
81 bases
Orientation:
Minus strand
chr1:207,974,863-208,042,495
(GRCh37/hg19)

Genomic View for MIR29B2 Gene

Genes around MIR29B2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR29B2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR29B2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR29B2 Gene

ORGUL Member Location for MIR29B2 Gene

ORGUL Member Location for MIR29B2 gene

No data available for GeneHancer (GH) Regulatory Elements for MIR29B2 Gene

Proteins for MIR29B2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIR29B2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR29B2 Gene

Domains & Families for MIR29B2 Gene

Gene Families for MIR29B2 Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR29B2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR29B2 Gene

Function for MIR29B2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Gene Ontology (GO) - Molecular Function for MIR29B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IMP 27030318
genes like me logo Genes that share ontologies with MIR29B2: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR29B2 Gene

Localization for MIR29B2 Gene

Gene Ontology (GO) - Cellular Components for MIR29B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
GO:0005634 nucleus IDA 17204650
GO:0005737 cytoplasm IDA 17204650
GO:0005739 mitochondrion IEA --
GO:0070062 extracellular exosome IDA 28159509
genes like me logo Genes that share ontologies with MIR29B2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR29B2 Gene

Pathways & Interactions for MIR29B2 Gene

genes like me logo Genes that share pathways with MIR29B2: view

Pathways by source for MIR29B2 Gene

1 BioSystems pathway for MIR29B2 Gene
1 KEGG pathway for MIR29B2 Gene

Interacting Proteins for MIR29B2 Gene

Gene Ontology (GO) - Biological Process for MIR29B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation IDA 19850741
GO:0010628 positive regulation of gene expression IGI 22269326
GO:0010629 negative regulation of gene expression IMP 27030318
GO:0010719 negative regulation of epithelial to mesenchymal transition IDA 25032858
GO:0030335 positive regulation of cell migration IDA 25435433
genes like me logo Genes that share ontologies with MIR29B2: view

No data available for SIGNOR curated interactions for MIR29B2 Gene

Drugs & Compounds for MIR29B2 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIR29B2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MIR29B2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR29B2 Gene

No ASD Table

Relevant External Links for MIR29B2 Gene

GeneLoc Exon Structure for
MIR29B2
ECgene alternative splicing isoforms for
MIR29B2

Expression for MIR29B2 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR29B2 Gene

mRNA expression in normal human tissues for MIR29B2 Gene
mRNA expression by GTEx for MIR29B2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR29B2 Gene:

MIR29B2
genes like me logo Genes that share expression patterns with MIR29B2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR29B2 Gene

Orthologs for MIR29B2 Gene

Evolution for MIR29B2 Gene

ENSEMBL:
Gene Tree for MIR29B2 (if available)
TreeFam:
Gene Tree for MIR29B2 (if available)

No data available for Orthologs for MIR29B2 Gene

Paralogs for MIR29B2 Gene

No data available for Paralogs for MIR29B2 Gene

Variants for MIR29B2 Gene

Sequence variations from dbSNP and Humsavar for MIR29B2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000416979 -- 207,802,346(-) G/A downstream_transcript_variant
rs1001828775 -- 207,802,550(-) G/A upstream_transcript_variant
rs1002530423 -- 207,804,166(-) T/C upstream_transcript_variant
rs1003668706 -- 207,802,574(-) T/G upstream_transcript_variant
rs1004661254 -- 207,804,188(-) C/T upstream_transcript_variant

Additional Variant Information for MIR29B2 Gene

Human Gene Mutation Database (HGMD)
MIR29B2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR29B2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR29B2 Gene

Disorders for MIR29B2 Gene

Additional Disease Information for MIR29B2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MIR29B2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR29B2 Gene

Publications for MIR29B2 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 44 58
  2. Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J … Zhao H (International journal of cancer 2009) 3 44 58
  3. Vertebrate microRNA genes. (PMID: 12624257) Lim LP … Bartel DP (Science (New York, N.Y.) 2003) 1 3 58
  4. Human Pericardial Fluid Contains Exosomes Enriched with Cardiovascular-Expressed MicroRNAs and Promotes Therapeutic Angiogenesis. (PMID: 28159509) Beltrami C … Emanueli C (Molecular therapy : the journal of the American Society of Gene Therapy 2017) 3 58
  5. MCL-1 is modulated in Crohn's disease fibrosis by miR-29b via IL-6 and IL-8. (PMID: 28190086) Nijhuis A … Silver A (Cell and tissue research 2017) 3 58

Products for MIR29B2 Gene

Sources for MIR29B2 Gene

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