MIR29B2 Gene(RNA Gene)

• microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

MIR29B2 (MicroRNA 29b-2) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR29B2 include Rhabdomyosarcoma and Leukemia, Chronic Lymphocytic. Among its related pathways are Metastatic brain tumor and MicroRNAs in cancer.

• miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

• nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

• HGNC(31620)
• Entrez Gene(407025)
• Ensembl(ENSG00000284203)
• RNACentral(MIR29B2)
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• Search for MIR29B2 at DataMed
• Search for MIR29B2 at HumanCyc

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR29B2 Gene

No data available for GeneHancer (GH) Regulatory Elements for MIR29B2 Gene

No data available for DME Specific Peptides for MIR29B2 Gene

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR29B2 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR29B2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR29B2 Gene

No data available for SIGNOR curated interactions for MIR29B2 Gene

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR29B2 Gene

No data available for Orthologs for MIR29B2 Gene

No data available for Paralogs for MIR29B2 Gene

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR29B2 Gene

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR29B2 Gene

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