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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR29B2 (MicroRNA 29b-2) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR29B2 include Rhabdomyosarcoma and Leukemia, Chronic Lymphocytic. Among its related pathways are MicroRNAs in cancer and Metastatic brain tumor.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH01J207800 | Enhancer | 0.3 | Ensembl | 600.7 | +1.9 | 1923 | 0.4 | POLR2A | MIR29B2 MIR29C RF00017-460 CD46 MIR29B2CHG CD34 | |
GH01J207804 | Enhancer | 1.1 | ENCODE dbSUPER | 0.7 | -4.4 | -4417 | 4.4 | PRDM10 IKZF1 JUND MTA2 PKNOX1 MTA1 ZNF740 KAT8 BRD9 DPF2 | CD46 MIR29B2 LOC148696 MIR29B2CHG CD34 | |
GH01J207815 | Promoter/Enhancer | 1.2 | Ensembl ENCODE dbSUPER | 0.4 | -13.3 | -13304 | 0.9 | JUND CTBP1 RUNX3 FOSL1 RUNX1 MAFK ZNF395 NR2F1 CREM NR2F6 | LOC148696 MIR29B2 CD46 MIR29B2CHG CD34 | |
GH01J207811 | Enhancer | 1 | ENCODE dbSUPER | 0.4 | -10.0 | -9971 | 2.1 | CTCF TFE3 JUND FOXA1 MTA2 REST ZNF740 SP1 ZNF24 HDAC1 | CD46 LOC148696 MIR29B2 MIR29B2CHG CD34 | |
GH01J207810 | Promoter/Enhancer | 0.7 | Ensembl dbSUPER | 0.4 | -8.6 | -8578 | 0.2 | ZNF584 CEBPB | LOC148696 MIR29B2 CD46 MIR29B2CHG CD34 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003730 | mRNA 3'-UTR binding | IDA | 23729669 |
GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IMP | 27030318 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | HDA | 26646931 |
GO:0005634 | nucleus | IDA | 17204650 |
GO:0005737 | cytoplasm | IDA | 17204650 |
GO:0005739 | mitochondrion | IEA | -- |
GO:0070062 | extracellular exosome | IDA | 28159509 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | MicroRNAs in cancer | ||
2 | Metastatic brain tumor |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001960 | negative regulation of cytokine-mediated signaling pathway | IDA | 23729669 |
GO:0008285 | negative regulation of cell proliferation | IDA | 19850741 |
GO:0010628 | positive regulation of gene expression | IGI | 22269326 |
GO:0010629 | negative regulation of gene expression | IMP | 27030318 |
GO:0010719 | negative regulation of epithelial to mesenchymal transition | IDA | 25032858 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000024463E_9606 | miRNA | 23 | 6 |
LncBase: hsa-miR-29b-3p, miRBase: MIMAT0000100, MirGeneDB: Hsa-Mir-29-P2a_3p, Hsa-Mir-29-P2b-v1_3p, TarBase: hsa-miR-29b-3p, ENA: EU154353.1:35774..35796:ncRNA, LM378787.1:1..23:ncRNA, LM608190.1:51..73:ncRNA, LM608191.1:52..74:ncRNA, |
URS00001E96DA_9606 | precursor_RNA | 81 | 5 |
HGNC: 31620, RefSeq: NR_029518, Ensembl: ENST00000385055 (view in UCSC) , miRBase: MI0000107, ENA: AF480543.1:1..81:misc_RNA, LM608191.1:1..81:precursor_RNA, |
URS0000403C02_9606 | miRNA | 22 | 5 |
RefSeq: NR_029518, LncBase: hsa-miR-29b-2-5p, miRBase: MIMAT0004515, TarBase: hsa-miR-29b-2-5p, ENA: EU154351.1:1071..1092:ncRNA, EU154352.1:1256..1277:ncRNA, LM380194.1:1..22:ncRNA, LM608191.1:11..32:ncRNA, |
URS00003266AE_9606 | precursor_RNA | 72 | 1 |
Rfam: RF00074, |
URS0000EFE51C_9606 | precursor_RNA | 65 | 1 |
MirGeneDB: Hsa-Mir-29-P2b-v1, |
Disorder | Aliases | PubMed IDs |
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rhabdomyosarcoma |
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leukemia, chronic lymphocytic |
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pancreatic cancer |
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prostate cancer |
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lung cancer |
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