microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR29B2 Gene

Subcategory (RNA class) for MIR29B2 Gene

miRNA

Number of RNA Genes sources:

5 / 14

Aliases for MIR29B2 Gene

  • MicroRNA 29b-2 2 3 5
  • Hsa-MiR-29b-2-5p 166 177
  • Hsa-MiR-29b-3p 166 177
  • Hsa-Mir-29b-2 3
  • MIMAT0004515 51
  • MIMAT0000100 51
  • Mir-29b-2 3
  • MI0000107 51
  • MIRN29B2 3
  • MiR-29b 3
  • MIR29B2 2
  • RF00074 172

External Ids for MIR29B2 Gene

Previous HGNC Symbols for MIR29B2 Gene

  • MIRN29B2

Previous GeneCards Identifiers for MIR29B2 Gene

  • GC01M206044
  • GC01M207976
  • GC01M207977
  • GC01M207984
  • GC01M207803
  • GC01M207809
  • GC01M207810
  • GC01M207808
  • GC01M207804
  • GC01M207805
  • GC01M207806

Summaries for MIR29B2 Gene

Entrez Gene Summary for MIR29B2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR29B2 Gene

MIR29B2 (MicroRNA 29b-2) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR29B2 include Rhabdomyosarcoma and Leukemia, Chronic Lymphocytic. Among its related pathways are Metastatic brain tumor and MicroRNAs in cancer.

Rfam classification for MIR29B2 Gene

  • mir-29 microRNA precursor

Additional gene information for MIR29B2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR29B2 Gene

Genomics for MIR29B2 Gene

GeneHancer (GH) Regulatory Elements for MIR29B2 Gene

Promoters and enhancers for MIR29B2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J207800 Enhancer 0.4 Ensembl 500.7 +1.9 1923 0.4 POLR2A E2F8 AGO2 MIR29B2 MIR29C RF00017-460 MIR29B2CHG
GH01J207804 Enhancer 1.1 ENCODE dbSUPER 0.7 -4.4 -4417 4.4 TCF12 FOS POLR2A ZNF263 ZBTB11 AFF1 ZNF740 CTBP1 MYC NCOR1 CD46 MIR29B2 LOC148696 MIR29B2CHG
GH01J207815 Promoter/Enhancer 1.2 Ensembl ENCODE dbSUPER 0.4 -13.3 -13304 0.9 RUNX1 CTBP1 FOSL1 ZNF395 NR2F1 MAFK STAT1 JUN NR2F6 MEIS2 LOC148696 MIR29B2 MIR29B2CHG
GH01J207811 Enhancer 1 ENCODE dbSUPER 0.4 -10.0 -9971 2.1 CTCF USF1 CLOCK REST ZNF740 MYC TOE1 TGIF2 CTBP1 HINFP CD46 LOC148696 MIR29B2 MIR29B2CHG
GH01J207810 Promoter/Enhancer 0.7 Ensembl dbSUPER 0.4 -8.6 -8578 0.2 ZNF584 CEBPB LOC148696 MIR29B2 MIR29B2CHG
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR29B2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR29B2 Gene

Genomic Locations for MIR29B2 Gene
chr1:207,802,443-207,802,523
(GRCh38/hg38)
Size:
81 bases
Orientation:
Minus strand
chr1:207,974,863-208,042,495
(GRCh37/hg19)
Size:
67,633 bases
Orientation:
Minus strand

Genomic View for MIR29B2 Gene

Genes around MIR29B2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR29B2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR29B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR29B2 Gene

Proteins for MIR29B2 Gene

Post-translational modifications for MIR29B2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR29B2 Gene

Domains & Families for MIR29B2 Gene

Gene Families for MIR29B2 Gene

genes like me logo Genes that share domains with MIR29B2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR29B2 Gene

Function for MIR29B2 Gene

Phenotypes From GWAS Catalog for MIR29B2 Gene

Gene Ontology (GO) - Molecular Function for MIR29B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IMP 27030318
genes like me logo Genes that share ontologies with MIR29B2: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR29B2 Gene

Localization for MIR29B2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR29B2 gene
Compartment Confidence
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MIR29B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
GO:0005634 nucleus IDA 17204650
GO:0005737 cytoplasm IDA 17204650
GO:0005739 mitochondrion IEA --
GO:0070062 extracellular exosome IDA 28159509
genes like me logo Genes that share ontologies with MIR29B2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR29B2 Gene

Pathways & Interactions for MIR29B2 Gene

PathCards logo

SuperPathways for MIR29B2 Gene

genes like me logo Genes that share pathways with MIR29B2: view

Pathways by source for MIR29B2 Gene

1 BioSystems pathway for MIR29B2 Gene
1 KEGG pathway for MIR29B2 Gene
;

Gene Ontology (GO) - Biological Process for MIR29B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation IDA 19850741
GO:0010628 positive regulation of gene expression IGI 22269326
GO:0010629 negative regulation of gene expression IMP 27030318
GO:0010719 negative regulation of epithelial to mesenchymal transition IDA 25032858
GO:0010867 positive regulation of triglyceride biosynthetic process ISS --
genes like me logo Genes that share ontologies with MIR29B2: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR29B2 Gene

Drugs & Compounds for MIR29B2 Gene

No Compound Related Data Available

Transcripts for MIR29B2 Gene

mRNA/cDNA for MIR29B2 Gene

7 RNACentral transcripts :
2 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
3 miRBase transcripts :
13 ENA transcripts :
2 LncBase transcripts :
1 Rfam transcripts :
2 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR29B2 Gene

No ASD Table

Relevant External Links for MIR29B2 Gene

GeneLoc Exon Structure for
MIR29B2

Expression for MIR29B2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR29B2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR29B2

genes like me logo Genes that share expression patterns with MIR29B2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR29B2 Gene

Orthologs for MIR29B2 Gene

Evolution for MIR29B2 Gene

ENSEMBL:
Gene Tree for MIR29B2 (if available)
TreeFam:
Gene Tree for MIR29B2 (if available)

No data available for Orthologs for MIR29B2 Gene

Paralogs for MIR29B2 Gene

No data available for Paralogs for MIR29B2 Gene

Variants for MIR29B2 Gene

Additional dbSNP identifiers (rs#s) for MIR29B2 Gene

Additional Variant Information for MIR29B2 Gene

Human Gene Mutation Database (HGMD)
MIR29B2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR29B2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR29B2 Gene

Disorders for MIR29B2 Gene

MalaCards: The human disease database

(7) MalaCards diseases for MIR29B2 Gene - From: miR2Disease and DISEASES

Disorder Aliases PubMed IDs
rhabdomyosarcoma
leukemia, chronic lymphocytic
  • cll
pancreatic cancer
  • pancreatic carcinoma
prostate cancer
  • prostate cancer, somatic
colorectal cancer
  • crc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR29B2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR29B2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR29B2 Gene

Publications for MIR29B2 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 41 54
  2. Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J … Zhao H (International journal of cancer 2009) 3 41 54
  3. LncRNA NEAT1/miR-29b-3p/BMP1 axis promotes osteogenic differentiation in human bone marrow-derived mesenchymal stem cells. (PMID: 30638953) Zhang Y … Chen Z (Pathology, research and practice 2019) 3 54
  4. Human AML activates the aryl hydrocarbon receptor pathway to impair NK cell development and function. (PMID: 30158248) Scoville SD … Mundy-Bosse BL (Blood 2018) 3 54
  5. MicroRNA-29b-2-5p inhibits cell proliferation by directly targeting Cbl-b in pancreatic ductal adenocarcinoma. (PMID: 29940895) Li C … Liu Y (BMC cancer 2018) 3 54

Products for MIR29B2 Gene

Sources for MIR29B2 Gene