microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR29B1 Gene

RNA type for MIR29B1 Gene

miRNA

Aliases for MIR29B1 Gene

External Ids for MIR29B1 Gene

Previous HGNC Symbols for MIR29B1 Gene

  • MIRN29B1

Previous GeneCards Identifiers for MIR29B1 Gene

  • GC07M130215
  • GC07M130562

Summaries for MIR29B1 Gene

Entrez Gene Summary for MIR29B1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR29B1 Gene

MIR29B1 (MicroRNA 29b-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR29B1 include Alzheimer Disease and Aortic Valve Disease 1. Among its related pathways are MicroRNAs in cancer and Alzheimers Disease.

Rfam classification for MIR29B1 Gene

  • mir-29 microRNA precursor

Additional gene information for MIR29B1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR29B1 Gene

Genomics for MIR29B1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR29B1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR29B1 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR29B1 Gene

Latest Assembly
chr7:130,877,459-130,877,539
(GRCh38/hg38)
Size:
81 bases
Orientation:
Minus strand

Previous Assembly
chr7:130,562,218-130,562,298
(GRCh37/hg19 by Entrez Gene)
Size:
81 bases
Orientation:
Minus strand

Genomic View for MIR29B1 Gene

Genes around MIR29B1 on UCSC Golden Path with GeneCards custom track
MIR29B1 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR29B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR29B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR29B1 Gene

Proteins for MIR29B1 Gene

Post-translational modifications for MIR29B1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR29B1 Gene

Domains & Families for MIR29B1 Gene

Gene Families for MIR29B1 Gene

genes like me logo Genes that share domains with MIR29B1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR29B1 Gene

Function for MIR29B1 Gene

Phenotypes From GWAS Catalog for MIR29B1 Gene

Gene Ontology (GO) - Molecular Function for MIR29B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003730 mRNA 3'-UTR binding IDA 18434550
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IMP 27030318
genes like me logo Genes that share ontologies with MIR29B1: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR29B1 Gene

Localization for MIR29B1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR29B1 gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MIR29B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
GO:0005634 nucleus IDA 17204650
GO:0005737 cytoplasm IDA 17204650
GO:0005739 mitochondrion IEA --
GO:0070062 extracellular exosome IDA 28159509
genes like me logo Genes that share ontologies with MIR29B1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR29B1 Gene

Pathways & Interactions for MIR29B1 Gene

PathCards logo

SuperPathways for MIR29B1 Gene

genes like me logo Genes that share pathways with MIR29B1: view

Pathways by source for MIR29B1 Gene

2 BioSystems pathways for MIR29B1 Gene
1 KEGG pathway for MIR29B1 Gene

Gene Ontology (GO) - Biological Process for MIR29B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001960 negative regulation of cytokine-mediated signaling pathway IDA 23729669
GO:0008285 negative regulation of cell proliferation IDA 19850741
GO:0010628 positive regulation of gene expression IGI 22269326
GO:0010629 negative regulation of gene expression IMP 27030318
GO:0010719 negative regulation of epithelial to mesenchymal transition IDA 25032858
genes like me logo Genes that share ontologies with MIR29B1: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR29B1 Gene

Drugs & Compounds for MIR29B1 Gene

No Compound Related Data Available

Transcripts for MIR29B1 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR29B1 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS00001123BD_9606 miRNA 24 6

RefSeq: NR_029517,

LncBase: hsa-miR-29b-1-5p,

miRBase: MIMAT0004514,

MirGeneDB: Hsa-Mir-29-P2a_5p,

TarBase: hsa-miR-29b-1-5p,

ENA: LM380193.1:1..24:ncRNA, LM608190.1:10..33:ncRNA,

URS000024463E_9606 miRNA 23 6

RefSeq: NR_029517, NR_029518,

LncBase: hsa-miR-29b-3p,

miRBase: MIMAT0000100,

MirGeneDB: Hsa-Mir-29-P2a_3p, Hsa-Mir-29-P2b-v1_3p,

TarBase: hsa-miR-29b-3p,

ENA: EU154353.1:35774..35796:ncRNA, LM378787.1:1..23:ncRNA, LM608190.1:51..73:ncRNA, LM608191.1:52..74:ncRNA,

URS0000150A7D_9606 pre_miRNA 81 4

RefSeq: NR_029517,

Ensembl: ENST00000385015 (view in UCSC) ,

miRBase: MI0000105,

ENA: AF480541.1:1..81:misc_RNA, AF480542.1:1..81:misc_RNA, LM608190.1:1..81:precursor_RNA,

URS000014CDF0_9606 precursor_RNA 40898 1

ENA: EU154353.1:1..40898:precursor_RNA,

URS00003D8A8C_9606 pre_miRNA 71 1

Rfam: RF00074,

MIR29B1 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR29B1 Gene

4 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR29B1 Gene

No ASD Table

Relevant External Links for MIR29B1 Gene

GeneLoc Exon Structure for
MIR29B1

Expression for MIR29B1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR29B1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR29B1

genes like me logo Genes that share expression patterns with MIR29B1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR29B1 Gene

Orthologs for MIR29B1 Gene

Evolution for MIR29B1 Gene

ENSEMBL:
Gene Tree for MIR29B1 (if available)
TreeFam:
Gene Tree for MIR29B1 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR29B1

No data available for Orthologs for MIR29B1 Gene

Paralogs for MIR29B1 Gene

No data available for Paralogs for MIR29B1 Gene

Variants for MIR29B1 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR29B1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR29B1 Gene

Variant ID Type Subtype PubMed ID
nsv608422 CNV gain 21841781

Additional Variant Information for MIR29B1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR29B1
Leiden Open Variation Database (LOVD)
MIR29B1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR29B1 Gene

Disorders for MIR29B1 Gene

MalaCards: The human disease database

(54) MalaCards diseases for MIR29B1 Gene - From: MID, COP, and GCD

Disorder Aliases PubMed IDs
alzheimer disease
  • ad
aortic valve disease 1
  • aovd1
aortic aneurysm
  • ruptured aortic aneurysm
pharynx cancer
  • pharyngeal cancer
nasopharyngeal disease
  • nasopharyngeal diseases
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR29B1

genes like me logo Genes that share disorders with MIR29B1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR29B1 Gene

Publications for MIR29B1 Gene

  1. Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J … Zhao H (International journal of cancer 2009) 3 40
  2. Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression. (PMID: 18434550) Hébert SS … De Strooper B (Proceedings of the National Academy of Sciences of the United States of America 2008) 3 72
  3. miRNAs as potential biomarkers for the progression of gastric cancer inhibit CREBZF and regulate migration of gastric adenocarcinoma cells. (PMID: 32218690) Kim YJ … Lee YC (International journal of medical sciences 2020) 3
  4. MiR-29b-3p cooperates with miR-29c-3p to affect the malignant biological behaviors in T-cell acute lymphoblastic leukemia via TFAP2C/GPX1 axis. (PMID: 32423796) Zhuang M … Zhang X (Biochemical and biophysical research communications 2020) 3
  5. The miRNA-29b Is Downregulated in Placenta During Gestational Diabetes Mellitus and May Alter Placenta Development by Regulating Trophoblast Migration and Invasion Through a HIF3A-Dependent Mechanism. (PMID: 32296392) Sun DG … Xia HF (Frontiers in endocrinology 2020) 3

Products for MIR29B1 Gene

Sources for MIR29B1 Gene