MIR29A Gene (RNA Gene)

MicroRNA 29a

GC07M130876
GIFtS:
22
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR29A Gene

Data sources for MIR29A Gene:

RNA type for MIR29A Gene

miRNA

Aliases for MIR29A Gene

External Ids for MIR29A Gene

Previous HGNC Symbols for MIR29A Gene

  • MIRN29
  • MIRN29A

Previous GeneCards Identifiers for MIR29A Gene

  • GC07M130214
  • GC07M130561

Summaries for MIR29A Gene

Entrez Gene Summary for MIR29A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR29A Gene

MIR29A (MicroRNA 29a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR29A include Muscular Dystrophy, Duchenne Type and Leukemia, Chronic Lymphocytic. Among its related pathways are MicroRNAs in cancer and Alzheimers Disease.

Rfam classification for MIR29A Gene

  • mir-29 microRNA precursor

Additional gene information for MIR29A Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR29A Gene

Genomics for MIR29A Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for MIR29A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR29A on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR29A Gene

Latest Assembly
chr7:130,876,747-130,876,810
(GRCh38/hg38)
Size:
64 bases
Orientation:
Minus strand

Previous Assembly
chr7:130,561,506-130,561,569
(GRCh37/hg19 by Entrez Gene)
Size:
64 bases
Orientation:
Minus strand

Genomic View for MIR29A Gene

Genes around MIR29A on UCSC Golden Path with GeneCards custom track
MIR29A in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR29A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR29A Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR29A Gene

Proteins for MIR29A Gene

Products:

  1. Antibodies for research
  2. Protein products for research
  3. Assay products for research

Post-translational modifications for MIR29A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR29A Gene

Domains & Families for MIR29A Gene

Gene Families for MIR29A Gene

HGNC:
genes like me logo Genes that share domains with MIR29A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR29A Gene

Function for MIR29A Gene

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  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Phenotypes From GWAS Catalog for MIR29A Gene

Gene Ontology (GO) - Molecular Function for MIR29A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003730 mRNA 3'-UTR binding IDA 18434550
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 18434550
genes like me logo Genes that share ontologies with MIR29A: view

CRISPR products for research

miRNA products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR29A Gene

Localization for MIR29A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR29A gene
Compartment Confidence
extracellular 3
plasma membrane 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
endosome 2
cytosol 2
peroxisome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MIR29A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
GO:0005737 cytoplasm IDA 17204650
GO:0005739 mitochondrion IEA --
GO:0070062 extracellular exosome IDA 28159509
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIR29A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR29A Gene

Pathways & Interactions for MIR29A Gene

PathCards logo

SuperPathways for MIR29A Gene

genes like me logo Genes that share pathways with MIR29A: view

Pathways by source for MIR29A Gene

2 BioSystems pathways for MIR29A Gene
1 KEGG pathway for MIR29A Gene

Gene Ontology (GO) - Biological Process for MIR29A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation IDA 24091622
GO:0010595 positive regulation of endothelial cell migration IDA 23426367
GO:0010628 positive regulation of gene expression IDA 21573166
GO:0010629 negative regulation of gene expression IDA 20570858
GO:0016525 negative regulation of angiogenesis IDA 28637396
genes like me logo Genes that share ontologies with MIR29A: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR29A Gene

Drugs & Compounds for MIR29A Gene

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  1. Drug products for research
No Compound Related Data Available

Transcripts for MIR29A Gene

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  3. Inhibitory RNAs for research
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Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR29A Gene

GeneCaRNA:The Human ncRNA Database 2021 Publication

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS00002F4D78_9606 miRNA 22 6

RefSeq: NR_029503,

LncBase: hsa-miR-29a-3p,

miRBase: MIMAT0000086,

MirGeneDB: Hsa-Mir-29-P1a_3p,

TarBase: hsa-miR-29a-3p,

ENA: EU154353.1:36494..36515:ncRNA, LM378773.1:1..22:ncRNA, LM608176.1:42..63:ncRNA,

URS00004E9304_9606 pre_miRNA 64 5

RefSeq: NR_029503,

Ensembl: ENST00000362111 (view in UCSC) ,

miRBase: MI0000087,

Rfam: RF00074,

ENA: LM608176.1:1..64:precursor_RNA,

URS0000076995_9606 miRNA 22 5

RefSeq: NR_029503,

LncBase: hsa-miR-29a-5p,

miRBase: MIMAT0004503,

TarBase: hsa-miR-29a-5p,

ENA: LM380182.1:1..22:ncRNA, LM608176.1:4..25:ncRNA,

URS000014CDF0_9606 precursor_RNA 40898 1

ENA: EU154353.1:1..40898:precursor_RNA,

URS0000EFE727_9606 precursor_RNA 61 1

MirGeneDB: Hsa-Mir-29-P1a,

MIR29A in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR29A Gene

2 NCBI additional mRNA sequence :

CRISPR products for research

miRNA products for research

Alternative Splicing Database (ASD) splice patterns (SP) for MIR29A Gene

No ASD Table

Relevant External Links for MIR29A Gene

GeneLoc Exon Structure for
MIR29A

Expression for MIR29A Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR29A Gene

mRNA expression in normal human tissues for MIR29A Gene
mRNA expression by GTEx for MIR29A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR29A

Evidence on tissue expression from TISSUES for MIR29A Gene

  • Blood(2.3)
  • Muscle(2.1)
  • Heart(2.1)
  • Liver(2.1)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with MIR29A: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR29A Gene

Orthologs for MIR29A Gene

Evolution for MIR29A Gene

ENSEMBL:
Gene Tree for MIR29A (if available)
TreeFam:
Gene Tree for MIR29A (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR29A

No data available for Orthologs for MIR29A Gene

Paralogs for MIR29A Gene

No data available for Paralogs for MIR29A Gene

Variants for MIR29A Gene

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  1. SNP Genotyping and Copy Number Assays for research

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR29A Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR29A Gene

Variant ID Type Subtype PubMed ID
nsv608422 CNV gain 21841781

Additional Variant Information for MIR29A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR29A
Leiden Open Variation Database (LOVD)
MIR29A

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR29A Gene

Disorders for MIR29A Gene

MalaCards: The human disease database

(62) MalaCards diseases for MIR29A Gene - From: MID, COP, and GCD

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR29A

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR29A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR29A Gene

Publications for MIR29A Gene

  1. Effects of microRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma. (PMID: 20041405) Xiong Y … Zhuang SM (Hepatology (Baltimore, Md.) 2010) 3 72
  2. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 40
  3. Chronic lymphocytic leukemia modeled in mouse by targeted miR-29 expression. (PMID: 20566844) Santanam U … Pekarsky Y (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 72
  4. MicroRNA miR-29 modulates expression of immunoinhibitory molecule B7-H3: potential implications for immune based therapy of human solid tumors. (PMID: 19584290) Xu H … Cheung NK (Cancer research 2009) 3 72
  5. Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression. (PMID: 18434550) Hébert SS … De Strooper B (Proceedings of the National Academy of Sciences of the United States of America 2008) 3 72

ExternalLinks

View latest publications for MIR29A gene in Mastermind

Products for MIR29A Gene

Sources for MIR29A Gene