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MIR29A Gene(RNA Gene)

MicroRNA 29a

GCID:
GC07M130876
GIFtS:
19
Genes Participants
UDN Logo

Aliases for MIR29A Gene

Subcategory (RNA class) for MIR29A Gene

miRNA

Quality Score for this RNA gene is

8.2

Aliases for MIR29A Gene

  • MicroRNA 29a 2 3 5
  • MicroRNA 29 2 3
  • Hsa-Mir-29a 3
  • Hsa-Mir-29 3
  • MiRNA29A 3
  • Mir-29a 3
  • MIRN29A 3
  • MIRN29 3

External Ids for MIR29A Gene

ORGUL Members for MIR29A Gene

Previous HGNC Symbols for MIR29A Gene

  • MIRN29
  • MIRN29A

Previous GeneCards Identifiers for MIR29A Gene

  • GC07M130214
  • GC07M130561

Summaries for MIR29A Gene

Entrez Gene Summary for MIR29A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR29A Gene

MIR29A (MicroRNA 29a) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR29A Gene - the ORGUL cluster for this gene includes several descriptions:

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

View fRNAdb secondary structures for MIR29A

Additional gene information for MIR29A Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR29A Gene

Genomics for MIR29A Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for MIR29A Gene

Promoters and enhancers for MIR29A Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH07I130873 Enhancer 1 ENCODE dbSUPER 550.8 +0.3 293 5.4 RB1 ARNT SIN3A RAD21 SCRT2 ZNF143 CREM ZHX1 DEK ZNF654 GC07M130879 GC07M130886 MIR29A MIR29B1 ENSG00000226380 GC07P130871 LINC00513 LINC-PINT
GH07I130908 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -39.2 -39215 15.2 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 IRF4 GC07P130916 PIR43822 COPG2 MIR29A RNU6-1010P LINC-PINT MKLN1-AS LINC00513 TMEM209 MKLN1
GH07I130954 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -82.3 -82257 9 HDGF ATF1 PKNOX1 FOXA2 SMAD1 ARNT SIN3A IRF4 ZNF766 ZNF207 COPG2 MIR29A RNU6-1010P LINC-PINT MKLN1 GC07M130950 GC07M131055
GH07I131006 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.3 -133.6 -133592 7.3 HDGF PKNOX1 ARNT NEUROD1 SIN3A ZNF2 ZNF766 E2F8 ZNF143 FOS RNU6-1010P LINC-PINT MKLN1 MIR29A KLHDC10 GC07M131055 GC07M130950
GH07I130937 Enhancer 1.4 Ensembl ENCODE dbSUPER 10.1 -66.6 -66613 11.1 HDGF PKNOX1 SMAD1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 YY1 MKLN1 MIR29A ENSG00000273319 GC07M130950 LINC-PINT
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR29A on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR29A Gene

Genomic Locations for MIR29A Gene
chr7:130,876,747-130,876,810
(GRCh38/hg38)
Size:
64 bases
Orientation:
Minus strand
chr7:130,561,495-130,598,069
(GRCh37/hg19)

Genomic View for MIR29A Gene

Genes around MIR29A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR29A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR29A Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR29A Gene

ORGUL Member Location for MIR29A Gene

ORGUL Member Location for MIR29A gene

Proteins for MIR29A Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIR29A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR29A Gene

Domains & Families for MIR29A Gene

Gene Families for MIR29A Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR29A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR29A Gene

Function for MIR29A Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Phenotypes From GWAS Catalog for MIR29A Gene

Gene Ontology (GO) - Molecular Function for MIR29A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 19584290
genes like me logo Genes that share ontologies with MIR29A: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR29A Gene

Localization for MIR29A Gene

Gene Ontology (GO) - Cellular Components for MIR29A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
GO:0005737 cytoplasm IDA 17204650
GO:0005739 mitochondrion IEA --
GO:0070062 extracellular exosome IDA 28159509
genes like me logo Genes that share ontologies with MIR29A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR29A Gene

Pathways & Interactions for MIR29A Gene

genes like me logo Genes that share pathways with MIR29A: view

Pathways by source for MIR29A Gene

2 BioSystems pathways for MIR29A Gene
1 KEGG pathway for MIR29A Gene

Interacting Proteins for MIR29A Gene

Gene Ontology (GO) - Biological Process for MIR29A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation IDA 24091622
GO:0010595 positive regulation of endothelial cell migration IDA 23426367
GO:0010628 positive regulation of gene expression IDA 21573166
GO:0010629 negative regulation of gene expression IDA 20570858
GO:0030335 positive regulation of cell migration IDA 21573166
genes like me logo Genes that share ontologies with MIR29A: view

No data available for SIGNOR curated interactions for MIR29A Gene

Drugs & Compounds for MIR29A Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIR29A Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

fRNAdb Secondary structures for MIR29A Gene

  • FR401283

mRNA/cDNA for MIR29A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR29A Gene

No ASD Table

Relevant External Links for MIR29A Gene

GeneLoc Exon Structure for
MIR29A
ECgene alternative splicing isoforms for
MIR29A

Expression for MIR29A Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR29A Gene

mRNA expression in normal human tissues for MIR29A Gene
mRNA expression by GTEx for MIR29A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR29A Gene:

MIR29A
genes like me logo Genes that share expression patterns with MIR29A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR29A Gene

Orthologs for MIR29A Gene

Evolution for MIR29A Gene

ENSEMBL:
Gene Tree for MIR29A (if available)
TreeFam:
Gene Tree for MIR29A (if available)

No data available for Orthologs for MIR29A Gene

Paralogs for MIR29A Gene

No data available for Paralogs for MIR29A Gene

Variants for MIR29A Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for MIR29A Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000549166 -- 130,878,608(-) C/G upstream_transcript_variant
rs1000643866 -- 130,878,268(-) C/T upstream_transcript_variant
rs1005208224 -- 130,877,036(-) T/G upstream_transcript_variant
rs1006194073 -- 130,877,364(-) G/C upstream_transcript_variant
rs1007315390 -- 130,878,704(-) C/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR29A Gene

Variant ID Type Subtype PubMed ID
nsv608422 CNV gain 21841781

Additional Variant Information for MIR29A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR29A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR29A Gene

Disorders for MIR29A Gene

Additional Disease Information for MIR29A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MIR29A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR29A Gene

Publications for MIR29A Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 44 58
  2. Human Pericardial Fluid Contains Exosomes Enriched with Cardiovascular-Expressed MicroRNAs and Promotes Therapeutic Angiogenesis. (PMID: 28159509) Beltrami C … Emanueli C (Molecular therapy : the journal of the American Society of Gene Therapy 2017) 3 58
  3. Interplay of mitochondria apoptosis regulatory factors and microRNAs in valvular heart disease. (PMID: 28888871) Jan MI … Murtaza I (Archives of biochemistry and biophysics 2017) 3 58
  4. miR-29a/b/c function as invasion suppressors for gliomas by targeting CDC42 and predict the prognosis of patients. (PMID: 28787434) Shi C … Yu S (British journal of cancer 2017) 3 58
  5. Altered Expression of miRNAs Is Related to Larynx Cancer TNM Stage and Patients' Smoking Status. (PMID: 28430523) Bruzgielewicz A … Majsterek I (DNA and cell biology 2017) 3 58

Products for MIR29A Gene

Sources for MIR29A Gene

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