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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR29A (MicroRNA 29a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR29A include Muscular Dystrophy, Duchenne Type and Alzheimer Disease. Among its related pathways are MicroRNAs in cancer and Metastatic brain tumor.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 19584290 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | HDA | 26646931 |
GO:0005737 | cytoplasm | IDA | 17204650 |
GO:0005739 | mitochondrion | IEA | -- |
GO:0070062 | extracellular exosome | IDA | 28159509 |
GO:1903561 | extracellular vesicle | HDA | 28798470 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | MicroRNAs in cancer | ||
2 | Alzheimers Disease | ||
3 | Metastatic brain tumor |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0008285 | negative regulation of cell proliferation | IDA | 24091622 |
GO:0010595 | positive regulation of endothelial cell migration | IDA | 23426367 |
GO:0010628 | positive regulation of gene expression | IDA | 21573166 |
GO:0010629 | negative regulation of gene expression | IDA | 20570858 |
GO:0016525 | negative regulation of angiogenesis | IDA | 28637396 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS00004E9304_9606 | precursor_RNA | 64 | 6 |
HGNC: 31616, RefSeq: NR_029503, Ensembl: ENST00000362111 (view in UCSC) , miRBase: MI0000087, Rfam: RF00074, |
URS00002F4D78_9606 | miRNA | 22 | 6 |
RefSeq: NR_029503, LncBase: hsa-miR-29a-3p, miRBase: MIMAT0000086, MirGeneDB: Hsa-Mir-29-P1a_3p, TarBase: hsa-miR-29a-3p, ENA: EU154353.1:36494..36515:ncRNA, LM378773.1:1..22:ncRNA, LM608176.1:42..63:ncRNA, |
URS0000076995_9606 | miRNA | 22 | 5 |
RefSeq: NR_029503, LncBase: hsa-miR-29a-5p, miRBase: MIMAT0004503, TarBase: hsa-miR-29a-5p, |
URS000014CDF0_9606 | precursor_RNA | 40898 | 1 | |
URS0000EFE727_9606 | precursor_RNA | 61 | 1 |
MirGeneDB: Hsa-Mir-29-P1a, |
Disorder | Aliases | PubMed IDs |
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muscular dystrophy, duchenne type |
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alzheimer disease |
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leukemia, chronic lymphocytic |
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diabetes mellitus, noninsulin-dependent |
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hepatocellular carcinoma |
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