microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR298 Gene

Data sources for MIR298 Gene:

Subcategory (RNA class) for MIR298 Gene

miRNA

Aliases for MIR298 Gene

External Ids for MIR298 Gene

Previous HGNC Symbols for MIR298 Gene

  • MIRN298

Previous GeneCards Identifiers for MIR298 Gene

  • GC20M056836
  • GC20M056837
  • GC20M057393

Summaries for MIR298 Gene

Entrez Gene Summary for MIR298 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR298 Gene

MIR298 (MicroRNA 298) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR298 include Alzheimer Disease.

Rfam classification for MIR298 Gene

Additional gene information for MIR298 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR298 Gene

Genomics for MIR298 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR298 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J058817 Enhancer 0.7 Ensembl ENCODE 250.7 -0.7 -728 2.9 BCL11A FOXA2 TCF7L2 BATF NRF1 JUNB BHLHE40 EGR2 RUNX3 ENSG00000268649 HSALNG0131284-002 MIR296 MIR298 GNAS-AS1 ENSG00000268333 GNAS AJ251759 NPEPL1
GH20J058844 Enhancer 0.4 Ensembl ENCODE 12.1 -26.5 -26489 0.8 CREB1 MIR296 MIR298 ENSG00000276722 ENSG00000274491 GNAS GNAS-AS1 AJ251759 NELFCD
GH20J058778 Enhancer 0.3 Ensembl 12.3 +39.4 39412 0.2 SPI1 MIR296 MIR298 GNAS GNAS-AS1 PIEZO1P2 LOC105372695 HSALNG0131277 NPEPL1
GH20J058779 Enhancer 0.3 Ensembl 12.3 +37.1 37112 1.2 EZH2 MIR296 MIR298 GNAS GNAS-AS1 ENSG00000254419 PIEZO1P2 LOC105372695 HSALNG0131277 NPEPL1
GH20J058782 Enhancer 0.3 ENCODE 12.3 +34.5 34494 1.7 EZH2 PIEZO1P2 MIR296 MIR298 GNAS GNAS-AS1 HSALNG0131277 LOC105372695 NPEPL1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR298 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR298 Gene

Latest Assembly
chr20:58,818,226-58,818,313
(GRCh38/hg38)
Size:
88 bases
Orientation:
Minus strand

Previous Assembly
chr20:57,393,281-57,393,368
(GRCh37/hg19 by Entrez Gene)
Size:
88 bases
Orientation:
Minus strand

chr20:57,393,281-57,393,368
(GRCh37/hg19 by Ensembl)
Size:
88 bases
Orientation:
Minus strand

Genomic View for MIR298 Gene

Genes around MIR298 on UCSC Golden Path with GeneCards custom track
MIR298 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR298 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR298 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR298 Gene

Proteins for MIR298 Gene

Post-translational modifications for MIR298 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR298 Gene

Domains & Families for MIR298 Gene

Gene Families for MIR298 Gene

HGNC:
genes like me logo Genes that share domains with MIR298: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR298 Gene

Function for MIR298 Gene

Phenotypes From GWAS Catalog for MIR298 Gene

Gene Ontology (GO) - Molecular Function for MIR298 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003730 mRNA 3'-UTR binding IDA 31942037
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 20190813
genes like me logo Genes that share ontologies with MIR298: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR298 Gene

Localization for MIR298 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR298 gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR298 Gene

Pathways & Interactions for MIR298 Gene

PathCards logo

SuperPathways for MIR298 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR298 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA, IEA --
GO:0035278 miRNA mediated inhibition of translation IDA 20190813
GO:0042985 negative regulation of amyloid precursor protein biosynthetic process IDA 31942037
GO:1902430 negative regulation of amyloid-beta formation IDA 31942037
genes like me logo Genes that share ontologies with MIR298: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR298 Gene

Drugs & Compounds for MIR298 Gene

No Compound Related Data Available

Transcripts for MIR298 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR298 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000069C337_9606 pre_miRNA 88 4

RefSeq: NR_030580,

Ensembl: ENST00000401212 (view in UCSC) ,

miRBase: MI0005523,

Rfam: RF00773,

URS000075E8F5_9606 miRNA 24 4

RefSeq: NR_030580,

LncBase: hsa-miR-298,

miRBase: MIMAT0004901,

TarBase: hsa-miR-298,

URS0001BC43BF_9606 pre_miRNA 88 1

Rfam: RF00773,

MIR298 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for MIR298 Gene

No ASD Table

Relevant External Links for MIR298 Gene

GeneLoc Exon Structure for
MIR298

No data available for mRNA/cDNA for MIR298 Gene

Expression for MIR298 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR298 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR298

genes like me logo Genes that share expression patterns with MIR298: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR298 Gene

Orthologs for MIR298 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for MIR298 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-298 31
  • 100 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir298 31
  • 72 (a)
OneToOne
Species where no ortholog for MIR298 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR298 Gene

ENSEMBL:
Gene Tree for MIR298 (if available)
TreeFam:
Gene Tree for MIR298 (if available)

Paralogs for MIR298 Gene

No data available for Paralogs for MIR298 Gene

Variants for MIR298 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR298 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Additional Variant Information for MIR298 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR298

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR298 Gene

Disorders for MIR298 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR298 Gene - From: MID and COP

Disorder Aliases PubMed IDs
alzheimer disease
  • ad
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR298

genes like me logo Genes that share disorders with MIR298: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR298 Gene

Publications for MIR298 Gene

  1. MicroRNA-298 reduces levels of human amyloid-β precursor protein (APP), β-site APP-converting enzyme 1 (BACE1) and specific tau protein moieties. (PMID: 31942037) Chopra N … Lahiri DK (Molecular psychiatry 2020) 3
  2. LncRNA GAS6-AS2 promotes bladder cancer proliferation and metastasis via GAS6-AS2/miR-298/CDK9 axis. (PMID: 30394665) Rui X … Leng J (Journal of cellular and molecular medicine 2019) 3
  3. Long non-coding RNA UCA1 promoted the growth of adrenocortical cancer cells via modulating the miR-298-CDK6 axis. (PMID: 30935924) Guo N … Zhang Y (Gene 2019) 3
  4. MicroRNA-298 represses hepatocellular carcinoma progression by inhibiting CTNND1-mediated Wnt/β-catenin signaling. (PMID: 29990836) Cao N … Zhang H (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018) 3
  5. LINC01287 regulates tumorigenesis and invasion via miR-298/MYB in hepatocellular carcinoma. (PMID: 30133116) Mo Y … Che S (Journal of cellular and molecular medicine 2018) 3

Products for MIR298 Gene

Sources for MIR298 Gene