microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR28 Gene

Subcategory (RNA class) for MIR28 Gene

miRNA

Number of RNA Genes sources:

5 / 14

Aliases for MIR28 Gene

  • MicroRNA 28 2 3 5
  • Hsa-MiR-28-5p 166 177
  • Hsa-MiR-28-3p 166 177
  • MIMAT0000085 51
  • MIMAT0004502 51
  • Hsa-Mir-28 3
  • MI0000086 51
  • RF00655 172
  • MiR-28 3
  • MIRN28 3
  • MIR28 2

External Ids for MIR28 Gene

Previous HGNC Symbols for MIR28 Gene

  • MIRN28

Previous GeneCards Identifiers for MIR28 Gene

  • GC03P189891
  • GC03P188406

Summaries for MIR28 Gene

Entrez Gene Summary for MIR28 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR28 Gene

MIR28 (MicroRNA 28) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR28 include Kidney Cancer and Glioma. Among its related pathways are MicroRNAs in cancer.

Rfam classification for MIR28 Gene

Additional gene information for MIR28 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR28 Gene

Genomics for MIR28 Gene

GeneHancer (GH) Regulatory Elements for MIR28 Gene

Promoters and enhancers for MIR28 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J188583 Promoter/Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10.2 -104.1 -104086 2.4 JUND FOS CTCF FOSL2 CEBPB ZNF205 SPI1 NR2F2 NFE2 ZFHX2 MIR28 lnc-BCL6-10 piR-38580-217 LPP
GH03J188788 Enhancer 1.2 FANTOM5 Ensembl ENCODE 10.2 +104.6 104620 13.6 JUND FOS CTCF CREB1 SMC3 RAD21 SPI1 USF1 EZH2 ZNF513 HSALNG0031474 MIR28 LPP piR-55641-002
GH03J188279 Enhancer 1.2 Ensembl ENCODE dbSUPER 9.9 -405.2 -405180 10.4 EP300 CTCF NCOR1 JUND FOS ZIC2 REST RFX1 SKI TEAD1 BCL6 LPP MIR28 hsa-miR-5095-361 lnc-BCL6-9
GH03J188210 Promoter/Enhancer 1.2 Ensembl ENCODE dbSUPER 9.4 -472.7 -472702 11.6 REST ATF2 CREB1 ZBTB17 NR3C1 POLR2A SPI1 RXRA SMARCA4 TFAP4 ENSG00000234238 LPP BCL6 MIR28 RF00994-713 piR-38580-216
GH03J188606 Enhancer 1 FANTOM5 Ensembl ENCODE dbSUPER 10.6 -82.6 -82580 4.4 SPI1 CHD4 KDM1A ZNF280D GATA1 MIR28 lnc-BCL6-10 piR-38580-217 LPP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR28 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR28 Gene

Genomic Locations for MIR28 Gene
chr3:188,688,781-188,688,866
(GRCh38/hg38)
Size:
86 bases
Orientation:
Plus strand
chr3:188,406,569-188,406,654
(GRCh37/hg19)
Size:
86 bases
Orientation:
Plus strand

Genomic View for MIR28 Gene

Genes around MIR28 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR28 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR28 Gene

Proteins for MIR28 Gene

Post-translational modifications for MIR28 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR28 Gene

Domains & Families for MIR28 Gene

Gene Families for MIR28 Gene

genes like me logo Genes that share domains with MIR28: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR28 Gene

Function for MIR28 Gene

Phenotypes From GWAS Catalog for MIR28 Gene

Gene Ontology (GO) - Molecular Function for MIR28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 20190813
genes like me logo Genes that share ontologies with MIR28: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR28 Gene

Localization for MIR28 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR28 gene
Compartment Confidence
extracellular 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MIR28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR28: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR28 Gene

Pathways & Interactions for MIR28 Gene

PathCards logo

SuperPathways for MIR28 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR28: view

Pathways by source for MIR28 Gene

1 KEGG pathway for MIR28 Gene
;

Gene Ontology (GO) - Biological Process for MIR28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035278 miRNA mediated inhibition of translation IDA 20190813
genes like me logo Genes that share ontologies with MIR28: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR28 Gene

Drugs & Compounds for MIR28 Gene

No Compound Related Data Available

Transcripts for MIR28 Gene

mRNA/cDNA for MIR28 Gene

4 RNACentral transcripts :
1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
3 miRBase transcripts :
7 ENA transcripts :
2 LncBase transcripts :
1 Rfam transcripts :
2 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR28 Gene

No ASD Table

Relevant External Links for MIR28 Gene

GeneLoc Exon Structure for
MIR28

Expression for MIR28 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR28 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR28

genes like me logo Genes that share expression patterns with MIR28: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR28 Gene

Orthologs for MIR28 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR28 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-28 31
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-28 31
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-28 31
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir28 31
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 68 (a)
ManyToMany
-- 31
  • 66 (a)
ManyToMany
-- 31
  • 63 (a)
ManyToMany
-- 31
  • 62 (a)
ManyToMany
-- 31
  • 59 (a)
ManyToMany
-- 31
  • 51 (a)
ManyToMany
Species where no ortholog for MIR28 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR28 Gene

ENSEMBL:
Gene Tree for MIR28 (if available)
TreeFam:
Gene Tree for MIR28 (if available)

Paralogs for MIR28 Gene

No data available for Paralogs for MIR28 Gene

Variants for MIR28 Gene

Additional dbSNP identifiers (rs#s) for MIR28 Gene

Additional Variant Information for MIR28 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR28

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR28 Gene

Disorders for MIR28 Gene

MalaCards: The human disease database

(43) MalaCards diseases for MIR28 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
kidney cancer
  • renal cell carcinoma
glioma
melanoma
  • malignant melanoma
myeloproliferative neoplasm
  • campomelic dysplasia
glucose metabolism disease
  • disorder of glucose metabolism
- elite association - COSMIC cancer census association via MalaCards
Search MIR28 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MIR28

genes like me logo Genes that share disorders with MIR28: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR28 Gene

Publications for MIR28 Gene

  1. Decreased levels of miR-28-5p and miR-361-3p and increased levels of insulin-like growth factor 1 mRNA in mononuclear cells from patients with hereditary hemorrhagic telangiectasia 1. (PMID: 30512964) Cannavicci A … Kutryk MJB (Canadian journal of physiology and pharmacology 2019) 3 54
  2. Platelet miR-28 expression level and thrombocytosis in MPN patients. (PMID: 30480878) Stolyar MA … Olkhovskiy IA (International journal of laboratory hematology 2019) 3 54
  3. [Expression Analysis and Epigenetics of MicroRNA-28-5p in Multiple Myeloma]. (PMID: 31607309) Gao YN … Ma YP (Zhongguo shi yan xue ye xue za zhi 2019) 3 54
  4. Epigenetic silencing of LPP/miR-28 in multiple myeloma. (PMID: 28775176) Li Z … Chim CS (Journal of clinical pathology 2018) 3 54
  5. Triose-phosphate isomerase is a novel target of miR-22 and miR-28, with implications in tumorigenesis. (PMID: 29856481) Lone SN … Ul Hussain M (Journal of cellular physiology 2018) 3 54

Products for MIR28 Gene

Sources for MIR28 Gene