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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR28 (MicroRNA 28) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR28 include Kidney Cancer and Melanoma. Among its related pathways are MicroRNAs in cancer.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003730 | mRNA 3'-UTR binding | IDA | 26754294 |
GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 20190813 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | IDA | 26646931 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | MicroRNAs in cancer |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0035195 | gene silencing by miRNA | IDA, IEA | -- |
GO:0035278 | miRNA mediated inhibition of translation | IDA | 20190813 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000048B329_9606 | precursor_RNA | 86 | 6 |
HGNC: 31615, RefSeq: NR_029502, Ensembl: ENST00000384918 (view in UCSC) , miRBase: MI0000086, Rfam: RF00655, |
URS00001799A3_9606 | miRNA | 22 | 6 |
RefSeq: NR_029502, LncBase: hsa-miR-28-3p, miRBase: MIMAT0004502, MirGeneDB: Hsa-Mir-28-P1_3p, TarBase: hsa-miR-28-3p, |
URS00003E47B1_9606 | miRNA | 22 | 6 |
RefSeq: NR_029502, LncBase: hsa-miR-28-5p, miRBase: MIMAT0000085, MirGeneDB: Hsa-Mir-28-P1_5p, TarBase: hsa-miR-28-5p, ENA: AJ421750.1:1..22:misc_RNA, LM378772.1:1..22:ncRNA, LM608175.1:14..35:ncRNA, |
URS0000EFC259_9606 | precursor_RNA | 63 | 1 |
MirGeneDB: Hsa-Mir-28-P1, |
URS0000CAD556_9606 | miRNA | 20 | 1 |
ENA: MF281433.1:1..20:ncRNA, |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-28 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | cfa-mir-28 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | bta-mir-28 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Mir28 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany |
Disorder | Aliases | PubMed IDs |
---|---|---|
kidney cancer |
|
|
melanoma |
|
|
glioma |
|
|
t-cell adult acute lymphocytic leukemia |
|
|
myeloproliferative neoplasm |
|
|