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MIR28 Gene(RNA Gene)

MicroRNA 28

GCID:
GC03P188688
GIFtS:
17
Genes Participants
UDN Logo

Aliases for MIR28 Gene

Subcategory (RNA class) for MIR28 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR28 Gene

  • MicroRNA 28 2 3 5
  • Hsa-Mir-28 3
  • MiR-28 3
  • MIRN28 3

External Ids for MIR28 Gene

Previous HGNC Symbols for MIR28 Gene

  • MIRN28

Previous GeneCards Identifiers for MIR28 Gene

  • GC03P189891
  • GC03P188406

Summaries for MIR28 Gene

Entrez Gene Summary for MIR28 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR28 Gene

MIR28 (MicroRNA 28) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

Additional gene information for MIR28 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR28 Gene

Genomics for MIR28 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for MIR28 Gene

Promoters and enhancers for MIR28 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH03I188686 Enhancer 1.2 FANTOM5 Ensembl ENCODE 550.8 -0.9 -869 3.4 CTCF FOXA2 TAF1 MAX RAD21 YY1 HNF4G RXRA CEBPB REST MIR28 LPP-AS1 LPP
GH03I188583 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 10.2 -104.1 -104145 2.5 CTCF RAD21 ZFHX2 GATA3 NFE2 FOSL2 FOS HOMEZ NFE2L2 RXRA MIR28 LPP-AS1 LPP
GH03I188578 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 10.1 -109.9 -109927 1.6 POLR2A MAX HNF4A FOS REST RAD21 PRDM1 NR2F2 MIR28 LPP-AS1 LPP
GH03I188281 Enhancer 1.2 Ensembl ENCODE dbSUPER 9.9 -404.0 -404003 5.8 ELF3 PKNOX1 FOXA2 NFIB ARID4B FEZF1 RAD21 RARA YY1 ZNF121 BCL6 BCL6-AS1 LPP MIR28 FLJ42393 LPP-AS1
GH03I188788 Enhancer 1.1 FANTOM5 Ensembl ENCODE 9.6 +100.1 100147 1.6 JUN HLF ZNF133 FEZF1 CEBPG ATF2 ZNF335 JUND ZNF692 CEBPA MIR28 GC03P188886 LPP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR28 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR28 Gene

Genomic Locations for MIR28 Gene
chr3:188,688,781-188,688,866
(GRCh38/hg38)
Size:
86 bases
Orientation:
Plus strand
chr3:188,406,569-188,406,654
(GRCh37/hg19)

Genomic View for MIR28 Gene

Genes around MIR28 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR28 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR28 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR28 Gene

Proteins for MIR28 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIR28 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR28 Gene

Domains & Families for MIR28 Gene

Gene Families for MIR28 Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR28: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR28 Gene

Function for MIR28 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Phenotypes From GWAS Catalog for MIR28 Gene

Gene Ontology (GO) - Molecular Function for MIR28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 20190813
genes like me logo Genes that share ontologies with MIR28: view

Animal Model Products

Clone Products

  • Addgene plasmids for MIR28

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR28 Gene

Localization for MIR28 Gene

Gene Ontology (GO) - Cellular Components for MIR28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR28: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR28 Gene

Pathways & Interactions for MIR28 Gene

SuperPathways for MIR28 Gene

PathCards logo More details on SuperPathways for MIR28
SuperPathway Contained pathways
1 MicroRNAs in cancer
MicroRNAs in cancer
-
genes like me logo Genes that share pathways with MIR28: view

Pathways by source for MIR28 Gene

1 KEGG pathway for MIR28 Gene

Interacting Proteins for MIR28 Gene

Gene Ontology (GO) - Biological Process for MIR28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035278 miRNA mediated inhibition of translation IDA 20190813
genes like me logo Genes that share ontologies with MIR28: view

No data available for SIGNOR curated interactions for MIR28 Gene

Drugs & Compounds for MIR28 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIR28 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MIR28 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

  • Addgene plasmids for MIR28

Alternative Splicing Database (ASD) splice patterns (SP) for MIR28 Gene

No ASD Table

Relevant External Links for MIR28 Gene

GeneLoc Exon Structure for
MIR28
ECgene alternative splicing isoforms for
MIR28

Expression for MIR28 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR28 Gene

mRNA expression in normal human tissues for MIR28 Gene
mRNA expression by GTEx for MIR28 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR28 Gene:

MIR28
genes like me logo Genes that share expression patterns with MIR28: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR28 Gene

Orthologs for MIR28 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR28 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ptr-mir-28 34
  • 100 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia cfa-mir-28 34
  • 99 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia bta-mir-28 34
  • 98 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Mir28 34
  • 92 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia -- 34
  • 71 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 34
  • 68 (a)
 ManyToMany
-- 34
  • 66 (a)
 ManyToMany
-- 34
  • 63 (a)
 ManyToMany
-- 34
  • 62 (a)
 ManyToMany
-- 34
  • 59 (a)
 ManyToMany
-- 34
  • 51 (a)
 ManyToMany
Species where no ortholog for MIR28 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR28 Gene

ENSEMBL:
Gene Tree for MIR28 (if available)
TreeFam:
Gene Tree for MIR28 (if available)

Paralogs for MIR28 Gene

No data available for Paralogs for MIR28 Gene

Variants for MIR28 Gene

Sequence variations from dbSNP and Humsavar for MIR28 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1001463218 -- 188,688,632(+) G/A upstream_transcript_variant
rs1001606079 -- 188,687,270(+) G/A upstream_transcript_variant
rs1002266526 -- 188,688,699(+) C/G/T upstream_transcript_variant
rs1004975323 -- 188,686,966(+) A/G upstream_transcript_variant
rs1007818344 -- 188,687,947(+) T/C upstream_transcript_variant

Additional Variant Information for MIR28 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR28

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR28 Gene

Disorders for MIR28 Gene

Additional Disease Information for MIR28

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MIR28 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR28 Gene

Publications for MIR28 Gene

  1. Posttranscriptional Interaction Between miR-450a-5p and miR-28-5p and STAT1 mRNA Triggers Osteoblastic Differentiation of Human Mesenchymal Stem Cells. (PMID: 28407302) Dernowsek JA … Passos GA (Journal of cellular biochemistry 2017) 3 58
  2. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3 58
  3. MiR-28-3p as a potential plasma marker in diagnosis of pulmonary embolism. (PMID: 26702486) Zhou X … Chen Y (Thrombosis research 2016) 3 58
  4. MicroRNA 28-5p regulates ATP-binding cassette transporter A1 via inhibiting extracellular signal-regulated kinase 2. (PMID: 26718613) Liu J … Zhou YT (Molecular medicine reports 2016) 3 58
  5. miR-28-5p-IL-34-macrophage feedback loop modulates hepatocellular carcinoma metastasis. (PMID: 26754294) Zhou SL … Zhou J (Hepatology (Baltimore, Md.) 2016) 3 58

Products for MIR28 Gene

  • Addgene plasmids for MIR28

Sources for MIR28 Gene

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