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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR27B (MicroRNA 27b) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR27B include Non-Alcoholic Fatty Liver Disease and Oral Squamous Cell Carcinoma. Among its related pathways are MicroRNAs in cardiomyocyte hypertrophy and MicroRNAs in cancer.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH09J095084 | Enhancer | 0.8 | Ensembl ENCODE dbSUPER | 600.7 | -0.1 | -123 | 3 | HNRNPL ESR1 RBM22 CTCF POLR2A | MIR23B MIR24-1 MIR27B MIR3074 lnc-MFSD14B-20 NONHSAG052915.2 AOPEP FANCC | |
GH09J095016 | Promoter/Enhancer | 1.5 | Ensembl ENCODE dbSUPER | 12.2 | -63.6 | -63598 | 10.7 | GATAD2A PRDM10 ZNF629 TFE3 IKZF1 CTCF RCOR2 ZNF7 FOXA1 PRDM1 | MIR23B MIR27B MIR3074 AOPEP lnc-MFSD14B-18 lnc-MFSD14B-7 NONHSAG052915.2 FANCC | |
GH09J095060 | Enhancer | 1.2 | Ensembl ENCODE dbSUPER | 13.7 | -21.3 | -21349 | 6.2 | GATAD2A TFE3 RXRB IRF2 SP1 GABPA TOE1 CEBPA FOXK2 SOX13 | MIR6081 MIR23B MIR27B MIR3074 AOPEP piR-43107-304 NONHSAG052915.2 FANCC | |
GH09J095053 | Promoter/Enhancer | 1.2 | Ensembl ENCODE dbSUPER | 12.6 | -28.6 | -28573 | 6.2 | PRDM10 ZNF629 FOXA1 ZIC2 POLR2A ZBTB44 SP1 TCF7L2 CEBPB OSR2 | MIR23B MIR27B MIR3074 MIR6081 piR-43107-304 NONHSAG052915.2 AOPEP FANCC |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IGI | 21536891 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | HDA | 26646931 |
GO:0070062 | extracellular exosome | IDA | 28159509 |
GO:1903561 | extracellular vesicle | HDA | 28798470 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | MicroRNAs in cancer | ||
2 | MicroRNAs in cardiomyocyte hypertrophy | ||
3 | miRNAs involved in DNA damage response |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0010628 | positive regulation of gene expression | IDA | 26520906 |
GO:0010629 | negative regulation of gene expression | IDA | 24608080 |
GO:0010804 | negative regulation of tumor necrosis factor-mediated signaling pathway | IGI | 31124343 |
GO:0010872 | regulation of cholesterol esterification | IDA | 24608080 |
GO:0010989 | negative regulation of low-density lipoprotein particle clearance | IDA | 26520906 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000059311D_9606 | miRNA | 21 | 6 |
RefSeq: NR_029665, LncBase: hsa-miR-27b-3p, miRBase: MIMAT0000419, MirGeneDB: Hsa-Mir-27-P2_3p, TarBase: hsa-miR-27b-3p, |
URS000075B0A5_9606 | precursor_RNA | 97 | 5 |
HGNC: 31614, RefSeq: NR_029665, Ensembl: ENST00000385129 (view in UCSC) , miRBase: MI0000440, |
URS0000330617_9606 | miRNA | 22 | 5 |
RefSeq: NR_029665, LncBase: hsa-miR-27b-5p, miRBase: MIMAT0004588, TarBase: hsa-miR-27b-5p, |
URS0000695404_9606 | precursor_RNA | 83 | 1 |
Rfam: RF00644, |
URS0000EFEEBA_9606 | precursor_RNA | 64 | 1 |
MirGeneDB: Hsa-Mir-27-P2, |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-27b 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Mir27b 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | cfa-mir-27b 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | bta-mir-27b 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | mdo-mir-27b 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | oan-mir-27b 31 |
|
OneToMany | |
Chicken (Gallus gallus) |
Aves | gga-mir-27b 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | aca-mir-27b 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | dre-mir-27b 31 |
|
OneToOne |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1038106 | CNV | gain | 25217958 |
nsv1147999 | OTHER | inversion | 26484159 |
nsv831656 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
non-alcoholic fatty liver disease |
|
|
oral squamous cell carcinoma |
|
|
body mass index quantitative trait locus 11 |
|
|
leukemia, acute lymphoblastic |
|
|
leukemia, acute myeloid |
|