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MIR27B Gene(RNA Gene)

MicroRNA 27b

GCID:
GC09P095098
GIFtS:
20
Genes Participants
UDN Logo

Aliases for MIR27B Gene

Subcategory (RNA class) for MIR27B Gene

miRNA

Quality Score for this RNA gene is

13

Aliases for MIR27B Gene

  • MicroRNA 27b 2 3 5
  • Hsa-Mir-27b 3
  • MiRNA27B 3
  • MIR-27b 3
  • MIRN27B 3

External Ids for MIR27B Gene

ORGUL Members for MIR27B Gene

Previous HGNC Symbols for MIR27B Gene

  • MIRN27B

Previous GeneCards Identifiers for MIR27B Gene

  • GC09P096891
  • GC09P097848
  • GC09P097850
  • GC09P097858
  • GC09P097866
  • GC09P095088
  • GC09P095089
  • GC09P095091
  • GC09P095092
  • GC09P095093
  • GC09P095094
  • GC09P095095
  • GC09P095097

Summaries for MIR27B Gene

Entrez Gene Summary for MIR27B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR27B Gene

MIR27B (MicroRNA 27b) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR27B include Nonalcoholic Fatty Liver Disease and Body Mass Index Quantitative Trait Locus 11. Among its related pathways are MicroRNAs in cancer and MicroRNAs in cardiomyocyte hypertrophy.

Additional gene information for MIR27B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR27B Gene

Genomics for MIR27B Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for MIR27B Gene

Promoters and enhancers for MIR27B Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH09J095084 Enhancer 0.4 ENCODE dbSUPER 650.7 +0.4 384 2 GC09P095099 GC09P095100 GC09P095102 GC09P095103 GC09P095104 MIR23B MIR24-1 MIR27B MIR3074 C9orf3
GH09J095016 Enhancer 1.4 Ensembl ENCODE dbSUPER 12.2 -63.6 -63598 10.7 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 YY1 FOS NFYC REST KAT8 MIR23B MIR27B MIR3074 C9orf3 MIR6081 LOC101928119
GH09J095053 Enhancer 1.1 Ensembl ENCODE dbSUPER 12.6 -28.6 -28573 6.2 JUN MAX FEZF1 ZIC2 HIC1 ZNF335 ZFHX2 ZNF213 POLR2A PRDM10 MIR23B MIR27B MIR3074 MIR6081 LOC101928119 C9orf3
GH09J095060 Enhancer 1 ENCODE dbSUPER 13.7 -21.5 -21478 6 FOXA2 ARID4B RAD21 RARA YY1 EGR1 CREM THAP11 RXRA SP5 MIR6081 MIR23B MIR27B MIR3074 C9orf3 LOC101928119
GH09J095106 Enhancer 0.6 ENCODE dbSUPER 12.7 +22.2 22175 2.3 ZNF316 MAFK PIR48893 MIR23B MIR27B MIR3074 PIR51992 FANCC C9orf3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR27B on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR27B Gene

Genomic Locations for MIR27B Gene
chr9:95,085,445-95,085,541
(GRCh38/hg38)
Size:
97 bases
Orientation:
Plus strand
chr9:97,847,727-97,847,823
(GRCh37/hg19)

Genomic View for MIR27B Gene

Genes around MIR27B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR27B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR27B Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR27B Gene

Proteins for MIR27B Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIR27B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR27B Gene

Domains & Families for MIR27B Gene

Gene Families for MIR27B Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR27B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR27B Gene

Function for MIR27B Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Gene Ontology (GO) - Molecular Function for MIR27B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 22184411
genes like me logo Genes that share ontologies with MIR27B: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR27B Gene

Localization for MIR27B Gene

Gene Ontology (GO) - Cellular Components for MIR27B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
GO:0070062 extracellular exosome IDA 28159509
genes like me logo Genes that share ontologies with MIR27B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR27B Gene

Pathways & Interactions for MIR27B Gene

genes like me logo Genes that share pathways with MIR27B: view

Pathways by source for MIR27B Gene

1 KEGG pathway for MIR27B Gene

Interacting Proteins for MIR27B Gene

Gene Ontology (GO) - Biological Process for MIR27B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010989 negative regulation of low-density lipoprotein particle clearance IDA 26520906
GO:0035195 gene silencing by miRNA IDA 24177325
GO:0035278 miRNA mediated inhibition of translation IDA 22184411
GO:0035924 cellular response to vascular endothelial growth factor stimulus IDA 22184411
GO:0042632 cholesterol homeostasis IDA 26520906
genes like me logo Genes that share ontologies with MIR27B: view

No data available for SIGNOR curated interactions for MIR27B Gene

Drugs & Compounds for MIR27B Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIR27B Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MIR27B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(3) RNA Central transcripts :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR27B Gene

No ASD Table

Relevant External Links for MIR27B Gene

GeneLoc Exon Structure for
MIR27B
ECgene alternative splicing isoforms for
MIR27B

Expression for MIR27B Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR27B Gene

mRNA expression in normal human tissues for MIR27B Gene
mRNA expression by GTEx for MIR27B Gene

mRNA differential expression in normal tissues according to GTEx for MIR27B Gene

This gene is overexpressed in Artery - Coronary (x5.0), Artery - Aorta (x4.4), and Skin - Not Sun Exposed (Suprapubic) (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of MIR27B Gene:

MIR27B
genes like me logo Genes that share expression patterns with MIR27B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR27B Gene

Orthologs for MIR27B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR27B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ptr-mir-27b 34
  • 100 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Mir27b 34
  • 100 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia cfa-mir-27b 34
  • 99 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia bta-mir-27b 34
  • 97 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia mdo-mir-27b 34
  • 93 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia oan-mir-27b 34
  • 69 (a)
 OneToMany
chicken
(Gallus gallus)
 Aves gga-mir-27b 34
  • 93 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia aca-mir-27b 34
  • 92 (a)
 OneToOne
zebrafish
(Danio rerio)
 Actinopterygii dre-mir-27b 34
  • 85 (a)
 OneToOne
Species where no ortholog for MIR27B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR27B Gene

ENSEMBL:
Gene Tree for MIR27B (if available)
TreeFam:
Gene Tree for MIR27B (if available)

Paralogs for MIR27B Gene

No data available for Paralogs for MIR27B Gene

Variants for MIR27B Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for MIR27B Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1001095373 -- 95,084,453(+) G/A upstream_transcript_variant
rs1001546394 -- 95,084,261(+) C/A upstream_transcript_variant
rs1002272038 -- 95,084,790(+) A/G upstream_transcript_variant
rs1002624887 -- 95,085,142(+) C/T upstream_transcript_variant
rs1003368832 -- 95,083,475(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR27B Gene

Variant ID Type Subtype PubMed ID
nsv1038106 CNV gain 25217958
nsv1147999 OTHER inversion 26484159
nsv831656 CNV loss 17160897

Additional Variant Information for MIR27B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR27B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR27B Gene

Disorders for MIR27B Gene

MalaCards: The human disease database

(8) MalaCards diseases for MIR27B Gene - From: miR2Disease and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR27B

Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR27B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR27B Gene

Publications for MIR27B Gene

  1. Overexpression of MicroRNA-27b Inhibits Proliferation, Migration, and Invasion via Suppression of MET Expression. (PMID: 28081743) Zhou H … Xia K (Oncology research 2017) 3 58
  2. Long Noncoding RNA CIR Promotes Chondrocyte Extracellular Matrix Degradation in Osteoarthritis by Acting as a Sponge For Mir-27b. (PMID: 28934732) Li YF … Luo YT (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017) 3 58
  3. miR-27b inhibits gastric cancer metastasis by targeting NR2F2. (PMID: 27844448) Feng Q … Guan W (Protein & cell 2017) 3 58
  4. Are pulmonary fibrosis and Alzheimer's disease linked? Shared dysregulation of two miRNA species and downstream pathways accompany both disorders. (PMID: 29222197) Lahiri DK … Greig NH (The Journal of biological chemistry 2017) 3 58
  5. MicroRNA miR-27 Inhibits Adenovirus Infection by Suppressing the Expression of SNAP25 and TXN2. (PMID: 28356525) Machitani M … Mizuguchi H (Journal of virology 2017) 3 58

Products for MIR27B Gene

Sources for MIR27B Gene

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