microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR27B Gene

Subcategory (RNA class) for MIR27B Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR27B Gene

  • MicroRNA 27b 2 3 5
  • Hsa-MiR-27b-5p 163 173
  • Hsa-MiR-27b-3p 163 173
  • Hsa-Mir-27b 2 3
  • MIR-27b 2 3
  • MIR27B 2 5
  • Hsa-Mir-27-P2 178
  • MIMAT0000419 50
  • MIMAT0004588 50
  • MI0000440 50
  • MiRNA27B 3
  • MIRN27B 3
  • RF00644 168

External Ids for MIR27B Gene

Previous HGNC Symbols for MIR27B Gene

  • MIRN27B

Previous GeneCards Identifiers for MIR27B Gene

  • GC09P096891
  • GC09P097848
  • GC09P097850
  • GC09P097858
  • GC09P097866
  • GC09P095088
  • GC09P095089
  • GC09P095100
  • GC09P095102
  • GC09P095099
  • GC09P095098
  • GC09P095091
  • GC09P095092
  • GC09P095093
  • GC09P095094
  • GC09P095095

Summaries for MIR27B Gene

Entrez Gene Summary for MIR27B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR27B Gene

MIR27B (MicroRNA 27b) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR27B include Non-Alcoholic Fatty Liver Disease and Oral Squamous Cell Carcinoma. Among its related pathways are MicroRNAs in cardiomyocyte hypertrophy and MicroRNAs in cancer.

Rfam classification for MIR27B Gene

Additional gene information for MIR27B Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR27B Gene

Genomics for MIR27B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR27B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J095084 Enhancer 0.8 Ensembl ENCODE dbSUPER 600.7 -0.1 -123 3 HNRNPL ESR1 RBM22 CTCF POLR2A MIR23B MIR24-1 MIR27B MIR3074 lnc-MFSD14B-20 NONHSAG052915.2 AOPEP FANCC
GH09J095016 Promoter/Enhancer 1.5 Ensembl ENCODE dbSUPER 12.2 -63.6 -63598 10.7 GATAD2A PRDM10 ZNF629 TFE3 IKZF1 CTCF RCOR2 ZNF7 FOXA1 PRDM1 MIR23B MIR27B MIR3074 AOPEP lnc-MFSD14B-18 lnc-MFSD14B-7 NONHSAG052915.2 FANCC
GH09J095060 Enhancer 1.2 Ensembl ENCODE dbSUPER 13.7 -21.3 -21349 6.2 GATAD2A TFE3 RXRB IRF2 SP1 GABPA TOE1 CEBPA FOXK2 SOX13 MIR6081 MIR23B MIR27B MIR3074 AOPEP piR-43107-304 NONHSAG052915.2 FANCC
GH09J095053 Promoter/Enhancer 1.2 Ensembl ENCODE dbSUPER 12.6 -28.6 -28573 6.2 PRDM10 ZNF629 FOXA1 ZIC2 POLR2A ZBTB44 SP1 TCF7L2 CEBPB OSR2 MIR23B MIR27B MIR3074 MIR6081 piR-43107-304 NONHSAG052915.2 AOPEP FANCC
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR27B on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR27B Gene

Genomic Locations for MIR27B Gene
chr9:95,085,445-95,085,541
(GRCh38/hg38)
Size:
97 bases
Orientation:
Plus strand
chr9:97,847,727-97,847,823
(GRCh37/hg19)
Size:
97 bases
Orientation:
Plus strand

Genomic View for MIR27B Gene

Genes around MIR27B on UCSC Golden Path with GeneCards custom track
MIR27B in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR27B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR27B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR27B Gene

Proteins for MIR27B Gene

Post-translational modifications for MIR27B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR27B Gene

Domains & Families for MIR27B Gene

Gene Families for MIR27B Gene

genes like me logo Genes that share domains with MIR27B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR27B Gene

Function for MIR27B Gene

Gene Ontology (GO) - Molecular Function for MIR27B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IGI 21536891
genes like me logo Genes that share ontologies with MIR27B: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR27B Gene

Localization for MIR27B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR27B gene
Compartment Confidence
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 2
cytosol 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MIR27B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
GO:0070062 extracellular exosome IDA 28159509
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIR27B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR27B Gene

Pathways & Interactions for MIR27B Gene

genes like me logo Genes that share pathways with MIR27B: view

Pathways by source for MIR27B Gene

1 KEGG pathway for MIR27B Gene

Gene Ontology (GO) - Biological Process for MIR27B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010628 positive regulation of gene expression IDA 26520906
GO:0010629 negative regulation of gene expression IDA 24608080
GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway IGI 31124343
GO:0010872 regulation of cholesterol esterification IDA 24608080
GO:0010989 negative regulation of low-density lipoprotein particle clearance IDA 26520906
genes like me logo Genes that share ontologies with MIR27B: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR27B Gene

Drugs & Compounds for MIR27B Gene

No Compound Related Data Available

Transcripts for MIR27B Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR27B Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000059311D_9606 miRNA 21 6

RefSeq: NR_029665,

LncBase: hsa-miR-27b-3p,

miRBase: MIMAT0000419,

MirGeneDB: Hsa-Mir-27-P2_3p,

TarBase: hsa-miR-27b-3p,

ENA: LM379037.1:1..21:ncRNA, LM608480.1:61..81:ncRNA,

URS000075B0A5_9606 precursor_RNA 97 5

HGNC: 31614,

RefSeq: NR_029665,

Ensembl: ENST00000385129 (view in UCSC) ,

miRBase: MI0000440,

ENA: LM608480.1:1..97:precursor_RNA,

URS0000330617_9606 miRNA 22 5

RefSeq: NR_029665,

LncBase: hsa-miR-27b-5p,

miRBase: MIMAT0004588,

TarBase: hsa-miR-27b-5p,

ENA: LM380266.1:1..22:ncRNA, LM608480.1:19..40:ncRNA,

URS0000695404_9606 precursor_RNA 83 1

Rfam: RF00644,

URS0000EFEEBA_9606 precursor_RNA 64 1

MirGeneDB: Hsa-Mir-27-P2,

MIR27B in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR27B Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR27B Gene

No ASD Table

Relevant External Links for MIR27B Gene

GeneLoc Exon Structure for
MIR27B

Expression for MIR27B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR27B Gene

mRNA differential expression in normal tissues according to GTEx for MIR27B Gene

This gene is overexpressed in Artery - Coronary (x5.0), Artery - Aorta (x4.4), and Skin - Not Sun Exposed (Suprapubic) (x4.3).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR27B

Evidence on tissue expression from TISSUES for MIR27B Gene

  • Blood(2.2)
  • Liver(2.1)
  • Heart(2.1)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with MIR27B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR27B Gene

Orthologs for MIR27B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR27B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-27b 31
  • 100 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir27b 31
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-27b 31
  • 99 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-27b 31
  • 97 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-27b 31
  • 93 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-27b 31
  • 69 (a)
OneToMany
Chicken
(Gallus gallus)
Aves gga-mir-27b 31
  • 93 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-27b 31
  • 92 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-27b 31
  • 85 (a)
OneToOne
Species where no ortholog for MIR27B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR27B Gene

ENSEMBL:
Gene Tree for MIR27B (if available)
TreeFam:
Gene Tree for MIR27B (if available)

Paralogs for MIR27B Gene

No data available for Paralogs for MIR27B Gene

Variants for MIR27B Gene

Additional dbSNP identifiers (rs#s) for MIR27B Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR27B Gene

Variant ID Type Subtype PubMed ID
nsv1038106 CNV gain 25217958
nsv1147999 OTHER inversion 26484159
nsv831656 CNV loss 17160897

Additional Variant Information for MIR27B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR27B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR27B Gene

Disorders for MIR27B Gene

MalaCards: The human disease database

(30) MalaCards diseases for MIR27B Gene - From: miR2Disease, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR27B

genes like me logo Genes that share disorders with MIR27B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR27B Gene

Publications for MIR27B Gene

  1. Effects of plasma concentration of micro-RNA Mir-27b and CYP3A4*22 on equilibrium concentration of alprazolam in patients with anxiety disorders comorbid with alcohol use disorder. (PMID: 32112986) Zastrozhin MS … Sychev DA (Gene 2020) 3
  2. miR-27b-mediated suppression of aquaporin-11 expression in hepatocytes reduces HCV genomic RNA levels but not viral titers. (PMID: 31046802) Sakurai F … Mizuguchi H (Virology journal 2019) 3
  3. Downregulation of microRNA-27b-3p via aberrant DNA methylation contributes to malignant behavior of gastric cancer cells by targeting GSPT1. (PMID: 31539861) Zhang C … Dai DQ (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019) 3
  4. MicroRNA-27b-3p inhibits apoptosis of chondrocyte in rheumatoid arthritis by targeting HIPK2. (PMID: 31066587) Zhou Y … Xia D (Artificial cells, nanomedicine, and biotechnology 2019) 3
  5. LINC00520 targeting miR-27b-3p regulates OSMR expression level to promote acute kidney injury development through the PI3K/AKT signaling pathway. (PMID: 30684280) Tian X … Wang C (Journal of cellular physiology 2019) 3

Products for MIR27B Gene

Sources for MIR27B Gene