Aliases for MIR27B Gene
Subcategory (RNA class) for MIR27B Gene
miRNA
Quality Score for this RNA gene is
3
External Ids for MIR27B Gene
- HGNC: 31614
- Entrez Gene: 407019
- Ensembl: ENSG00000207864
- OMIM: 610636
- miRBase: hsa-mir-27b
Previous HGNC Symbols for MIR27B Gene
- MIRN27B
Previous GeneCards Identifiers for MIR27B Gene
- GC09P096891
- GC09P097848
- GC09P097850
- GC09P097858
- GC09P097866
- GC09P095088
- GC09P095089
- GC09P095091
- GC09P095092
- GC09P095093
- GC09P095094
- GC09P095095
Summaries for MIR27B Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR27B Gene
MIR27B (MicroRNA 27b) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are miRNAs involved in DNA damage response and MicroRNAs in cancer.
Additional gene information for MIR27B Gene
- Monarch Initiative
- Search for MIR27B at DataMed
- Search for MIR27B at HumanCyc
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR27B Gene
Genomics for MIR27B Gene
GeneHancer (GH) Regulatory Elements for MIR27B Gene
Promoters and enhancers for MIR27B Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH09I095084 | Enhancer | 0.4 | ENCODE dbSUPER | 550.8 | +0.4 | 384 | 2 | GC09P095098 GC09P095099 GC09P095100 GC09P095102 GC09P095103 MIR23B MIR24-1 MIR27B MIR3074 C9orf3 | ||
| GH09I095016 | Enhancer | 1.4 | Ensembl ENCODE dbSUPER | 12.2 | -63.6 | -63598 | 10.7 | PKNOX1 ATF1 FOXA2 ARID4B SIN3A DMAP1 ZNF48 YY1 FOS ATF7 | MIR23B MIR27B MIR3074 C9orf3 MIR6081 LOC101928119 | |
| GH09I095053 | Enhancer | 1.1 | Ensembl ENCODE dbSUPER | 12.6 | -28.6 | -28573 | 6.2 | ZNF449 JUN MAX FEZF1 ZIC2 HIC1 ZNF335 ZFHX2 ZNF213 POLR2A | MIR23B MIR27B MIR3074 MIR6081 LOC101928119 C9orf3 | |
| GH09I095060 | Enhancer | 1 | ENCODE dbSUPER | 13.7 | -21.5 | -21478 | 6 | FOXA2 ARID4B RAD21 RARA YY1 CREM THAP11 RXRA SP5 USF2 | MIR6081 MIR23B MIR27B MIR3074 C9orf3 LOC101928119 | |
| GH09I095106 | Enhancer | 0.6 | ENCODE dbSUPER | 12.7 | +22.2 | 22175 | 2.3 | ZNF316 MAFK | PIR48893 MIR23B MIR27B MIR3074 PIR51992 FANCC C9orf3 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around MIR27B on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for MIR27B Gene
Genomic Locations for MIR27B Gene
- chr9:95,085,445-95,085,541
- (GRCh38/hg38)
- Size:
- 97 bases
- Orientation:
- Plus strand
- chr9:97,847,727-97,847,823
- (GRCh37/hg19)
Genomic View for MIR27B Gene
Genes around MIR27B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9q22.32 by Ensembl
- 9q22.32 by Entrez Gene
- 9q22.32 by HGNC
MIR27B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR27B Gene
Proteins for MIR27B Gene
Post-translational modifications for MIR27B Gene
No Post-translational modifications
Antibody Products
- Search GeneTex for Antibodies for MIR27B
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR27B
- Origene Custom Protein Services for MIR27B
- Search GeneTex for Proteins for MIR27B
No data available for DME Specific Peptides for MIR27B Gene
Domains & Families for MIR27B Gene
Gene Families for MIR27B Gene
- HGNC:
Graphical View of Domain Structure for InterPro Entry
No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR27B Gene
Function for MIR27B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 22184411 |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR27B
-
- Search ViGene Biosciences for MIR27B
CRISPR Products
- Browse CRISPR knockouts for MIR27B
- Applied Biological Materials CRISPR for MIR27B
-
Vectors and viruses for KO, Activation, Repression, and more
Inhibitory RNA Products
- Search ViGene Biosciences for MIR27B
Clone Products
- GenScript: Custom all cDNA clones Services for MIR27B
- VectorBuilder custom plasmid, inducible vectors for MIR27B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR27B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MIR27B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR27B Gene
Localization for MIR27B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | IDA | 26646931 |
| GO:0070062 | extracellular exosome | IDA | 28159509 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR27B Gene
Pathways & Interactions for MIR27B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | MicroRNAs in cancer | ||
| 2 | MicroRNAs in cardiomyocyte hypertrophy | ||
| 3 | miRNAs involved in DNA damage response | ||
Pathways by source for MIR27B Gene
2 BioSystems pathways for MIR27B Gene
1 KEGG pathway for MIR27B Gene
Interacting Proteins for MIR27B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0035195 | gene silencing by miRNA | IDA | 26395742 |
| GO:0035278 | miRNA mediated inhibition of translation | IDA | 22184411 |
| GO:0035924 | cellular response to vascular endothelial growth factor stimulus | IDA | 22184411 |
| GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis | IDA | 22184411 |
| GO:1903589 | positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis | IDA | 22184411 |
No data available for SIGNOR curated interactions for MIR27B Gene
Transcripts for MIR27B Gene
mRNA/cDNA for MIR27B Gene
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for MIR27B
- Applied Biological Materials CRISPR for MIR27B
-
Vectors and viruses for KO, Activation, Repression, and more
Inhibitory RNA Products
- Search ViGene Biosciences for MIR27B
Clone Products
- GenScript: Custom all cDNA clones Services for MIR27B
- VectorBuilder custom plasmid, inducible vectors for MIR27B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR27B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MIR27B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for MIR27B Gene
mRNA differential expression in normal tissues according to GTEx for MIR27B Gene
This gene is overexpressed in Artery - Coronary (x5.0), Artery - Aorta (x4.4), and Skin - Not Sun Exposed (Suprapubic) (x4.3).
NURSA nuclear receptor signaling pathways regulating expression of MIR27B Gene:
MIR27BPrimer Products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR27B Gene
Orthologs for MIR27B Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| mouse (Mus musculus) |
Mammalia | Mir27b 34 |
|
OneToOne | |
| chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-27b 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | cfa-mir-27b 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | bta-mir-27b 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | mdo-mir-27b 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | oan-mir-27b 34 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | gga-mir-27b 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | aca-mir-27b 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | dre-mir-27b 34 |
|
OneToOne |
- Species where no ortholog for MIR27B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for MIR27B Gene
No data available for Paralogs for MIR27B Gene
Variants for MIR27B Gene
| SNP ID | Clin | Chr 09 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1001095373 | -- | 95,084,453(+) | G/A | upstream_transcript_variant | |
| rs1001546394 | -- | 95,084,261(+) | C/A | upstream_transcript_variant | |
| rs1002272038 | -- | 95,084,790(+) | A/G | upstream_transcript_variant | |
| rs1002624887 | -- | 95,085,142(+) | C/T | upstream_transcript_variant | |
| rs1003368832 | -- | 95,083,475(+) | C/T | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1038106 | CNV | gain | 25217958 |
| nsv1147999 | OTHER | inversion | 26484159 |
| nsv831656 | CNV | loss | 17160897 |
Additional Variant Information for MIR27B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR27B
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR27B Gene
Disorders for MIR27B Gene
Additional Disease Information for MIR27B
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for MIR27B Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR27B Gene
Publications for MIR27B Gene
- Human Pericardial Fluid Contains Exosomes Enriched with Cardiovascular-Expressed MicroRNAs and Promotes Therapeutic Angiogenesis. (PMID: 28159509) Beltrami C … Emanueli C (Molecular therapy : the journal of the American Society of Gene Therapy 2017) 3 58
- Long Noncoding RNA CIR Promotes Chondrocyte Extracellular Matrix Degradation in Osteoarthritis by Acting as a Sponge For Mir-27b. (PMID: 28934732) Li YF … Luo YT (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017) 3 58
- MicroRNA-27b functions as a new inhibitor of ovarian cancer-mediated vasculogenic mimicry through suppression of VE-cadherin expression. (PMID: 28396577) Liu W … Cao Z (RNA (New York, N.Y.) 2017) 3 58
- MicroRNA miR-27 Inhibits Adenovirus Infection by Suppressing the Expression of SNAP25 and TXN2. (PMID: 28356525) Machitani M … Mizuguchi H (Journal of virology 2017) 3 58
- Promising therapeutic role of miR-27b in tumor. (PMID: 28351320) Ding L … Tang J (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 58
Products for MIR27B Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
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- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
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- Custom Antibody Services
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- Custom Assay Services
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- Browse OriGene qPCR primer pairs and template standards
- Browse CRISPR knockouts for MIR27B
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MIR27B
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- Sino Biological Transfection Reagent
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- Browse Antibodies at Cloud-Clone Corp.
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- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR27B
- VectorBuilder custom plasmid, inducible vectors for MIR27B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR27B
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneTex for Antibodies for MIR27B
- Search GeneTex for Proteins for MIR27B
- Search ViGene Biosciences for MIR27B
Sources for MIR27B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems