Subcategory (RNA class) for MIR27A Gene
Quality Score for this RNA gene is
External Ids for MIR27A Gene
ORGUL Members for MIR27A Gene
Previous HGNC Symbols for MIR27A Gene
Previous GeneCards Identifiers for MIR27A Gene
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR27A Gene
MIR27A (MicroRNA 27a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR27A include Leukemia and Gastric Cancer. Among its related pathways are miRNAs involved in DNA damage response and MicroRNAs in cancer.
fRNAdb sequence ontologies for MIR27A Gene - the ORGUL cluster for this gene includes several descriptions:
miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.
pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.