microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR27A Gene

Subcategory (RNA class) for MIR27A Gene

miRNA

Number of RNA Genes sources:

6 / 14

Aliases for MIR27A Gene

  • MicroRNA 27a 2 3 5
  • Hsa-MiR-27a-3p 166 177
  • Hsa-MiR-27a-5p 166 177
  • MIMAT0004501 51
  • MIMAT0000084 51
  • Hsa-Mir-27a 3
  • MI0000085 51
  • Mir-27a 3
  • MIRN27A 3
  • RF00644 172
  • MIR27A 2
  • 6MFN_C 171
  • MIR27 3

External Ids for MIR27A Gene

Additional External Ids for MIR27A Gene

Previous HGNC Symbols for MIR27A Gene

  • MIRN27A

Previous GeneCards Identifiers for MIR27A Gene

  • GC19M013846
  • GC19M013852
  • GC19M013948
  • GC19M013952
  • GC19M013957
  • GC19M013964
  • GC19M013861
  • GC19M013866
  • GC19M013939
  • GC19M013946
  • GC19M013965
  • GC19M013871
  • GC19M013877
  • GC19M013885
  • GC19M013895
  • GC19M013901
  • GC19M013912
  • GC19M013919
  • GC19M013930

Summaries for MIR27A Gene

Entrez Gene Summary for MIR27A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR27A Gene

MIR27A (MicroRNA 27a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR27A include Leukemia and Gastric Cancer. Among its related pathways are miRNAs involved in DNA damage response and MicroRNAs in cancer.

Rfam classification for MIR27A Gene

Additional gene information for MIR27A Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR27A Gene

Genomics for MIR27A Gene

GeneHancer (GH) Regulatory Elements for MIR27A Gene

Promoters and enhancers for MIR27A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J013793 Promoter/Enhancer 2 Ensembl ENCODE CraniofacialAtlas dbSUPER 12.7 +40.7 40674 5.5 EP300 FOXK2 CTCF ZSCAN5C NRF1 MYC POLR2G USF1 SP1 JUND ENSG00000267582 lnc-C19orf57-8 ZSWIM4 ENSG00000267519 C19orf53 MRI1 MIR23A MIR24-2 MIR27A FARSA
GH19J013787 Enhancer 0.9 ENCODE CraniofacialAtlas 12.6 +47.5 47461 4 RFX1 POLR2A HDAC2 RBM25 NR2F2 CEBPG SPI1 USF1 BCOR GABPA piR-57461-105 C19orf53 MIR23A MIR24-2 MIR27A MRI1 MISP3 lnc-C19orf57-8
GH19J013833 Promoter/Enhancer 2.4 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.4 -8.0 -8045 23.2 EP300 HNRNPK ZBTB40 ZNF217 CTCF ZSCAN5C NRF1 TCF12 ZNF300 POLR2G ENSG00000267519 LOC284454 lnc-ZSWIM4-1 CCDC130 ZNF333 RPS6P25 MRI1 TRMT1 RFX1 DCAF15
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR27A on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR27A Gene

Genomic Locations for MIR27A Gene
chr19:13,836,440-13,836,521
(GRCh38/hg38)
Size:
82 bases
Orientation:
Minus strand
chr19:13,947,254-13,947,331
(GRCh37/hg19)
Size:
78 bases
Orientation:
Minus strand

Genomic View for MIR27A Gene

Genes around MIR27A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR27A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR27A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR27A Gene

Proteins for MIR27A Gene

Post-translational modifications for MIR27A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR27A Gene

Domains & Families for MIR27A Gene

Gene Families for MIR27A Gene

genes like me logo Genes that share domains with MIR27A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR27A Gene

Function for MIR27A Gene

Phenotypes From GWAS Catalog for MIR27A Gene

Gene Ontology (GO) - Molecular Function for MIR27A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044212 transcription regulatory region DNA binding NAS 26318398
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IGI 21536891
genes like me logo Genes that share ontologies with MIR27A: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR27A Gene

Localization for MIR27A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR27A gene
Compartment Confidence
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 2
cytosol 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MIR27A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR27A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR27A Gene

Pathways & Interactions for MIR27A Gene

genes like me logo Genes that share pathways with MIR27A: view

Pathways by source for MIR27A Gene

1 BioSystems pathway for MIR27A Gene
1 KEGG pathway for MIR27A Gene
;

Gene Ontology (GO) - Biological Process for MIR27A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010629 negative regulation of gene expression IDA 24608080
GO:0010872 regulation of cholesterol esterification IDA 24608080
GO:0010989 negative regulation of low-density lipoprotein particle clearance IDA 26318398
GO:0035195 gene silencing by miRNA IGI 21536891
GO:0035278 miRNA mediated inhibition of translation IDA 26318398
genes like me logo Genes that share ontologies with MIR27A: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR27A Gene

Drugs & Compounds for MIR27A Gene

(2) Drugs for MIR27A Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Capecitabine Approved, Investigational Pharma RNA processing inhibitor and thymidylate synthase inhibitor, F-pyrimidines 1594
Fluorouracil Approved Pharma RNA processing inhibitor and thymidylate synthase inhibitor 2258
genes like me logo Genes that share compounds with MIR27A: view

Transcripts for MIR27A Gene

mRNA/cDNA for MIR27A Gene

5 RNACentral transcripts :
1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
3 miRBase transcripts :
6 ENA transcripts :
2 LncBase transcripts :
1 PDBe transcripts :
  • 6MFN_C
1 Rfam transcripts :
2 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR27A Gene

No ASD Table

Relevant External Links for MIR27A Gene

GeneLoc Exon Structure for
MIR27A

Expression for MIR27A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR27A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR27A

genes like me logo Genes that share expression patterns with MIR27A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR27A Gene

Orthologs for MIR27A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR27A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-27a 31
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-27a 31
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-27a 31
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir27a 31
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-27a 31
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-27a 31
  • 67 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia aca-mir-27a 31
  • 66 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii dre-mir-27c-2 31 31
  • 55 (a)
ManyToMany
dre-mir-27d 31
  • 54 (a)
ManyToMany
dre-mir-27e 31
  • 45 (a)
ManyToMany
dre-mir-27a 31
  • 41 (a)
ManyToMany
Species where no ortholog for MIR27A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR27A Gene

ENSEMBL:
Gene Tree for MIR27A (if available)
TreeFam:
Gene Tree for MIR27A (if available)

Paralogs for MIR27A Gene

No data available for Paralogs for MIR27A Gene

Variants for MIR27A Gene

Additional dbSNP identifiers (rs#s) for MIR27A Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR27A Gene

Variant ID Type Subtype PubMed ID
nsv833757 CNV loss 17160897
nsv953979 CNV deletion 24416366

Additional Variant Information for MIR27A Gene

Human Gene Mutation Database (HGMD)
MIR27A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR27A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR27A Gene

Disorders for MIR27A Gene

MalaCards: The human disease database

(84) MalaCards diseases for MIR27A Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
leukemia
  • leukemias
gastric cancer
  • gastric cancer, somatic
hepatocellular carcinoma
  • hcc
breast cancer
  • breast cancer, familial
non-alcoholic fatty liver disease
  • nafld
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR27A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR27A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR27A Gene

Publications for MIR27A Gene

  1. Single nucleotide polymorphisms in miRNA binding sites and miRNA genes as breast/ovarian cancer risk modifiers in Jewish high-risk women. (PMID: 19950226) Kontorovich T … Friedman E (International journal of cancer 2010) 3 41 54
  2. Hsa-mir-27a genetic variant contributes to gastric cancer susceptibility through affecting miR-27a and target gene expression. (PMID: 20666778) Sun Q … Wang B (Cancer science 2010) 3 41 54
  3. A genetic variant in the pre-miR-27a oncogene is associated with a reduced familial breast cancer risk. (PMID: 19921425) Yang R … Burwinkel B (Breast cancer research and treatment 2010) 3 41 54
  4. A polymorphism of microRNA 27a genome region is associated with the development of gastric mucosal atrophy in Japanese male subjects. (PMID: 17546506) Arisawa T … Nakano H (Digestive diseases and sciences 2007) 3 23 54
  5. MicroRNA-27a regulates angiotensin II-induced vascular smooth muscle cell proliferation and migration by targeting α-smooth muscle-actin in vitro. (PMID: 30654940) Xu MM … Li HH (Biochemical and biophysical research communications 2019) 3 54

Products for MIR27A Gene

Sources for MIR27A Gene