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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...
Aliases for MIR26B Gene
RNA type for MIR26B Gene
miRNA
Aliases for MIR26B Gene
- MicroRNA 26b (HGNC, NCBI Entrez Gene, Ensembl)
- Hsa-MiR-26b-5p (LncBase, TarBase)
- Hsa-MiR-26b-3p (LncBase, TarBase)
- Hsa-Mir-26b (HGNC, NCBI Entrez Gene)
- MIMAT0000083 (miRBase)
- MIMAT0004500 (miRBase)
- MI0000084 (miRBase)
- MIRN26B (NCBI Entrez Gene)
- MiR-26b (NCBI Entrez Gene)
- RF00244 (Rfam)
- MIR26B (Ensembl)
External Ids for MIR26B Gene
- HGNC: 31612
- NCBI Entrez Gene: 407017
- Ensembl: ENSG00000199121
- OMIM®: 612152
- miRBase: hsa-mir-26b
Previous HGNC Symbols for MIR26B Gene
- MIRN26B
Previous GeneCards Identifiers for MIR26B Gene
- GC02P218976
- GC02P219267
Summaries for MIR26B Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR26B Gene
MIR26B (MicroRNA 26b) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR26B include Pituitary Adenoma and Alzheimer Disease. Among its related pathways are MicroRNAs in cancer and Parkinsons Disease Pathway.
Rfam classification for MIR26B Gene
-
mir-26 microRNA precursor family
Additional gene information for MIR26B Gene
- HGNC (31612)
- NCBI Entrez Gene (407017)
- Ensembl (ENSG00000199121)
- OMIM® (612152)
- Open Targets Platform(ENSG00000199121)
- Alliance of Genome Resources
- Search for MIR26B at DataMed
- Search for MIR26B at HumanCyc
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR26B Gene
Genomics for MIR26B Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MIR26B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MIR26B on the GeneHancer Hub at the UCSC Golden Path
Genomic Locations for MIR26B Gene
Latest Assembly
- chr2:218,402,646-218,402,722
- (GRCh38/hg38)
- Size:
- 77 bases
- Orientation:
- Plus strand
Previous Assembly
- chr2:219,267,369-219,267,445
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 77 bases
- Orientation:
- Plus strand
Genomic View for MIR26B Gene
Genes around MIR26B on UCSC Golden Path with GeneCards custom track
MIR26B in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path
- Cytogenetic band:
-
- 2q35 by HGNC
- 2q35 by Entrez Gene
- 2q35 by Ensembl
MIR26B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR26B Gene
Proteins for MIR26B Gene
Post-translational modifications for MIR26B Gene
No Post-translational modifications
No data available for DME Specific Peptides for MIR26B Gene
Domains & Families for MIR26B Gene
Gene Families for MIR26B Gene
- HGNC:
No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR26B Gene
Function for MIR26B Gene
Phenotypes From GWAS Catalog for MIR26B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 24027266 |
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MIR26B - Starting at $85 >
- * MIR26B CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
miRNA products for research
Inhibitory RNAs for research
Clone products for research
- Applied Biological Materials (abm): Clones for MIR26B - Starting at $45 >
- * MIR26B as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
Cell Lines for research
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR26B Gene
Localization for MIR26B Gene
| Compartment | Confidence |
|---|---|
| plasma membrane | 1 |
| extracellular | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | HDA | 26646931 |
| GO:1903561 | extracellular vesicle | HDA | 28798470 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR26B Gene
Pathways & Interactions for MIR26B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | MicroRNAs in cancer | ||
| 2 | Parkinsons Disease Pathway | ||
Pathways by source for MIR26B Gene
1 BioSystems pathway for MIR26B Gene
1 KEGG pathway for MIR26B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0032682 | negative regulation of chemokine production | IDA | 26222045 |
| GO:0032688 | negative regulation of interferon-beta production | IDA | 26222045 |
| GO:0035195 | gene silencing by miRNA | IDA,IEA | -- |
| GO:0045787 | positive regulation of cell cycle | ISS | 24027266 |
| GO:0050687 | negative regulation of defense response to virus | IDA | 26222045 |
No data available for Interacting Proteins and SIGNOR curated interactions for MIR26B Gene
Transcripts for MIR26B Gene
Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR26B Gene
| RNAcentral Transcript ID | RNA Type | Length (nts) | # of Sources | Source Identifiers and Annotations |
|---|---|---|---|---|
| URS0000316FA5_9606 | miRNA | 21 | 5 |
RefSeq: NR_029500, LncBase: hsa-miR-26b-5p, miRBase: MIMAT0000083, TarBase: hsa-miR-26b-5p, |
| URS000075C05A_9606 | pre_miRNA | 77 | 4 |
RefSeq: NR_029500, Ensembl: ENST00000362251 (view in UCSC) , miRBase: MI0000084, |
| URS000021C6A8_9606 | miRNA | 21 | 2 |
RefSeq: NR_029500, miRBase: MIMAT0004500, |
| URS000003ABC4_9606 | miRNA | 22 | 4 |
LncBase: hsa-miR-26b-3p, MirGeneDB: Hsa-Mir-26-P1_3p, TarBase: hsa-miR-26b-3p, |
| URS00000E73CB_9606 | miRNA | 22 | 2 |
MirGeneDB: Hsa-Mir-26-P1_5p, |
MIR26B in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path
Additional transcripts not in RNAcentral for MIR26B Gene
- 2 NCBI additional mRNA sequence :
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MIR26B - Starting at $85 >
- * MIR26B CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
miRNA products for research
Inhibitory RNAs for research
Clone products for research
- Applied Biological Materials (abm): Clones for MIR26B - Starting at $45 >
- * MIR26B as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
Relevant External Links for MIR26B Gene
- GeneLoc Exon Structure for
- MIR26B
Expression for MIR26B Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR26B
Primer products for research
-
OriGene qPCR primer pairs for MIR26B
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR26B Gene
Orthologs for MIR26B Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Dog (Canis familiaris) |
Mammalia | cfa-mir-26b 30 |
|
OneToOne | |
| Chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-26b 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | bta-mir-26b 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | mdo-mir-26-2 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Mir26b 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | oan-mir-26-1 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | aca-mir-26-1 30 |
|
ManyToMany | |
| Zebrafish (Danio rerio) |
Actinopterygii | dre-mir-26b 30 |
|
OneToOne |
- Species where no ortholog for MIR26B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for MIR26B Gene
- ENSEMBL:
- Gene Tree for MIR26B (if available)
- TreeFam:
- Gene Tree for MIR26B (if available)
- Alliance of Genome Resources:
- Additional Orthologs for MIR26B
Paralogs for MIR26B Gene
No data available for Paralogs for MIR26B Gene
Variants for MIR26B Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Additional Variant Information for MIR26B Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR26B Gene
Disorders for MIR26B Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| pituitary adenoma |
|
|
| alzheimer disease |
|
|
| oral squamous cell carcinoma |
|
|
| schizophrenia |
|
|
| diabetes mellitus |
|
Search MIR26B in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MIR26B
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for MIR26B Gene
Publications for MIR26B Gene
- The enemy within: intronic miR-26b represses its host gene, ctdsp2, to regulate neurogenesis. (PMID: 22215805) Han J … Gage FH (Genes & development 2012) 2 3
- MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia. (PMID: 20347265) Xu Y … Liu P (Schizophrenia research 2010) 3 40
- Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 40
- MicroRNA expression, survival, and response to interferon in liver cancer. (PMID: 19812400) Ji J … Wang XW (The New England journal of medicine 2009) 3 72
- Long noncoding RNA LINC00657 induced by SP1 contributes to the non-small cell lung cancer progression through targeting miR-26b-5p/COMMD8 axis. (PMID: 31566716) Zhang R … Peng Z (Journal of cellular physiology 2020) 3
ExternalLinks
Products for MIR26B Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR26B
- Origene Custom Protein Services for MIR26B
- Browse OriGene Inhibitory RNA Products For MIR26B
- OriGene qPCR primer pairs for MIR26B
- Browse CRISPR knockouts for MIR26B
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MIR26B
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for MIR26B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for MIR26B
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MIR26B
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for MIR26B
Sources for MIR26B Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources