Free for academic non-profit institutions. Other users need a Commercial license
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR26B (MicroRNA 26b) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR26B include Pituitary Adenoma and Oral Squamous Cell Carcinoma. Among its related pathways are Parkinsons Disease Pathway and MicroRNAs in cancer.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 24027266 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | HDA | 26646931 |
GO:1903561 | extracellular vesicle | HDA | 28798470 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | MicroRNAs in cancer | ||
2 | Parkinsons Disease Pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0035195 | gene silencing by miRNA | IDA,IEA | -- |
GO:0035548 | negative regulation of interferon-beta secretion | IDA | 26222045 |
GO:0045787 | positive regulation of cell cycle | ISS | 24027266 |
GO:0050687 | negative regulation of defense response to virus | IDA | 26222045 |
GO:0051607 | defense response to virus | IDA | 26222045 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000075C05A_9606 | precursor_RNA | 77 | 5 |
HGNC: 31612, RefSeq: NR_029500, Ensembl: ENST00000362251 (view in UCSC) , miRBase: MI0000084, |
URS0000316FA5_9606 | miRNA | 21 | 5 |
RefSeq: NR_029500, LncBase: hsa-miR-26b-5p, miRBase: MIMAT0000083, TarBase: hsa-miR-26b-5p, |
URS000021C6A8_9606 | miRNA | 21 | 2 |
RefSeq: NR_029500, miRBase: MIMAT0004500, |
URS000003ABC4_9606 | miRNA | 22 | 4 |
LncBase: hsa-miR-26b-3p, MirGeneDB: Hsa-Mir-26-P1_3p, TarBase: hsa-miR-26b-3p, |
URS00000E73CB_9606 | miRNA | 22 | 2 |
MirGeneDB: Hsa-Mir-26-P1_5p, |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Dog (Canis familiaris) |
Mammalia | cfa-mir-26b 31 |
|
OneToOne | |
Chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-26b 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | bta-mir-26b 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | mdo-mir-26-2 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Mir26b 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | oan-mir-26-1 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | aca-mir-26-1 31 |
|
ManyToMany | |
Zebrafish (Danio rerio) |
Actinopterygii | dre-mir-26b 31 |
|
OneToOne |
Disorder | Aliases | PubMed IDs |
---|---|---|
pituitary adenoma |
|
|
oral squamous cell carcinoma |
|
|
diabetes mellitus |
|
|
alzheimer disease |
|
|
schizophrenia |
|