microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR26B Gene

Subcategory (RNA class) for MIR26B Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR26B Gene

  • MicroRNA 26b 2 3 5
  • Hsa-MiR-26b-5p 163 173
  • Hsa-MiR-26b-3p 163 173
  • Hsa-Mir-26b 2 3
  • MIR26B 2 5
  • Hsa-Mir-26-P1 178
  • MIMAT0000083 50
  • MIMAT0004500 50
  • MI0000084 50
  • MIRN26B 3
  • MiR-26b 3
  • RF00244 168

External Ids for MIR26B Gene

Previous HGNC Symbols for MIR26B Gene

  • MIRN26B

Previous GeneCards Identifiers for MIR26B Gene

  • GC02P218976
  • GC02P219267

Summaries for MIR26B Gene

Entrez Gene Summary for MIR26B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR26B Gene

MIR26B (MicroRNA 26b) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR26B include Pituitary Adenoma and Oral Squamous Cell Carcinoma. Among its related pathways are Parkinsons Disease Pathway and MicroRNAs in cancer.

Rfam classification for MIR26B Gene

  • mir-26 microRNA precursor family

Additional gene information for MIR26B Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR26B Gene

Genomics for MIR26B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR26B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J218393 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 -1.6 -1639 14.4 SP1 HNRNPL CREB1 GATAD2A CTCF ATF7 TEAD4 PRDM10 ZNF629 REST CTDSP1 ENSG00000273361 HSALNG0022261 MIR26B CNOT9 AAMP ANKZF1 STK36 USP37 ZNF142
GH02J218281 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 12 -112.4 -112408 17.9 SP1 HNRNPL CREB1 GATAD2A CTCF ZBTB33 PRDM10 REST ZNF629 TFE3 TMBIM1 ENSG00000261338 SLC11A1 USP37 CTDSP1 MIR26B CNOT9 ARPC2 PNKD CATIP-AS1
GH02J218301 Enhancer 1.1 ENCODE dbSUPER 12 -101.1 -101057 0.9 GATAD2A CTCF PRDM10 RCOR2 ZNF7 JUND ZNF143 PKNOX1 ZNF24 RXRB RF00017-3426 PNKD SLC11A1 CTDSP1 MIR26B AAMP lnc-GPBAR1-2 TMBIM1 CATIP
GH02J218470 Enhancer 0.7 FANTOM5 Ensembl ENCODE 12.2 +69.4 69355 3.6 ETV6 HMBOX1 SPI1 CNOT9 MIR26B TMBIM1 AAMP PNKD PLCD4 USP37 lnc-ZNF142-4-001 VIL1
GH02J218423 Promoter 0.5 EPDnew 13.1 +21.2 21170 0.1 RBFOX2 POLR2A VIL1 MIR26B PLCD4 lnc-ZNF142-4-001 USP37
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR26B on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR26B Gene

Genomic Locations for MIR26B Gene
chr2:218,402,646-218,402,722
(GRCh38/hg38)
Size:
77 bases
Orientation:
Plus strand
chr2:219,267,369-219,267,445
(GRCh37/hg19)
Size:
77 bases
Orientation:
Plus strand

Genomic View for MIR26B Gene

Genes around MIR26B on UCSC Golden Path with GeneCards custom track
MIR26B in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR26B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR26B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR26B Gene

Proteins for MIR26B Gene

Post-translational modifications for MIR26B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR26B Gene

Domains & Families for MIR26B Gene

Gene Families for MIR26B Gene

genes like me logo Genes that share domains with MIR26B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR26B Gene

Function for MIR26B Gene

Phenotypes From GWAS Catalog for MIR26B Gene

Gene Ontology (GO) - Molecular Function for MIR26B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 24027266
genes like me logo Genes that share ontologies with MIR26B: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR26B Gene

Localization for MIR26B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR26B gene
Compartment Confidence
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MIR26B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIR26B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR26B Gene

Pathways & Interactions for MIR26B Gene

PathCards logo

SuperPathways for MIR26B Gene

genes like me logo Genes that share pathways with MIR26B: view

Pathways by source for MIR26B Gene

1 BioSystems pathway for MIR26B Gene
1 KEGG pathway for MIR26B Gene

Gene Ontology (GO) - Biological Process for MIR26B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:0035548 negative regulation of interferon-beta secretion IDA 26222045
GO:0045787 positive regulation of cell cycle ISS 24027266
GO:0050687 negative regulation of defense response to virus IDA 26222045
GO:0051607 defense response to virus IDA 26222045
genes like me logo Genes that share ontologies with MIR26B: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR26B Gene

Drugs & Compounds for MIR26B Gene

No Compound Related Data Available

Transcripts for MIR26B Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR26B Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075C05A_9606 precursor_RNA 77 5

HGNC: 31612,

RefSeq: NR_029500,

Ensembl: ENST00000362251 (view in UCSC) ,

miRBase: MI0000084,

ENA: LM608173.1:1..77:precursor_RNA,

URS0000316FA5_9606 miRNA 21 5

RefSeq: NR_029500,

LncBase: hsa-miR-26b-5p,

miRBase: MIMAT0000083,

TarBase: hsa-miR-26b-5p,

ENA: LM378770.1:1..21:ncRNA, LM608173.1:12..32:ncRNA,

URS000021C6A8_9606 miRNA 21 2

RefSeq: NR_029500,

miRBase: MIMAT0004500,

URS000003ABC4_9606 miRNA 22 4

LncBase: hsa-miR-26b-3p,

MirGeneDB: Hsa-Mir-26-P1_3p,

TarBase: hsa-miR-26b-3p,

ENA: LM380179.1:1..22:ncRNA, LM608173.1:47..68:ncRNA,

URS00000E73CB_9606 miRNA 22 2

MirGeneDB: Hsa-Mir-26-P1_5p,

ENA: AJ421748.1:1..22:misc_RNA,

MIR26B in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR26B Gene

2 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR26B Gene

No ASD Table

Relevant External Links for MIR26B Gene

GeneLoc Exon Structure for
MIR26B

Expression for MIR26B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR26B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR26B

Evidence on tissue expression from TISSUES for MIR26B Gene

  • Blood(2.2)
  • Nervous system(2)
  • Heart(2)
genes like me logo Genes that share expression patterns with MIR26B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR26B Gene

Orthologs for MIR26B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR26B Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia cfa-mir-26b 31
  • 100 (a)
OneToOne
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-26b 31
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-26b 31
  • 89 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-26-2 31
  • 84 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir26b 31
  • 82 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-26-1 31
  • 67 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-26-1 31
  • 65 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-26b 31
  • 52 (a)
OneToOne
Species where no ortholog for MIR26B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR26B Gene

ENSEMBL:
Gene Tree for MIR26B (if available)
TreeFam:
Gene Tree for MIR26B (if available)

Paralogs for MIR26B Gene

No data available for Paralogs for MIR26B Gene

Variants for MIR26B Gene

Additional dbSNP identifiers (rs#s) for MIR26B Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR26B Gene

Variant ID Type Subtype PubMed ID
nsv3166 CNV insertion 18451855
nsv519829 CNV loss 19592680

Additional Variant Information for MIR26B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR26B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR26B Gene

Disorders for MIR26B Gene

MalaCards: The human disease database

(27) MalaCards diseases for MIR26B Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
pituitary adenoma
  • adenoma of the pituitary gland
oral squamous cell carcinoma
  • mouth squamous cell carcinoma
diabetes mellitus
  • diabetes
alzheimer disease
  • ad
schizophrenia
  • sczd
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR26B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with MIR26B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR26B Gene

Publications for MIR26B Gene

  1. The enemy within: intronic miR-26b represses its host gene, ctdsp2, to regulate neurogenesis. (PMID: 22215805) Han J … Gage FH (Genes & development 2012) 2 3
  2. MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia. (PMID: 20347265) Xu Y … Liu P (Schizophrenia research 2010) 3 41
  3. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 41
  4. TRIM44 activates the AKT/mTOR signal pathway to induce melanoma progression by stabilizing TLR4. (PMID: 30922374) Wei CY … Gu JY (Journal of experimental & clinical cancer research : CR 2019) 3
  5. DEPDC1, negatively regulated by miR-26b, facilitates cell proliferation via the up-regulation of FOXM1 expression in TNBC. (PMID: 30419349) Zhang L … Ma J (Cancer letters 2019) 3

Products for MIR26B Gene

Sources for MIR26B Gene