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MIR26B Gene(RNA Gene)

MicroRNA 26b

GCID:
GC02P218402
GIFtS:
21
Genes Participants
UDN Logo

Aliases for MIR26B Gene

Subcategory (RNA class) for MIR26B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR26B Gene

  • MicroRNA 26b 2 3 5
  • Hsa-Mir-26b 3
  • MiR-26b 3
  • MIRN26B 3

External Ids for MIR26B Gene

ORGUL Members for MIR26B Gene

Previous HGNC Symbols for MIR26B Gene

  • MIRN26B

Previous GeneCards Identifiers for MIR26B Gene

  • GC02P218976
  • GC02P219267

Summaries for MIR26B Gene

Entrez Gene Summary for MIR26B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR26B Gene

MIR26B (MicroRNA 26b) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR26B include Hypertensive Nephropathy. Among its related pathways are MicroRNAs in cancer and Parkinsons Disease Pathway.

Additional gene information for MIR26B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR26B Gene

Genomics for MIR26B Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for MIR26B Gene

Promoters and enhancers for MIR26B Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH02I218393 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 550.8 -1.6 -1639 14.4 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 CTDSP1 GC02P218403 ENSG00000273361 MIR26B CNOT9 AAMP USP37 STK36 ANKZF1 BCS1L
GH02I218281 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12 -112.4 -112408 17.9 MLX DMAP1 IRF4 YY1 ZNF143 SP3 NFYC MEF2D GLIS1 RCOR2 TMBIM1 ENSG00000261338 SLC11A1 ANKZF1 CTDSP1 MIR26B CNOT9 ARPC2 PNKD CATIP-AS1
GH02I218301 Enhancer 1.4 Ensembl ENCODE dbSUPER 12 -101.1 -101057 0.9 PKNOX1 FOXA2 ARNT ZFP64 ARID4B DMAP1 ZNF2 ZNF48 YY1 GTF3C2 PNKD SLC11A1 CTDSP1 MIR26B AAMP TMBIM1 LOC105373880
GH02I218470 Enhancer 0.8 FANTOM5 Ensembl ENCODE 12.2 +68.8 68835 1.9 HMBOX1 ETV6 CNOT9 MIR26B TMBIM1 AAMP PNKD USP37 RN7SKP38 VIL1
GH02I218408 Enhancer 0.4 dbSUPER 0.4 +5.9 5874 0.3 IKZF1 CBFA2T3 SUPT5H MIR26B VIL1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR26B on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR26B Gene

Genomic Locations for MIR26B Gene
chr2:218,402,646-218,402,722
(GRCh38/hg38)
Size:
77 bases
Orientation:
Plus strand
chr2:219,267,369-219,267,445
(GRCh37/hg19)

Genomic View for MIR26B Gene

Genes around MIR26B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR26B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR26B Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR26B Gene

Proteins for MIR26B Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIR26B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR26B Gene

Domains & Families for MIR26B Gene

Gene Families for MIR26B Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR26B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR26B Gene

Function for MIR26B Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Phenotypes From GWAS Catalog for MIR26B Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR26B Gene

Localization for MIR26B Gene

Gene Ontology (GO) - Cellular Components for MIR26B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR26B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR26B Gene

Pathways & Interactions for MIR26B Gene

genes like me logo Genes that share pathways with MIR26B: view

Pathways by source for MIR26B Gene

1 BioSystems pathway for MIR26B Gene
1 KEGG pathway for MIR26B Gene

Interacting Proteins for MIR26B Gene

Gene Ontology (GO) - Biological Process for MIR26B Gene

None

No data available for SIGNOR curated interactions for MIR26B Gene

Drugs & Compounds for MIR26B Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIR26B Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MIR26B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR26B Gene

No ASD Table

Relevant External Links for MIR26B Gene

GeneLoc Exon Structure for
MIR26B
ECgene alternative splicing isoforms for
MIR26B

Expression for MIR26B Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR26B Gene

mRNA expression in normal human tissues for MIR26B Gene
mRNA expression by GTEx for MIR26B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR26B Gene:

MIR26B
genes like me logo Genes that share expression patterns with MIR26B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR26B Gene

Orthologs for MIR26B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR26B Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
 Mammalia cfa-mir-26b 34
  • 100 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia ptr-mir-26b 34
  • 100 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia bta-mir-26b 34
  • 89 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia mdo-mir-26-2 34
  • 84 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Mir26b 34
  • 82 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia oan-mir-26-1 34
  • 67 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia aca-mir-26-1 34
  • 65 (a)
 ManyToMany
zebrafish
(Danio rerio)
 Actinopterygii dre-mir-26b 34
  • 52 (a)
 OneToOne
Species where no ortholog for MIR26B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR26B Gene

ENSEMBL:
Gene Tree for MIR26B (if available)
TreeFam:
Gene Tree for MIR26B (if available)

Paralogs for MIR26B Gene

No data available for Paralogs for MIR26B Gene

Variants for MIR26B Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for MIR26B Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000081277 -- 218,401,932(+) C/G upstream_transcript_variant
rs1001753386 -- 218,402,042(+) A/G upstream_transcript_variant
rs1001828632 -- 218,403,196(+) C/T downstream_transcript_variant
rs1002155078 -- 218,403,017(+) C/A downstream_transcript_variant
rs1003585231 -- 218,400,962(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR26B Gene

Variant ID Type Subtype PubMed ID
nsv3166 CNV insertion 18451855
nsv519829 CNV loss 19592680

Additional Variant Information for MIR26B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR26B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR26B Gene

Disorders for MIR26B Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR26B Gene - From: GeneCards

Disorder Aliases PubMed IDs
hypertensive nephropathy
  • hnp1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR26B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR26B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR26B Gene

Publications for MIR26B Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 44 58
  2. MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia. (PMID: 20347265) Xu Y … Liu P (Schizophrenia research 2010) 3 44 58
  3. Expression of miRNA-26b-5p and its target TRPS1 is associated with radiation exposure in post-Chernobyl breast cancer. (PMID: 28944451) Wilke CM … Unger K (International journal of cancer 2018) 3 58
  4. MicroRNA profiling identifies miR-7-5p and miR-26b-5p as differentially expressed in hypertensive patients with left ventricular hypertrophy. (PMID: 29069223) Kaneto CM … Lima PSP (Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2017) 3 58
  5. The Tyr113His T/C rs1051740 and 'very slow' phenotype of the EPHX1 gene alters miR-26b-5p and miR-1207-5p expression in pregnancy. (PMID: 28789952) Naidoo P … Chuturgoon AA (Gene 2017) 3 58

Products for MIR26B Gene

Sources for MIR26B Gene

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