MIR26A2 Gene (RNA Gene)

MicroRNA 26a-2

GC12M057824
GIFtS:
20
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR26A2 Gene

Subcategory (RNA class) for MIR26A2 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR26A2 Gene

  • MicroRNA 26a-2 2 3 5
  • Hsa-MiR-26a-2-3p 163 173
  • Hsa-MiR-26a-5p 163 173
  • Hsa-Mir-26a-2 2 3
  • MIR26A2 2 5
  • Hsa-Mir-26-P2 178
  • MIMAT0004681 50
  • MIMAT0000082 50
  • Mir-26a-2 3
  • MI0000750 50
  • MIRN26A2 3
  • RF00244 168

External Ids for MIR26A2 Gene

Previous HGNC Symbols for MIR26A2 Gene

  • MIRN26A2

Previous GeneCards Identifiers for MIR26A2 Gene

  • GC12M056507
  • GC12M058218

Summaries for MIR26A2 Gene

Entrez Gene Summary for MIR26A2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR26A2 Gene

MIR26A2 (MicroRNA 26a-2) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR26A2 include Hepatocellular Carcinoma and Oropouche Fever. Among its related pathways are Parkinsons Disease Pathway and MicroRNAs in cancer.

Rfam classification for MIR26A2 Gene

  • mir-26 microRNA precursor family

Additional gene information for MIR26A2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR26A2 Gene

Genomics for MIR26A2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for MIR26A2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR26A2 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR26A2 Gene

Genomic Locations for MIR26A2 Gene
chr12:57,824,609-57,824,692
(GRCh38/hg38)
Size:
84 bases
Orientation:
Minus strand
chr12:58,218,392-58,218,475
(GRCh37/hg19)
Size:
84 bases
Orientation:
Minus strand

Genomic View for MIR26A2 Gene

Genes around MIR26A2 on UCSC Golden Path with GeneCards custom track
MIR26A2 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR26A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR26A2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR26A2 Gene

Proteins for MIR26A2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIR26A2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR26A2 Gene

Domains & Families for MIR26A2 Gene

Gene Families for MIR26A2 Gene

HGNC:
genes like me logo Genes that share domains with MIR26A2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR26A2 Gene

Function for MIR26A2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Phenotypes From GWAS Catalog for MIR26A2 Gene

Gene Ontology (GO) - Molecular Function for MIR26A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 18713946
genes like me logo Genes that share ontologies with MIR26A2: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR26A2 Gene

Localization for MIR26A2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR26A2 gene
Compartment Confidence
extracellular 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MIR26A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 25203061
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIR26A2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR26A2 Gene

Pathways & Interactions for MIR26A2 Gene

PathCards logo

SuperPathways for MIR26A2 Gene

genes like me logo Genes that share pathways with MIR26A2: view

Pathways by source for MIR26A2 Gene

1 BioSystems pathway for MIR26A2 Gene
1 KEGG pathway for MIR26A2 Gene

Gene Ontology (GO) - Biological Process for MIR26A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007179 transforming growth factor beta receptor signaling pathway IDA 20857419
GO:0008285 negative regulation of cell proliferation IDA 18713946
GO:0010459 negative regulation of heart rate ISS --
GO:0030336 negative regulation of cell migration IDA 23389848
GO:0030514 negative regulation of BMP signaling pathway IDA 24047927
genes like me logo Genes that share ontologies with MIR26A2: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR26A2 Gene

Drugs & Compounds for MIR26A2 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIR26A2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR26A2 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000015D23B_9606 miRNA 22 6

RefSeq: NR_029847,

LncBase: hsa-miR-26a-2-3p,

miRBase: MIMAT0004681,

MirGeneDB: Hsa-Mir-26-P2_3p,

TarBase: hsa-miR-26a-2-3p,

ENA: LM380345.1:1..22:ncRNA, LM608677.1:52..73:ncRNA,

URS000019B0F7_9606 miRNA 22 6

RefSeq: NR_029499, NR_029847,

LncBase: hsa-miR-26a-5p,

miRBase: MIMAT0000082,

MirGeneDB: Hsa-Mir-26-P2_5p, Hsa-Mir-26-P3_5p,

TarBase: hsa-miR-26a-5p,

ENA: AJ421747.1:1..22:misc_RNA, LM378769.1:1..22:ncRNA, LM608172.1:10..31:ncRNA, LM608677.1:14..35:ncRNA,

URS000075C1BF_9606 precursor_RNA 84 5

HGNC: 31611,

RefSeq: NR_029847,

Ensembl: ENST00000385054 (view in UCSC) ,

miRBase: MI0000750,

ENA: LM608677.1:1..84:precursor_RNA,

URS00001832E2_9606 precursor_RNA 74 1

Rfam: RF00244,

URS0000EFD841_9606 precursor_RNA 61 1

MirGeneDB: Hsa-Mir-26-P2,

MIR26A2 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR26A2 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR26A2 Gene

No ASD Table

Relevant External Links for MIR26A2 Gene

GeneLoc Exon Structure for
MIR26A2

Expression for MIR26A2 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR26A2 Gene

mRNA expression in normal human tissues for MIR26A2 Gene
mRNA expression by GTEx for MIR26A2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR26A2

genes like me logo Genes that share expression patterns with MIR26A2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR26A2 Gene

Orthologs for MIR26A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR26A2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia ptr-mir-26a-2 31
  • 100 (a)
 OneToOne
Cow
(Bos Taurus)
 Mammalia bta-mir-26a-2 31
  • 100 (a)
 OneToOne
Dog
(Canis familiaris)
 Mammalia cfa-mir-26a-2 31
  • 98 (a)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Mir26a-2 31
  • 88 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia mdo-mir-26-1 31
  • 83 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves -- 31
  • 66 (a)
 ManyToMany
Lizard
(Anolis carolinensis)
 Reptilia -- 31
  • 73 (a)
 OneToOne
Zebrafish
(Danio rerio)
 Actinopterygii dre-mir-26a-1 31
  • 72 (a)
 ManyToMany
Species where no ortholog for MIR26A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR26A2 Gene

ENSEMBL:
Gene Tree for MIR26A2 (if available)
TreeFam:
Gene Tree for MIR26A2 (if available)

Paralogs for MIR26A2 Gene

No data available for Paralogs for MIR26A2 Gene

Variants for MIR26A2 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Additional dbSNP identifiers (rs#s) for MIR26A2 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR26A2 Gene

Variant ID Type Subtype PubMed ID
nsv559046 CNV gain 21841781
nsv726 CNV insertion 18451855
nsv983335 CNV duplication 23825009

Additional Variant Information for MIR26A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR26A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR26A2 Gene

Disorders for MIR26A2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MIR26A2 Gene - From: miR2Disease and DISEASES

Disorder Aliases PubMed IDs
hepatocellular carcinoma
  • hcc
oropouche fever
  • oropouche virus disease
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR26A2

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR26A2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR26A2 Gene

Publications for MIR26A2 Gene

  1. miR‑26a inhibits ovarian cancer cell proliferation, migration and invasion by targeting TCF12. (PMID: 31789414) Gao S … Zhang Y (Oncology reports 2020) 3
  2. Regulation of ETAA1-mediated ATR activation couples DNA replication fidelity and genome stability. (PMID: 31615875) Achuthankutty D … Mailand N (The Journal of cell biology 2019) 3
  3. Annexin 1-nuclear factor-κB-microRNA-26a regulatory pathway in the metastasis of non-small cell lung cancer. (PMID: 30756482) Guan X … Zhang Y (Thoracic cancer 2019) 3
  4. Long Noncoding RNA MALAT1 Acts as a Competing Endogenous RNA to Regulate TGF-β2 Induced Epithelial-Mesenchymal Transition of Lens Epithelial Cells by a MicroRNA-26a-Dependent Mechanism. (PMID: 31143769) Dong N (BioMed research international 2019) 3
  5. MiR-26a and miR-26b downregulate the expression of sucrase-isomaltase enzyme: A new chapter in diabetes treatment. (PMID: 31493868) Mehraban MH … Ghasemi Y (Biochemical and biophysical research communications 2019) 3

ExternalLinks

View latest publications for MIR26A2 gene in Mastermind

Products for MIR26A2 Gene

Sources for MIR26A2 Gene