Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR26A2 Gene

Subcategory (RNA class) for MIR26A2 Gene


Quality Score for this RNA gene is


Aliases for MIR26A2 Gene

  • MicroRNA 26a-2 2 3 5
  • Hsa-Mir-26a-2 3
  • Mir-26a-2 3
  • MIRN26A2 3

External Ids for MIR26A2 Gene

Previous HGNC Symbols for MIR26A2 Gene

  • MIRN26A2

Previous GeneCards Identifiers for MIR26A2 Gene

  • GC12M056507
  • GC12M058218

Summaries for MIR26A2 Gene

Entrez Gene Summary for MIR26A2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR26A2 Gene

MIR26A2 (MicroRNA 26a-2) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are miRs in Muscle Cell Differentiation and MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR26A2 Gene - the ORGUL cluster for this gene includes several descriptions:

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR26A2

Additional gene information for MIR26A2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR26A2 Gene

Genomics for MIR26A2 Gene

GeneHancer (GH) Regulatory Elements for MIR26A2 Gene

Promoters and enhancers for MIR26A2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I057821 Enhancer 0.5 dbSUPER 550.8 +1.6 1638 3.9 ZNF189 SCRT2 ZIC2 SUPT5H GC12M057851 GC12P057827 PIR47521 MIR26A2 PIR52958 PIR37302 PIR54139 PIR31374 GC12P057819 CTDSP2
GH12I057886 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE dbSUPER 11.8 -68.6 -68603 13.7 HDGF PKNOX1 SMAD1 SIN3A ZNF2 IRF4 ZNF143 FOS SP3 JUNB LOC101927608 ATP23 EEF1AKMT3 CTDSP2 TSFM MIR26A2 AVIL RNU6-1083P MARCH9 LOC283387
GH12I057905 Enhancer 1.4 Ensembl ENCODE dbSUPER 11.5 -80.9 -80937 0.9 CLOCK ARNT ARID4B SIN3A ZNF2 IRF4 YY1 ZNF213 E2F8 ZNF143 ATP23 MIR26A2 RNU6-1083P CTDSP2 AVIL TSFM CYP27B1 EEF1AKMT3 METTL1 CDK4
GH12I057868 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 11.4 -44.7 -44674 2 PKNOX1 POLR2A SCRT2 KLF17 FOXP2 ZBTB8A EEF1AKMT3 AVIL CTDSP2 MIR26A2 TSFM METTL1 CYP27B1 RNU6-1083P CDK4 MARCH9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR26A2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR26A2 Gene

Genomic Locations for MIR26A2 Gene
84 bases
Minus strand

Genomic View for MIR26A2 Gene

Genes around MIR26A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR26A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR26A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR26A2 Gene

ORGUL Member Location for MIR26A2 Gene

ORGUL Member Location for MIR26A2 gene

Proteins for MIR26A2 Gene

Post-translational modifications for MIR26A2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR26A2 Gene

Domains & Families for MIR26A2 Gene

Gene Families for MIR26A2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR26A2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR26A2 Gene

Function for MIR26A2 Gene

Gene Ontology (GO) - Molecular Function for MIR26A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 20660482
genes like me logo Genes that share ontologies with MIR26A2: view

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR26A2 Gene

Localization for MIR26A2 Gene

Gene Ontology (GO) - Cellular Components for MIR26A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 25203061
genes like me logo Genes that share ontologies with MIR26A2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR26A2 Gene

Pathways & Interactions for MIR26A2 Gene

genes like me logo Genes that share pathways with MIR26A2: view

Pathways by source for MIR26A2 Gene

2 BioSystems pathways for MIR26A2 Gene
1 KEGG pathway for MIR26A2 Gene

Interacting Proteins for MIR26A2 Gene

Gene Ontology (GO) - Biological Process for MIR26A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010459 negative regulation of heart rate ISS --
GO:0035195 gene silencing by miRNA IDA 20660482
GO:0060371 regulation of atrial cardiac muscle cell membrane depolarization ISS --
GO:1903609 negative regulation of inward rectifier potassium channel activity ISS --
genes like me logo Genes that share ontologies with MIR26A2: view

No data available for SIGNOR curated interactions for MIR26A2 Gene

Drugs & Compounds for MIR26A2 Gene

No Compound Related Data Available

Transcripts for MIR26A2 Gene

fRNAdb Secondary structures for MIR26A2 Gene

  • hsa-mir-26a-2_MI0000750_Homo_sapiens_miR-26a-2_stem-loop_hairpin

mRNA/cDNA for MIR26A2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR26A2 Gene

No ASD Table

Relevant External Links for MIR26A2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR26A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR26A2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR26A2 Gene:

genes like me logo Genes that share expression patterns with MIR26A2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR26A2 Gene

Orthologs for MIR26A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR26A2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia bta-mir-26a-2 34
  • 100 (a)
(Pan troglodytes)
Mammalia ptr-mir-26a-2 34
  • 100 (a)
(Canis familiaris)
Mammalia cfa-mir-26a-2 34
  • 98 (a)
(Mus musculus)
Mammalia Mir26a-2 34
  • 88 (a)
(Monodelphis domestica)
Mammalia mdo-mir-26-1 34
  • 83 (a)
(Gallus gallus)
Aves -- 34
  • 66 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 73 (a)
(Danio rerio)
Actinopterygii dre-mir-26a-1 34
  • 72 (a)
Species where no ortholog for MIR26A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR26A2 Gene

Gene Tree for MIR26A2 (if available)
Gene Tree for MIR26A2 (if available)

Paralogs for MIR26A2 Gene

No data available for Paralogs for MIR26A2 Gene

Variants for MIR26A2 Gene

Sequence variations from dbSNP and Humsavar for MIR26A2 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000709137 -- 57,825,205(-) G/A upstream_transcript_variant
rs1000739833 -- 57,825,596(-) G/T upstream_transcript_variant
rs1001632263 -- 57,824,464(-) C/T downstream_transcript_variant
rs1001934922 -- 57,825,646(-) A/AA upstream_transcript_variant
rs1002366166 -- 57,825,875(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR26A2 Gene

Variant ID Type Subtype PubMed ID
nsv559046 CNV gain 21841781
nsv726 CNV insertion 18451855
nsv983335 CNV duplication 23825009

Additional Variant Information for MIR26A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR26A2 Gene

Disorders for MIR26A2 Gene

Additional Disease Information for MIR26A2

No disorders were found for MIR26A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR26A2 Gene

Publications for MIR26A2 Gene

  1. Identification of novel genes coding for small expressed RNAs. (PMID: 11679670) Lagos-Quintana M … Tuschl T (Science (New York, N.Y.) 2001) 1 3 58
  2. MiR-26 enhances chemosensitivity and promotes apoptosis of hepatocellular carcinoma cells through inhibiting autophagy. (PMID: 28079894) Jin F … Li L (Cell death & disease 2017) 3 58
  3. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3 58
  4. MicroRNA-26a suppresses epithelial-mesenchymal transition in human hepatocellular carcinoma by repressing enhancer of zeste homolog 2. (PMID: 26733151) Ma DN … Tang ZY (Journal of hematology & oncology 2016) 3 58
  5. MiR-26 down-regulates TNF-α/NF-κB signalling and IL-6 expression by silencing HMGA1 and MALT1. (PMID: 27025651) Chen CY … Shyu AB (Nucleic acids research 2016) 3 58

Products for MIR26A2 Gene

Sources for MIR26A2 Gene

Loading form....