microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR26A1 Gene

Subcategory (RNA class) for MIR26A1 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR26A1 Gene

  • MicroRNA 26a-1 2 3 5
  • Hsa-MiR-26a-1-3p 163 173
  • Hsa-MiR-26a-5p 163 173
  • Hsa-Mir-26a-1 2 3
  • MIR26A1 2 5
  • Hsa-Mir-26-P3 178
  • MIMAT0000082 50
  • MIMAT0004499 50
  • Mir-26a-1 3
  • MI0000083 50
  • MIRN26A1 3
  • RF00244 168
  • MIR26A 3

External Ids for MIR26A1 Gene

Previous HGNC Symbols for MIR26A1 Gene

  • MIRN26A1

Previous GeneCards Identifiers for MIR26A1 Gene

  • GC03P037988
  • GC03P038010

Summaries for MIR26A1 Gene

Entrez Gene Summary for MIR26A1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR26A1 Gene

MIR26A1 (MicroRNA 26a-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR26A1 include Colorectal Cancer and Non-Alcoholic Fatty Liver Disease. Among its related pathways are Parkinsons Disease Pathway and MicroRNAs in cancer.

Rfam classification for MIR26A1 Gene

  • mir-26 microRNA precursor family

Additional gene information for MIR26A1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR26A1 Gene

Genomics for MIR26A1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR26A1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J037967 Enhancer 1 Ensembl ENCODE dbSUPER 600.7 -0.6 -637 3.9 GATAD2A CTCF TEAD4 REST RAD21 TRIM22 CTBP1 YY1 SMC3 RBM22 MIR26A1 RF00244 CTDSPL ITGA9-AS1 VILL piR-32214-486
GH03J037901 Enhancer 1.7 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.6 -63.7 -63703 19 SP1 HNRNPL GATAD2A CTCF TFE3 SOX13 IKZF1 RCOR2 BACH1 RELA CTDSPL C3orf35 ITGA9-AS1 MIR26A1 VILL SLC22A14 piR-42491-152 piR-32214-486
GH03J037940 Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.8 -24.9 -24903 8.6 PRDM10 IKZF1 FOXA1 PKNOX1 HDAC1 ZNF600 SOX6 EP300 ZBTB20 SP1 CTDSPL ITGA9-AS1 MIR26A1 VILL piR-32214-486 piR-42491-152
GH03J037961 Enhancer 1.2 Ensembl ENCODE dbSUPER 0.4 -5.8 -5815 4.8 HNRNPL GATAD2A REST RXRB IRF2 SP1 CEBPA SOX13 NFE2 ZKSCAN8 VILL CTDSPL ITGA9-AS1 piR-32214-486 MIR26A1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR26A1 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR26A1 Gene

Genomic Locations for MIR26A1 Gene
chr3:37,969,404-37,969,480
(GRCh38/hg38)
Size:
77 bases
Orientation:
Plus strand
chr3:38,010,895-38,010,971
(GRCh37/hg19)
Size:
77 bases
Orientation:
Plus strand

Genomic View for MIR26A1 Gene

Genes around MIR26A1 on UCSC Golden Path with GeneCards custom track
MIR26A1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR26A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR26A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR26A1 Gene

Proteins for MIR26A1 Gene

Post-translational modifications for MIR26A1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR26A1 Gene

Domains & Families for MIR26A1 Gene

Gene Families for MIR26A1 Gene

genes like me logo Genes that share domains with MIR26A1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR26A1 Gene

Function for MIR26A1 Gene

Gene Ontology (GO) - Molecular Function for MIR26A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 18713946
genes like me logo Genes that share ontologies with MIR26A1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR26A1 Gene

Localization for MIR26A1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR26A1 gene
Compartment Confidence
extracellular 1

Gene Ontology (GO) - Cellular Components for MIR26A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 25203061
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIR26A1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR26A1 Gene

Pathways & Interactions for MIR26A1 Gene

PathCards logo

SuperPathways for MIR26A1 Gene

genes like me logo Genes that share pathways with MIR26A1: view

Pathways by source for MIR26A1 Gene

1 BioSystems pathway for MIR26A1 Gene
1 KEGG pathway for MIR26A1 Gene

Gene Ontology (GO) - Biological Process for MIR26A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007179 transforming growth factor beta receptor signaling pathway IDA 20857419
GO:0008285 negative regulation of cell proliferation IDA 18713946
GO:0010459 negative regulation of heart rate ISS --
GO:0030336 negative regulation of cell migration IDA 23389848
GO:0030514 negative regulation of BMP signaling pathway IDA 24047927
genes like me logo Genes that share ontologies with MIR26A1: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR26A1 Gene

Drugs & Compounds for MIR26A1 Gene

No Compound Related Data Available

Transcripts for MIR26A1 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR26A1 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00000C0D3F_9606 miRNA 22 6

RefSeq: NR_029499,

LncBase: hsa-miR-26a-1-3p,

miRBase: MIMAT0004499,

MirGeneDB: Hsa-Mir-26-P3_3p,

TarBase: hsa-miR-26a-1-3p,

ENA: HB859652.1:1..22:misc_RNA, LM380178.1:1..22:ncRNA, LM608172.1:49..70:ncRNA,

URS000019B0F7_9606 miRNA 22 6

RefSeq: NR_029499, NR_029847,

LncBase: hsa-miR-26a-5p,

miRBase: MIMAT0000082,

MirGeneDB: Hsa-Mir-26-P2_5p, Hsa-Mir-26-P3_5p,

TarBase: hsa-miR-26a-5p,

ENA: AJ421747.1:1..22:misc_RNA, LM378769.1:1..22:ncRNA, LM608172.1:10..31:ncRNA, LM608677.1:14..35:ncRNA,

URS000023C301_9606 precursor_RNA 77 5

HGNC: 31610,

RefSeq: NR_029499,

Ensembl: ENST00000362205 (view in UCSC) ,

miRBase: MI0000083,

ENA: LM608172.1:1..77:precursor_RNA,

URS000068669B_9606 precursor_RNA 74 1

Rfam: RF00244,

URS00007251C9_9606 precursor_RNA 72 1

Rfam: RF00244,

MIR26A1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR26A1 Gene

2 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR26A1 Gene

No ASD Table

Relevant External Links for MIR26A1 Gene

GeneLoc Exon Structure for
MIR26A1

Expression for MIR26A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR26A1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR26A1

genes like me logo Genes that share expression patterns with MIR26A1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR26A1 Gene

Orthologs for MIR26A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR26A1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-26a-1 31
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-26a-1 31
  • 94 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir26a-1 31
  • 84 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-26a-1 31
  • 78 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-26-3 31
  • 77 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-26-2 31
  • 62 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-26a 31
  • 81 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-26-2 31
  • 50 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-26a-3 31
  • 42 (a)
OneToOne
Species where no ortholog for MIR26A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR26A1 Gene

ENSEMBL:
Gene Tree for MIR26A1 (if available)
TreeFam:
Gene Tree for MIR26A1 (if available)

Paralogs for MIR26A1 Gene

No data available for Paralogs for MIR26A1 Gene

Variants for MIR26A1 Gene

Additional dbSNP identifiers (rs#s) for MIR26A1 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR26A1 Gene

Variant ID Type Subtype PubMed ID
esv2759140 CNV loss 17122850
nsv428416 CNV loss 18775914
nsv522017 CNV loss 19592680
nsv590094 CNV loss 21841781

Additional Variant Information for MIR26A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR26A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR26A1 Gene

Disorders for MIR26A1 Gene

MalaCards: The human disease database

(16) MalaCards diseases for MIR26A1 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
colorectal cancer
  • crc
non-alcoholic fatty liver disease
  • nafld
hepatocellular carcinoma
  • hcc
lung cancer
  • adenocarcinoma of lung
oropouche fever
  • oropouche virus disease
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR26A1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR26A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR26A1 Gene

Publications for MIR26A1 Gene

  1. Genetic variation in MicroRNA genes and risk of oral premalignant lesions. (PMID: 19851984) Clague J … Wu X (Molecular carcinogenesis 2010) 3 41
  2. Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma. (PMID: 20732906) Lin J … Wu X (Carcinogenesis 2010) 3 41
  3. Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk. (PMID: 19138993) Ye Y … Wu X (Cancer prevention research (Philadelphia, Pa.) 2008) 3 41
  4. miR‑26a inhibits ovarian cancer cell proliferation, migration and invasion by targeting TCF12. (PMID: 31789414) Gao S … Zhang Y (Oncology reports 2020) 3
  5. MiR-26a-5p Inhibits Cell Proliferation and Enhances Doxorubicin Sensitivity in HCC Cells via Targeting AURKA. (PMID: 31570091) Yuan YL … Li Y (Technology in cancer research & treatment 2019) 3

Products for MIR26A1 Gene

Sources for MIR26A1 Gene