microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR25 Gene

RNA type for MIR25 Gene

miRNA

Aliases for MIR25 Gene

External Ids for MIR25 Gene

Previous HGNC Symbols for MIR25 Gene

  • MIRN25

Previous GeneCards Identifiers for MIR25 Gene

  • GC07M099535
  • GC07M099691

Summaries for MIR25 Gene

Entrez Gene Summary for MIR25 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR25 Gene

MIR25 (MicroRNA 25) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR25 include Brain Cancer and Myeloma, Multiple. Among its related pathways are MicroRNAs in cancer and miRNAs involved in DNA damage response.

Rfam classification for MIR25 Gene

Additional gene information for MIR25 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR25 Gene

Genomics for MIR25 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR25 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J100094 Promoter/Enhancer 1 EPDnew Ensembl 250.7 -0.2 -158 1.2 ZNF600 POLR2A ZIC2 SMAD5 MAFF ZNF316 MAFK SUPT5H ZNF2 MAFG MIR106B MIR25 MIR93 piR-36984 piR-47148 AZGP1 MBLAC1 AP4M1 AGFG2 ZKSCAN1
GH07J100040 Enhancer 1.1 Ensembl ENCODE dbSUPER 11 +52.2 52183 2.1 IKZF1 FOXA2 CTBP1 RXRA TAL1 THRB PRDM6 PRDM10 TCF7L2 SOX5 lnc-ZSCAN21-2 AP4M1 ZSCAN21 ZKSCAN1 MCM7 COPS6 MIR106B MIR25 MIR93 PILRA
GH07J100061 Enhancer 1 Ensembl ENCODE 11.9 +31.8 31842 1.2 IKZF1 ZNF600 NCOR1 NFIC MBD2 TAF9B NKRF TAL1 ZNF316 RBM22 COPS6 MIR106B MIR25 MIR93 MCM7 ZKSCAN1 TRIM4 piR-32504 piR-50617 ZSCAN21
GH07J100044 Enhancer 0.6 ENCODE 11 +48.8 48770 0.2 CTCF ELF1 RXRA SIN3A NRF1 RAD21 HNF4A MAX EGR1 ZNF687 ZKSCAN1 COPS6 MIR106B MIR25 MIR93 MCM7 HSALNG0059949 ZSCAN21 HSALNG0059947 lnc-ZSCAN21-2
GH07J100137 Enhancer 0.5 ENCODE 10.8 -44.5 -44525 0.8 ELF1 EBF1 NFE2 TCF7L2 PKNOX1 FOXA1 TCF7 IKZF1 RUNX3 PVRIG TRAPPC14 GAL3ST4 GPC2 STAG3 CASTOR3 MCM7 AP4M1 MIR106B MIR25
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR25 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR25 Gene

Latest Assembly
chr7:100,093,560-100,093,643
(GRCh38/hg38)
Size:
84 bases
Orientation:
Minus strand

Previous Assembly
chr7:99,691,183-99,691,266
(GRCh37/hg19 by Entrez Gene)
Size:
84 bases
Orientation:
Minus strand

chr7:99,691,183-99,691,266
(GRCh37/hg19 by Ensembl)
Size:
84 bases
Orientation:
Minus strand

Genomic View for MIR25 Gene

Genes around MIR25 on UCSC Golden Path with GeneCards custom track
MIR25 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR25 Gene

Proteins for MIR25 Gene

Post-translational modifications for MIR25 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR25 Gene

Domains & Families for MIR25 Gene

Gene Families for MIR25 Gene

genes like me logo Genes that share domains with MIR25: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR25 Gene

Function for MIR25 Gene

Gene Ontology (GO) - Molecular Function for MIR25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 18728182
genes like me logo Genes that share ontologies with MIR25: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR25 Gene

Localization for MIR25 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR25 gene
Compartment Confidence
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MIR25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 18766170
genes like me logo Genes that share ontologies with MIR25: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR25 Gene

Pathways & Interactions for MIR25 Gene

genes like me logo Genes that share pathways with MIR25: view

Pathways by source for MIR25 Gene

1 KEGG pathway for MIR25 Gene

Gene Ontology (GO) - Biological Process for MIR25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:0055022 negative regulation of cardiac muscle tissue growth ISS --
GO:1903243 negative regulation of cardiac muscle hypertrophy in response to stress ISS --
genes like me logo Genes that share ontologies with MIR25: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR25 Gene

Drugs & Compounds for MIR25 Gene

No Compound Related Data Available

Transcripts for MIR25 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR25 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS00004F9744_9606 miRNA 22 6

RefSeq: NR_029498,

LncBase: hsa-miR-25-3p,

miRBase: MIMAT0000081,

MirGeneDB: Hsa-Mir-92-P2c_3p,

TarBase: hsa-miR-25-3p,

ENA: AJ421746.1:1..22:misc_RNA, LM378768.1:1..22:ncRNA, LM608171.1:52..73:ncRNA,

URS00000C85B2_9606 pre_miRNA 84 5

RefSeq: NR_029498,

Ensembl: ENST00000384816 (view in UCSC) ,

miRBase: MI0000082,

Rfam: RF02020,

ENA: LM608171.1:1..84:precursor_RNA,

URS00001A9746_9606 miRNA 21 5

RefSeq: NR_029498,

LncBase: hsa-miR-25-5p,

miRBase: MIMAT0004498,

TarBase: hsa-miR-25-5p,

ENA: LM380177.1:1..21:ncRNA, LM608171.1:14..34:ncRNA,

URS0000EFC8B7_9606 pre_miRNA 61 1

MirGeneDB: Hsa-Mir-92-P2c,

URS000053B290_9606 miRNA 23 1

MirGeneDB: Hsa-Mir-92-P2c_5p,

MIR25 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR25 Gene

2 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR25 Gene

No ASD Table

Relevant External Links for MIR25 Gene

GeneLoc Exon Structure for
MIR25

Expression for MIR25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR25 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR25

Evidence on tissue expression from TISSUES for MIR25 Gene

  • Blood(2.1)
genes like me logo Genes that share expression patterns with MIR25: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR25 Gene

Orthologs for MIR25 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR25 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-25 30
  • 100 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir25 30
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-25 30
  • 99 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-25 30
  • 98 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-25 30
  • 96 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 86 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-25 30
  • 74 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea csa-mir-92b 30
  • 36 (a)
OneToOne
Species where no ortholog for MIR25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR25 Gene

ENSEMBL:
Gene Tree for MIR25 (if available)
TreeFam:
Gene Tree for MIR25 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR25

Paralogs for MIR25 Gene

No data available for Paralogs for MIR25 Gene

Variants for MIR25 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR25 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR25 Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV deletion 23290073
nsv469687 CNV loss 16826518
nsv510966 OTHER complex 20534489
nsv607931 CNV loss 21841781

Additional Variant Information for MIR25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR25
Leiden Open Variation Database (LOVD)
MIR25

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR25 Gene

Disorders for MIR25 Gene

MalaCards: The human disease database

(38) MalaCards diseases for MIR25 Gene - From: MID, COP, and GCD

Disorder Aliases PubMed IDs
brain cancer
  • adult brain tumor
myeloma, multiple
  • multiple myeloma, susceptibility to
gastric cancer
  • gastric cancer, somatic
hepatocellular carcinoma
  • hcc
pancreatic cancer
  • pancreatic carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search MIR25 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MIR25

genes like me logo Genes that share disorders with MIR25: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR25 Gene

Publications for MIR25 Gene

  1. Role of the miR-106b-25 microRNA cluster in hepatocellular carcinoma. (PMID: 19486339) Li Y … Tan TM (Cancer science 2009) 3 72
  2. Functional links between clustered microRNAs: suppression of cell-cycle inhibitors by microRNA clusters in gastric cancer. (PMID: 19153141) Kim YK … Kim VN (Nucleic acids research 2009) 3 72
  3. MicroRNAs regulate critical genes associated with multiple myeloma pathogenesis. (PMID: 18728182) Pichiorri F … Croce CM (Proceedings of the National Academy of Sciences of the United States of America 2008) 3 72
  4. Exosomes secreted by chronic hepatitis B patients with PNALT and liver inflammation grade ≥ A2 promoted the progression of liver cancer by transferring miR-25-3p to inhibit the co-expression of TCF21 and HHIP. (PMID: 32525231) Ouyang Y … Fu X (Cell proliferation 2020) 3
  5. Long non‑coding RNA LINC00858 promotes TP53‑wild‑type colorectal cancer progression by regulating the microRNA‑25‑3p/SMAD7 axis. (PMID: 32323793) Zhan J … Fu Q (Oncology reports 2020) 3

Products for MIR25 Gene

Sources for MIR25 Gene