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Aliases for MIR25 Gene

Subcategory (RNA class) for MIR25 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR25 Gene

  • MicroRNA 25 2 3 5
  • Hsa-Mir-25 3
  • MiR-25 3
  • MIRN25 3

External Ids for MIR25 Gene

Previous HGNC Symbols for MIR25 Gene

  • MIRN25

Previous GeneCards Identifiers for MIR25 Gene

  • GC07M099535
  • GC07M099691

Summaries for MIR25 Gene

Entrez Gene Summary for MIR25 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR25 Gene

MIR25 (MicroRNA 25) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are miRNA targets in ECM and membrane receptors and miRNAs involved in DNA damage response.

Additional gene information for MIR25 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR25 Gene

Genomics for MIR25 Gene

GeneHancer (GH) Regulatory Elements for MIR25 Gene

Promoters and enhancers for MIR25 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I100040 Enhancer 1 ENCODE dbSUPER 11 +51.9 51945 1.6 PKNOX1 FOXA2 RAD21 THRB TCF12 SCRT2 FOS RCOR1 PAF1 RXRA AP4M1 ZSCAN21 ZKSCAN1 COPS6 MIR106B MIR25 MIR93 MCM7 PILRA GC07P100039
GH07I100061 Enhancer 0.8 ENCODE 11.9 +31.8 31814 0.8 HDAC1 HDGF PKNOX1 TAF9B ARNT TCF12 GATA2 NCOA1 MBD2 NFIC COPS6 MIR106B MIR93 MIR25 MCM7 ZKSCAN1 TRIM4 GC07M100100 PIR44616 ZSCAN21
GH07I100137 Enhancer 0.8 Ensembl ENCODE 10.8 -44.5 -44525 0.8 PKNOX1 CLOCK EBF1 ELF1 FOXA1 GATA3 IKZF1 NFE2 RUNX3 TCF7L2 PVRIG C7orf43 GAL3ST4 GPC2 STAG3 GATS AP4M1 MCM7 MIR106B MIR25
GH07I100044 Enhancer 0.6 ENCODE 11 +48.8 48770 0.2 SMARCA5 CTCF ZNF687 NRF1 MAX SIN3A MNT ELF1 RAD21 GABPA ZKSCAN1 COPS6 MIR25 MIR93 MIR106B MCM7 ZSCAN21 GC07P100039
GH07I100048 Enhancer 0.3 ENCODE 11 +44.7 44720 0 ZNF610 PIR43713 ZSCAN21 ZKSCAN1 COPS6 MIR25 MIR93 MIR106B MCM7 GC07P100039
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR25 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR25 Gene

Genomic Locations for MIR25 Gene
chr7:100,093,560-100,093,643
(GRCh38/hg38)
Size:
84 bases
Orientation:
Minus strand
chr7:99,691,183-99,691,266
(GRCh37/hg19)

Genomic View for MIR25 Gene

Genes around MIR25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR25 Gene

Proteins for MIR25 Gene

Post-translational modifications for MIR25 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR25 Gene

Domains & Families for MIR25 Gene

Gene Families for MIR25 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR25: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR25 Gene

Function for MIR25 Gene

Gene Ontology (GO) - Molecular Function for MIR25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 18728182
genes like me logo Genes that share ontologies with MIR25: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR25 Gene

Localization for MIR25 Gene

Gene Ontology (GO) - Cellular Components for MIR25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR25: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR25 Gene

Pathways & Interactions for MIR25 Gene

genes like me logo Genes that share pathways with MIR25: view

Pathways by source for MIR25 Gene

1 KEGG pathway for MIR25 Gene

Interacting Proteins for MIR25 Gene

Gene Ontology (GO) - Biological Process for MIR25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA 18728182
GO:0055022 negative regulation of cardiac muscle tissue growth ISS --
GO:1903243 negative regulation of cardiac muscle hypertrophy in response to stress ISS --
genes like me logo Genes that share ontologies with MIR25: view

No data available for SIGNOR curated interactions for MIR25 Gene

Drugs & Compounds for MIR25 Gene

No Compound Related Data Available

Transcripts for MIR25 Gene

mRNA/cDNA for MIR25 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR25 Gene

No ASD Table

Relevant External Links for MIR25 Gene

GeneLoc Exon Structure for
MIR25
ECgene alternative splicing isoforms for
MIR25

Expression for MIR25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR25 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR25 Gene:

MIR25
genes like me logo Genes that share expression patterns with MIR25: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR25 Gene

Orthologs for MIR25 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR25 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Mir25 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-25 34
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-25 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-25 34
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-25 34
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 86 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-25 34
  • 74 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-92b 34
  • 36 (a)
OneToOne
Species where no ortholog for MIR25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR25 Gene

ENSEMBL:
Gene Tree for MIR25 (if available)
TreeFam:
Gene Tree for MIR25 (if available)

Paralogs for MIR25 Gene

No data available for Paralogs for MIR25 Gene

Variants for MIR25 Gene

Sequence variations from dbSNP and Humsavar for MIR25 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000404937 -- 100,093,901(-) G/A upstream_transcript_variant
rs1001565564 -- 100,095,549(-) T/A upstream_transcript_variant
rs1002645151 -- 100,095,414(-) A/T upstream_transcript_variant
rs1004644878 -- 100,094,617(-) A/G upstream_transcript_variant
rs1005528214 -- 100,095,446(-) C/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR25 Gene

Variant ID Type Subtype PubMed ID
nsv607931 CNV loss 21841781
nsv510966 OTHER complex 20534489
nsv469687 CNV loss 16826518
esv2734888 CNV deletion 23290073

Additional Variant Information for MIR25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR25 Gene

Disorders for MIR25 Gene

Additional Disease Information for MIR25

No disorders were found for MIR25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR25 Gene

Publications for MIR25 Gene

  1. miR-25-3p reverses epithelial-mesenchymal transition via targeting Sema4C in cisplatin-resistance cervical cancer cells. (PMID: 27743413) Song J … Li Y (Cancer science 2017) 3 58
  2. Amplified 7q21-22 gene MCM7 and its intronic miR-25 suppress COL1A2 associated genes to sustain intestinal gastric cancer features. (PMID: 28059478) Tamilzhalagan S … Ganesan K (Molecular carcinogenesis 2017) 3 58
  3. MicroRNA-25 suppresses proliferation, migration, and invasion of osteosarcoma by targeting SOX4. (PMID: 28705117) Chen B … Pan S (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 58
  4. Variations in MicroRNA-25 Expression Influence the Severity of Diabetic Kidney Disease. (PMID: 28923913) Liu Y … Zhao B (Journal of the American Society of Nephrology : JASN 2017) 3 58
  5. miR-25/93 mediates hypoxia-induced immunosuppression by repressing cGAS. (PMID: 28920955) Wu MZ … Izpisua Belmonte JC (Nature cell biology 2017) 3 58

Products for MIR25 Gene

Sources for MIR25 Gene

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