microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR24-2 Gene

Subcategory (RNA class) for MIR24-2 Gene

miRNA

Number of RNA Genes sources:

5 / 14

Aliases for MIR24-2 Gene

  • MicroRNA 24-2 2 3 5
  • Hsa-MiR-24-2-5p 166 177
  • Hsa-MiR-24-3p 166 177
  • Hsa-Mir-24-2 3
  • MIMAT0004497 51
  • MIMAT0000080 51
  • MiRNA24-2 3
  • MI0000081 51
  • MiR-24-2 3
  • MIRN24-2 3
  • RF00178 172
  • MIR24-2 2

External Ids for MIR24-2 Gene

Additional External Ids for MIR24-2 Gene

Previous HGNC Symbols for MIR24-2 Gene

  • MIRN24-2

Previous GeneCards Identifiers for MIR24-2 Gene

  • GC19M013845
  • GC19M013851
  • GC19M013947
  • GC19M013860
  • GC19M013865
  • GC19M013938
  • GC19M013944
  • GC19M013963
  • GC19M013870
  • GC19M013876
  • GC19M013881
  • GC19M013893
  • GC19M013899
  • GC19M013910
  • GC19M013916
  • GC19M013929

Summaries for MIR24-2 Gene

Entrez Gene Summary for MIR24-2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR24-2 Gene

MIR24-2 (MicroRNA 24-2) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR24-2 include Hepatocellular Carcinoma and Glioma Susceptibility 1.

Rfam classification for MIR24-2 Gene

  • mir-24 microRNA precursor family

Additional gene information for MIR24-2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR24-2 Gene

Genomics for MIR24-2 Gene

GeneHancer (GH) Regulatory Elements for MIR24-2 Gene

Promoters and enhancers for MIR24-2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR24-2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR24-2 Gene

Genomic Locations for MIR24-2 Gene
chr19:13,836,286-13,836,359
(GRCh38/hg38)
Size:
74 bases
Orientation:
Minus strand
chr19:13,945,330-13,947,173
(GRCh37/hg19)
Size:
1,844 bases
Orientation:
Minus strand

Genomic View for MIR24-2 Gene

Genes around MIR24-2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR24-2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR24-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR24-2 Gene

Proteins for MIR24-2 Gene

Post-translational modifications for MIR24-2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR24-2 Gene

Domains & Families for MIR24-2 Gene

Gene Families for MIR24-2 Gene

genes like me logo Genes that share domains with MIR24-2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR24-2 Gene

Function for MIR24-2 Gene

Phenotypes From GWAS Catalog for MIR24-2 Gene

Gene Ontology (GO) - Molecular Function for MIR24-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IMP 23836801
genes like me logo Genes that share ontologies with MIR24-2: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR24-2 Gene

Localization for MIR24-2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR24-2 gene
Compartment Confidence
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MIR24-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
GO:0070062 extracellular exosome IDA 28159509
genes like me logo Genes that share ontologies with MIR24-2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR24-2 Gene

Pathways & Interactions for MIR24-2 Gene

PathCards logo

SuperPathways for MIR24-2 Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for MIR24-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010667 negative regulation of cardiac muscle cell apoptotic process ISS --
GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway ISS --
GO:0016525 negative regulation of angiogenesis IDA 23774796
GO:0035195 gene silencing by miRNA IMP 23774796
GO:0043537 negative regulation of blood vessel endothelial cell migration IDA 21788589
genes like me logo Genes that share ontologies with MIR24-2: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR24-2 Gene

Drugs & Compounds for MIR24-2 Gene

No Compound Related Data Available

Transcripts for MIR24-2 Gene

mRNA/cDNA for MIR24-2 Gene

5 RNACentral transcripts :
2 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
3 miRBase transcripts :
10 ENA transcripts :
2 LncBase transcripts :
1 Rfam transcripts :
2 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR24-2 Gene

No ASD Table

Relevant External Links for MIR24-2 Gene

GeneLoc Exon Structure for
MIR24-2

Expression for MIR24-2 Gene

mRNA differential expression in normal tissues according to GTEx for MIR24-2 Gene

This gene is overexpressed in Whole Blood (x4.8).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR24-2

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR24-2 Gene

Orthologs for MIR24-2 Gene

Evolution for MIR24-2 Gene

ENSEMBL:
Gene Tree for MIR24-2 (if available)
TreeFam:
Gene Tree for MIR24-2 (if available)

No data available for Orthologs for MIR24-2 Gene

Paralogs for MIR24-2 Gene

No data available for Paralogs for MIR24-2 Gene

Variants for MIR24-2 Gene

Additional dbSNP identifiers (rs#s) for MIR24-2 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR24-2 Gene

Variant ID Type Subtype PubMed ID
nsv833757 CNV loss 17160897
nsv953979 CNV deletion 24416366

Additional Variant Information for MIR24-2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR24-2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR24-2 Gene

Disorders for MIR24-2 Gene

MalaCards: The human disease database

(6) MalaCards diseases for MIR24-2 Gene - From: miR2Disease and DISEASES

Disorder Aliases PubMed IDs
hepatocellular carcinoma
  • hcc
glioma susceptibility 1
  • glm1
pancreatic cancer
  • pancreatic carcinoma
gastric cancer
  • gastric cancer, somatic
lung cancer
  • adenocarcinoma of lung
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR24-2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR24-2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR24-2 Gene

Publications for MIR24-2 Gene

  1. MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia. (PMID: 20347265) Xu Y … Liu P (Schizophrenia research 2010) 3 41 54
  2. Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J … Zhao H (International journal of cancer 2009) 3 41 54
  3. ANRIL acts as onco-lncRNA by regulation of microRNA-24/c-Myc, MEK/ERK and Wnt/β-catenin pathway in retinoblastoma. (PMID: 30703428) Yu F … Zhao G (International journal of biological macromolecules 2019) 3 54
  4. Long Noncoding RNA LINC00472 Inhibits Proliferation and Promotes Apoptosis of Lung Adenocarcinoma Cells via Regulating miR-24-3p/ DEDD. (PMID: 30175664) Su C … Liu Z (Technology in cancer research & treatment 2018) 3 54
  5. miR‑24 may be a negative regulator of menin in lung cancer. (PMID: 29565463) Pan Y … Chen Y (Oncology reports 2018) 3 54

Products for MIR24-2 Gene

Sources for MIR24-2 Gene