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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...
Aliases for MIR24-1 Gene
RNA type for MIR24-1 Gene
miRNA
Aliases for MIR24-1 Gene
- MicroRNA 24-1 (HGNC, NCBI Entrez Gene, Ensembl)
- Hsa-MiR-24-1-5p (LncBase, TarBase)
- Hsa-MiR-24-3p (LncBase, TarBase)
- Hsa-Mir-24-1 (HGNC, NCBI Entrez Gene)
- MIMAT0000080 (miRBase)
- MIMAT0000079 (miRBase)
- MicroRNA-24 (NCBI Entrez Gene)
- MiRNA24-1 (NCBI Entrez Gene)
- MI0000080 (miRBase)
- MIRN24-1 (NCBI Entrez Gene)
- MiR-24-1 (NCBI Entrez Gene)
- MIR24-1 (Ensembl)
- RF00178 (Rfam)
- MIR189 (NCBI Entrez Gene)
External Ids for MIR24-1 Gene
- HGNC: 31607
- NCBI Entrez Gene: 407012
- Ensembl: ENSG00000284459
- OMIM®: 609705
- miRBase: hsa-mir-24-1
Previous HGNC Symbols for MIR24-1 Gene
- MIRN24-1
Previous GeneCards Identifiers for MIR24-1 Gene
- GC09P096892
- GC09P097849
- GC09P097851
- GC09P097859
- GC09P097867
- GC09P094727
Summaries for MIR24-1 Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR24-1 Gene
MIR24-1 (MicroRNA 24-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR24-1 include Pituitary Adenoma and Leukemia, Chronic Lymphocytic. Among its related pathways are Peptide hormone metabolism and Hepatitis C and Hepatocellular Carcinoma.
Rfam classification for MIR24-1 Gene
-
mir-24 microRNA precursor family
Additional gene information for MIR24-1 Gene
- Monarch Initiative
- Alliance of Genome Resources
- Search for MIR24-1 at DataMed
- Search for MIR24-1 at HumanCyc
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR24-1 Gene
Genomics for MIR24-1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MIR24-1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH09J095084 | Enhancer | 0.7 | Ensembl ENCODE dbSUPER | 250.7 | -0.3 | -320 | 2.6 | RBM22 POLR2A CTCF | MIR23B MIR24-1 MIR27B MIR3074 lnc-MFSD14B-20 NONHSAG052915.2 FANCC AOPEP |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MIR24-1 on the GeneHancer Hub at the UCSC Golden Path
Genomic Locations for MIR24-1 Gene
Latest Assembly
- chr9:95,086,021-95,086,088
- (GRCh38/hg38)
- Size:
- 68 bases
- Orientation:
- Plus strand
Previous Assembly
- chr9:97,848,303-97,848,370
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 68 bases
- Orientation:
- Plus strand
Genomic View for MIR24-1 Gene
Genes around MIR24-1 on UCSC Golden Path with GeneCards custom track
MIR24-1 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path
- Cytogenetic band:
-
- 9q22.32 by HGNC
- 9q22.32 by Entrez Gene
- 9q22.32 by Ensembl
MIR24-1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR24-1 Gene
Proteins for MIR24-1 Gene
Post-translational modifications for MIR24-1 Gene
No Post-translational modifications
No data available for DME Specific Peptides for MIR24-1 Gene
Domains & Families for MIR24-1 Gene
Gene Families for MIR24-1 Gene
- HGNC:
No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR24-1 Gene
Function for MIR24-1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003730 | mRNA 3'-UTR binding | IDA | 25100943 |
| GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IMP | 23836801 |
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MIR24-1 - Starting at $85 >
- * MIR24-1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
miRNA products for research
Inhibitory RNAs for research
Clone products for research
- Applied Biological Materials (abm): Clones for MIR24-1 - Starting at $45 >
- * MIR24-1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
Cell Lines for research
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR24-1 Gene
Localization for MIR24-1 Gene
| Compartment | Confidence |
|---|---|
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | IDA | 26646931 |
| GO:0070062 | extracellular exosome | IDA | 28159509 |
| GO:1903561 | extracellular vesicle | HDA | 28798470 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR24-1 Gene
Pathways & Interactions for MIR24-1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Peptide hormone metabolism | ||
| 2 | Metabolism of proteins | ||
| 3 | Hepatitis C and Hepatocellular Carcinoma | ||
Pathways by source for MIR24-1 Gene
1 BioSystems pathway for MIR24-1 Gene
3 Reactome pathways for MIR24-1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0010667 | negative regulation of cardiac muscle cell apoptotic process | ISS | -- |
| GO:0010804 | negative regulation of tumor necrosis factor-mediated signaling pathway | ISS | -- |
| GO:0016525 | negative regulation of angiogenesis | IDA | 23774796 |
| GO:0032689 | negative regulation of interferon-gamma production | IDA | 24704866 |
| GO:0035195 | gene silencing by miRNA | IMP | 23774796 |
No data available for Interacting Proteins and SIGNOR curated interactions for MIR24-1 Gene
Transcripts for MIR24-1 Gene
Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR24-1 Gene
| RNAcentral Transcript ID | RNA Type | Length (nts) | # of Sources | Source Identifiers and Annotations |
|---|---|---|---|---|
| URS000059273E_9606 | miRNA | 22 | 6 |
LncBase: hsa-miR-24-3p, miRBase: MIMAT0000080, MirGeneDB: Hsa-Mir-24-P1_3p, Hsa-Mir-24-P2_3p, TarBase: hsa-miR-24-3p, ENA: View 6 records in RNAcentral |
| URS00003A9237_9606 | pre_miRNA | 68 | 5 |
RefSeq: NR_029496, Ensembl: ENST00000637495 (view in UCSC) , miRBase: MI0000080, Rfam: RF00178, |
| URS00002D0FC3_9606 | miRNA | 22 | 5 |
RefSeq: NR_029496, LncBase: hsa-miR-24-1-5p, miRBase: MIMAT0000079, TarBase: hsa-miR-24-1-5p, |
| URS0001BCA1A9_9606 | pre_miRNA | 65 | 1 |
Rfam: RF00178, |
| URS0000EFC7F4_9606 | pre_miRNA | 61 | 1 |
MirGeneDB: Hsa-Mir-24-P2, |
MIR24-1 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path
Additional transcripts not in RNAcentral for MIR24-1 Gene
- 3 NCBI additional mRNA sequence :
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MIR24-1 - Starting at $85 >
- * MIR24-1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
miRNA products for research
Inhibitory RNAs for research
Clone products for research
- Applied Biological Materials (abm): Clones for MIR24-1 - Starting at $45 >
- * MIR24-1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
Relevant External Links for MIR24-1 Gene
- GeneLoc Exon Structure for
- MIR24-1
Expression for MIR24-1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR24-1
No Expression Related Data Available
Primer products for research
-
OriGene qPCR primer pairs for MIR24-1
Gene Expression Assays for research
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR24-1 Gene
Orthologs for MIR24-1 Gene
Evolution for MIR24-1 Gene
- ENSEMBL:
- Gene Tree for MIR24-1 (if available)
- TreeFam:
- Gene Tree for MIR24-1 (if available)
- Alliance of Genome Resources:
- Additional Orthologs for MIR24-1
No data available for Orthologs for MIR24-1 Gene
Paralogs for MIR24-1 Gene
No data available for Paralogs for MIR24-1 Gene
Variants for MIR24-1 Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1038106 | CNV | gain | 25217958 |
| nsv1147999 | OTHER | inversion | 26484159 |
| nsv831656 | CNV | loss | 17160897 |
Additional Variant Information for MIR24-1 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR24-1 Gene
Disorders for MIR24-1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| pituitary adenoma |
|
|
| leukemia, chronic lymphocytic |
|
|
| pancreatic cancer |
|
|
| irritable bowel syndrome |
|
|
| tic disorder |
|
|
Search MIR24-1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MIR24-1
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for MIR24-1 Gene
Publications for MIR24-1 Gene
- MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia. (PMID: 20347265) Xu Y … Liu P (Schizophrenia research 2010) 3 40
- Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J … Zhao H (International journal of cancer 2009) 3 40
- Long non‑coding RNA CASC2 suppresses pancreatic cancer cell growth and progression by regulating the miR‑24/MUC6 axis. (PMID: 31894271) Xu DF … Zhou JH (International journal of oncology 2020) 3
- Knockdown of lncRNA CCAT1 enhances sensitivity of paclitaxel in prostate cancer via regulating miR-24-3p and FSCN1. (PMID: 32089062) Li X … Sun J (Cancer biology & therapy 2020) 3
- miR-24-3p/KLF8 Signaling Axis Contributes to LUAD Metastasis by Regulating EMT. (PMID: 32411796) Jing P … Gu Z (Journal of immunology research 2020) 3
ExternalLinks
Products for MIR24-1 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR24-1
- Origene Custom Protein Services for MIR24-1
- Browse OriGene Inhibitory RNA Products For MIR24-1
- OriGene qPCR primer pairs for MIR24-1
- Browse CRISPR knockouts for MIR24-1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MIR24-1
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for MIR24-1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for MIR24-1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MIR24-1
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for MIR24-1
Sources for MIR24-1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources