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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR24-1 (MicroRNA 24-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR24-1 include Pituitary Adenoma and Leukemia, Chronic Lymphocytic. Among its related pathways are Peptide hormone metabolism and Hepatitis C and Hepatocellular Carcinoma.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH09J095084 | Enhancer | 0.8 | Ensembl ENCODE dbSUPER | 600.7 | -0.7 | -699 | 3 | HNRNPL ESR1 RBM22 CTCF POLR2A | MIR23B MIR24-1 MIR27B MIR3074 lnc-MFSD14B-20 NONHSAG052915.2 AOPEP FANCC |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IMP | 23836801 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | IDA | 26646931 |
GO:0070062 | extracellular exosome | IDA | 28159509 |
GO:1903561 | extracellular vesicle | HDA | 28798470 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Peptide hormone metabolism | ||
2 | Metabolism of proteins | ||
3 | Hepatitis C and Hepatocellular Carcinoma |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0010667 | negative regulation of cardiac muscle cell apoptotic process | ISS | -- |
GO:0010804 | negative regulation of tumor necrosis factor-mediated signaling pathway | ISS | -- |
GO:0016525 | negative regulation of angiogenesis | IDA | 23774796 |
GO:0035195 | gene silencing by miRNA | IMP | 23774796 |
GO:0043537 | negative regulation of blood vessel endothelial cell migration | IDA | 21788589 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS00003A9237_9606 | precursor_RNA | 68 | 6 |
HGNC: 31607, RefSeq: NR_029496, Ensembl: ENST00000637495 (view in UCSC) , miRBase: MI0000080, Rfam: RF00178, |
URS000059273E_9606 | miRNA | 22 | 6 |
LncBase: hsa-miR-24-3p, miRBase: MIMAT0000080, MirGeneDB: Hsa-Mir-24-P1_3p, Hsa-Mir-24-P2_3p, TarBase: hsa-miR-24-3p, ENA: View 6 records in RNAcentral |
URS00002D0FC3_9606 | miRNA | 22 | 5 |
RefSeq: NR_029496, LncBase: hsa-miR-24-1-5p, miRBase: MIMAT0000079, TarBase: hsa-miR-24-1-5p, |
URS00006C6AFC_9606 | precursor_RNA | 65 | 1 |
Rfam: RF00178, |
URS0000EFC7F4_9606 | precursor_RNA | 61 | 1 |
MirGeneDB: Hsa-Mir-24-P2, |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1038106 | CNV | gain | 25217958 |
nsv1147999 | OTHER | inversion | 26484159 |
nsv831656 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
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pituitary adenoma |
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leukemia, chronic lymphocytic |
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pancreatic cancer |
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tic disorder |
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irritable bowel syndrome |
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