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Aliases for MIR24-1 Gene

Subcategory (RNA class) for MIR24-1 Gene

miRNA

Quality Score for this RNA gene is

13

Aliases for MIR24-1 Gene

  • MicroRNA 24-1 2 3 5
  • Hsa-Mir-24-1 3
  • MicroRNA-24 3
  • MiRNA24-1 3
  • MiR-24-1 3
  • MIRN24-1 3
  • MIR189 3

External Ids for MIR24-1 Gene

ORGUL Members for MIR24-1 Gene

Previous HGNC Symbols for MIR24-1 Gene

  • MIRN24-1

Previous GeneCards Identifiers for MIR24-1 Gene

  • GC09P096892
  • GC09P097849
  • GC09P097851
  • GC09P097859
  • GC09P097867
  • GC09P094727

Summaries for MIR24-1 Gene

Entrez Gene Summary for MIR24-1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR24-1 Gene

MIR24-1 (MicroRNA 24-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR24-1 include Pituitary Adenoma and Leukemia, Chronic Lymphocytic. Among its related pathways are Peptide hormone metabolism and Hepatitis C and Hepatocellular Carcinoma.

Additional gene information for MIR24-1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR24-1 Gene

Genomics for MIR24-1 Gene

GeneHancer (GH) Regulatory Elements for MIR24-1 Gene

Promoters and enhancers for MIR24-1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J095084 Enhancer 0.4 ENCODE dbSUPER 650.7 -0.2 -192 2 GC09P095099 GC09P095100 GC09P095102 GC09P095103 GC09P095104 MIR23B MIR24-1 MIR27B MIR3074 C9orf3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR24-1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR24-1 Gene

Genomic Locations for MIR24-1 Gene
chr9:95,086,021-95,086,088
(GRCh38/hg38)
Size:
68 bases
Orientation:
Plus strand
chr9:97,848,303-97,848,370
(GRCh37/hg19)
Size:
68 bases
Orientation:
Plus strand

Genomic View for MIR24-1 Gene

Genes around MIR24-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR24-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR24-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR24-1 Gene

Proteins for MIR24-1 Gene

Post-translational modifications for MIR24-1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR24-1 Gene

Domains & Families for MIR24-1 Gene

Gene Families for MIR24-1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR24-1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR24-1 Gene

Function for MIR24-1 Gene

Gene Ontology (GO) - Molecular Function for MIR24-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IMP 23836801
genes like me logo Genes that share ontologies with MIR24-1: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR24-1 Gene

Localization for MIR24-1 Gene

Gene Ontology (GO) - Cellular Components for MIR24-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
GO:0070062 extracellular exosome IDA 28159509
genes like me logo Genes that share ontologies with MIR24-1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR24-1 Gene

Pathways & Interactions for MIR24-1 Gene

genes like me logo Genes that share pathways with MIR24-1: view

Pathways by source for MIR24-1 Gene

Interacting Proteins for MIR24-1 Gene

Gene Ontology (GO) - Biological Process for MIR24-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010667 negative regulation of cardiac muscle cell apoptotic process ISS --
GO:0016525 negative regulation of angiogenesis IDA 23774796
GO:0035195 gene silencing by miRNA IMP 23774796
GO:0043537 negative regulation of blood vessel endothelial cell migration IDA 21788589
GO:0061049 cell growth involved in cardiac muscle cell development ISS --
genes like me logo Genes that share ontologies with MIR24-1: view

No data available for SIGNOR curated interactions for MIR24-1 Gene

Drugs & Compounds for MIR24-1 Gene

No Compound Related Data Available

Transcripts for MIR24-1 Gene

mRNA/cDNA for MIR24-1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(3) RNA Central transcripts :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR24-1 Gene

No ASD Table

Relevant External Links for MIR24-1 Gene

GeneLoc Exon Structure for
MIR24-1
ECgene alternative splicing isoforms for
MIR24-1

Expression for MIR24-1 Gene

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR24-1 Gene

Orthologs for MIR24-1 Gene

Evolution for MIR24-1 Gene

ENSEMBL:
Gene Tree for MIR24-1 (if available)
TreeFam:
Gene Tree for MIR24-1 (if available)

No data available for Orthologs for MIR24-1 Gene

Paralogs for MIR24-1 Gene

No data available for Paralogs for MIR24-1 Gene

Variants for MIR24-1 Gene

Sequence variations from dbSNP and Humsavar for MIR24-1 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000887918 -- 95,086,259(+) T/C downstream_transcript_variant
rs1001095373 -- 95,084,453(+) G/A upstream_transcript_variant
rs1001236818 -- 95,086,454(+) C/T downstream_transcript_variant
rs1001546394 -- 95,084,261(+) C/A upstream_transcript_variant
rs1002272038 -- 95,084,790(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR24-1 Gene

Variant ID Type Subtype PubMed ID
nsv1038106 CNV gain 25217958
nsv1147999 OTHER inversion 26484159
nsv831656 CNV loss 17160897

Additional Variant Information for MIR24-1 Gene

Human Gene Mutation Database (HGMD)
MIR24-1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR24-1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR24-1 Gene

Disorders for MIR24-1 Gene

MalaCards: The human disease database

(7) MalaCards diseases for MIR24-1 Gene - From: miR2Disease

Disorder Aliases PubMed IDs
pituitary adenoma
  • adenoma of the pituitary gland
leukemia, chronic lymphocytic
  • cll
thyroid cancer, nonmedullary, 1
  • nmtc1
glioblastoma
  • glioblastoma multiforme
pancreatic cancer
  • pancreatic carcinoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR24-1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR24-1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR24-1 Gene

Publications for MIR24-1 Gene

  1. MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia. (PMID: 20347265) Xu Y … Liu P (Schizophrenia research 2010) 3 44 58
  2. Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J … Zhao H (International journal of cancer 2009) 3 44 58
  3. MiR-24 induces chemotherapy resistance and hypoxic advantage in breast cancer. (PMID: 28061479) Roscigno G … Condorelli G (Oncotarget 2017) 3 58
  4. The role of miR-24 as a race related genetic factor in prostate cancer. (PMID: 28157714) Hashimoto Y … Dahiya R (Oncotarget 2017) 3 58
  5. Human Pericardial Fluid Contains Exosomes Enriched with Cardiovascular-Expressed MicroRNAs and Promotes Therapeutic Angiogenesis. (PMID: 28159509) Beltrami C … Emanueli C (Molecular therapy : the journal of the American Society of Gene Therapy 2017) 3 58

Products for MIR24-1 Gene

Sources for MIR24-1 Gene

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