Aliases for MIR24-1 Gene
Subcategory (RNA class) for MIR24-1 Gene
miRNA
Quality Score for this RNA gene is
13
Aliases for MIR24-1 Gene
External Ids for MIR24-1 Gene
- HGNC: 31607
- Entrez Gene: 407012
- Ensembl: ENSG00000284459
- OMIM: 609705
- miRBase: hsa-mir-24-1
Previous HGNC Symbols for MIR24-1 Gene
- MIRN24-1
Previous GeneCards Identifiers for MIR24-1 Gene
- GC09P096892
- GC09P097849
- GC09P097851
- GC09P097859
- GC09P097867
- GC09P094727
Summaries for MIR24-1 Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR24-1 Gene
MIR24-1 (MicroRNA 24-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR24-1 include Pituitary Adenoma and Leukemia, Chronic Lymphocytic. Among its related pathways are Peptide hormone metabolism and Hepatitis C and Hepatocellular Carcinoma.
Additional gene information for MIR24-1 Gene
- Monarch Initiative
- Search for MIR24-1 at DataMed
- Search for MIR24-1 at HumanCyc
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR24-1 Gene
Genomics for MIR24-1 Gene
GeneHancer (GH) Regulatory Elements for MIR24-1 Gene
Promoters and enhancers for MIR24-1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH09J095084 | Enhancer | 0.4 | ENCODE dbSUPER | 650.7 | -0.2 | -192 | 2 | GC09P095099 GC09P095100 GC09P095102 GC09P095103 GC09P095104 MIR23B MIR24-1 MIR27B MIR3074 C9orf3 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around MIR24-1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for MIR24-1 Gene
Genomic Locations for MIR24-1 Gene
- chr9:95,086,021-95,086,088
- (GRCh38/hg38)
- Size:
- 68 bases
- Orientation:
- Plus strand
- chr9:97,848,303-97,848,370
- (GRCh37/hg19)
- Size:
- 68 bases
- Orientation:
- Plus strand
Genomic View for MIR24-1 Gene
Genes around MIR24-1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9q22.32 by Entrez Gene
- 9q22.32 by HGNC
- 9q22.32 by Ensembl
MIR24-1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR24-1 Gene
Proteins for MIR24-1 Gene
Post-translational modifications for MIR24-1 Gene
No Post-translational modifications
Antibody Products
- Search GeneTex for Antibodies for MIR24-1
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR24-1
- Origene Custom Protein Services for MIR24-1
- Search GeneTex for Proteins for MIR24-1
No data available for DME Specific Peptides for MIR24-1 Gene
Domains & Families for MIR24-1 Gene
Gene Families for MIR24-1 Gene
- HGNC:
Graphical View of Domain Structure for InterPro Entry
No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR24-1 Gene
Function for MIR24-1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IMP | 23836801 |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR24-1
-
CRISPR Products
- Browse CRISPR knockouts for MIR24-1
- Applied Biological Materials CRISPR for MIR24-1
-
Vectors and viruses for KO, Activation, Repression, and more
miRNA Products
Inhibitory RNA Products
Clone Products
- GenScript: Custom all cDNA clones Services for MIR24-1
- VectorBuilder custom plasmid, inducible vectors for MIR24-1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR24-1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MIR24-1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR24-1 Gene
Localization for MIR24-1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | IDA | 26646931 |
| GO:0070062 | extracellular exosome | IDA | 28159509 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR24-1 Gene
Pathways & Interactions for MIR24-1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Peptide hormone metabolism | ||
| 2 | Metabolism of proteins | ||
| 3 | Hepatitis C and Hepatocellular Carcinoma | ||
Pathways by source for MIR24-1 Gene
1 BioSystems pathway for MIR24-1 Gene
3 Reactome pathways for MIR24-1 Gene
Interacting Proteins for MIR24-1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0010667 | negative regulation of cardiac muscle cell apoptotic process | ISS | -- |
| GO:0016525 | negative regulation of angiogenesis | IDA | 23774796 |
| GO:0035195 | gene silencing by miRNA | IMP | 23774796 |
| GO:0043537 | negative regulation of blood vessel endothelial cell migration | IDA | 21788589 |
| GO:0061049 | cell growth involved in cardiac muscle cell development | ISS | -- |
No data available for SIGNOR curated interactions for MIR24-1 Gene
Transcripts for MIR24-1 Gene
mRNA/cDNA for MIR24-1 Gene
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000637495 68 bps
- (3) RNA Central transcripts :
CRISPR Products
- Browse CRISPR knockouts for MIR24-1
- Applied Biological Materials CRISPR for MIR24-1
-
Vectors and viruses for KO, Activation, Repression, and more
miRNA Products
Inhibitory RNA Products
Clone Products
- GenScript: Custom all cDNA clones Services for MIR24-1
- VectorBuilder custom plasmid, inducible vectors for MIR24-1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR24-1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MIR24-1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for MIR24-1 Gene
No Expression Related Data Available
Primer Products
Gene Expression Assay Products
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR24-1 Gene
Orthologs for MIR24-1 Gene
No data available for Orthologs for MIR24-1 Gene
Paralogs for MIR24-1 Gene
No data available for Paralogs for MIR24-1 Gene
Variants for MIR24-1 Gene
| SNP ID | Clin | Chr 09 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000887918 | -- | 95,086,259(+) | T/C | downstream_transcript_variant | |
| rs1001095373 | -- | 95,084,453(+) | G/A | upstream_transcript_variant | |
| rs1001236818 | -- | 95,086,454(+) | C/T | downstream_transcript_variant | |
| rs1001546394 | -- | 95,084,261(+) | C/A | upstream_transcript_variant | |
| rs1002272038 | -- | 95,084,790(+) | A/G | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1038106 | CNV | gain | 25217958 |
| nsv1147999 | OTHER | inversion | 26484159 |
| nsv831656 | CNV | loss | 17160897 |
Additional Variant Information for MIR24-1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR24-1 Gene
Disorders for MIR24-1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| pituitary adenoma |
|
|
| leukemia, chronic lymphocytic |
|
|
| thyroid cancer, nonmedullary, 1 |
|
|
| glioblastoma |
|
|
| pancreatic cancer |
|
Search MIR24-1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MIR24-1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for MIR24-1 Gene
Publications for MIR24-1 Gene
- MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia. (PMID: 20347265) Xu Y … Liu P (Schizophrenia research 2010) 3 44 58
- Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J … Zhao H (International journal of cancer 2009) 3 44 58
- MiR-24 induces chemotherapy resistance and hypoxic advantage in breast cancer. (PMID: 28061479) Roscigno G … Condorelli G (Oncotarget 2017) 3 58
- The role of miR-24 as a race related genetic factor in prostate cancer. (PMID: 28157714) Hashimoto Y … Dahiya R (Oncotarget 2017) 3 58
- Human Pericardial Fluid Contains Exosomes Enriched with Cardiovascular-Expressed MicroRNAs and Promotes Therapeutic Angiogenesis. (PMID: 28159509) Beltrami C … Emanueli C (Molecular therapy : the journal of the American Society of Gene Therapy 2017) 3 58
Products for MIR24-1 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
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- Browse Immunoprecipitation Assays
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- Custom Antibody Services
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Custom all cDNA clones Services for MIR24-1
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR24-1
- VectorBuilder custom plasmid, inducible vectors for MIR24-1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR24-1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for MIR24-1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for MIR24-1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MIR24-1
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for MIR24-1
Sources for MIR24-1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt