microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR23C Gene

Subcategory (RNA class) for MIR23C Gene

miRNA

Number of RNA Genes sources:

4 / 14

Aliases for MIR23C Gene

  • MicroRNA 23c 2 3 5
  • Hsa-MiR-23c 166 177
  • MIMAT0018000 51
  • Hsa-Mir-23c 3
  • MI0016010 51
  • Mir-23c 3
  • MIR23C 2

External Ids for MIR23C Gene

Previous GeneCards Identifiers for MIR23C Gene

  • GC0XU901672

Summaries for MIR23C Gene

Entrez Gene Summary for MIR23C Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR23C Gene

MIR23C (MicroRNA 23c) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

Additional gene information for MIR23C Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR23C Gene

Genomics for MIR23C Gene

GeneHancer (GH) Regulatory Elements for MIR23C Gene

Promoters and enhancers for MIR23C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ020028 Enhancer 0.9 Ensembl ENCODE 0.4 -12.6 -12634 2.4 TCF7 TEAD1 SIN3A MAFF USF1 SAP130 GATA3 ELF1 SMAD4 IKZF1 BCLAF3 SH3KBP1 MIR23C lnc-BCLAF3-1 RF00017-8202 MAP7D2
GH0XJ020026 Enhancer 0.4 Ensembl 0.4 -9.4 -9414 0.8 JUND FOSL2 GABPA BCLAF3 SH3KBP1 MIR23C lnc-BCLAF3-1 RF00017-8202 MAP7D2
GH0XJ020001 Enhancer 0.4 Ensembl 0.4 +15.6 15586 0.4 RAD21 FOXA1 CTCF MAP7D2 piR-50443-400 MIR23C RF00017-8202
GH0XJ020027 Enhancer 0.3 Ensembl 0.4 -10.8 -10814 0.8 HLF SH3KBP1 MIR23C lnc-BCLAF3-1 RF00017-8202 MAP7D2
GH0XJ020008 Enhancer 0.2 Ensembl 0.4 +9.5 9486 0.2 MIR23C piR-50443-400 RF00017-8202 MAP7D2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR23C on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR23C Gene

Genomic Locations for MIR23C Gene
chrX:20,017,088-20,017,187
(GRCh38/hg38)
Size:
100 bases
Orientation:
Minus strand
chrX:20,035,206-20,035,305
(GRCh37/hg19)
Size:
100 bases
Orientation:
Minus strand

Genomic View for MIR23C Gene

Genes around MIR23C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR23C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR23C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR23C Gene

Proteins for MIR23C Gene

Post-translational modifications for MIR23C Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR23C Gene

Domains & Families for MIR23C Gene

Gene Families for MIR23C Gene

HGNC:
genes like me logo Genes that share domains with MIR23C: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR23C Gene

Function for MIR23C Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR23C Gene

Localization for MIR23C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR23C gene
Compartment Confidence
plasma membrane 1
extracellular 1
mitochondrion 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR23C Gene

Pathways & Interactions for MIR23C Gene

PathCards logo

SuperPathways for MIR23C Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR23C: view

Pathways by source for MIR23C Gene

1 KEGG pathway for MIR23C Gene
;

Gene Ontology (GO) - Biological Process for MIR23C Gene

None

No data available for Interacting Proteins and SIGNOR curated interactions for MIR23C Gene

Drugs & Compounds for MIR23C Gene

No Compound Related Data Available

Transcripts for MIR23C Gene

mRNA/cDNA for MIR23C Gene

2 RNACentral transcripts :
1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
2 miRBase transcripts :
3 ENA transcripts :
1 LncBase transcripts :
1 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR23C Gene

No ASD Table

Relevant External Links for MIR23C Gene

GeneLoc Exon Structure for
MIR23C

Expression for MIR23C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR23C Gene

genes like me logo Genes that share expression patterns with MIR23C: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR23C Gene

Orthologs for MIR23C Gene

Evolution for MIR23C Gene

ENSEMBL:
Gene Tree for MIR23C (if available)
TreeFam:
Gene Tree for MIR23C (if available)

No data available for Orthologs for MIR23C Gene

Paralogs for MIR23C Gene

No data available for Paralogs for MIR23C Gene

Variants for MIR23C Gene

Additional dbSNP identifiers (rs#s) for MIR23C Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR23C Gene

Variant ID Type Subtype PubMed ID
esv3573634 CNV loss 25503493

Additional Variant Information for MIR23C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR23C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR23C Gene

Disorders for MIR23C Gene

Additional Disease Information for MIR23C

No disorders were found for MIR23C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR23C Gene

Publications for MIR23C Gene

  1. LncRNA KTN1-AS1 promotes tumor growth of hepatocellular carcinoma by targeting miR-23c/ERBB2IP axis. (PMID: 30551364) Zhang L … Tu K (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019) 3 54
  2. miR-23c suppresses tumor growth of human hepatocellular carcinoma by attenuating ERBB2IP. (PMID: 30103114) Zhang L … Liu Q (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018) 3 54
  3. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 54
  4. Ultra-high throughput sequencing-based small RNA discovery and discrete statistical biomarker analysis in a collection of cervical tumours and matched controls. (PMID: 20459774) Witten D … Lui WO (BMC biology 2010) 3 54
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 54

Products for MIR23C Gene

Sources for MIR23C Gene