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Aliases for MIR23B Gene

Subcategory (RNA class) for MIR23B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR23B Gene

  • MicroRNA 23b 2 3 5
  • Hsa-Mir-23b 3
  • MiRNA23B 3
  • Mir-23b 3
  • MIRN23B 3

External Ids for MIR23B Gene

ORGUL Members for MIR23B Gene

Previous HGNC Symbols for MIR23B Gene

  • MIRN23B

Previous GeneCards Identifiers for MIR23B Gene

  • GC09P096890
  • GC09P097847

Summaries for MIR23B Gene

Entrez Gene Summary for MIR23B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR23B Gene

MIR23B (MicroRNA 23b) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Spinal Cord Injury and miRNAs involved in DNA damage response.

Additional gene information for MIR23B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR23B Gene

Genomics for MIR23B Gene

GeneHancer (GH) Regulatory Elements for MIR23B Gene

Promoters and enhancers for MIR23B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I095084 Enhancer 0.4 ENCODE dbSUPER 550.8 +0.6 621 2 GC09P095098 GC09P095099 GC09P095100 GC09P095102 GC09P095103 MIR23B MIR24-1 MIR27B MIR3074 C9orf3
GH09I095016 Enhancer 1.4 Ensembl ENCODE dbSUPER 12.2 -63.4 -63361 10.7 PKNOX1 ATF1 FOXA2 ARID4B SIN3A DMAP1 ZNF48 YY1 FOS ATF7 MIR23B MIR27B MIR3074 C9orf3 MIR6081 LOC101928119
GH09I095053 Enhancer 1.1 Ensembl ENCODE dbSUPER 12.6 -28.3 -28336 6.2 ZNF449 JUN MAX FEZF1 ZIC2 HIC1 ZNF335 ZFHX2 ZNF213 POLR2A MIR23B MIR27B MIR3074 MIR6081 LOC101928119 C9orf3
GH09I095060 Enhancer 1 ENCODE dbSUPER 13.7 -21.2 -21241 6 FOXA2 ARID4B RAD21 RARA YY1 CREM THAP11 RXRA SP5 USF2 MIR6081 MIR23B MIR27B MIR3074 C9orf3 LOC101928119
GH09I095106 Enhancer 0.6 ENCODE dbSUPER 12.7 +22.4 22412 2.3 ZNF316 MAFK PIR48893 MIR23B MIR27B MIR3074 PIR51992 FANCC C9orf3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR23B on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR23B Gene

Genomic Locations for MIR23B Gene
chr9:95,085,208-95,085,304
(GRCh38/hg38)
Size:
97 bases
Orientation:
Plus strand
chr9:97,847,490-97,847,586
(GRCh37/hg19)

Genomic View for MIR23B Gene

Genes around MIR23B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR23B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR23B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR23B Gene

Proteins for MIR23B Gene

Post-translational modifications for MIR23B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR23B Gene

Domains & Families for MIR23B Gene

Gene Families for MIR23B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR23B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR23B Gene

Function for MIR23B Gene

Gene Ontology (GO) - Molecular Function for MIR23B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 28111633
genes like me logo Genes that share ontologies with MIR23B: view

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR23B Gene

Localization for MIR23B Gene

Gene Ontology (GO) - Cellular Components for MIR23B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR23B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR23B Gene

Pathways & Interactions for MIR23B Gene

genes like me logo Genes that share pathways with MIR23B: view

Pathways by source for MIR23B Gene

2 BioSystems pathways for MIR23B Gene
1 KEGG pathway for MIR23B Gene

Interacting Proteins for MIR23B Gene

Gene Ontology (GO) - Biological Process for MIR23B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010628 positive regulation of gene expression IGI 28111633
GO:0010629 negative regulation of gene expression IDA 28111633
GO:0035195 gene silencing by miRNA IDA 28111633
GO:0060045 positive regulation of cardiac muscle cell proliferation IDA 28111633
GO:0061049 cell growth involved in cardiac muscle cell development ISS --
genes like me logo Genes that share ontologies with MIR23B: view

No data available for SIGNOR curated interactions for MIR23B Gene

Drugs & Compounds for MIR23B Gene

No Compound Related Data Available

Transcripts for MIR23B Gene

mRNA/cDNA for MIR23B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR23B Gene

No ASD Table

Relevant External Links for MIR23B Gene

GeneLoc Exon Structure for
MIR23B
ECgene alternative splicing isoforms for
MIR23B

Expression for MIR23B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR23B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR23B Gene:

MIR23B
genes like me logo Genes that share expression patterns with MIR23B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR23B Gene

Orthologs for MIR23B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR23B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-23b 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-23b 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-23b 34
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-23b 34
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir23b 34
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-23b 34
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-23b 34
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-23b 34
  • 90 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CR847548.1 34
  • 86 (a)
OneToMany
dre-mir-23b 34
  • 83 (a)
OneToMany
Species where no ortholog for MIR23B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR23B Gene

ENSEMBL:
Gene Tree for MIR23B (if available)
TreeFam:
Gene Tree for MIR23B (if available)

Paralogs for MIR23B Gene

No data available for Paralogs for MIR23B Gene

Variants for MIR23B Gene

Sequence variations from dbSNP and Humsavar for MIR23B Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1001095373 -- 95,084,453(+) G/A upstream_transcript_variant
rs1001546394 -- 95,084,261(+) C/A upstream_transcript_variant
rs1002272038 -- 95,084,790(+) A/G upstream_transcript_variant
rs1002624887 -- 95,085,142(+) C/T upstream_transcript_variant
rs1003368832 -- 95,083,475(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR23B Gene

Variant ID Type Subtype PubMed ID
nsv1038106 CNV gain 25217958
nsv1147999 OTHER inversion 26484159
nsv831656 CNV loss 17160897

Additional Variant Information for MIR23B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR23B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR23B Gene

Disorders for MIR23B Gene

Additional Disease Information for MIR23B

No disorders were found for MIR23B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR23B Gene

Publications for MIR23B Gene

  1. Regulation and biological roles of the multifaceted miRNA-23b (MIR23B). (PMID: 29101066) Wang W … van Wijnen AJ (Gene 2018) 3 58
  2. MicroRNAs miR-23a-3p, miR-23b-3p, and miR-149-5p Regulate the Expression of Proapoptotic BH3-Only Proteins DP5 and PUMA in Human Pancreatic β-Cells. (PMID: 27737950) Grieco FA … Eizirik DL (Diabetes 2017) 3 58
  3. Long non-coding RNA tumor suppressor candidate 7 advances chemotherapy sensitivity of endometrial carcinoma through targeted silencing of miR-23b. (PMID: 28653877) Shang C … Meng L (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 58
  4. MiR-23b controls ALDH1A1 expression in cervical cancer stem cells. (PMID: 28449663) Wang W … Li L (BMC cancer 2017) 3 58
  5. Human papillomavirus type 16 E6 suppresses microRNA-23b expression in human cervical cancer cells through DNA methylation of the host gene C9orf3. (PMID: 28077801) Yeung CL … Kwok TT (Oncotarget 2017) 3 58

Products for MIR23B Gene

Sources for MIR23B Gene

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