microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR23B Gene

Subcategory (RNA class) for MIR23B Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR23B Gene

  • MicroRNA 23b 2 3 5
  • Hsa-MiR-23b-5p 163 173
  • Hsa-MiR-23b-3p 163 173
  • Hsa-Mir-23b 2 3
  • MIR23B 2 5
  • Hsa-Mir-23-P2 178
  • MIMAT0000418 50
  • MIMAT0004587 50
  • MI0000439 50
  • MiRNA23B 3
  • MIRN23B 3
  • Mir-23b 3
  • RF00642 168

External Ids for MIR23B Gene

Previous HGNC Symbols for MIR23B Gene

  • MIRN23B

Previous GeneCards Identifiers for MIR23B Gene

  • GC09P096890
  • GC09P097847

Summaries for MIR23B Gene

Entrez Gene Summary for MIR23B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR23B Gene

MIR23B (MicroRNA 23b) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR23B include Melanoma and Prostate Cancer. Among its related pathways are MicroRNAs in cancer and Spinal Cord Injury.

Rfam classification for MIR23B Gene

Additional gene information for MIR23B Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR23B Gene

Genomics for MIR23B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR23B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J095084 Enhancer 0.8 Ensembl ENCODE dbSUPER 600.7 +0.1 114 3 HNRNPL ESR1 RBM22 CTCF POLR2A MIR23B MIR24-1 MIR27B MIR3074 lnc-MFSD14B-20 NONHSAG052915.2 AOPEP FANCC
GH09J095016 Promoter/Enhancer 1.5 Ensembl ENCODE dbSUPER 12.2 -63.4 -63361 10.7 GATAD2A PRDM10 ZNF629 TFE3 IKZF1 CTCF RCOR2 ZNF7 FOXA1 PRDM1 MIR23B MIR27B MIR3074 AOPEP lnc-MFSD14B-18 lnc-MFSD14B-7 NONHSAG052915.2 FANCC
GH09J095060 Enhancer 1.2 Ensembl ENCODE dbSUPER 13.7 -21.1 -21112 6.2 GATAD2A TFE3 RXRB IRF2 SP1 GABPA TOE1 CEBPA FOXK2 SOX13 MIR6081 MIR23B MIR27B MIR3074 AOPEP piR-43107-304 NONHSAG052915.2 FANCC
GH09J095053 Promoter/Enhancer 1.2 Ensembl ENCODE dbSUPER 12.6 -28.3 -28336 6.2 PRDM10 ZNF629 FOXA1 ZIC2 POLR2A ZBTB44 SP1 TCF7L2 CEBPB OSR2 MIR23B MIR27B MIR3074 MIR6081 piR-43107-304 NONHSAG052915.2 AOPEP FANCC
GH09J095076 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 0.4 -5.8 -5807 7.6 ATF7 TEAD4 ZIC2 ESR1 ATF3 POLR2A RBM22 ZFHX2 CTCF GATA3 FANCC AOPEP PTCH1 MIR23B MIR6081 NONHSAG052915.2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR23B on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR23B Gene

Genomic Locations for MIR23B Gene
chr9:95,085,208-95,085,304
(GRCh38/hg38)
Size:
97 bases
Orientation:
Plus strand
chr9:97,847,490-97,847,586
(GRCh37/hg19)
Size:
97 bases
Orientation:
Plus strand

Genomic View for MIR23B Gene

Genes around MIR23B on UCSC Golden Path with GeneCards custom track
MIR23B in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR23B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR23B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR23B Gene

Proteins for MIR23B Gene

Post-translational modifications for MIR23B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR23B Gene

Domains & Families for MIR23B Gene

Gene Families for MIR23B Gene

genes like me logo Genes that share domains with MIR23B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR23B Gene

Function for MIR23B Gene

Gene Ontology (GO) - Molecular Function for MIR23B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IGI --
genes like me logo Genes that share ontologies with MIR23B: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR23B Gene

Localization for MIR23B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR23B gene
Compartment Confidence
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 2
cytosol 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MIR23B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA --
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIR23B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR23B Gene

Pathways & Interactions for MIR23B Gene

genes like me logo Genes that share pathways with MIR23B: view

Pathways by source for MIR23B Gene

2 BioSystems pathways for MIR23B Gene
1 KEGG pathway for MIR23B Gene

Gene Ontology (GO) - Biological Process for MIR23B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010628 positive regulation of gene expression IGI --
GO:0010629 negative regulation of gene expression IDA --
GO:0010871 negative regulation of receptor biosynthetic process IDA --
GO:0035195 gene silencing by miRNA IGI,IEA --
GO:0035924 cellular response to vascular endothelial growth factor stimulus IGI --
genes like me logo Genes that share ontologies with MIR23B: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR23B Gene

Drugs & Compounds for MIR23B Gene

No Compound Related Data Available

Transcripts for MIR23B Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR23B Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000055BB1F_9606 miRNA 22 6

RefSeq: NR_029664,

LncBase: hsa-miR-23b-5p,

miRBase: MIMAT0004587,

MirGeneDB: Hsa-Mir-23-P2_5p,

TarBase: hsa-miR-23b-5p,

ENA: LM380265.1:1..22:ncRNA, LM608479.1:20..41:ncRNA,

URS0000283D0A_9606 precursor_RNA 97 5

HGNC: 31606,

RefSeq: NR_029664,

Ensembl: ENST00000384832 (view in UCSC) ,

miRBase: MI0000439,

ENA: LM608479.1:1..97:precursor_RNA,

URS00004E57E7_9606 miRNA 23 3

RefSeq: NR_029664,

miRBase: MIMAT0000418,

MirGeneDB: Hsa-Mir-23-P2_3p,

URS0000183BED_9606 miRNA 21 3

LncBase: hsa-miR-23b-3p,

TarBase: hsa-miR-23b-3p,

ENA: HB859651.1:1..21:misc_RNA, LM379036.1:1..21:ncRNA, LM608479.1:58..78:ncRNA,

URS000024C472_9606 precursor_RNA 75 1

Rfam: RF00642,

MIR23B in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR23B Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR23B Gene

No ASD Table

Relevant External Links for MIR23B Gene

GeneLoc Exon Structure for
MIR23B

Expression for MIR23B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR23B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR23B

Evidence on tissue expression from TISSUES for MIR23B Gene

  • Blood(2.2)
  • Heart(2)
genes like me logo Genes that share expression patterns with MIR23B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR23B Gene

Orthologs for MIR23B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR23B Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
Mammalia bta-mir-23b 31
  • 100 (a)
OneToOne
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-23b 31
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-23b 31
  • 100 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-23b 31
  • 97 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir23b 31
  • 96 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-23b 31
  • 71 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-23b 31
  • 90 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-23b 31
  • 90 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii CR847548.1 31
  • 86 (a)
OneToMany
dre-mir-23b 31
  • 83 (a)
OneToMany
Species where no ortholog for MIR23B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR23B Gene

ENSEMBL:
Gene Tree for MIR23B (if available)
TreeFam:
Gene Tree for MIR23B (if available)

Paralogs for MIR23B Gene

No data available for Paralogs for MIR23B Gene

Variants for MIR23B Gene

Additional dbSNP identifiers (rs#s) for MIR23B Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR23B Gene

Variant ID Type Subtype PubMed ID
nsv1038106 CNV gain 25217958
nsv1147999 OTHER inversion 26484159
nsv831656 CNV loss 17160897

Additional Variant Information for MIR23B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR23B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR23B Gene

Disorders for MIR23B Gene

MalaCards: The human disease database

(53) MalaCards diseases for MIR23B Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
melanoma
  • malignant melanoma
prostate cancer
  • prostate cancer, somatic
hepatocellular carcinoma
  • hcc
leiomyoma, uterine
  • ul
ovarian serous carcinoma
  • ovarian serous adenocarcinoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR23B

genes like me logo Genes that share disorders with MIR23B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR23B Gene

Publications for MIR23B Gene

  1. Sleeping beauty genetic screen identifies miR-23b::BTBD7 gene interaction as crucial for colorectal cancer metastasis. (PMID: 31303496) Grisard E … Nicoloso MS (EBioMedicine 2019) 3
  2. Adipose-derived exosomes deliver miR-23a/b to regulate tumor growth in hepatocellular cancer by targeting the VHL/HIF axis. (PMID: 31321740) Liu Y … Chen L (Journal of physiology and biochemistry 2019) 3
  3. Circulating microRNA-23b as a new biomarker for rheumatoid arthritis. (PMID: 31176730) Liu X … Wang Y (Gene 2019) 3
  4. MicroRNA-23b-3p promotes the proliferation, migration, and epithelial-mesenchymal transition of lens epithelial cells by targeting Sprouty2. (PMID: 31235073) Liu W … Wang L (Acta histochemica 2019) 3
  5. miR-23b and miR-27b are oncogenic microRNAs in breast cancer: evidence from a CRISPR/Cas9 deletion study. (PMID: 31253120) Hannafon BN … Ding WQ (BMC cancer 2019) 3

Products for MIR23B Gene

Sources for MIR23B Gene