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Aliases for MIR23A Gene

Subcategory (RNA class) for MIR23A Gene

miRNA

Quality Score for this RNA gene is

25.2

Aliases for MIR23A Gene

  • MicroRNA 23a 2 3 5
  • Hsa-Mir-23a 3
  • MiRNA23A 3
  • Mir-23a 3
  • MIRN23A 3

External Ids for MIR23A Gene

Previous HGNC Symbols for MIR23A Gene

  • MIRN23A

Previous GeneCards Identifiers for MIR23A Gene

  • GC19M013847
  • GC19M013853
  • GC19M013950
  • GC19M013953
  • GC19M013958
  • GC19M013968
  • GC19M013862
  • GC19M013867
  • GC19M013872
  • GC19M013878
  • GC19M013886
  • GC19M013896
  • GC19M013902
  • GC19M013913
  • GC19M013920
  • GC19M013932

Summaries for MIR23A Gene

Entrez Gene Summary for MIR23A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR23A Gene

MIR23A (MicroRNA 23a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR23A include Hepatocellular Carcinoma and Ovarian Serous Carcinoma. Among its related pathways are MicroRNAs in cancer and MicroRNAs in cardiomyocyte hypertrophy.

fRNAdb sequence ontologies for MIR23A Gene - the ORGUL cluster for this gene includes several descriptions:

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR23A

Additional gene information for MIR23A Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR23A Gene

Genomics for MIR23A Gene

GeneHancer (GH) Regulatory Elements for MIR23A Gene

Promoters and enhancers for MIR23A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J013793 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 12.7 +40.8 40812 5.5 SP1 ZFX ELF3 ZNF687 CEBPG FOS MLLT1 TRIM24 ZBTB7A SP7 ENSG00000267582 GC19P013795 ZSWIM4 ENSG00000267519 CACNA1A DDX39A MAST1 C19orf53 MRI1 NANOS3
GH19J013787 Enhancer 0.7 ENCODE 12.6 +47.6 47599 4 ZNF687 CEBPG IKZF1 POLR2A RFX1 HDAC2 BCOR CEBPB JUN MAX C19orf53 MIR23A MIR24-2 MIR27A MRI1 MISP3 GC19P013795
GH19J013833 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE dbSUPER 0.4 -7.9 -7913 23.1 SREBF1 ZKSCAN8 MNT SP1 ZFX CBFA2T2 ELF3 ZNF652 GTF2F1 MLLT1 ENSG00000267519 GC19M013946 CCDC130 ZNF333 MRI1 TRMT1 DCAF15 RFX1 DDX39A SYCE2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR23A on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR23A Gene

Genomic Locations for MIR23A Gene
chr19:13,836,587-13,836,659
(GRCh38/hg38)
Size:
73 bases
Orientation:
Minus strand
chr19:13,947,401-13,947,473
(GRCh37/hg19)
Size:
73 bases
Orientation:
Minus strand

Genomic View for MIR23A Gene

Genes around MIR23A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR23A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR23A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR23A Gene

ORGUL Member Location for MIR23A Gene

ORGUL Member Location for MIR23A gene

Proteins for MIR23A Gene

Post-translational modifications for MIR23A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR23A Gene

Domains & Families for MIR23A Gene

Gene Families for MIR23A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR23A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR23A Gene

Function for MIR23A Gene

Phenotypes From GWAS Catalog for MIR23A Gene

Gene Ontology (GO) - Molecular Function for MIR23A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IGI 21536891
genes like me logo Genes that share ontologies with MIR23A: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR23A Gene

Localization for MIR23A Gene

Gene Ontology (GO) - Cellular Components for MIR23A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 18766170
GO:0035068 micro-ribonucleoprotein complex IEA --
GO:0070062 extracellular exosome IDA 28159509
genes like me logo Genes that share ontologies with MIR23A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR23A Gene

Pathways & Interactions for MIR23A Gene

genes like me logo Genes that share pathways with MIR23A: view

Pathways by source for MIR23A Gene

1 KEGG pathway for MIR23A Gene

Interacting Proteins for MIR23A Gene

Gene Ontology (GO) - Biological Process for MIR23A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IGI 21536891
GO:0035924 cellular response to vascular endothelial growth factor stimulus IGI 21536891
GO:0043116 negative regulation of vascular permeability IDA 27741223
GO:0061049 cell growth involved in cardiac muscle cell development ISS --
GO:0070374 positive regulation of ERK1 and ERK2 cascade IGI 21536891
genes like me logo Genes that share ontologies with MIR23A: view

No data available for SIGNOR curated interactions for MIR23A Gene

Drugs & Compounds for MIR23A Gene

No Compound Related Data Available

Transcripts for MIR23A Gene

fRNAdb Secondary structures for MIR23A Gene

  • AF480558

mRNA/cDNA for MIR23A Gene

(4) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(3) RNA Central transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR23A Gene

No ASD Table

Relevant External Links for MIR23A Gene

GeneLoc Exon Structure for
MIR23A
ECgene alternative splicing isoforms for
MIR23A

Expression for MIR23A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR23A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR23A Gene:

MIR23A
genes like me logo Genes that share expression patterns with MIR23A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR23A Gene

Orthologs for MIR23A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR23A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-23a 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-23a 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-23a 35
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir23a 35
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-23a 35
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-23a 35 35
  • 69 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia aca-mir-23a 35
  • 72 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-23a-3 35
  • 60 (a)
OneToMany
dre-mir-23a-1 35
  • 56 (a)
OneToMany
dre-mir-23a-4 35 35
  • 47 (a)
OneToMany
Species where no ortholog for MIR23A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR23A Gene

ENSEMBL:
Gene Tree for MIR23A (if available)
TreeFam:
Gene Tree for MIR23A (if available)

Paralogs for MIR23A Gene

No data available for Paralogs for MIR23A Gene

Variants for MIR23A Gene

Sequence variations from dbSNP and Humsavar for MIR23A Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000538048 -- 13,837,030(-) A/G upstream_transcript_variant
rs1001463246 -- 13,838,118(-) G/C upstream_transcript_variant
rs1001573587 -- 13,837,391(-) T/C upstream_transcript_variant
rs1001978328 -- 13,838,043(-) T/A upstream_transcript_variant
rs1003195008 -- 13,837,157(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR23A Gene

Variant ID Type Subtype PubMed ID
nsv833757 CNV loss 17160897
nsv953979 CNV deletion 24416366

Additional Variant Information for MIR23A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR23A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR23A Gene

Disorders for MIR23A Gene

MalaCards: The human disease database

(13) MalaCards diseases for MIR23A Gene - From: miR2Disease

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR23A

genes like me logo Genes that share disorders with MIR23A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR23A Gene

Publications for MIR23A Gene

  1. miR‑23a downregulation modulates the inflammatory response by targeting ATG12‑mediated autophagy. (PMID: 29845275) Si X … Guan XD (Molecular medicine reports 2018) 3 58
  2. Effect of the LncRNA GAS5-MiR-23a-ATG3 Axis in Regulating Autophagy in Patients with Breast Cancer. (PMID: 30007957) Gu J … He Z (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018) 3 58
  3. MiR-23a regulates the proliferation and migration of human pulmonary artery smooth muscle cells (HPASMCs) through targeting BMPR2/Smad1 signaling. (PMID: 29864909) Zhang Y … Han Y (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018) 3 58
  4. miR-23a acts as an oncogene in pancreatic carcinoma by targeting FOXP2. (PMID: 29141872) Diao H … Qin R (Journal of investigative medicine : the official publication of the American Federation for Clinical Research 2018) 3 58
  5. Knockdown of Long Non-Coding RNA GAS5 Increases miR-23a by Targeting ATG3 Involved in Autophagy and Cell Viability. (PMID: 30078013) Li L … Dai H (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018) 3 58

Products for MIR23A Gene

Sources for MIR23A Gene

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