microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR23A Gene

Subcategory (RNA class) for MIR23A Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR23A Gene

  • MicroRNA 23a 2 3 5
  • Hsa-MiR-23a-3p 163 173
  • Hsa-MiR-23a-5p 163 173
  • Hsa-Mir-23a 2 3
  • MIR23A 2 5
  • Hsa-Mir-23-P1 178
  • MIMAT0004496 50
  • MIMAT0000078 50
  • MI0000079 50
  • MiRNA23A 3
  • MIRN23A 3
  • Mir-23a 3
  • RF00642 168

External Ids for MIR23A Gene

Additional External Ids for MIR23A Gene

Previous HGNC Symbols for MIR23A Gene

  • MIRN23A

Previous GeneCards Identifiers for MIR23A Gene

  • GC19M013847
  • GC19M013853
  • GC19M013950
  • GC19M013953
  • GC19M013958
  • GC19M013968
  • GC19M013862
  • GC19M013867
  • GC19M013940
  • GC19M013954
  • GC19M013966
  • GC19M013988
  • GC19M013872
  • GC19M013878
  • GC19M013886
  • GC19M013896
  • GC19M013902
  • GC19M013913
  • GC19M013920
  • GC19M013932

Summaries for MIR23A Gene

Entrez Gene Summary for MIR23A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR23A Gene

MIR23A (MicroRNA 23a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR23A include Hepatocellular Carcinoma and Heart Disease. Among its related pathways are MicroRNAs in cardiomyocyte hypertrophy and MicroRNAs in cancer.

Rfam classification for MIR23A Gene

Additional gene information for MIR23A Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR23A Gene

Genomics for MIR23A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR23A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J013793 Promoter/Enhancer 2 Ensembl ENCODE CraniofacialAtlas dbSUPER 12.7 +40.8 40816 5.5 CEBPG SP1 CREB1 GATAD2A TEAD4 PRDM10 ZNF629 REST IKZF1 KDM1A ENSG00000267582 lnc-C19orf57-8 ZSWIM4 ENSG00000267519 C19orf53 MRI1 MIR23A MIR24-2 MIR27A FARSA
GH19J013787 Enhancer 0.8 ENCODE CraniofacialAtlas 12.6 +47.6 47603 4 KDM1A RFX1 POLR2A CEBPB HDAC2 NR2F2 IKZF1 BCOR CEBPG SPI1 piR-57461-105 C19orf53 MIR23A MIR24-2 MIR27A MRI1 MISP3 lnc-C19orf57-8 ZSWIM4
GH19J013833 Promoter/Enhancer 2.4 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.4 -7.9 -7903 23.2 ZNF221 SP1 HNRNPL CREB1 GATAD2A CTCF ZBTB33 ATF7 TEAD4 PRDM10 ENSG00000267519 LOC284454 lnc-ZSWIM4-1 CCDC130 ZNF333 TRMT1 RPS6P25 ASF1B MRI1 RFX1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR23A on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR23A Gene

Genomic Locations for MIR23A Gene
chr19:13,836,583-13,836,663
(GRCh38/hg38)
Size:
81 bases
Orientation:
Minus strand
chr19:13,947,401-13,947,473
(GRCh37/hg19)
Size:
73 bases
Orientation:
Minus strand

Genomic View for MIR23A Gene

Genes around MIR23A on UCSC Golden Path with GeneCards custom track
MIR23A in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR23A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR23A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR23A Gene

Proteins for MIR23A Gene

Post-translational modifications for MIR23A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR23A Gene

Domains & Families for MIR23A Gene

Gene Families for MIR23A Gene

genes like me logo Genes that share domains with MIR23A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR23A Gene

Function for MIR23A Gene

Phenotypes From GWAS Catalog for MIR23A Gene

Gene Ontology (GO) - Molecular Function for MIR23A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IGI 21536891
genes like me logo Genes that share ontologies with MIR23A: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR23A Gene

Localization for MIR23A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR23A gene
Compartment Confidence
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
endosome 2
cytosol 2
peroxisome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MIR23A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 18766170
GO:0070062 extracellular exosome IDA 28159509
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIR23A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR23A Gene

Pathways & Interactions for MIR23A Gene

genes like me logo Genes that share pathways with MIR23A: view

Pathways by source for MIR23A Gene

1 KEGG pathway for MIR23A Gene

Gene Ontology (GO) - Biological Process for MIR23A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IGI 21536891
GO:0035924 cellular response to vascular endothelial growth factor stimulus IGI 21536891
GO:0043116 negative regulation of vascular permeability IDA 27741223
GO:0061049 cell growth involved in cardiac muscle cell development ISS --
GO:0070374 positive regulation of ERK1 and ERK2 cascade IGI 21536891
genes like me logo Genes that share ontologies with MIR23A: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR23A Gene

Drugs & Compounds for MIR23A Gene

No Compound Related Data Available

Transcripts for MIR23A Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR23A Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00001CC864_9606 precursor_RNA 73 6

HGNC: 31605,

RefSeq: NR_029495,

Ensembl: ENST00000385245 (view in UCSC) , ENST00000673161 (view in UCSC) ,

miRBase: MI0000079,

Rfam: RF00642,

ENA: LM608168.1:1..73:precursor_RNA,

URS00005070A9_9606 miRNA 22 6

RefSeq: NR_029495,

LncBase: hsa-miR-23a-5p,

miRBase: MIMAT0004496,

MirGeneDB: Hsa-Mir-23-P1_5p,

TarBase: hsa-miR-23a-5p,

ENA: LM380175.1:1..22:ncRNA, LM608168.1:9..30:ncRNA,

URS00005540D2_9606 miRNA 21 5

RefSeq: NR_029495,

LncBase: hsa-miR-23a-3p,

miRBase: MIMAT0000078,

TarBase: hsa-miR-23a-3p,

ENA: AJ421743.1:1..21:misc_RNA, HB859650.1:1..21:misc_RNA, LM378765.1:1..21:ncRNA, LM608168.1:45..65:ncRNA,

URS0000391DB6_9606 miRNA 22 2

MirGeneDB: Hsa-Mir-23-P1_3p,

ENA: AF480526.1:1..22:ncRNA,

URS00001EF8BC_9606 misc_RNA 81 1

ENA: AF480558.1:1..81:misc_RNA,

MIR23A in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR23A Gene

4 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR23A Gene

No ASD Table

Relevant External Links for MIR23A Gene

GeneLoc Exon Structure for
MIR23A

Expression for MIR23A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR23A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR23A

Evidence on tissue expression from TISSUES for MIR23A Gene

  • Blood(2.5)
  • Muscle(2.3)
  • Heart(2.3)
  • Nervous system(2.1)
  • Liver(2.1)
  • Skin(2)
genes like me logo Genes that share expression patterns with MIR23A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR23A Gene

Orthologs for MIR23A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR23A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-23a 31
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-23a 31
  • 99 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-23a 31
  • 99 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir23a 31
  • 91 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-23a 31
  • 89 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-23a 31 31
  • 69 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia aca-mir-23a 31
  • 72 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-23a-3 31
  • 60 (a)
OneToMany
dre-mir-23a-1 31
  • 56 (a)
OneToMany
dre-mir-23a-4 31 31
  • 47 (a)
OneToMany
Species where no ortholog for MIR23A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR23A Gene

ENSEMBL:
Gene Tree for MIR23A (if available)
TreeFam:
Gene Tree for MIR23A (if available)

Paralogs for MIR23A Gene

No data available for Paralogs for MIR23A Gene

Variants for MIR23A Gene

Additional dbSNP identifiers (rs#s) for MIR23A Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR23A Gene

Variant ID Type Subtype PubMed ID
nsv833757 CNV loss 17160897
nsv953979 CNV deletion 24416366

Additional Variant Information for MIR23A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR23A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR23A Gene

Disorders for MIR23A Gene

MalaCards: The human disease database

(47) MalaCards diseases for MIR23A Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
hepatocellular carcinoma
  • hcc
heart disease
  • congenital heart disease
ovarian serous carcinoma
  • ovarian serous adenocarcinoma
autism spectrum disorder
  • asd
leukemia, acute lymphoblastic
  • all
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with MIR23A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR23A Gene

Publications for MIR23A Gene

  1. MicroRNA-23a suppresses the apoptosis of inflammatory macrophages and foam cells in atherogenesis by targeting HSP90. (PMID: 31884108) Qiao Y … Luo S (Gene 2020) 3
  2. Identification of microRNAs in granulosa cells from patients with different levels of ovarian reserve function and the potential regulatory function of miR-23a in granulosa cell apoptosis. (PMID: 30453069) Luo H … Zhang Y (Gene 2019) 3
  3. MicroRNA-23a promotes colorectal cancer cell migration and proliferation by targeting at MARK1. (PMID: 31281935) Tang X … Wang D (Acta biochimica et biophysica Sinica 2019) 3
  4. Altered expression of microRNA-23a in psoriatic arthritis modulates synovial fibroblast pro-inflammatory mechanisms via phosphodiesterase 4B. (PMID: 30181004) Wade SM … Fearon U (Journal of autoimmunity 2019) 3
  5. Long noncoding RNA NEAT1 modulates cell proliferation and apoptosis by regulating miR-23a-3p/SMC1A in acute myeloid leukemia. (PMID: 30246348) Zhao C … Qi L (Journal of cellular physiology 2019) 3

Products for MIR23A Gene

Sources for MIR23A Gene