microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR2278 Gene

Subcategory (RNA class) for MIR2278 Gene

miRNA

Number of RNA Genes sources:

4 / 17

Aliases for MIR2278 Gene

  • MicroRNA 2278 2 3 5
  • Hsa-Mir-2278 2 3
  • Hsa-MiR-2278 163 173
  • MIR2278 2 5
  • MIMAT0011778 50
  • MI0011285 50
  • Mir-2278 3

External Ids for MIR2278 Gene

Previous GeneCards Identifiers for MIR2278 Gene

  • GC00U930250
  • GC09U901331
  • GC09P097572
  • GC09P067180

Summaries for MIR2278 Gene

Entrez Gene Summary for MIR2278 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR2278 Gene

MIR2278 (MicroRNA 2278) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR2278 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR2278 Gene

Genomics for MIR2278 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR2278 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J094811 Enhancer 0.6 Ensembl dbSUPER 600.7 +1.4 1438 0.4 ESR1 ESRRA SIN3A KLF9 CTCF MIR2278 lnc-MFSD14B-16 ENSG00000230815 AOPEP FANCC
GH09J094810 Enhancer 0.3 Ensembl dbSUPER 600.7 +0.8 839 0.4 MIR2278 lnc-MFSD14B-16 ENSG00000230815 AOPEP FANCC
GH09J094911 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.2 +110.8 110840 19.6 CREB1 GATAD2A TEAD4 PRDM10 ZNF629 RFX1 NFKBIZ RCOR2 TARDBP ZHX2 piR-50443-382 ERCC6L2 MIR2278 ENSG00000271155 ENSG00000232063 FBP1 ZNF169 FANCC AOPEP lnc-FANCC-74
GH09J094899 Promoter/Enhancer 1.3 Ensembl ENCODE dbSUPER 12.4 +92.4 92391 5.7 GATAD2A RBFOX2 RXRB REST CEBPA SOX13 CEBPB ETS1 TCF7 SP1 ENSG00000236095 MIR2278 FBP1 ZNF169 lnc-FANCC-74 AOPEP FANCC
GH09J094935 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +127.3 127296 3.3 CREB1 ZNF629 LEF1 IKZF1 JUND PHF21A NR2C1 BRD9 DPF2 HDAC1 ENSG00000224764 MIR2278 FBP1 LOC101928119 piR-50443-382 AOPEP FANCC
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR2278 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR2278 Gene

Genomic Locations for MIR2278 Gene
chr9:94,809,962-94,810,057
(GRCh38/hg38)
Size:
96 bases
Orientation:
Plus strand
chr9:97,572,244-97,572,339
(GRCh37/hg19)
Size:
96 bases
Orientation:
Plus strand

Genomic View for MIR2278 Gene

Genes around MIR2278 on UCSC Golden Path with GeneCards custom track
MIR2278 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR2278 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR2278 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR2278 Gene

Proteins for MIR2278 Gene

Post-translational modifications for MIR2278 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR2278 Gene

Domains & Families for MIR2278 Gene

Gene Families for MIR2278 Gene

HGNC:
genes like me logo Genes that share domains with MIR2278: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR2278 Gene

Function for MIR2278 Gene

Phenotypes From GWAS Catalog for MIR2278 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR2278 Gene

Localization for MIR2278 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR2278 gene
Compartment Confidence
plasma membrane 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR2278 Gene

Pathways & Interactions for MIR2278 Gene

PathCards logo

SuperPathways for MIR2278 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR2278 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR2278 Gene

Drugs & Compounds for MIR2278 Gene

No Compound Related Data Available

Transcripts for MIR2278 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR2278 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075C899_9606 precursor_RNA 96 5

HGNC: 37315,

RefSeq: NR_031755,

Ensembl: ENST00000516344 (view in UCSC) ,

miRBase: MI0011285,

ENA: LM610743.1:1..96:precursor_RNA,

URS000059EB31_9606 miRNA 22 5

RefSeq: NR_031755,

LncBase: hsa-miR-2278,

miRBase: MIMAT0011778,

TarBase: hsa-miR-2278,

ENA: LM381271.1:1..22:ncRNA, LM610743.1:16..37:ncRNA,

MIR2278 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR2278 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR2278 Gene

No ASD Table

Relevant External Links for MIR2278 Gene

GeneLoc Exon Structure for
MIR2278

Expression for MIR2278 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR2278 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR2278

genes like me logo Genes that share expression patterns with MIR2278: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR2278 Gene

Orthologs for MIR2278 Gene

Evolution for MIR2278 Gene

ENSEMBL:
Gene Tree for MIR2278 (if available)
TreeFam:
Gene Tree for MIR2278 (if available)

No data available for Orthologs for MIR2278 Gene

Paralogs for MIR2278 Gene

No data available for Paralogs for MIR2278 Gene

Variants for MIR2278 Gene

Additional dbSNP identifiers (rs#s) for MIR2278 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR2278 Gene

Variant ID Type Subtype PubMed ID
esv3621113 CNV gain 21293372
nsv1147999 OTHER inversion 26484159

Additional Variant Information for MIR2278 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR2278

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR2278 Gene

Disorders for MIR2278 Gene

No disorders were found for MIR2278 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR2278 Gene

Publications for MIR2278 Gene

  1. Revealing genome-wide mRNA and microRNA expression patterns in leukemic cells highlighted "hsa-miR-2278" as a tumor suppressor for regain of chemotherapeutic imatinib response due to targeting STAT5A. (PMID: 25953263) Kaymaz BT … Can BK (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2015) 3
  2. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3
  3. Identification and analysis of miRNAs in human breast cancer and teratoma samples using deep sequencing. (PMID: 19508715) Nygaard S … Litman T (BMC medical genomics 2009) 3
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR2278 Gene

Sources for MIR2278 Gene