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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR224 (MicroRNA 224) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR224 include Hepatocellular Carcinoma and Oral Squamous Cell Carcinoma. Among its related pathways are MicroRNAs in cancer.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH0XJ151981 | Enhancer | 1 | Ensembl ENCODE | 12.5 | -25.4 | -25443 | 7 | GATAD2A ZNF629 TFE3 RFX1 IKZF1 JUND REST GABPA SOX6 GATAD2B | MIR224 MAGEA4 MAGEA4-AS1 GABRE LOC105373369 lnc-MAGEA4-2 lnc-GABRE-2 MAGEA5 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | HDA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | MicroRNAs in cancer |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0035195 | gene silencing by miRNA | IDA,IEA | -- |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS0000184017_9606 | precursor_RNA | 81 | 6 |
HGNC: 31604, RefSeq: NR_029638, Ensembl: ENST00000384889 (view in UCSC) , miRBase: MI0000301, Rfam: RF00680, |
URS00001E8884_9606 | miRNA | 23 | 5 |
RefSeq: NR_029638, LncBase: hsa-miR-224-3p, miRBase: MIMAT0009198, TarBase: hsa-miR-224-3p, ENA: AY940872.1:1..23:ncRNA, LM381141.1:1..23:ncRNA, LM608369.1:53..75:ncRNA, |
URS0000D55DFB_9606 | miRNA | 25 | 2 |
RefSeq: NR_029638, miRBase: MIMAT0000281, |
URS00002BBD4E_9606 | miRNA | 21 | 3 |
LncBase: hsa-miR-224-5p, TarBase: hsa-miR-224-5p, |
URS0000EFD8E1_9606 | precursor_RNA | 70 | 1 |
MirGeneDB: Hsa-Mir-224, |
Disorder | Aliases | PubMed IDs |
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hepatocellular carcinoma |
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oral squamous cell carcinoma |
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pancreatic ductal adenocarcinoma |
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melanoma |
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prostate cancer |
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