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MIR224 Gene(RNA Gene)

MicroRNA 224

GCID:
GC0XM151958
GIFtS:
17
Genes Participants
UDN Logo

Aliases for MIR224 Gene

Subcategory (RNA class) for MIR224 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR224 Gene

  • MicroRNA 224 2 3 5
  • Hsa-Mir-224 3
  • MiRNA224 3
  • MIRN224 3

External Ids for MIR224 Gene

ORGUL Members for MIR224 Gene

Previous HGNC Symbols for MIR224 Gene

  • MIRN224

Previous GeneCards Identifiers for MIR224 Gene

  • GC0XM150877
  • GC0XM151127

Summaries for MIR224 Gene

Entrez Gene Summary for MIR224 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR224 Gene

MIR224 (MicroRNA 224) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

Additional gene information for MIR224 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR224 Gene

Genomics for MIR224 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for MIR224 Gene

Promoters and enhancers for MIR224 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH0XI151981 Enhancer 1.1 Ensembl ENCODE 12.5 -25.6 -25642 6.4 FOXA2 ZNF766 FOS REST ZNF592 MBD2 NFIL3 SMARCA4 ETV4 STAT3 MIR224 MAGEA4 LOC105373368 GABRE GC0XM152046
GH0XI151916 Promoter 0.5 EPDnew 0.3 +42.4 42416 0.1 MAGEA4 LOC105373368 MIR224
GH0XI151917 Promoter 0.5 EPDnew 0.3 +41.8 41772 0.1 MAGEA4 LOC105373368 MIR224
GH0XI151918 Promoter 0.5 EPDnew 0.3 +40.4 40420 0.1 MAGEA4 LOC105373368 MIR224
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR224 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR224 Gene

Genomic Locations for MIR224 Gene
chrX:151,958,578-151,958,658
(GRCh38/hg38)
Size:
81 bases
Orientation:
Minus strand
chrX:151,127,050-151,127,130
(GRCh37/hg19)

Genomic View for MIR224 Gene

Genes around MIR224 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR224 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR224 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR224 Gene

Proteins for MIR224 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIR224 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR224 Gene

Domains & Families for MIR224 Gene

Gene Families for MIR224 Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR224: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR224 Gene

Function for MIR224 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Gene Ontology (GO) - Molecular Function for MIR224 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 23770133
genes like me logo Genes that share ontologies with MIR224: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR224 Gene

Localization for MIR224 Gene

Gene Ontology (GO) - Cellular Components for MIR224 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR224: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR224 Gene

Pathways & Interactions for MIR224 Gene

SuperPathways for MIR224 Gene

PathCards logo More details on SuperPathways for MIR224
SuperPathway Contained pathways
1 MicroRNAs in cancer
MicroRNAs in cancer
-
genes like me logo Genes that share pathways with MIR224: view

Pathways by source for MIR224 Gene

1 KEGG pathway for MIR224 Gene

Interacting Proteins for MIR224 Gene

Gene Ontology (GO) - Biological Process for MIR224 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA 23770133
genes like me logo Genes that share ontologies with MIR224: view

No data available for SIGNOR curated interactions for MIR224 Gene

Drugs & Compounds for MIR224 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIR224 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MIR224 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR224 Gene

No ASD Table

Relevant External Links for MIR224 Gene

GeneLoc Exon Structure for
MIR224
ECgene alternative splicing isoforms for
MIR224

Expression for MIR224 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR224 Gene

mRNA expression in normal human tissues for MIR224 Gene
mRNA expression by GTEx for MIR224 GenemRNA expression by BioGPS for MIR224 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR224 Gene:

MIR224
genes like me logo Genes that share expression patterns with MIR224: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR224 Gene

Orthologs for MIR224 Gene

Evolution for MIR224 Gene

ENSEMBL:
Gene Tree for MIR224 (if available)
TreeFam:
Gene Tree for MIR224 (if available)

No data available for Orthologs for MIR224 Gene

Paralogs for MIR224 Gene

No data available for Paralogs for MIR224 Gene

Variants for MIR224 Gene

Sequence variations from dbSNP and Humsavar for MIR224 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1002349623 -- 151,958,984(-) C/T upstream_transcript_variant
rs1002401779 -- 151,958,398(-) C/A downstream_transcript_variant
rs1006712303 -- 151,958,081(-) A/G downstream_transcript_variant
rs1010099404 -- 151,960,635(-) G/A upstream_transcript_variant
rs1012489166 -- 151,959,304(-) G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR224 Gene

Variant ID Type Subtype PubMed ID
nsv510867 CNV deletion 20534489

Additional Variant Information for MIR224 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR224

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR224 Gene

Disorders for MIR224 Gene

Additional Disease Information for MIR224

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MIR224 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR224 Gene

Publications for MIR224 Gene

  1. The TAZ-miR-224-SMAD4 axis promotes tumorigenesis in osteosarcoma. (PMID: 28055015) Ma J … Fan S (Cell death & disease 2017) 3 58
  2. Hypoxia-inducible microRNA-224 promotes the cell growth, migration and invasion by directly targeting RASSF8 in gastric cancer. (PMID: 28173803) He C … Xu H (Molecular cancer 2017) 3 58
  3. Long non-coding RNA FTH1P3 facilitates uveal melanoma cell growth and invasion through miR-224-5p. (PMID: 29095823) Zheng X … Liu Y (PloS one 2017) 3 58
  4. Downregulation of miR-224 and let-7i contribute to cell survival and chemoresistance in chronic myeloid leukemia cells by regulating ST3GAL IV expression. (PMID: 28512058) Zhou H … Jia L (Gene 2017) 3 58
  5. Integrative miRNA and mRNA analysis in penile carcinomas reveals markers and pathways with potential clinical impact. (PMID: 28122331) Kuasne H … Rogatto SR (Oncotarget 2017) 3 58

Products for MIR224 Gene

Sources for MIR224 Gene

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