microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR224 Gene

Subcategory (RNA class) for MIR224 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR224 Gene

  • MIMAT0000281 50
  • MIMAT0009198 50
  • MI0000301 50
  • MiRNA224 3
  • MIRN224 3
  • RF00680 168

External Ids for MIR224 Gene

Previous HGNC Symbols for MIR224 Gene

  • MIRN224

Previous GeneCards Identifiers for MIR224 Gene

  • GC0XM150877
  • GC0XM151127

Summaries for MIR224 Gene

Entrez Gene Summary for MIR224 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR224 Gene

MIR224 (MicroRNA 224) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR224 include Hepatocellular Carcinoma and Oral Squamous Cell Carcinoma. Among its related pathways are MicroRNAs in cancer.

Rfam classification for MIR224 Gene

Additional gene information for MIR224 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR224 Gene

Genomics for MIR224 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR224 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ151981 Enhancer 1 Ensembl ENCODE 12.5 -25.4 -25443 7 GATAD2A ZNF629 TFE3 RFX1 IKZF1 JUND REST GABPA SOX6 GATAD2B MIR224 MAGEA4 MAGEA4-AS1 GABRE LOC105373369 lnc-MAGEA4-2 lnc-GABRE-2 MAGEA5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR224 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR224 Gene

Genomic Locations for MIR224 Gene
chrX:151,958,578-151,958,658
(GRCh38/hg38)
Size:
81 bases
Orientation:
Minus strand
chrX:151,127,050-151,127,130
(GRCh37/hg19)
Size:
81 bases
Orientation:
Minus strand

Genomic View for MIR224 Gene

Genes around MIR224 on UCSC Golden Path with GeneCards custom track
MIR224 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR224 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR224 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR224 Gene

Proteins for MIR224 Gene

Post-translational modifications for MIR224 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR224 Gene

Domains & Families for MIR224 Gene

Gene Families for MIR224 Gene

HGNC:
genes like me logo Genes that share domains with MIR224: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR224 Gene

Function for MIR224 Gene

Gene Ontology (GO) - Molecular Function for MIR224 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA --
genes like me logo Genes that share ontologies with MIR224: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR224 Gene

Localization for MIR224 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR224 gene
Compartment Confidence
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MIR224 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA --
genes like me logo Genes that share ontologies with MIR224: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR224 Gene

Pathways & Interactions for MIR224 Gene

PathCards logo

SuperPathways for MIR224 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR224: view

Pathways by source for MIR224 Gene

1 KEGG pathway for MIR224 Gene

Gene Ontology (GO) - Biological Process for MIR224 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA,IEA --
genes like me logo Genes that share ontologies with MIR224: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR224 Gene

Drugs & Compounds for MIR224 Gene

No Compound Related Data Available

Transcripts for MIR224 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR224 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS0000184017_9606 precursor_RNA 81 6

HGNC: 31604,

RefSeq: NR_029638,

Ensembl: ENST00000384889 (view in UCSC) ,

miRBase: MI0000301,

Rfam: RF00680,

ENA: LM608369.1:1..81:precursor_RNA,

URS00001E8884_9606 miRNA 23 5

RefSeq: NR_029638,

LncBase: hsa-miR-224-3p,

miRBase: MIMAT0009198,

TarBase: hsa-miR-224-3p,

ENA: AY940872.1:1..23:ncRNA, LM381141.1:1..23:ncRNA, LM608369.1:53..75:ncRNA,

URS0000D55DFB_9606 miRNA 25 2

RefSeq: NR_029638,

miRBase: MIMAT0000281,

URS00002BBD4E_9606 miRNA 21 3

LncBase: hsa-miR-224-5p,

TarBase: hsa-miR-224-5p,

ENA: LM378920.1:1..21:ncRNA, LM608369.1:8..28:ncRNA,

URS0000EFD8E1_9606 precursor_RNA 70 1

MirGeneDB: Hsa-Mir-224,

MIR224 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR224 Gene

No ASD Table

Relevant External Links for MIR224 Gene

GeneLoc Exon Structure for
MIR224

No data available for mRNA/cDNA for MIR224 Gene

Expression for MIR224 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR224 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR224

Evidence on tissue expression from TISSUES for MIR224 Gene

  • Liver(2.2)
genes like me logo Genes that share expression patterns with MIR224: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR224 Gene

Orthologs for MIR224 Gene

Evolution for MIR224 Gene

ENSEMBL:
Gene Tree for MIR224 (if available)
TreeFam:
Gene Tree for MIR224 (if available)

No data available for Orthologs for MIR224 Gene

Paralogs for MIR224 Gene

No data available for Paralogs for MIR224 Gene

Variants for MIR224 Gene

Additional dbSNP identifiers (rs#s) for MIR224 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR224 Gene

Variant ID Type Subtype PubMed ID
nsv510867 CNV deletion 20534489

Additional Variant Information for MIR224 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR224

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR224 Gene

Disorders for MIR224 Gene

MalaCards: The human disease database

(47) MalaCards diseases for MIR224 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
hepatocellular carcinoma
  • hcc
oral squamous cell carcinoma
  • mouth squamous cell carcinoma
pancreatic ductal adenocarcinoma
  • ductal adenocarcinoma of the pancreas
melanoma
  • malignant melanoma
prostate cancer
  • prostate cancer, somatic
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR224

genes like me logo Genes that share disorders with MIR224: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR224 Gene

Publications for MIR224 Gene

  1. FOXM1-Activated LINC01094 Promotes Clear Cell Renal Cell Carcinoma Development via MicroRNA 224-5p/CHSY1. (PMID: 31767633) Jiang Y … Gu W (Molecular and cellular biology 2020) 3
  2. Mechanism of exosomal microRNA-224 in development of hepatocellular carcinoma and its diagnostic and prognostic value. (PMID: 31057302) Cui Y … Cang SD (World journal of gastroenterology 2019) 3
  3. Diagnostic Performance of microRNA-122 and microRNA-224 in Hepatitis C Virus-Induced Hepatocellular Carcinoma (HCC). (PMID: 31450927) Shehab-Eldeen S … Omar T (Asian Pacific journal of cancer prevention : APJCP 2019) 3
  4. The HIF‑1α/miR‑224‑3p/ATG5 axis affects cell mobility and chemosensitivity by regulating hypoxia‑induced protective autophagy in glioblastoma and astrocytoma. (PMID: 30569180) Huang S … He X (Oncology reports 2019) 3
  5. Downregulation of miR-224-5p Promotes Migration and Proliferation in Human Dental Pulp Stem Cells. (PMID: 31396530) Ke Z … Lv H (BioMed research international 2019) 3

Products for MIR224 Gene

Sources for MIR224 Gene