microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR223 Gene

Subcategory (RNA class) for MIR223 Gene

miRNA

Quality Score for this RNA gene is

17

Aliases for MIR223 Gene

  • MicroRNA 223 2 3 5
  • Hsa-MiR-223-5p 168 179
  • Hsa-MiR-223-3p 168 179
  • MIMAT0000280 53
  • MIMAT0004570 53
  • Hsa-Mir-223 3
  • MI0000300 53
  • MiRNA223 3
  • Mir-223 3
  • MIRN223 3
  • RF00664 174
  • MIR223 2

External Ids for MIR223 Gene

Previous HGNC Symbols for MIR223 Gene

  • MIRN223

Previous GeneCards Identifiers for MIR223 Gene

  • GC0XP065156
  • GC0XP065238

Summaries for MIR223 Gene

Entrez Gene Summary for MIR223 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR223 Gene

MIR223 (MicroRNA 223) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR223 include Neutrophilia, Hereditary and Leukemia, Chronic Myeloid. Among its related pathways are MicroRNAs in cancer.

Rfam classification for MIR223 Gene

Additional gene information for MIR223 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR223 Gene

Genomics for MIR223 Gene

GeneHancer (GH) Regulatory Elements for MIR223 Gene

Promoters and enhancers for MIR223 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ065985 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 13.3 -31.9 -31891 2.6 CTCF CC2D1A MAX RAD21 CBFA2T2 MLLT1 PRDM1 IKZF1 ARID2 REST MIR223 MSN piR-38051-325 5MWI_A-205 ENSG00000237311
GH0XJ065693 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 11.9 -320.9 -320901 8 ZNF785 ZNF24 MYC ETV6 MAX TEAD4 ZNF148 NKRF CBFA2T2 MLLT1 MSN MIR223 lnc-ZC3H12B-7 NONHSAG054658.2
GH0XJ065719 Enhancer 1.1 Ensembl ENCODE dbSUPER 12.2 -296.5 -296469 10 ETV6 RELA RAD21 ZNF280D SP7 ZNF687 CREM KLF14 IKZF1 CREB1 MIR223 NONHSAG054658.2 lnc-ZC3H12B-7 MSN
GH0XJ066045 Enhancer 1 FANTOM5 ENCODE 13 +27.9 27949 2.6 ZNF24 SP1 SMARCE1 ETV6 RELA NKRF MLLT1 CREM ZBED1 EGR1 MIR223 MSN VSIG4 LOC392485 lnc-VSIG4-1
GH0XJ065932 Enhancer 1 Ensembl ENCODE 11.4 -85.8 -85826 2.1 CTCF SMARCE1 ZNF362 CC2D1A ZNF280D ZNF473 SMARCA4 PRDM1 TRIM24 MTA1 lnc-MSN-4 MIR223 piR-33605-525 ENSG00000237311
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR223 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR223 Gene

Genomic Locations for MIR223 Gene
chrX:66,018,870-66,018,979
(GRCh38/hg38)
Size:
110 bases
Orientation:
Plus strand
chrX:65,238,712-65,238,821
(GRCh37/hg19)
Size:
110 bases
Orientation:
Plus strand

Genomic View for MIR223 Gene

Genes around MIR223 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR223 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR223 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR223 Gene

Proteins for MIR223 Gene

Post-translational modifications for MIR223 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR223 Gene

Domains & Families for MIR223 Gene

Gene Families for MIR223 Gene

HGNC:
genes like me logo Genes that share domains with MIR223: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR223 Gene

Function for MIR223 Gene

Phenotypes From GWAS Catalog for MIR223 Gene

Gene Ontology (GO) - Molecular Function for MIR223 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 27121304
genes like me logo Genes that share ontologies with MIR223: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR223 Gene

Localization for MIR223 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR223 gene
Compartment Confidence
extracellular 2
plasma membrane 1
cytoskeleton 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MIR223 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
GO:0016442 RISC complex IEA --
GO:0048471 perinuclear region of cytoplasm ISS --
genes like me logo Genes that share ontologies with MIR223: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR223 Gene

Pathways & Interactions for MIR223 Gene

PathCards logo

SuperPathways for MIR223 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR223: view

Pathways by source for MIR223 Gene

1 KEGG pathway for MIR223 Gene

Gene Ontology (GO) - Biological Process for MIR223 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010628 positive regulation of gene expression IDA 20080987
GO:0034260 negative regulation of GTPase activity IDA 27121304
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:0042742 defense response to bacterium ISS --
GO:0045649 regulation of macrophage differentiation ISS --
genes like me logo Genes that share ontologies with MIR223: view

No data available for SIGNOR curated interactions for MIR223 Gene

Drugs & Compounds for MIR223 Gene

No Compound Related Data Available

Transcripts for MIR223 Gene

mRNA/cDNA for MIR223 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(4) RNACentral transcripts :
(3) miRBase transcripts :
(2) TarBase transcripts :
(6) ENA transcripts :
(2) LncBase transcripts :
(1) Rfam transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR223 Gene

No ASD Table

Relevant External Links for MIR223 Gene

GeneLoc Exon Structure for
MIR223
ECgene alternative splicing isoforms for
MIR223

Expression for MIR223 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR223 Gene

mRNA differential expression in normal tissues according to GTEx for MIR223 Gene

This gene is overexpressed in Whole Blood (x49.2).

NURSA nuclear receptor signaling pathways regulating expression of MIR223 Gene:

MIR223

Evidence on tissue expression from TISSUES for MIR223 Gene

  • Blood(2.3)
genes like me logo Genes that share expression patterns with MIR223: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR223 Gene

Orthologs for MIR223 Gene

Evolution for MIR223 Gene

ENSEMBL:
Gene Tree for MIR223 (if available)
TreeFam:
Gene Tree for MIR223 (if available)

No data available for Orthologs for MIR223 Gene

Paralogs for MIR223 Gene

No data available for Paralogs for MIR223 Gene

Variants for MIR223 Gene

Sequence variations from dbSNP and Humsavar for MIR223 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000544380 -- 66,016,919(+) G/A upstream_transcript_variant
rs1001510722 -- 66,018,619(+) C/T upstream_transcript_variant
rs1004013580 -- 66,017,886(+) C/A upstream_transcript_variant
rs1004385637 -- 66,017,486(+) T/C upstream_transcript_variant
rs1004585345 -- 66,019,379(+) A/C downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR223 Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER inversion 17803354
esv3576919 CNV gain 25503493
nsv6933 CNV insertion 18451855

Additional Variant Information for MIR223 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR223

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR223 Gene

Disorders for MIR223 Gene

MalaCards: The human disease database

(32) MalaCards diseases for MIR223 Gene - From: miR2Disease, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR223

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR223: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR223 Gene

Publications for MIR223 Gene

  1. Human miR223 promoter as a novel myelo-specific promoter for chronic granulomatous disease gene therapy. (PMID: 23489116) Brendel C … Siler U (Human gene therapy methods 2013) 2 3 56
  2. miR-223 suppresses differentiation of tumor-induced CD11b⁺ Gr1⁺ myeloid-derived suppressor cells from bone marrow cells. (PMID: 21213211) Liu Q … Yang R (International journal of cancer 2011) 2 3 56
  3. Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J … Zhao H (International journal of cancer 2009) 3 43 56
  4. MicroRNA-223 is commonly repressed in hepatocellular carcinoma and potentiates expression of Stathmin1. (PMID: 18555017) Wong QW … Wong N (Gastroenterology 2008) 3 23 56
  5. miR-223-5p Suppresses Tumor Growth and Metastasis in Non-Small Cell Lung Cancer by Targeting E2F8. (PMID: 29615147) Dou L … Lv F (Oncology research 2019) 3 56

Products for MIR223 Gene

Sources for MIR223 Gene