microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR223 Gene

Subcategory (RNA class) for MIR223 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR223 Gene

  • MIMAT0004570 50
  • MI0000300 50
  • MiRNA223 3
  • MIRN223 3
  • Mir-223 3
  • RF00664 168

External Ids for MIR223 Gene

Previous HGNC Symbols for MIR223 Gene

  • MIRN223

Previous GeneCards Identifiers for MIR223 Gene

  • GC0XP065156
  • GC0XP065238

Summaries for MIR223 Gene

Entrez Gene Summary for MIR223 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR223 Gene

MIR223 (MicroRNA 223) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR223 include Neutrophilia, Hereditary and Leukemia, Chronic Myeloid. Among its related pathways are MicroRNAs in cancer.

Rfam classification for MIR223 Gene

Additional gene information for MIR223 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR223 Gene

Genomics for MIR223 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR223 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ065985 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 13.3 -31.9 -31891 2.6 CTCF IKZF1 RFX5 PRDM1 RFX1 PKNOX1 REST RAD21 BRD9 TRIM22 MIR223 MSN piR-38051-325 5MWI_A-192 VSIG4 ENSG00000237311
GH0XJ065693 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 11.9 -320.9 -320901 8 RFX1 IKZF1 PKNOX1 ZNF24 IKZF2 TRIM22 YY1 SOX6 POLR2A EP300 MSN MIR223 lnc-ZC3H12B-7 NONHSAG054658.2 VSIG4
GH0XJ065719 Enhancer 1.2 Ensembl ENCODE dbSUPER 12.2 -296.5 -296469 10 CREB1 ATF7 PRDM10 ZNF629 LEF1 ZNF692 RELA PATZ1 RAD21 TCF12 MIR223 NONHSAG054658.2 lnc-ZC3H12B-7 MSN VSIG4
GH0XJ066045 Enhancer 1.1 FANTOM5 ENCODE 13 +27.9 27949 2.6 SP1 LEF1 BACH1 STAT3 RELA TCF12 IKZF2 RCOR1 TRIM22 PKNOX1 MIR223 MSN lnc-VSIG4-1 VSIG4 HEPH
GH0XJ065932 Enhancer 1 Ensembl ENCODE 11.4 -85.8 -85826 2.1 CREB1 ZNF629 IKZF1 PRDM1 PKNOX1 MTA1 ZNF148 ATF7 RBAK ZNF140 lnc-MSN-4 MIR223 piR-33605-525 ENSG00000237311 VSIG4 MSN
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR223 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR223 Gene

Genomic Locations for MIR223 Gene
chrX:66,018,870-66,018,979
(GRCh38/hg38)
Size:
110 bases
Orientation:
Plus strand
chrX:65,238,712-65,238,821
(GRCh37/hg19)
Size:
110 bases
Orientation:
Plus strand

Genomic View for MIR223 Gene

Genes around MIR223 on UCSC Golden Path with GeneCards custom track
MIR223 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR223 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR223 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR223 Gene

Proteins for MIR223 Gene

Post-translational modifications for MIR223 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR223 Gene

Domains & Families for MIR223 Gene

Gene Families for MIR223 Gene

HGNC:
genes like me logo Genes that share domains with MIR223: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR223 Gene

Function for MIR223 Gene

Phenotypes From GWAS Catalog for MIR223 Gene

Gene Ontology (GO) - Molecular Function for MIR223 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 27121304
genes like me logo Genes that share ontologies with MIR223: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR223 Gene

Localization for MIR223 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR223 gene
Compartment Confidence
extracellular 3
plasma membrane 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
endosome 2
cytosol 2
lysosome 2
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MIR223 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
GO:0048471 perinuclear region of cytoplasm ISS --
genes like me logo Genes that share ontologies with MIR223: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR223 Gene

Pathways & Interactions for MIR223 Gene

PathCards logo

SuperPathways for MIR223 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR223: view

Pathways by source for MIR223 Gene

1 KEGG pathway for MIR223 Gene

Gene Ontology (GO) - Biological Process for MIR223 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010628 positive regulation of gene expression IDA 20080987
GO:0034260 negative regulation of GTPase activity IDA 27121304
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:0042742 defense response to bacterium ISS --
GO:0045649 regulation of macrophage differentiation ISS --
genes like me logo Genes that share ontologies with MIR223: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR223 Gene

Drugs & Compounds for MIR223 Gene

No Compound Related Data Available

Transcripts for MIR223 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR223 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000037EC34_9606 precursor_RNA 110 6

HGNC: 31603,

RefSeq: NR_029637,

Ensembl: ENST00000385204 (view in UCSC) ,

miRBase: MI0000300,

Rfam: RF00664,

ENA: LM608368.1:1..110:precursor_RNA,

URS00000B7E30_9606 miRNA 22 5

RefSeq: NR_029637,

LncBase: hsa-miR-223-3p,

miRBase: MIMAT0000280,

TarBase: hsa-miR-223-3p,

ENA: LM378919.1:1..22:ncRNA, LM608368.1:68..89:ncRNA,

URS0000485CBB_9606 miRNA 22 5

RefSeq: NR_029637,

LncBase: hsa-miR-223-5p,

miRBase: MIMAT0004570,

TarBase: hsa-miR-223-5p,

ENA: LM380248.1:1..22:ncRNA, LM608368.1:26..47:ncRNA,

URS0000EFE563_9606 precursor_RNA 66 1

MirGeneDB: Hsa-Mir-223,

URS00000D5CE2_9606 miRNA 23 1

MirGeneDB: Hsa-Mir-223_5p,

MIR223 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR223 Gene

2 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR223 Gene

No ASD Table

Relevant External Links for MIR223 Gene

GeneLoc Exon Structure for
MIR223

Expression for MIR223 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR223 Gene

mRNA differential expression in normal tissues according to GTEx for MIR223 Gene

This gene is overexpressed in Whole Blood (x49.2).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR223

Evidence on tissue expression from TISSUES for MIR223 Gene

  • Blood(2.9)
  • Heart(2.5)
  • Liver(2.4)
  • Muscle(2.4)
  • Bone marrow(2.3)
  • Lymph node(2.3)
  • Nervous system(2.3)
  • Saliva(2.2)
  • Skin(2.2)
  • Urine(2.1)
  • Kidney(2.1)
  • Intestine(2.1)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with MIR223: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR223 Gene

Orthologs for MIR223 Gene

Evolution for MIR223 Gene

ENSEMBL:
Gene Tree for MIR223 (if available)
TreeFam:
Gene Tree for MIR223 (if available)

No data available for Orthologs for MIR223 Gene

Paralogs for MIR223 Gene

No data available for Paralogs for MIR223 Gene

Variants for MIR223 Gene

Additional dbSNP identifiers (rs#s) for MIR223 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR223 Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER inversion 17803354
esv3576919 CNV gain 25503493
nsv6933 CNV insertion 18451855

Additional Variant Information for MIR223 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR223

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR223 Gene

Disorders for MIR223 Gene

MalaCards: The human disease database

(91) MalaCards diseases for MIR223 Gene - From: miR2Disease, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR223

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR223: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR223 Gene

Publications for MIR223 Gene

  1. Human miR223 promoter as a novel myelo-specific promoter for chronic granulomatous disease gene therapy. (PMID: 23489116) Brendel C … Siler U (Human gene therapy methods 2013) 2 3
  2. miR-223 suppresses differentiation of tumor-induced CD11b⁺ Gr1⁺ myeloid-derived suppressor cells from bone marrow cells. (PMID: 21213211) Liu Q … Yang R (International journal of cancer 2011) 2 3
  3. Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J … Zhao H (International journal of cancer 2009) 3 41
  4. MicroRNA-223 is commonly repressed in hepatocellular carcinoma and potentiates expression of Stathmin1. (PMID: 18555017) Wong QW … Wong N (Gastroenterology 2008) 3 23
  5. miR-223-5p Suppresses Tumor Growth and Metastasis in Non-Small Cell Lung Cancer by Targeting E2F8. (PMID: 29615147) Dou L … Lv F (Oncology research 2019) 3

Products for MIR223 Gene

Sources for MIR223 Gene