microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR221 Gene

Subcategory (RNA class) for MIR221 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR221 Gene

  • MicroRNA 221 2 3 5
  • Hsa-MiR-221-3p 163 173
  • Hsa-MiR-221-5p 163 173
  • Hsa-Mir-221 2 3
  • MIR221 2 5
  • Hsa-Mir-221-P1 178
  • MIMAT0004568 50
  • MIMAT0000278 50
  • MI0000298 50
  • MiRNA221 3
  • MIRN221 3
  • Mir-221 3
  • RF00651 168

External Ids for MIR221 Gene

Previous HGNC Symbols for MIR221 Gene

  • MIRN221

Previous GeneCards Identifiers for MIR221 Gene

  • GC0XM045492
  • GC0XM045605

Summaries for MIR221 Gene

Entrez Gene Summary for MIR221 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR221 Gene

MIR221 (MicroRNA 221) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR221 include Lung Leiomyoma and Thyroid Cancer, Nonmedullary, 1. Among its related pathways are Hematopoietic Stem Cell Differentiation and DNA Damage Response.

Rfam classification for MIR221 Gene

Additional gene information for MIR221 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR221 Gene

Genomics for MIR221 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR221 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ045745 Enhancer 0.4 dbSUPER 600.7 +0.2 230 0.8 CREB1 ATF7 ATF2 MIR221 MIR222 NONHSAG054344.2 MIR222HG DIPK2B KRBOX4
GH0XJ045707 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 13.5 +33.6 33629 9.7 FOXA1 RELA EED JUND CEBPB RUNX3 FOS IKZF1 PRDM1 NR2F1 MIR221 MIR222 lnc-KDM6A-8 piR-33730-110 DIPK2B KRBOX4
GH0XJ045719 Enhancer 0.3 Ensembl dbSUPER 13.7 +26.1 26065 0.4 lnc-CXorf36-4 MIR221 MIR222 ENSG00000204915 DIPK2B KRBOX4
GH0XJ045721 Enhancer 0.3 Ensembl dbSUPER 13.7 +25.5 25465 0.4 lnc-CXorf36-4 MIR221 MIR222 ENSG00000204915 DIPK2B KRBOX4
GH0XJ045228 Enhancer 0.3 Ensembl 4 +515.6 515565 5 SPI1 ZNF680 MIR221 DIPK2B RF00017-8368 ENSG00000229491
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR221 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR221 Gene

Genomic Locations for MIR221 Gene
chrX:45,746,157-45,746,266
(GRCh38/hg38)
Size:
110 bases
Orientation:
Minus strand
chrX:45,605,585-45,605,694
(GRCh37/hg19)
Size:
110 bases
Orientation:
Minus strand

Genomic View for MIR221 Gene

Genes around MIR221 on UCSC Golden Path with GeneCards custom track
MIR221 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR221 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR221 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR221 Gene

Proteins for MIR221 Gene

Post-translational modifications for MIR221 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR221 Gene

Domains & Families for MIR221 Gene

Gene Families for MIR221 Gene

HGNC:
genes like me logo Genes that share domains with MIR221: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR221 Gene

Function for MIR221 Gene

Gene Ontology (GO) - Molecular Function for MIR221 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IMP 20813046
genes like me logo Genes that share ontologies with MIR221: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR221 Gene

Localization for MIR221 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR221 gene
Compartment Confidence
extracellular 3
nucleus 3
plasma membrane 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
endosome 2
cytosol 2
peroxisome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MIR221 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 NOT extracellular space HDA 18766170
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIR221: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR221 Gene

Pathways & Interactions for MIR221 Gene

genes like me logo Genes that share pathways with MIR221: view

Pathways by source for MIR221 Gene

Gene Ontology (GO) - Biological Process for MIR221 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation IDA 23333386
GO:0009749 response to glucose IMP 19351599
GO:0010634 positive regulation of epithelial cell migration IGI 21673316
GO:0010718 positive regulation of epithelial to mesenchymal transition IGI 21673316
GO:0032705 negative regulation of interleukin-21 production IDA 28798470
genes like me logo Genes that share ontologies with MIR221: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR221 Gene

Drugs & Compounds for MIR221 Gene

No Compound Related Data Available

Transcripts for MIR221 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR221 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS0000170CF4_9606 miRNA 23 6

RefSeq: NR_029635,

LncBase: hsa-miR-221-3p,

miRBase: MIMAT0000278,

MirGeneDB: Hsa-Mir-221-P1_3p,

TarBase: hsa-miR-221-3p,

ENA: HB859648.1:1..23:misc_RNA, LM378917.1:1..23:ncRNA, LM608366.1:65..87:ncRNA,

URS0000245997_9606 precursor_RNA 110 5

HGNC: 31601,

RefSeq: NR_029635,

Ensembl: ENST00000385135 (view in UCSC) ,

miRBase: MI0000298,

ENA: LM608366.1:1..110:precursor_RNA,

URS0000593537_9606 miRNA 22 5

RefSeq: NR_029635,

LncBase: hsa-miR-221-5p,

miRBase: MIMAT0004568,

TarBase: hsa-miR-221-5p,

ENA: LM380246.1:1..22:ncRNA, LM608366.1:25..46:ncRNA,

URS0000647276_9606 precursor_RNA 70 1

Rfam: RF00651,

URS0000EFC463_9606 precursor_RNA 64 1

MirGeneDB: Hsa-Mir-221-P1,

MIR221 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR221 Gene

2 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR221 Gene

No ASD Table

Relevant External Links for MIR221 Gene

GeneLoc Exon Structure for
MIR221

Expression for MIR221 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR221 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR221

Evidence on tissue expression from TISSUES for MIR221 Gene

  • Blood(2.7)
  • Liver(2.5)
  • Heart(2.5)
  • Muscle(2.4)
  • Nervous system(2.3)
  • Lymph node(2.3)
  • Intestine(2.2)
  • Skin(2.2)
  • Kidney(2.1)
  • Pancreas(2.1)
  • Bone marrow(2.1)
  • Thyroid gland(2.1)
  • Urine(2.1)
  • Saliva(2)
genes like me logo Genes that share expression patterns with MIR221: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR221 Gene

Orthologs for MIR221 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR221 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-221 31
  • 100 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir221 31
  • 99 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-221 31
  • 97 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-221 31
  • 93 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-221 31
  • 93 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-221 31
  • 91 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-221 31
  • 91 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-221 31
  • 89 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-221 31
  • 78 (a)
OneToOne
Species where no ortholog for MIR221 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR221 Gene

ENSEMBL:
Gene Tree for MIR221 (if available)
TreeFam:
Gene Tree for MIR221 (if available)

Paralogs for MIR221 Gene

No data available for Paralogs for MIR221 Gene

Variants for MIR221 Gene

Additional dbSNP identifiers (rs#s) for MIR221 Gene

Additional Variant Information for MIR221 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR221

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR221 Gene

Disorders for MIR221 Gene

MalaCards: The human disease database

(88) MalaCards diseases for MIR221 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
lung leiomyoma
  • pulmonary leiomyoma
thyroid cancer, nonmedullary, 1
  • nmtc1
glioma
bladder cancer
  • bladder cancer, somatic
melanoma
  • malignant melanoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR221

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with MIR221: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR221 Gene

Publications for MIR221 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 41
  2. MicroRNA-221 regulates high glucose-induced endothelial dysfunction. (PMID: 19351599) Li Y … Geng YJ (Biochemical and biophysical research communications 2009) 3 23
  3. A high-throughput candidate gene mutation screen in lymphoproliferative and myeloproliferative neoplasias. (PMID: 19464057) Kreil S … Chase A (Leukemia research 2009) 3 41
  4. [Expression and Clinical Significance of MiR-146a and MiR-221 in Childhood Acute T Lymphoblastic Leukemia]. (PMID: 32319375) Li SW … Li ZX (Zhongguo shi yan xue ye xue za zhi 2020) 3
  5. MicroRNA-221-3p promotes pulmonary artery smooth muscle cells proliferation by targeting AXIN2 during pulmonary arterial hypertension. (PMID: 28694128) Nie X … Chen J (Vascular pharmacology 2019) 3

Products for MIR221 Gene

Sources for MIR221 Gene