Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR22 Gene

Subcategory (RNA class) for MIR22 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR22 Gene

  • MicroRNA 22 2 3 5
  • Hsa-Mir-22 3
  • MiR-22 3
  • MIRN22 3

External Ids for MIR22 Gene

Previous HGNC Symbols for MIR22 Gene

  • MIRN22

Previous GeneCards Identifiers for MIR22 Gene

  • GC17M001571
  • GC17M001617
  • GC17M001619
  • GC17M001624

Summaries for MIR22 Gene

Entrez Gene Summary for MIR22 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR22 Gene

MIR22 (MicroRNA 22) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR22 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR22 Gene

Genomics for MIR22 Gene

GeneHancer (GH) Regulatory Elements for MIR22 Gene

Promoters and enhancers for MIR22 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I001712 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 550.8 -1.8 -1787 7 MLX DMAP1 YBX1 YY1 ZNF143 SP3 NFYC MEF2D SSRP1 ZNF610 WDR81 GC17M001715 MIR22 MIR22HG SMYD4 PRPF8 GEMIN4 RPA1 SERPINF2 METTL16
GH17I001647 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.9 +64.4 64357 3.8 HDGF PKNOX1 CLOCK SMAD1 FOXA2 ZFP64 ARID4B SIN3A FEZF1 ZNF2 RILP SMYD4 METTL16 RPA1 HNRNPA1P16 DPH1 TLCD2 MIR22 MIR22HG WDR81
GH17I001782 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.7 -69.3 -69345 3.1 RB1 ARID4B SIN3A RAD21 SLC30A9 ZNF121 THAP11 MIXL1 ZNF654 RXRA SMYD4 SERPINF1 SERPINF2 RPA1 MIR22 MIR22HG WDR81 TLCD2 PIR53033
GH17I001785 Enhancer 1.1 Ensembl ENCODE dbSUPER 11.7 -73.4 -73397 3.4 ZBTB6 JUN MAX ZIC2 HIC1 FOSL1 ZNF121 ZNF366 POLR2A SMARCC2 SMYD4 SERPINF1 SERPINF2 RPA1 MIR22 MIR22HG WDR81 TLCD2 PIR53033
GH17I001778 Enhancer 1 Ensembl ENCODE dbSUPER 11.6 -65.7 -65690 2.3 ZBTB6 OSR2 PRDM6 POLR2A GLIS1 RCOR1 FOXP2 WT1 SP7 ZNF18 PIR54968 PIR53033 SMYD4 SERPINF2 TLCD2 MIR22HG WDR81 MIR22 RPA1 SERPINF1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR22 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR22 Gene

Genomic Locations for MIR22 Gene
chr17:1,713,903-1,713,987
(GRCh38/hg38)
Size:
85 bases
Orientation:
Minus strand
chr17:1,614,805-1,620,468
(GRCh37/hg19)

Genomic View for MIR22 Gene

Genes around MIR22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR22 Gene

Proteins for MIR22 Gene

Post-translational modifications for MIR22 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR22 Gene

Domains & Families for MIR22 Gene

Gene Families for MIR22 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR22: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR22 Gene

Function for MIR22 Gene

Phenotypes From GWAS Catalog for MIR22 Gene

Gene Ontology (GO) - Molecular Function for MIR22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 28112401
genes like me logo Genes that share ontologies with MIR22: view

Animal Model Products

Clone Products

  • Addgene plasmids for MIR22

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR22 Gene

Localization for MIR22 Gene

Gene Ontology (GO) - Cellular Components for MIR22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
GO:0070062 extracellular exosome IDA 28159509
genes like me logo Genes that share ontologies with MIR22: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR22 Gene

Pathways & Interactions for MIR22 Gene

SuperPathways for MIR22 Gene

No Data Available

Interacting Proteins for MIR22 Gene

Gene Ontology (GO) - Biological Process for MIR22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA 28112401
GO:0050729 positive regulation of inflammatory response IDA 28112401
GO:0051152 positive regulation of smooth muscle cell differentiation ISS --
genes like me logo Genes that share ontologies with MIR22: view

No data available for Pathways by source and SIGNOR curated interactions for MIR22 Gene

Drugs & Compounds for MIR22 Gene

No Compound Related Data Available

Transcripts for MIR22 Gene

mRNA/cDNA for MIR22 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

  • Addgene plasmids for MIR22

Alternative Splicing Database (ASD) splice patterns (SP) for MIR22 Gene

No ASD Table

Relevant External Links for MIR22 Gene

GeneLoc Exon Structure for
MIR22
ECgene alternative splicing isoforms for
MIR22

Expression for MIR22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR22 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR22 Gene:

MIR22
genes like me logo Genes that share expression patterns with MIR22: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR22 Gene

Orthologs for MIR22 Gene

Evolution for MIR22 Gene

ENSEMBL:
Gene Tree for MIR22 (if available)
TreeFam:
Gene Tree for MIR22 (if available)

No data available for Orthologs for MIR22 Gene

Paralogs for MIR22 Gene

No data available for Paralogs for MIR22 Gene

Variants for MIR22 Gene

Sequence variations from dbSNP and Humsavar for MIR22 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000631440 -- 1,715,013(-) C/T upstream_transcript_variant
rs1004524399 -- 1,715,678(-) G/A upstream_transcript_variant
rs1004567424 -- 1,714,557(-) G/C upstream_transcript_variant
rs1004598705 -- 1,714,260(-) C/T upstream_transcript_variant
rs1006244144 -- 1,714,352(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR22 Gene

Variant ID Type Subtype PubMed ID
nsv470568 CNV loss 18288195
nsv516886 CNV loss 19592680
nsv833335 CNV gain+loss 17160897
nsv9490 CNV loss 18304495

Additional Variant Information for MIR22 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR22

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR22 Gene

Disorders for MIR22 Gene

Additional Disease Information for MIR22

No disorders were found for MIR22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR22 Gene

Publications for MIR22 Gene

  1. Characterization of a novel panel of plasma microRNAs that discriminates between Mycobacterium tuberculosis infection and healthy individuals. (PMID: 28910318) Cui JY … Ling H (PloS one 2017) 3 58
  2. miR-22 suppresses tumorigenesis and improves radiosensitivity of breast cancer cells by targeting Sirt1. (PMID: 28882183) Zhang X … Wei X (Biological research 2017) 3 58
  3. Mir-22-3p Inhibits Arterial Smooth Muscle Cell Proliferation and Migration and Neointimal Hyperplasia by Targeting HMGB1 in Arteriosclerosis Obliterans. (PMID: 28848136) Huang SC … Wang SM (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017) 3 58
  4. The predicted target gene validation, function, and prognosis studies of miRNA-22 in colorectal cancer tissue. (PMID: 28347238) Li B … Zhang H (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 58
  5. Serially measured circulating miR-22-3p is a biomarker for adverse clinical outcome in patients with chronic heart failure: The Bio-SHiFT study. (PMID: 28274577) van Boven N … Kardys I (International journal of cardiology 2017) 3 58

Products for MIR22 Gene

  • Addgene plasmids for MIR22

Sources for MIR22 Gene

Content
Loading form....