microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR219B Gene

Data sources for MIR219B Gene:

RNA type for MIR219B Gene

miRNA

Aliases for MIR219B Gene

External Ids for MIR219B Gene

Previous HGNC Symbols for MIR219B Gene

  • MIR2964A

Previous GeneCards Identifiers for MIR219B Gene

  • GC09P131158
  • GC09P128393
  • GC09P128395
  • GC09P128398

Summaries for MIR219B Gene

Entrez Gene Summary for MIR219B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR219B Gene

MIR219B (MicroRNA 219b) is an RNA Gene, and is affiliated with the miRNA class.

Rfam classification for MIR219B Gene

  • mir-219 microRNA precursor family

Additional gene information for MIR219B Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR219B Gene

Genomics for MIR219B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR219B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR219B on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR219B Gene

Latest Assembly
chr9:128,392,621-128,392,708
(GRCh38/hg38)
Size:
88 bases
Orientation:
Plus strand

Previous Assembly
chr9:131,154,900-131,154,987
(GRCh37/hg19 by Entrez Gene)
Size:
88 bases
Orientation:
Plus strand

Genomic View for MIR219B Gene

Genes around MIR219B on UCSC Golden Path with GeneCards custom track
MIR219B in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR219B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR219B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR219B Gene

Proteins for MIR219B Gene

Post-translational modifications for MIR219B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR219B Gene

Domains & Families for MIR219B Gene

Gene Families for MIR219B Gene

genes like me logo Genes that share domains with MIR219B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR219B Gene

Function for MIR219B Gene

Phenotypes From GWAS Catalog for MIR219B Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR219B Gene

Localization for MIR219B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR219B gene
Compartment Confidence
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR219B Gene

Pathways & Interactions for MIR219B Gene

PathCards logo

SuperPathways for MIR219B Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR219B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR219B: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR219B Gene

Drugs & Compounds for MIR219B Gene

No Compound Related Data Available

Transcripts for MIR219B Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR219B Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS0000527B00_9606 miRNA 22 5

RefSeq: NR_039815,

miRBase: MIMAT0019747,

MirGeneDB: Hsa-Mir-219-P2-as_5p,

TarBase: hsa-miR-219b-5p,

ENA: FR772702.1:1..22:ncRNA, LM382548.1:1..22:ncRNA, LM611379.1:14..35:ncRNA,

URS000075EAD8_9606 pre_miRNA 88 4

RefSeq: NR_039815,

Ensembl: ENST00000637023 (view in UCSC) ,

miRBase: MI0017299,

ENA: LM611379.1:1..88:precursor_RNA,

URS0000603CA3_9606 miRNA 23 4

RefSeq: NR_039815,

miRBase: MIMAT0019748,

MirGeneDB: Hsa-Mir-219-P2-as_3p,

ENA: FR772701.1:1..23:ncRNA, LM382549.1:1..23:ncRNA, LM611379.1:56..78:ncRNA,

URS0000EFE738_9606 precursor_RNA 66 1

MirGeneDB: Hsa-Mir-219-P2-as,

MIR219B in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR219B Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR219B Gene

No ASD Table

Relevant External Links for MIR219B Gene

GeneLoc Exon Structure for
MIR219B

Expression for MIR219B Gene

No Expression Related Data Available

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR219B Gene

Orthologs for MIR219B Gene

Evolution for MIR219B Gene

ENSEMBL:
Gene Tree for MIR219B (if available)
TreeFam:
Gene Tree for MIR219B (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR219B

No data available for Orthologs for MIR219B Gene

Paralogs for MIR219B Gene

No data available for Paralogs for MIR219B Gene

Variants for MIR219B Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR219B Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR219B Gene

Variant ID Type Subtype PubMed ID
nsv831728 CNV loss 17160897

Additional Variant Information for MIR219B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR219B
Leiden Open Variation Database (LOVD)
MIR219B

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR219B Gene

Disorders for MIR219B Gene

Additional Disease Information for MIR219B

No disorders were found for MIR219B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR219B Gene

Publications for MIR219B Gene

  1. Modulation of NMDA receptor by miR-219 in the amygdala and hippocampus of patients with mesial temporal lobe epilepsy. (PMID: 32111564) Hamamoto O … Carlotti CG (Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2020) 3
  2. MicroRNA-219-5p inhibits wound healing by targeting TMEM98 in keratinocytes under normoxia and hypoxia condition. (PMID: 30338788) Tang Q … Ran H (European review for medical and pharmacological sciences 2018) 3
  3. miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades. (PMID: 21911355) Friedländer MR … Rajewsky N (Nucleic acids research 2012) 3
  4. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3
  5. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3

Products for MIR219B Gene

Sources for MIR219B Gene