microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR219A2 Gene

Data sources for MIR219A2 Gene:

RNA type for MIR219A2 Gene

miRNA

Aliases for MIR219A2 Gene

External Ids for MIR219A2 Gene

Previous HGNC Symbols for MIR219A2 Gene

  • MIRN219-2
  • MIR219-2

Previous GeneCards Identifiers for MIR219A2 Gene

  • GC09M131156

Summaries for MIR219A2 Gene

Entrez Gene Summary for MIR219A2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR219A2 Gene

MIR219A2 (MicroRNA 219a-2) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR219A2 include Psychotic Disorder and Disease Of Mental Health. Among its related pathways are Alzheimers Disease.

Rfam classification for MIR219A2 Gene

  • mir-219 microRNA precursor family

Additional gene information for MIR219A2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR219A2 Gene

Genomics for MIR219A2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR219A2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR219A2 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR219A2 Gene

Latest Assembly
chr9:128,392,618-128,392,714
(GRCh38/hg38)
Size:
97 bases
Orientation:
Minus strand

Previous Assembly
chr9:131,154,897-131,154,993
(GRCh37/hg19 by Entrez Gene)
Size:
97 bases
Orientation:
Minus strand

Genomic View for MIR219A2 Gene

Genes around MIR219A2 on UCSC Golden Path with GeneCards custom track
MIR219A2 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR219A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR219A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR219A2 Gene

Proteins for MIR219A2 Gene

Post-translational modifications for MIR219A2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR219A2 Gene

Domains & Families for MIR219A2 Gene

Gene Families for MIR219A2 Gene

genes like me logo Genes that share domains with MIR219A2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR219A2 Gene

Function for MIR219A2 Gene

Phenotypes From GWAS Catalog for MIR219A2 Gene

Gene Ontology (GO) - Molecular Function for MIR219A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA --
genes like me logo Genes that share ontologies with MIR219A2: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR219A2 Gene

Localization for MIR219A2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR219A2 Gene

Pathways & Interactions for MIR219A2 Gene

PathCards logo

SuperPathways for MIR219A2 Gene

SuperPathway Contained pathways
1 Alzheimers Disease
genes like me logo Genes that share pathways with MIR219A2: view

Pathways by source for MIR219A2 Gene

1 BioSystems pathway for MIR219A2 Gene

Gene Ontology (GO) - Biological Process for MIR219A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010977 negative regulation of neuron projection development IDA --
GO:0035195 gene silencing by miRNA TAS,IEA --
genes like me logo Genes that share ontologies with MIR219A2: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR219A2 Gene

Drugs & Compounds for MIR219A2 Gene

No Compound Related Data Available

Transcripts for MIR219A2 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR219A2 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS00004ACAAA_9606 miRNA 22 5

RefSeq: NR_029837,

miRBase: MIMAT0004675,

MirGeneDB: Hsa-Mir-219-P2_3p,

TarBase: hsa-miR-219a-2-3p,

ENA: AY882313.1:1..22:ncRNA, LM380339.1:1..22:ncRNA, LM608667.1:62..83:ncRNA,

URS000075B0B0_9606 pre_miRNA 97 4

RefSeq: NR_029837,

Ensembl: ENST00000385220 (view in UCSC) ,

miRBase: MI0000740,

ENA: LM608667.1:1..97:precursor_RNA,

URS0000565C8D_9606 miRNA 21 4

RefSeq: NR_029633, NR_029837,

miRBase: MIMAT0000276,

TarBase: hsa-miR-219a-5p,

ENA: AJ550423.1:1..21:ncRNA, LM378916.1:1..21:ncRNA, LM608365.1:21..41:ncRNA, LM608667.1:19..39:ncRNA,

URS00004E189F_9606 pre_miRNA 73 1

Rfam: RF00251,

URS0001BC9610_9606 pre_miRNA 73 1

Rfam: RF00251,

MIR219A2 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR219A2 Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR219A2 Gene

No ASD Table

Relevant External Links for MIR219A2 Gene

GeneLoc Exon Structure for
MIR219A2

Expression for MIR219A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR219A2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR219A2

genes like me logo Genes that share expression patterns with MIR219A2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR219A2 Gene

Orthologs for MIR219A2 Gene

Evolution for MIR219A2 Gene

ENSEMBL:
Gene Tree for MIR219A2 (if available)
TreeFam:
Gene Tree for MIR219A2 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR219A2

No data available for Orthologs for MIR219A2 Gene

Paralogs for MIR219A2 Gene

No data available for Paralogs for MIR219A2 Gene

Variants for MIR219A2 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR219A2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR219A2 Gene

Variant ID Type Subtype PubMed ID
nsv831728 CNV loss 17160897

Additional Variant Information for MIR219A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR219A2
Leiden Open Variation Database (LOVD)
MIR219A2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR219A2 Gene

Disorders for MIR219A2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MIR219A2 Gene - From: COP

Disorder Aliases PubMed IDs
psychotic disorder
  • mental or behavioural disorder
disease of mental health
  • mental health
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR219A2

genes like me logo Genes that share disorders with MIR219A2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR219A2 Gene

Publications for MIR219A2 Gene

  1. LBX2-AS1/miR-219a-2-3p/FUS/LBX2 positive feedback loop contributes to the proliferation of gastric cancer. (PMID: 31673844) Yang Z … Qiu X (Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2020) 3
  2. IgGs from Human Milk Hydrolyze microRNAs. (PMID: 32443717) Kompaneets IY … Nevinsky GA (Molecules (Basel, Switzerland) 2020) 3
  3. Modulation of NMDA receptor by miR-219 in the amygdala and hippocampus of patients with mesial temporal lobe epilepsy. (PMID: 32111564) Hamamoto O … Carlotti CG (Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2020) 3
  4. LncRNA HCP5 promotes triple negative breast cancer progression as a ceRNA to regulate BIRC3 by sponging miR-219a-5p. (PMID: 31215169) Wang L … Jiang W (Cancer medicine 2019) 3
  5. lncRNA MEG3 modified epithelial-mesenchymal transition of ovarian cancer cells by sponging miR-219a-5p and regulating EGFR. (PMID: 31161607) Wang L … Zhao S (Journal of cellular biochemistry 2019) 3

Products for MIR219A2 Gene

Sources for MIR219A2 Gene