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Aliases for MIR219A1 Gene

Subcategory (RNA class) for MIR219A1 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR219A1 Gene

  • MicroRNA 219a-1 2 3 5
  • MicroRNA 219-1 2 3
  • Hsa-Mir-219a-1 3
  • Hsa-Mir-219-1 3
  • Mir-219a-1 3
  • MIRN219-1 3
  • MRI219-1 3
  • MIR219-1 3
  • Mir-219 3

External Ids for MIR219A1 Gene

Previous HGNC Symbols for MIR219A1 Gene

  • MIRN219-1
  • MIR219-1

Previous GeneCards Identifiers for MIR219A1 Gene

  • GC06P033206

Summaries for MIR219A1 Gene

Entrez Gene Summary for MIR219A1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR219A1 Gene

MIR219A1 (MicroRNA 219a-1) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are miRNA targets in ECM and membrane receptors.

Additional gene information for MIR219A1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR219A1 Gene

Genomics for MIR219A1 Gene

GeneHancer (GH) Regulatory Elements for MIR219A1 Gene

Promoters and enhancers for MIR219A1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I033203 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 -1.4 -1432 5.8 DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC SSRP1 ZNF610 GLIS1 RING1 HSD17B8 GC06P033209 MIR219A1 BRD2 LEMD2 VPS52 RXRB HCG25 DAXX
GH06I033287 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 9.9 +81.7 81682 3.1 PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 POLR2B ZNF766 WDR46 PFDN6 MIR6834 TAPBP ZBTB22 KIFC1 PHF1 RPL35AP4 CUTA SYNGAP1
GH06I033016 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -189.0 -188968 5 MAX EBF1 CEBPG RAD21 RFX5 YY1 RELA POLR2A ETV6 IKZF2 HLA-DQA2 HLA-DPB1 HLA-DPA1 HLA-DQB2 HLA-DMA HLA-DMB HLA-DQB1 HLA-DOA HSD17B8 RPL32P1
GH06I033061 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 11.1 -145.7 -145660 0.7 ATF1 FOXA2 ETV1 CEBPG BATF KLF5 E4F1 IRF4 ZNF316 ELK1 HLA-DPA1 HLA-DQB1 TAP1 PSMB9 RNY4P10 RXRB SLC39A7 MIR219A1 HSD17B8 HLA-DPB1
GH06I032984 Enhancer 1.3 Ensembl ENCODE dbSUPER 10.2 -222.9 -222948 1.3 PKNOX1 CLOCK ATF1 ARID4B SIN3A ZNF2 IRF4 GLIS2 ARID2 ZNF143 HLA-DMB RING1 ENSG00000250264 TAP2 TAP1 PSMB9 HSD17B8 RXRB SLC39A7 RNY4P10
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR219A1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR219A1 Gene

Genomic Locations for MIR219A1 Gene
chr6:33,207,835-33,207,944
(GRCh38/hg38)
Size:
110 bases
Orientation:
Plus strand
chr6:33,175,612-33,175,721
(GRCh37/hg19)

Genomic View for MIR219A1 Gene

Genes around MIR219A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR219A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR219A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for MIR219A1 Gene

Post-translational modifications for MIR219A1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR219A1 Gene

Domains & Families for MIR219A1 Gene

Gene Families for MIR219A1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR219A1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR219A1 Gene

Function for MIR219A1 Gene

Phenotypes From GWAS Catalog for MIR219A1 Gene

Gene Ontology (GO) - Molecular Function for MIR219A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 25574843
genes like me logo Genes that share ontologies with MIR219A1: view

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR219A1 Gene

Localization for MIR219A1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR219A1 Gene

Pathways & Interactions for MIR219A1 Gene

genes like me logo Genes that share pathways with MIR219A1: view

Pathways by source for MIR219A1 Gene

1 BioSystems pathway for MIR219A1 Gene

Interacting Proteins for MIR219A1 Gene

Gene Ontology (GO) - Biological Process for MIR219A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA TAS 26363795
genes like me logo Genes that share ontologies with MIR219A1: view

No data available for SIGNOR curated interactions for MIR219A1 Gene

Drugs & Compounds for MIR219A1 Gene

No Compound Related Data Available

Transcripts for MIR219A1 Gene

mRNA/cDNA for MIR219A1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR219A1 Gene

No ASD Table

Relevant External Links for MIR219A1 Gene

GeneLoc Exon Structure for
MIR219A1
ECgene alternative splicing isoforms for
MIR219A1

Expression for MIR219A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR219A1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR219A1 Gene:

MIR219A1
genes like me logo Genes that share expression patterns with MIR219A1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR219A1 Gene

Orthologs for MIR219A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR219A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-219-1 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-219-1 34
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir219-1 34
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-219-2 34
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-219-2 34
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-219-2 34
  • 75 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-219-2 34
  • 61 (a)
ManyToMany
CR848045.1 34
  • 40 (a)
ManyToMany
dre-mir-219-3 34
  • 34 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-219 34
  • 48 (a)
OneToMany
Species where no ortholog for MIR219A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR219A1 Gene

ENSEMBL:
Gene Tree for MIR219A1 (if available)
TreeFam:
Gene Tree for MIR219A1 (if available)

Paralogs for MIR219A1 Gene

No data available for Paralogs for MIR219A1 Gene

Variants for MIR219A1 Gene

Sequence variations from dbSNP and Humsavar for MIR219A1 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1002924466 -- 33,206,914(+) C/T upstream_transcript_variant
rs1003134062 -- 33,206,898(+) AA/AAA upstream_transcript_variant
rs1003429229 -- 33,207,193(+) C/T upstream_transcript_variant
rs1005370806 -- 33,208,092(+) C/T downstream_transcript_variant
rs1005460187 -- 33,208,362(+) A/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR219A1 Gene

Variant ID Type Subtype PubMed ID
dgv10609n54 CNV loss 21841781
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1119076 CNV deletion 24896259
nsv522719 CNV loss 19592680
nsv830634 CNV loss 17160897

Additional Variant Information for MIR219A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR219A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR219A1 Gene

Disorders for MIR219A1 Gene

Additional Disease Information for MIR219A1

No disorders were found for MIR219A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR219A1 Gene

Publications for MIR219A1 Gene

  1. Predictive Value of MiR-219-1, MiR-938, MiR-34b/c, and MiR-218 Polymorphisms for Gastric Cancer Susceptibility and Prognosis. (PMID: 28298809) Wu Y … Jiang J (Disease markers 2017) 3 58
  2. MicroRNA-219-5p inhibits the proliferation, migration, and invasion of epithelial ovarian cancer cells by targeting the Twist/Wnt/β-catenin signaling pathway. (PMID: 28890378) Wei C … Sun X (Gene 2017) 3 58
  3. MiR-219 Protects Against Seizure in the Kainic Acid Model of Epilepsy. (PMID: 25394384) Zheng H … Zheng W (Molecular neurobiology 2016) 3 58
  4. The Role of MAPT in Neurodegenerative Diseases: Genetics, Mechanisms and Therapy. (PMID: 26363795) Zhang CC … Yu JT (Molecular neurobiology 2016) 3 58
  5. The TLX-miR-219 cascade regulates neural stem cell proliferation in neurodevelopment and schizophrenia iPSC model. (PMID: 26965827) Murai K … Shi Y (Nature communications 2016) 3 58

Products for MIR219A1 Gene

Sources for MIR219A1 Gene

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