microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR219A1 Gene

Data sources for MIR219A1 Gene:

RNA type for MIR219A1 Gene

miRNA

Aliases for MIR219A1 Gene

External Ids for MIR219A1 Gene

Previous HGNC Symbols for MIR219A1 Gene

  • MIRN219-1
  • MIR219-1

Previous GeneCards Identifiers for MIR219A1 Gene

  • GC06P033206

Summaries for MIR219A1 Gene

Entrez Gene Summary for MIR219A1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR219A1 Gene

MIR219A1 (MicroRNA 219a-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR219A1 include Lung Cancer and Hepatocellular Carcinoma. Among its related pathways are miRNA targets in ECM and membrane receptors.

Rfam classification for MIR219A1 Gene

  • mir-219 microRNA precursor family

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR219A1 Gene

Genomics for MIR219A1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR219A1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR219A1 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR219A1 Gene

Latest Assembly
chr6:33,207,835-33,207,944
(GRCh38/hg38)
Size:
110 bases
Orientation:
Plus strand

Previous Assembly
chr6:33,175,612-33,175,721
(GRCh37/hg19 by Entrez Gene)
Size:
110 bases
Orientation:
Plus strand

chr6:33,175,612-33,175,721
(GRCh37/hg19 by Ensembl)
Size:
110 bases
Orientation:
Plus strand

Alternative Locations (GRCh38/hg38)

  • chr6(ALT_REF_LOCI_2):4,619,336-4,619,445 (+)
  • chr6(ALT_REF_LOCI_3):4,451,334-4,451,443 (+)
  • chr6(ALT_REF_LOCI_4):4,627,312-4,627,421 (+)
  • chr6(ALT_REF_LOCI_5):4,643,788-4,643,897 (+)
  • chr6(ALT_REF_LOCI_6):4,402,243-4,402,352 (+)

Genomic View for MIR219A1 Gene

Genes around MIR219A1 on UCSC Golden Path with GeneCards custom track
MIR219A1 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR219A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR219A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR219A1 Gene

Proteins for MIR219A1 Gene

Post-translational modifications for MIR219A1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR219A1 Gene

Domains & Families for MIR219A1 Gene

Gene Families for MIR219A1 Gene

genes like me logo Genes that share domains with MIR219A1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR219A1 Gene

Function for MIR219A1 Gene

Phenotypes From GWAS Catalog for MIR219A1 Gene

Gene Ontology (GO) - Molecular Function for MIR219A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 25574843
genes like me logo Genes that share ontologies with MIR219A1: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR219A1 Gene

Localization for MIR219A1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR219A1 gene
Compartment Confidence
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR219A1 Gene

Pathways & Interactions for MIR219A1 Gene

PathCards logo

SuperPathways for MIR219A1 Gene

genes like me logo Genes that share pathways with MIR219A1: view

Pathways by source for MIR219A1 Gene

1 BioSystems pathway for MIR219A1 Gene

Gene Ontology (GO) - Biological Process for MIR219A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010977 negative regulation of neuron projection development IDA 25574843
GO:0035195 gene silencing by miRNA TAS 26363795
genes like me logo Genes that share ontologies with MIR219A1: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR219A1 Gene

Drugs & Compounds for MIR219A1 Gene

No Compound Related Data Available

Transcripts for MIR219A1 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR219A1 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS00000BD1DE_9606 miRNA 22 5

RefSeq: NR_029633,

LncBase: hsa-miR-219a-1-3p,

miRBase: MIMAT0004567,

TarBase: hsa-miR-219a-1-3p,

ENA: LM380245.1:1..22:ncRNA, LM608365.1:62..83:ncRNA,

URS0000173F7B_9606 pre_miRNA 110 4

RefSeq: NR_029633,

Ensembl: ENST00000362166 (view in UCSC) ,

miRBase: MI0000296,

ENA: LM608365.1:1..110:precursor_RNA,

URS0000565C8D_9606 miRNA 21 4

RefSeq: NR_029633, NR_029837,

miRBase: MIMAT0000276,

TarBase: hsa-miR-219a-5p,

ENA: AJ550423.1:1..21:ncRNA, LM378916.1:1..21:ncRNA, LM608365.1:21..41:ncRNA, LM608667.1:19..39:ncRNA,

URS000071E20F_9606 pre_miRNA 72 1

Rfam: RF00251,

URS0001BC84D0_9606 pre_miRNA 72 1

Rfam: RF00251,

MIR219A1 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR219A1 Gene

2 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR219A1 Gene

No ASD Table

Relevant External Links for MIR219A1 Gene

GeneLoc Exon Structure for
MIR219A1

Expression for MIR219A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR219A1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR219A1

genes like me logo Genes that share expression patterns with MIR219A1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR219A1 Gene

Orthologs for MIR219A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR219A1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-219-1 30
  • 99 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-219-1 30
  • 97 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir219-1 30
  • 96 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-219-2 30
  • 95 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-219-2 30
  • 84 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-219-2 30
  • 75 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-219-2 30
  • 61 (a)
ManyToMany
CR848045.1 30
  • 40 (a)
ManyToMany
dre-mir-219-3 30
  • 34 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea csa-mir-219 30
  • 48 (a)
OneToMany
Species where no ortholog for MIR219A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR219A1 Gene

ENSEMBL:
Gene Tree for MIR219A1 (if available)
TreeFam:
Gene Tree for MIR219A1 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR219A1

Paralogs for MIR219A1 Gene

No data available for Paralogs for MIR219A1 Gene

Variants for MIR219A1 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR219A1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR219A1 Gene

Variant ID Type Subtype PubMed ID
dgv10609n54 CNV loss 21841781
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1119076 CNV deletion 24896259
nsv522719 CNV loss 19592680
nsv830634 CNV loss 17160897

Additional Variant Information for MIR219A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR219A1
Leiden Open Variation Database (LOVD)
MIR219A1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR219A1 Gene

Disorders for MIR219A1 Gene

MalaCards: The human disease database

(11) MalaCards diseases for MIR219A1 Gene - From: MID, COP, and GCD

Disorder Aliases PubMed IDs
lung cancer
  • lung cancer, susceptibility to
hepatocellular carcinoma
  • hcc
sacrum chordoma
infratentorial cancer
  • brain neoplasm, infratentorial
pancreas disease
  • abnormality of the pancreas
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR219A1

genes like me logo Genes that share disorders with MIR219A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR219A1 Gene

Publications for MIR219A1 Gene

  1. XB130, regulated by miR-203, miR-219, and miR-4782-3p, mediates the proliferation and metastasis of non-small-cell lung cancer cells. (PMID: 32159887) Wang Q … Zhou J (Molecular carcinogenesis 2020) 3
  2. HOTAIR inhibits the proliferation of glioblastoma cells by targeting miR-219. (PMID: 32176624) Li H … Guan C (Cancer biomarkers : section A of Disease markers 2020) 3
  3. MicroRNA-219a-5p suppresses intestinal inflammation through inhibiting Th1/Th17-mediated immune responses in inflammatory bowel disease. (PMID: 31628427) Shi Y … Xu Y (Mucosal immunology 2020) 3
  4. Modulation of NMDA receptor by miR-219 in the amygdala and hippocampus of patients with mesial temporal lobe epilepsy. (PMID: 32111564) Hamamoto O … Carlotti CG (Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2020) 3
  5. LncRNA HCP5 promotes triple negative breast cancer progression as a ceRNA to regulate BIRC3 by sponging miR-219a-5p. (PMID: 31215169) Wang L … Jiang W (Cancer medicine 2019) 3

Products for MIR219A1 Gene

Sources for MIR219A1 Gene