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Aliases for MIR218-2 Gene

Subcategory (RNA class) for MIR218-2 Gene


Quality Score for this RNA gene is


Aliases for MIR218-2 Gene

  • MicroRNA 218-2 2 3 5
  • Hsa-Mir-218-2 3
  • Mir-218-2 3
  • MIRN218-2 3

External Ids for MIR218-2 Gene

Previous HGNC Symbols for MIR218-2 Gene

  • MIRN218-2

Previous GeneCards Identifiers for MIR218-2 Gene

  • GC05M168130
  • GC05M168195

Summaries for MIR218-2 Gene

Entrez Gene Summary for MIR218-2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR218-2 Gene

MIR218-2 (MicroRNA 218-2) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

fRNAdb sequence ontologies for MIR218-2 Gene - the ORGUL cluster for this gene includes several descriptions:

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR218-2

Additional gene information for MIR218-2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR218-2 Gene

Genomics for MIR218-2 Gene

GeneHancer (GH) Regulatory Elements for MIR218-2 Gene

Promoters and enhancers for MIR218-2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I168793 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 12.2 -26.0 -25951 1.6 ATF1 GLI4 GLIS2 ATF7 KLF13 SP3 REST TSHZ1 ZNF518A NFIL3 ENSG00000254192 RARS PANK3 MIR218-2 ENSG00000202345 LOC105377713 SLIT3
GH05I168851 Enhancer 0.9 Ensembl ENCODE 9.8 -84.1 -84061 1.7 ZBTB21 EBF1 BMI1 RFX5 CTBP1 GATA3 GATA2 POLR2A PATZ1 ZSCAN5C MIR218-2 LOC105377713 ENSG00000202345 SLIT3
GH05I168817 Enhancer 0.7 dbSUPER 11.1 -52.6 -52557 6.5 PKNOX1 TAF1 MAX ZMYM3 EBF1 CEBPG MCM2 BATF ZIC2 YY1 MIR218-2 LOC101927969 SLIT3 ENSG00000202345 LOC105377713
GH05I168787 Enhancer 0.5 dbSUPER 12.2 -21.5 -21494 4 PKNOX1 ZNF157 HLF ZSCAN4 RCOR1 CHD2 NR2C2 ENSG00000202345 GC05P168792 MIR218-2 LOC101927969 ENSG00000248965 SLIT3 GC05M168784
GH05I168734 Enhancer 0.5 ENCODE 11.2 +33.4 33414 0.1 PKNOX1 EBF1 RUNX3 RFX5 LOC101927969 SLIT3 MIR218-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR218-2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR218-2 Gene

Genomic Locations for MIR218-2 Gene
110 bases
Minus strand

Genomic View for MIR218-2 Gene

Genes around MIR218-2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR218-2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR218-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR218-2 Gene

ORGUL Member Location for MIR218-2 Gene

ORGUL Member Location for MIR218-2 gene

Proteins for MIR218-2 Gene

Post-translational modifications for MIR218-2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR218-2 Gene

Domains & Families for MIR218-2 Gene

Gene Families for MIR218-2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR218-2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR218-2 Gene

Function for MIR218-2 Gene

Phenotypes From GWAS Catalog for MIR218-2 Gene

Gene Ontology (GO) - Molecular Function for MIR218-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 19913496
genes like me logo Genes that share ontologies with MIR218-2: view

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR218-2 Gene

Localization for MIR218-2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR218-2 Gene

Pathways & Interactions for MIR218-2 Gene

genes like me logo Genes that share pathways with MIR218-2: view

Pathways by source for MIR218-2 Gene

1 BioSystems pathway for MIR218-2 Gene

Interacting Proteins for MIR218-2 Gene

Gene Ontology (GO) - Biological Process for MIR218-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation IDA 27057632
GO:0030336 negative regulation of cell migration IDA 27057632
GO:0032966 negative regulation of collagen biosynthetic process IDA 19913496
GO:0035195 gene silencing by miRNA IDA 21385766
GO:0035278 miRNA mediated inhibition of translation IDA 19913496
genes like me logo Genes that share ontologies with MIR218-2: view

No data available for SIGNOR curated interactions for MIR218-2 Gene

Drugs & Compounds for MIR218-2 Gene

No Compound Related Data Available

Transcripts for MIR218-2 Gene

fRNAdb Secondary structures for MIR218-2 Gene

  • hsa-miR-218-5p_MIMAT0000275_Homo_sapiens_miR-218-5p_mature
  • hsa-miR-218-2-3p_MIMAT0004566_Homo_sapiens_miR-218-2-3p_mature

mRNA/cDNA for MIR218-2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR218-2 Gene

No ASD Table

Relevant External Links for MIR218-2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR218-2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR218-2 Gene

genes like me logo Genes that share expression patterns with MIR218-2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR218-2 Gene

Orthologs for MIR218-2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR218-2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia bta-mir-218-2 34
  • 100 (a)
(Canis familiaris)
Mammalia cfa-mir-218-2 34
  • 100 (a)
(Pan troglodytes)
Mammalia ptr-mir-218-2 34
  • 100 (a)
(Mus musculus)
Mammalia Mir218-2 34
  • 95 (a)
(Monodelphis domestica)
Mammalia mdo-mir-218-2 34
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia oan-mir-218-2 34
  • 90 (a)
(Gallus gallus)
Aves gga-mir-218-2 34
  • 80 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 62 (a)
(Danio rerio)
Actinopterygii dre-mir-218a-2 34
  • 73 (a)
Species where no ortholog for MIR218-2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR218-2 Gene

Gene Tree for MIR218-2 (if available)
Gene Tree for MIR218-2 (if available)

Paralogs for MIR218-2 Gene

No data available for Paralogs for MIR218-2 Gene

Variants for MIR218-2 Gene

Sequence variations from dbSNP and Humsavar for MIR218-2 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000966654 -- 168,767,991(-) C/T downstream_transcript_variant
rs1001251795 -- 168,767,725(-) C/T downstream_transcript_variant
rs1003409949 -- 168,769,443(-) G/A upstream_transcript_variant
rs1003565153 -- 168,770,015(-) A/G upstream_transcript_variant
rs1004022113 -- 168,768,067(-) G/C downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR218-2 Gene

Variant ID Type Subtype PubMed ID
nsv1028080 CNV gain 25217958
nsv462513 CNV loss 19166990
nsv600258 CNV loss 21841781

Additional Variant Information for MIR218-2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR218-2 Gene

Disorders for MIR218-2 Gene

Additional Disease Information for MIR218-2

No disorders were found for MIR218-2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR218-2 Gene

Publications for MIR218-2 Gene

  1. Vertebrate microRNA genes. (PMID: 12624257) Lim LP … Bartel DP (Science (New York, N.Y.) 2003) 1 3 58
  2. MALAT1 Is Associated with Poor Response to Oxaliplatin-Based Chemotherapy in Colorectal Cancer Patients and Promotes Chemoresistance through EZH2. (PMID: 28069878) Li P … Wang C (Molecular cancer therapeutics 2017) 3 58
  3. miR-218 inhibited tumor angiogenesis by targeting ROBO1 in gastric cancer. (PMID: 28323002) Zhang X … Tie J (Gene 2017) 3 58
  4. MicroRNA Profiling Reveals a Role for MicroRNA-218-5p in the Pathogenesis of Chronic Obstructive Pulmonary Disease. (PMID: 27409149) Conickx G … Brusselle GG (American journal of respiratory and critical care medicine 2017) 3 58
  5. miR-218 suppresses gastric cancer cell cycle progression through the CDK6/Cyclin D1/E2F1 axis in a feedback loop. (PMID: 28634044) Deng M … He Z (Cancer letters 2017) 3 58

Products for MIR218-2 Gene

Sources for MIR218-2 Gene

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