microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR218-2 Gene

Subcategory (RNA class) for MIR218-2 Gene

miRNA

Number of RNA Genes sources:

5 / 14

Aliases for MIR218-2 Gene

  • MicroRNA 218-2 2 3 5
  • Hsa-MiR-218-2-3p 166 177
  • Hsa-MiR-218-5p 166 177
  • Hsa-Mir-218-2 3
  • MIMAT0004566 51
  • MIMAT0000275 51
  • Mir-218-2 3
  • MIRN218-2 3
  • MI0000295 51
  • MIR218-2 2
  • RF00255 172

External Ids for MIR218-2 Gene

Previous HGNC Symbols for MIR218-2 Gene

  • MIRN218-2

Previous GeneCards Identifiers for MIR218-2 Gene

  • GC05M168130
  • GC05M168195

Summaries for MIR218-2 Gene

Entrez Gene Summary for MIR218-2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR218-2 Gene

MIR218-2 (MicroRNA 218-2) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR218-2 include Lung Cancer. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

Rfam classification for MIR218-2 Gene

  • mir-218 microRNA precursor family

Additional gene information for MIR218-2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR218-2 Gene

Genomics for MIR218-2 Gene

GeneHancer (GH) Regulatory Elements for MIR218-2 Gene

Promoters and enhancers for MIR218-2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J168767 Enhancer 0.6 Ensembl 500.7 +1.9 1891 0.7 TRIM28 ZNF263 NFE2 JUND ZNF398 MEIS2 KLF10 ZBTB12 GATA2 PRDM10 MIR218-2 RF00994-880 SLIT3
GH05J168787 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 12.2 -26.0 -26046 11.4 EP300 ZSCAN5C RBAK ZNF639 ZNF10 ZIC2 ZBTB10 TRIM28 TOE1 MYC ENSG00000254192 RARS1 MIR218-2 ENSG00000254042 SLIT3 ENSG00000248965 ENSG00000202345 HSALNG0046451
GH05J168851 Enhancer 1.1 Ensembl ENCODE CraniofacialAtlas 9.8 -83.9 -83946 2.4 ZSCAN5C RFX1 CTBP1 MXI1 OSR2 MYNN WT1 ZBTB17 GATA3 ZNF263 MIR218-2 HSALNG0046451 HSALNG0046453 SLIT3
GH05J168813 Enhancer 0.9 Ensembl 11.1 -45.5 -45546 2.4 PHB2 ZBTB11 AFF1 REST MYC MXI1 HDAC3 NCOR1 NEUROD1 TRIM25 MIR218-2 ENSG00000254042 SLIT3 HSALNG0046451 ENSG00000202345
GH05J168747 Enhancer 0.7 Ensembl 12.2 +20.2 20210 1.3 CTCF ZIC2 GABPA REST MYC RAD21 CTBP1 SMC3 ZBTB17 ZNF707 MIR218-2 ENSG00000254042 SLIT3 FBLL1 RF00994-880
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR218-2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR218-2 Gene

Genomic Locations for MIR218-2 Gene
chr5:168,768,146-168,768,255
(GRCh38/hg38)
Size:
110 bases
Orientation:
Minus strand
chr5:168,195,151-168,195,260
(GRCh37/hg19)
Size:
110 bases
Orientation:
Minus strand

Genomic View for MIR218-2 Gene

Genes around MIR218-2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR218-2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR218-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR218-2 Gene

Proteins for MIR218-2 Gene

Post-translational modifications for MIR218-2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR218-2 Gene

Domains & Families for MIR218-2 Gene

Gene Families for MIR218-2 Gene

genes like me logo Genes that share domains with MIR218-2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR218-2 Gene

Function for MIR218-2 Gene

Gene Ontology (GO) - Molecular Function for MIR218-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 19913496
genes like me logo Genes that share ontologies with MIR218-2: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR218-2 Gene

Localization for MIR218-2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR218-2 Gene

Pathways & Interactions for MIR218-2 Gene

genes like me logo Genes that share pathways with MIR218-2: view

Pathways by source for MIR218-2 Gene

1 BioSystems pathway for MIR218-2 Gene
;

Gene Ontology (GO) - Biological Process for MIR218-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation IDA 27057632
GO:0030336 negative regulation of cell migration IDA 27057632
GO:0032966 negative regulation of collagen biosynthetic process IDA 19913496
GO:0035195 gene silencing by miRNA IDA 21067317
GO:0035278 miRNA mediated inhibition of translation IDA 19913496
genes like me logo Genes that share ontologies with MIR218-2: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR218-2 Gene

Drugs & Compounds for MIR218-2 Gene

No Compound Related Data Available

Transcripts for MIR218-2 Gene

mRNA/cDNA for MIR218-2 Gene

4 RNACentral transcripts :
2 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
3 miRBase transcripts :
7 ENA transcripts :
2 LncBase transcripts :
1 Rfam transcripts :
2 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR218-2 Gene

No ASD Table

Relevant External Links for MIR218-2 Gene

GeneLoc Exon Structure for
MIR218-2

Expression for MIR218-2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR218-2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR218-2

genes like me logo Genes that share expression patterns with MIR218-2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR218-2 Gene

Orthologs for MIR218-2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR218-2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia cfa-mir-218-2 31
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-218-2 31
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-218-2 31
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir218-2 31
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-218-2 31
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-218-2 31
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-218-2 31
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 62 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-218a-2 31
  • 73 (a)
OneToMany
Species where no ortholog for MIR218-2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR218-2 Gene

ENSEMBL:
Gene Tree for MIR218-2 (if available)
TreeFam:
Gene Tree for MIR218-2 (if available)

Paralogs for MIR218-2 Gene

No data available for Paralogs for MIR218-2 Gene

Variants for MIR218-2 Gene

Additional dbSNP identifiers (rs#s) for MIR218-2 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR218-2 Gene

Variant ID Type Subtype PubMed ID
nsv1028080 CNV gain 25217958
nsv462513 CNV loss 19166990
nsv600258 CNV loss 21841781

Additional Variant Information for MIR218-2 Gene

Human Gene Mutation Database (HGMD)
MIR218-2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR218-2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR218-2 Gene

Disorders for MIR218-2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR218-2 Gene - From: miR2Disease

Disorder Aliases PubMed IDs
lung cancer
  • adenocarcinoma of lung
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR218-2

genes like me logo Genes that share disorders with MIR218-2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR218-2 Gene

Publications for MIR218-2 Gene

  1. Long noncoding RNA LINC-PINT inhibits non-small cell lung cancer progression through sponging miR-218-5p/PDCD4. (PMID: 31010333) Zhang L … Bu L (Artificial cells, nanomedicine, and biotechnology 2019) 3 54
  2. Legionella pneumophila infection-mediated regulation of RICTOR via miR-218 in U937 macrophage cells. (PMID: 30509489) Koriyama T … Hashiguchi T (Biochemical and biophysical research communications 2019) 3 54
  3. miR-218 inhibits gastric tumorigenesis through regulating Bmi-1/Akt signaling pathway. (PMID: 30420101) Wu Y … Hou P (Pathology, research and practice 2019) 3 54
  4. Metastatic breast cancer cells overexpress and secrete miR-218 to regulate type I collagen deposition by osteoblasts. (PMID: 30348200) Liu X … Wang SE (Breast cancer research : BCR 2018) 3 54
  5. miR-23b and miR-218 silencing increase Muscleblind-like expression and alleviate myotonic dystrophy phenotypes in mammalian models. (PMID: 29946070) Cerro-Herreros E … Artero R (Nature communications 2018) 3 54

Products for MIR218-2 Gene

Sources for MIR218-2 Gene