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Aliases for MIR216B Gene

Subcategory (RNA class) for MIR216B Gene


Quality Score for this RNA gene is


Aliases for MIR216B Gene

  • MicroRNA 216b 2 3 5
  • Hsa-Mir-216b 3
  • Mir-216b 3
  • MIRN216B 3

External Ids for MIR216B Gene

Previous HGNC Symbols for MIR216B Gene

  • MIRN216B

Previous GeneCards Identifiers for MIR216B Gene

  • GC02M056083
  • GC02M056227

Summaries for MIR216B Gene

Entrez Gene Summary for MIR216B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR216B Gene

MIR216B (MicroRNA 216b) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR216B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR216B Gene

Genomics for MIR216B Gene

GeneHancer (GH) Regulatory Elements for MIR216B Gene

Promoters and enhancers for MIR216B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I056008 Enhancer 1 Ensembl ENCODE dbSUPER 0.4 -8.3 -8344 2 CTCF MXI1 ZNF654 USF1 RFX1 JUN MAX SIN3A REST MNT MIR217 MIR216A EFEMP1 GC02P056001 MIR216B MIR217HG ENSG00000272180 LOC105374690
GH02I056015 Enhancer 0.8 Ensembl ENCODE dbSUPER 0.4 -15.2 -15155 0.9 ZNF692 REST PRDM1 MIR216A MIR217 GC02P056001 MIR216B MIR217HG ENSG00000272180 LOC105374690
GH02I056013 Enhancer 0.7 ENCODE dbSUPER 0.4 -13.4 -13421 0.5 PKNOX1 POLR2A SIN3A ZIC2 MIR216A MIR217 MIR216B GC02P056001 MIR217HG ENSG00000272180 LOC105374690
GH02I056021 Enhancer 0.7 ENCODE dbSUPER 0.3 -20.5 -20486 0.2 ZNF362 ZNF449 STAT3 TCF7L2 ZBTB17 MIR216B GC02P056001 MIR217HG ENSG00000272180 LOC105374690
GH02I056012 Enhancer 0.4 FANTOM5 dbSUPER 0.4 -11.6 -11592 0.1 EFEMP1 MIR217 MIR216A MIR216B GC02P056001 MIR217HG ENSG00000272180 LOC105374690
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR216B on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR216B Gene

Genomic Locations for MIR216B Gene
82 bases
Minus strand

Genomic View for MIR216B Gene

Genes around MIR216B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR216B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR216B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR216B Gene

Proteins for MIR216B Gene

Post-translational modifications for MIR216B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR216B Gene

Domains & Families for MIR216B Gene

Gene Families for MIR216B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR216B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR216B Gene

Function for MIR216B Gene

Phenotypes From GWAS Catalog for MIR216B Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR216B Gene

Localization for MIR216B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR216B Gene

Pathways & Interactions for MIR216B Gene

SuperPathways for MIR216B Gene

No Data Available

Interacting Proteins for MIR216B Gene

Gene Ontology (GO) - Biological Process for MIR216B Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR216B Gene

Drugs & Compounds for MIR216B Gene

No Compound Related Data Available

Transcripts for MIR216B Gene

mRNA/cDNA for MIR216B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR216B Gene

No ASD Table

Relevant External Links for MIR216B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR216B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR216B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR216B Gene:

genes like me logo Genes that share expression patterns with MIR216B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR216B Gene

Orthologs for MIR216B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR216B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-216b 34
  • 100 (a)
(Bos Taurus)
Mammalia bta-mir-216b 34
  • 93 (a)
(Mus musculus)
Mammalia Mir216b 34
  • 88 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia oan-mir-216b 34
  • 77 (a)
(Gallus gallus)
Aves gga-mir-216b 34
  • 79 (a)
(Anolis carolinensis)
Reptilia aca-mir-216b 34
  • 73 (a)
(Danio rerio)
Actinopterygii dre-mir-216b 34
  • 71 (a)
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-216a 34
  • 42 (a)
Species where no ortholog for MIR216B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR216B Gene

Gene Tree for MIR216B (if available)
Gene Tree for MIR216B (if available)

Paralogs for MIR216B Gene

No data available for Paralogs for MIR216B Gene

Variants for MIR216B Gene

Sequence variations from dbSNP and Humsavar for MIR216B Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000001151 -- 56,002,678(-) C/G upstream_transcript_variant
rs1000605865 -- 56,002,712(-) C/T upstream_transcript_variant
rs1001582421 -- 56,002,071(-) T/C upstream_transcript_variant
rs1003189061 -- 56,000,919(-) G/C upstream_transcript_variant
rs1005438137 -- 56,001,641(-) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR216B Gene

Variant ID Type Subtype PubMed ID
esv3575244 CNV gain 25503493
esv2759051 CNV gain 17122850

Additional Variant Information for MIR216B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR216B Gene

Disorders for MIR216B Gene

Additional Disease Information for MIR216B

No disorders were found for MIR216B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR216B Gene

Publications for MIR216B Gene

  1. miR-216b suppresses breast cancer growth and metastasis by targeting SDCBP. (PMID: 27720715) Jana S … Bhattacharyya A (Biochemical and biophysical research communications 2017) 3 58
  2. Predictive Value of Plasma MicroRNA-216a/b in the Diagnosis of Esophageal Squamous Cell Carcinoma. (PMID: 26989293) Dong S … He F (Disease markers 2016) 3 58
  3. The HIF-2α-MALAT1-miR-216b axis regulates multi-drug resistance of hepatocellular carcinoma cells via modulating autophagy. (PMID: 27524242) Yuan P … Fan J (Biochemical and biophysical research communications 2016) 3 58
  4. Regulation of UGT2B Expression and Activity by miR-216b-5p in Liver Cancer Cell Lines. (PMID: 27474751) Dluzen DF … Lazarus P (The Journal of pharmacology and experimental therapeutics 2016) 3 58
  5. MiR-216b is involved in pathogenesis and progression of hepatocellular carcinoma through HBx-miR-216b-IGF2BP2 signaling pathway. (PMID: 25741595) Liu FY … Chen XP (Cell death & disease 2015) 3 58

Products for MIR216B Gene

Sources for MIR216B Gene

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