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MIR216A Gene(RNA Gene)

MicroRNA 216a

GCID:
GC02M055988
GIFtS:
17
Genes Participants
UDN Logo

Aliases for MIR216A Gene

Subcategory (RNA class) for MIR216A Gene

miRNA

Quality Score for this RNA gene is

8.2

Aliases for MIR216A Gene

  • MicroRNA 216a 2 3 5
  • MicroRNA 216 2 3
  • Hsa-Mir-216a 3
  • Hsa-Mir-216 3
  • MiRNA216 3
  • Mir-216a 3
  • MIRN216A 3
  • Mir-216 3
  • MIRN216 3
  • MIR216 3

External Ids for MIR216A Gene

ORGUL Members for MIR216A Gene

Previous HGNC Symbols for MIR216A Gene

  • MIRN216
  • MIRN216A

Previous GeneCards Identifiers for MIR216A Gene

  • GC02M056072
  • GC02M056216

Summaries for MIR216A Gene

Entrez Gene Summary for MIR216A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR216A Gene

MIR216A (MicroRNA 216a) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR216A Gene

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR216A

Additional gene information for MIR216A Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR216A Gene

Genomics for MIR216A Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for MIR216A Gene

Promoters and enhancers for MIR216A Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH02I056008 Enhancer 1 Ensembl ENCODE dbSUPER 11.1 -20.1 -20080 2 CTCF MXI1 ZNF654 USF1 RFX1 JUN MAX SIN3A REST MNT MIR217 MIR216A EFEMP1 GC02P056001 MIR216B MIR217HG ENSG00000272180 LOC105374690
GH02I055957 Enhancer 0.9 Ensembl ENCODE 10.9 +30.4 30375 1.4 PKNOX1 MXI1 JUN MAX SIN3A RAD21 RFX5 CTBP1 GATA3 SCRT2 EFEMP1 MIR217 MIR216A ENSG00000240401 ENSG00000272180 LOC105374690 GC02P055982
GH02I056015 Enhancer 0.8 Ensembl ENCODE dbSUPER 11.1 -26.9 -26891 0.9 ZNF692 REST PRDM1 MIR216A MIR217 GC02P056001 MIR216B MIR217HG ENSG00000272180 LOC105374690
GH02I055965 Enhancer 0.7 Ensembl ENCODE 11.8 +22.8 22808 1.8 IKZF1 JUN MNT NR2F2 MIR216A EFEMP1 ENSG00000240401 ENSG00000272180 GC02P055982 LOC105374690 MIR217HG
GH02I056013 Enhancer 0.7 ENCODE dbSUPER 11.1 -25.2 -25157 0.5 PKNOX1 POLR2A SIN3A ZIC2 MIR216A MIR217 MIR216B GC02P056001 MIR217HG ENSG00000272180 LOC105374690
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR216A on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR216A Gene

Genomic Locations for MIR216A Gene
chr2:55,988,950-55,989,059
(GRCh38/hg38)
Size:
110 bases
Orientation:
Minus strand
chr2:56,216,085-56,216,194
(GRCh37/hg19)

Genomic View for MIR216A Gene

Genes around MIR216A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR216A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR216A Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR216A Gene

ORGUL Member Location for MIR216A Gene

ORGUL Member Location for MIR216A gene

Proteins for MIR216A Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIR216A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR216A Gene

Domains & Families for MIR216A Gene

Gene Families for MIR216A Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR216A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR216A Gene

Function for MIR216A Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Phenotypes From GWAS Catalog for MIR216A Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR216A Gene

Localization for MIR216A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR216A Gene

Pathways & Interactions for MIR216A Gene

SuperPathways for MIR216A Gene

PathCards logo More details on SuperPathways for MIR216A
No Data Available

Interacting Proteins for MIR216A Gene

Gene Ontology (GO) - Biological Process for MIR216A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR216A Gene

Drugs & Compounds for MIR216A Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIR216A Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

fRNAdb Secondary structures for MIR216A Gene

  • FR306832

mRNA/cDNA for MIR216A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR216A Gene

No ASD Table

Relevant External Links for MIR216A Gene

GeneLoc Exon Structure for
MIR216A
ECgene alternative splicing isoforms for
MIR216A

Expression for MIR216A Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR216A Gene

mRNA expression in normal human tissues for MIR216A Gene
mRNA expression by GTEx for MIR216A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR216A Gene:

MIR216A
genes like me logo Genes that share expression patterns with MIR216A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR216A Gene

Orthologs for MIR216A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR216A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ptr-mir-216a 34
  • 98 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia cfa-mir-216a 34
  • 97 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia mdo-mir-216 34
  • 96 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia bta-mir-216a 34
  • 94 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Mir216a 34
  • 92 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia oan-mir-216a 34
  • 73 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves gga-mir-216a 34
  • 87 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia aca-mir-216a 34
  • 84 (a)
 OneToOne
zebrafish
(Danio rerio)
 Actinopterygii dre-mir-216a 34
  • 69 (a)
 OneToOne
sea squirt
(Ciona savignyi)
 Ascidiacea csa-mir-216a 34
  • 58 (a)
 OneToMany
Species where no ortholog for MIR216A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR216A Gene

ENSEMBL:
Gene Tree for MIR216A (if available)
TreeFam:
Gene Tree for MIR216A (if available)

Paralogs for MIR216A Gene

No data available for Paralogs for MIR216A Gene

Variants for MIR216A Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for MIR216A Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000796040 -- 55,989,609(-) G/A upstream_transcript_variant
rs1000912132 -- 55,989,803(-) C/T upstream_transcript_variant
rs1001997320 -- 55,990,852(-) C/T upstream_transcript_variant
rs1005245076 -- 55,989,149(-) G/A upstream_transcript_variant
rs1005699332 -- 55,990,518(-) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR216A Gene

Variant ID Type Subtype PubMed ID
esv2759051 CNV gain 17122850
esv3575244 CNV gain 25503493

Additional Variant Information for MIR216A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR216A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR216A Gene

Disorders for MIR216A Gene

Additional Disease Information for MIR216A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MIR216A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR216A Gene

Publications for MIR216A Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 44 58
  2. SNHG16/miR-216-5p/ZEB1 signal pathway contributes to the tumorigenesis of cervical cancer cells. (PMID: 29126969) Zhu H … Ye W (Archives of biochemistry and biophysics 2018) 3 58
  3. YB-1 expression promotes pancreatic cancer metastasis that is inhibited by microRNA-216a. (PMID: 28782557) Lu J … Wang Z (Experimental cell research 2017) 3 58
  4. Down-regulation of KIAA1199/CEMIP by miR-216a suppresses tumor invasion and metastasis in colorectal cancer. (PMID: 28213952) Zhang D … Zhang T (International journal of cancer 2017) 3 58
  5. Circulating microRNA 216 as a Marker for the Early Identification of Severe Acute Pancreatitis. (PMID: 28183420) Zhang XX … Xia Q (The American journal of the medical sciences 2017) 3 58

Products for MIR216A Gene

Sources for MIR216A Gene

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