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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR216A (MicroRNA 216a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR216A include Microvascular Complications Of Diabetes 3 and Pancreatic Ductal Adenocarcinoma.
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000013ABA3_9606 | precursor_RNA | 110 | 5 |
HGNC: 31593, RefSeq: NR_029629, Ensembl: ENST00000385063 (view in UCSC) , miRBase: MI0000292, |
URS0000318E24_9606 | miRNA | 22 | 4 |
RefSeq: NR_029629, miRBase: MIMAT0000273, TarBase: hsa-miR-216a-5p, |
URS000075D097_9606 | miRNA | 22 | 3 |
RefSeq: NR_029629, miRBase: MIMAT0022844, ENA: LM608361.1:58..79:ncRNA, |
URS00006307B0_9606 | precursor_RNA | 89 | 1 |
Rfam: RF00654, |
URS0000EFD15A_9606 | precursor_RNA | 63 | 1 |
MirGeneDB: Hsa-Mir-216-P1a, |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-216a 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | cfa-mir-216a 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | mdo-mir-216 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | bta-mir-216a 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Mir216a 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | oan-mir-216a 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | gga-mir-216a 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | aca-mir-216a 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | dre-mir-216a 31 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | csa-mir-216a 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2759051 | CNV | gain | 17122850 |
esv3575244 | CNV | gain | 25503493 |
Disorder | Aliases | PubMed IDs |
---|---|---|
microvascular complications of diabetes 3 |
|
|
pancreatic ductal adenocarcinoma |
|
|
nasopharyngeal carcinoma |
|
|
melanoma |
|
|
lung cancer |
|