microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR216A Gene

Subcategory (RNA class) for MIR216A Gene

miRNA

Number of RNA Genes sources:

5 / 17

Aliases for MIR216A Gene

  • MicroRNA 216a 2 3 5
  • MicroRNA 216 2 3
  • Hsa-Mir-216a 2 3
  • Hsa-Mir-216 2 3
  • MIR216A 2 5
  • Hsa-MiR-216a-5p 173
  • Hsa-Mir-216-P1a 178
  • MIMAT0022844 50
  • MIMAT0000273 50
  • MI0000292 50
  • MIRN216A 3
  • MiRNA216 3
  • Mir-216a 3
  • MIRN216 3
  • Mir-216 3
  • RF00654 168
  • MIR216 3

External Ids for MIR216A Gene

Previous HGNC Symbols for MIR216A Gene

  • MIRN216
  • MIRN216A

Previous GeneCards Identifiers for MIR216A Gene

  • GC02M056072
  • GC02M056216

Summaries for MIR216A Gene

Entrez Gene Summary for MIR216A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR216A Gene

MIR216A (MicroRNA 216a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR216A include Microvascular Complications Of Diabetes 3 and Pancreatic Ductal Adenocarcinoma.

Rfam classification for MIR216A Gene

Additional gene information for MIR216A Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR216A Gene

Genomics for MIR216A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR216A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR216A on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR216A Gene

Genomic Locations for MIR216A Gene
chr2:55,988,950-55,989,059
(GRCh38/hg38)
Size:
110 bases
Orientation:
Minus strand
chr2:56,216,085-56,216,194
(GRCh37/hg19)
Size:
110 bases
Orientation:
Minus strand

Genomic View for MIR216A Gene

Genes around MIR216A on UCSC Golden Path with GeneCards custom track
MIR216A in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR216A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR216A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR216A Gene

Proteins for MIR216A Gene

Post-translational modifications for MIR216A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR216A Gene

Domains & Families for MIR216A Gene

Gene Families for MIR216A Gene

genes like me logo Genes that share domains with MIR216A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR216A Gene

Function for MIR216A Gene

Phenotypes From GWAS Catalog for MIR216A Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR216A Gene

Localization for MIR216A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR216A gene
Compartment Confidence
extracellular 2
nucleus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR216A Gene

Pathways & Interactions for MIR216A Gene

PathCards logo

SuperPathways for MIR216A Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR216A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR216A: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR216A Gene

Drugs & Compounds for MIR216A Gene

No Compound Related Data Available

Transcripts for MIR216A Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR216A Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000013ABA3_9606 precursor_RNA 110 5

HGNC: 31593,

RefSeq: NR_029629,

Ensembl: ENST00000385063 (view in UCSC) ,

miRBase: MI0000292,

ENA: LM608361.1:1..110:precursor_RNA,

URS0000318E24_9606 miRNA 22 4

RefSeq: NR_029629,

miRBase: MIMAT0000273,

TarBase: hsa-miR-216a-5p,

ENA: LM378913.1:1..22:ncRNA, LM608361.1:19..40:ncRNA,

URS000075D097_9606 miRNA 22 3

RefSeq: NR_029629,

miRBase: MIMAT0022844,

ENA: LM608361.1:58..79:ncRNA,

URS00006307B0_9606 precursor_RNA 89 1

Rfam: RF00654,

URS0000EFD15A_9606 precursor_RNA 63 1

MirGeneDB: Hsa-Mir-216-P1a,

MIR216A in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR216A Gene

2 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR216A Gene

No ASD Table

Relevant External Links for MIR216A Gene

GeneLoc Exon Structure for
MIR216A

Expression for MIR216A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR216A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR216A

genes like me logo Genes that share expression patterns with MIR216A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR216A Gene

Orthologs for MIR216A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR216A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-216a 31
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-216a 31
  • 97 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-216 31
  • 96 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-216a 31
  • 94 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir216a 31
  • 92 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-216a 31
  • 73 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-216a 31
  • 87 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-216a 31
  • 84 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-216a 31
  • 69 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea csa-mir-216a 31
  • 58 (a)
OneToMany
Species where no ortholog for MIR216A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR216A Gene

ENSEMBL:
Gene Tree for MIR216A (if available)
TreeFam:
Gene Tree for MIR216A (if available)

Paralogs for MIR216A Gene

No data available for Paralogs for MIR216A Gene

Variants for MIR216A Gene

Additional dbSNP identifiers (rs#s) for MIR216A Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR216A Gene

Variant ID Type Subtype PubMed ID
esv2759051 CNV gain 17122850
esv3575244 CNV gain 25503493

Additional Variant Information for MIR216A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR216A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR216A Gene

Disorders for MIR216A Gene

MalaCards: The human disease database

(8) MalaCards diseases for MIR216A Gene - From: miR2Disease and DISEASES

Disorder Aliases PubMed IDs
microvascular complications of diabetes 3
  • end-stage renal disease, diabetic
pancreatic ductal adenocarcinoma
  • ductal adenocarcinoma of the pancreas
nasopharyngeal carcinoma
  • npc
melanoma
  • malignant melanoma
lung cancer
  • adenocarcinoma of lung
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR216A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR216A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR216A Gene

Publications for MIR216A Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 41
  2. Ox-LDL-induced lncRNA MALAT1 promotes autophagy in human umbilical vein endothelial cells by sponging miR-216a-5p and regulating Beclin-1 expression. (PMID: 31029709) Wang K … Gao T (European journal of pharmacology 2019) 3
  3. BRD4 promotes the stemness of gastric cancer cells via attenuating miR-216a-3p-mediated inhibition of Wnt/β-catenin signaling. (PMID: 30876979) Song H … Song J (European journal of pharmacology 2019) 3
  4. DANCR contributed to hepatocellular carcinoma malignancy via sponging miR-216a-5p and modulating KLF12. (PMID: 30430564) Wang J … Deng Y (Journal of cellular physiology 2019) 3
  5. LncRNA DANCR contributes to tumor progression via targetting miR-216a-5p in breast cancer: lncRNA DANCR contributes to tumor progression. (PMID: 30910842) Tao W … Pang D (Bioscience reports 2019) 3

Products for MIR216A Gene

Sources for MIR216A Gene