microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR215 Gene

Subcategory (RNA class) for MIR215 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR215 Gene

  • MicroRNA 215 2 3 5
  • Hsa-MiR-215-5p 163 173
  • Hsa-Mir-215 2 3
  • MIR215 2 5
  • Hsa-Mir-192-P2 178
  • MIMAT0000272 50
  • MIMAT0026476 50
  • MI0000291 50
  • MiRNA215 3
  • MIRN215 3
  • Mir-215 3
  • RF00130 168

External Ids for MIR215 Gene

Previous HGNC Symbols for MIR215 Gene

  • MIRN215

Previous GeneCards Identifiers for MIR215 Gene

  • GC01M218359
  • GC01M220291

Summaries for MIR215 Gene

Entrez Gene Summary for MIR215 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR215 Gene

MIR215 (MicroRNA 215) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR215 include Gastric Cancer and Colorectal Cancer. Among its related pathways are MicroRNAs in cancer.

Rfam classification for MIR215 Gene

  • mir-192/215 microRNA precursor

Additional gene information for MIR215 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR215 Gene

Genomics for MIR215 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR215 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J220158 Enhancer 0.3 ENCODE 12.4 -41.6 -41592 1.7 CEBPB CEBPG IARS2 MIR194-1 MIR215 EPRS1 RAB3GAP2 lnc-BPNT1-1 MIR664A lnc-BPNT1-2
GH01J220114 Enhancer 1.3 Ensembl ENCODE dbSUPER 0.7 -2.3 -2334 11.1 CTCF PRDM10 ZNF629 ZNF512 LEF1 IKZF1 ZNF692 JUND PRDM1 MTA2 RPS15AP12 EPRS1 ZC3H11B RIMKLBP2 RAB3GAP2 ENSG00000272823 MIR194-1 MIR215 RF00257-001 lnc-RAB3GAP2-1
GH01J220113 Enhancer 0.8 Ensembl dbSUPER 0.7 +4.7 4661 0.6 CTCF TRIM22 HDGF CUX1 RAD21 HOMEZ CHAMP1 ZNF143 MEIS2 ZHX1 LOC105373475 RPS15AP12 MIR215 IARS2 lnc-RAB3GAP2-1 RAB3GAP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR215 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR215 Gene

Genomic Locations for MIR215 Gene
chr1:220,117,853-220,117,962
(GRCh38/hg38)
Size:
110 bases
Orientation:
Minus strand
chr1:220,291,195-220,291,304
(GRCh37/hg19)
Size:
110 bases
Orientation:
Minus strand

Genomic View for MIR215 Gene

Genes around MIR215 on UCSC Golden Path with GeneCards custom track
MIR215 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR215 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR215 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR215 Gene

Proteins for MIR215 Gene

Post-translational modifications for MIR215 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR215 Gene

Domains & Families for MIR215 Gene

Gene Families for MIR215 Gene

genes like me logo Genes that share domains with MIR215: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR215 Gene

Function for MIR215 Gene

Gene Ontology (GO) - Molecular Function for MIR215 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 28798470
genes like me logo Genes that share ontologies with MIR215: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR215 Gene

Localization for MIR215 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR215 gene
Compartment Confidence
extracellular 2
cytoskeleton 2
nucleus 2
plasma membrane 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MIR215 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIR215: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR215 Gene

Pathways & Interactions for MIR215 Gene

PathCards logo

SuperPathways for MIR215 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR215: view

Pathways by source for MIR215 Gene

1 KEGG pathway for MIR215 Gene

Gene Ontology (GO) - Biological Process for MIR215 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032705 negative regulation of interleukin-21 production IDA 28798470
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:0045391 negative regulation of interleukin-21 biosynthetic process IDA --
genes like me logo Genes that share ontologies with MIR215: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR215 Gene

Drugs & Compounds for MIR215 Gene

No Compound Related Data Available

Transcripts for MIR215 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR215 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00000F31F4_9606 precursor_RNA 110 5

HGNC: 31592,

RefSeq: NR_029628,

Ensembl: ENST00000384858 (view in UCSC) ,

miRBase: MI0000291,

ENA: LM608360.1:1..110:precursor_RNA,

URS0000315B13_9606 miRNA 21 5

RefSeq: NR_029628,

LncBase: hsa-miR-215-5p,

miRBase: MIMAT0000272,

TarBase: hsa-miR-215-5p,

ENA: AJ550418.1:1..21:ncRNA, LM378912.1:1..21:ncRNA, LM608360.1:27..47:ncRNA,

URS000075D75C_9606 miRNA 23 4

RefSeq: NR_029628,

miRBase: MIMAT0026476,

MirGeneDB: Hsa-Mir-192-P2_3p,

ENA: LM608360.1:64..86:ncRNA,

URS0000651765_9606 precursor_RNA 105 1

Rfam: RF00130,

URS0000EFC7B3_9606 precursor_RNA 61 1

MirGeneDB: Hsa-Mir-192-P2,

MIR215 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR215 Gene

2 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR215 Gene

No ASD Table

Relevant External Links for MIR215 Gene

GeneLoc Exon Structure for
MIR215

Expression for MIR215 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR215 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR215

Evidence on tissue expression from TISSUES for MIR215 Gene

  • Intestine(2.2)
genes like me logo Genes that share expression patterns with MIR215: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR215 Gene

Orthologs for MIR215 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR215 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-215 31
  • 99 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-215 31
  • 89 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-215 31
  • 87 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-215 31
  • 83 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir215 31
  • 73 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 73 (a)
OneToMany
oan-mir-215 31
  • 72 (a)
OneToMany
Chicken
(Gallus gallus)
Aves gga-mir-215 31
  • 75 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-215 31
  • 66 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-192 31
  • 66 (a)
OneToMany
Species where no ortholog for MIR215 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR215 Gene

ENSEMBL:
Gene Tree for MIR215 (if available)
TreeFam:
Gene Tree for MIR215 (if available)

Paralogs for MIR215 Gene

No data available for Paralogs for MIR215 Gene

Variants for MIR215 Gene

Additional dbSNP identifiers (rs#s) for MIR215 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR215 Gene

Variant ID Type Subtype PubMed ID
esv2665152 CNV deletion 23128226
esv3547011 CNV deletion 23714750
esv3588893 CNV loss 21293372
nsv832636 CNV loss 17160897
nsv947468 CNV deletion 23825009

Additional Variant Information for MIR215 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR215

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR215 Gene

Disorders for MIR215 Gene

MalaCards: The human disease database

(7) MalaCards diseases for MIR215 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
gastric cancer
  • gastric cancer, somatic
colorectal cancer
  • crc
esophagus adenocarcinoma
  • oesophageal adenocarcinoma
psoriasis
oral squamous cell carcinoma
  • mouth squamous cell carcinoma
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with MIR215: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR215 Gene

Publications for MIR215 Gene

  1. MicroRNA-215-3p Suppresses the Growth, Migration, and Invasion of Colorectal Cancer by Targeting FOXM1. (PMID: 31607224) Tang X … Cheng Z (Technology in cancer research & treatment 2019) 3
  2. miR-192/215-5p act as tumor suppressors and link Crohn's disease and colorectal cancer by targeting common metabolic pathways: An integrated informatics analysis and experimental study. (PMID: 31020657) Zhao H … Tan J (Journal of cellular physiology 2019) 3
  3. MicroRNA-215-5p Treatment Suppresses Mesothelioma Progression via the MDM2-p53-Signaling Axis. (PMID: 31227395) Singh A … Hoang CD (Molecular therapy : the journal of the American Society of Gene Therapy 2019) 3
  4. Tumor suppressor miR-215 counteracts hypoxia-induced colon cancer stem cell activity. (PMID: 30790680) Ullmann P … Letellier E (Cancer letters 2019) 3
  5. MicroRNA-215 as a Diagnostic Marker in Egyptian Patients with Hepatocellular Carcinoma. (PMID: 31554369) El Mahdy HA … Hassouna MM (Asian Pacific journal of cancer prevention : APJCP 2019) 3

Products for MIR215 Gene

Sources for MIR215 Gene