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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR214 (MicroRNA 214) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR214 include Cervical Cancer and Ovarian Cancer. Among its related pathways are MicroRNAs in cancer.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH01J171434 | Enhancer | 0.8 | FANTOM5 ENCODE | 5 | +703.9 | 703909 | 2.2 | ATF7 SCRT2 CEBPB JUND NFE2 JUN FOS GABPA MAX NFIC | PRRC2C FMO4 MIR214 lnc-MYOC-4 RNU6-290P RF00026-083 | |
GH01J172681 | Enhancer | 0.9 | Ensembl ENCODE dbSUPER | 4.3 | -543.2 | -543193 | 3.4 | TEAD4 ZNF512 NFE2 ZNF316 MAFG MAFK NFE2L2 MAFF BACH1 FOXA3 | RNU6-693P FASLG C1orf105 MIR214 RF00017-398 TNFSF18 | |
GH01J172137 | Promoter/Enhancer | 2.3 | UCNEbase EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER | 0.7 | -3.7 | -3708 | 9.6 | PRDM1 JUND CEBPB USF1 ZFHX2 RCOR1 ZNF366 YY1 JUN GLIS1 | DNM3OS RNU6-157P MIR199A2 MIR214 MIR3120 C1orf105 DNM3 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 24011070 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IDA | 24158985 |
GO:0048471 | perinuclear region of cytoplasm | IDA | 24158985 |
GO:1903561 | extracellular vesicle | HDA | 28798470 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | MicroRNAs in cancer |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0008285 | negative regulation of cell proliferation | IDA | 25656649 |
GO:0010593 | negative regulation of lamellipodium assembly | ISS | -- |
GO:0010629 | negative regulation of gene expression | IDA | 27144530 |
GO:0016525 | negative regulation of angiogenesis | ISS | -- |
GO:0030336 | negative regulation of cell migration | IDA | 25656649 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS0000160683_9606 | precursor_RNA | 110 | 6 |
HGNC: 31591, RefSeq: NR_029627, Ensembl: ENST00000385214 (view in UCSC) , miRBase: MI0000290, Rfam: RF00660, |
URS00002C11C3_9606 | miRNA | 22 | 6 |
RefSeq: NR_029627, LncBase: hsa-miR-214-3p, miRBase: MIMAT0000271, MirGeneDB: Hsa-Mir-214-v1_3p, TarBase: hsa-miR-214-3p, ENA: FJ623959.1:5999..6020:ncRNA, HB859647.1:1..22:misc_RNA, LM378911.1:1..22:ncRNA, LM608359.1:71..92:ncRNA, |
URS00004DAA89_9606 | miRNA | 22 | 6 |
RefSeq: NR_029627, LncBase: hsa-miR-214-5p, miRBase: MIMAT0004564, MirGeneDB: Hsa-Mir-214-v1_5p, TarBase: hsa-miR-214-5p, ENA: FJ623959.1:5958..5979:ncRNA, LM380243.1:1..22:ncRNA, LM608359.1:30..51:ncRNA, |
URS0000EFC831_9606 | precursor_RNA | 64 | 1 |
MirGeneDB: Hsa-Mir-214-v1, Hsa-Mir-214-v2, |
URS000042BD45_9606 | miRNA | 23 | 1 |
MirGeneDB: Hsa-Mir-214-v2_3p, |
Disorder | Aliases | PubMed IDs |
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cervical cancer |
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ovarian cancer |
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ovarian serous carcinoma |
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intrahepatic cholangiocarcinoma |
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vascular disease |
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