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Aliases for MIR214 Gene

Subcategory (RNA class) for MIR214 Gene

miRNA

Quality Score for this RNA gene is

13

Aliases for MIR214 Gene

  • MicroRNA 214 2 3 5
  • Hsa-Mir-214 3
  • MiRNA214 3
  • Mir-214 3
  • MIRN214 3

External Ids for MIR214 Gene

Previous HGNC Symbols for MIR214 Gene

  • MIRN214

Previous GeneCards Identifiers for MIR214 Gene

  • GC01M170375
  • GC01M172180
  • GC01M172182
  • GC01M172188
  • GC01M172192
  • GC01M172198
  • GC01M172215
  • GC01M172195
  • GC01M172191
  • GC01M172204
  • GC01M172208
  • GC01M172211
  • GC01M172214

Summaries for MIR214 Gene

Entrez Gene Summary for MIR214 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR214 Gene

MIR214 (MicroRNA 214) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR214 include Cervical Cancer and Ovarian Cancer. Among its related pathways are MicroRNAs in cancer.

Additional gene information for MIR214 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR214 Gene

Genomics for MIR214 Gene

GeneHancer (GH) Regulatory Elements for MIR214 Gene

Promoters and enhancers for MIR214 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J171434 Enhancer 0.9 FANTOM5 ENCODE 5 +703.9 703909 2.2 CEBPB SCRT2 JUN NFE2 JUND MAX FOS GABPA EP300 STAT3 PRRC2C FMO4 MIR214 CYCSP53 GC01M171420
GH01J172679 Enhancer 0.7 Ensembl 4.3 -541.3 -541294 2.4 CBFA2T2 BACH1 MAFK TRIM24 ZNF512 NFE2L2 ZNF316 MGA NFE2 MAFG RNU6-693P FASLG C1orf105 MIR214 SLC25A38P1
GH01J172137 Promoter/Enhancer 1.7 UCNEbase Ensembl ENCODE dbSUPER 0.7 -3.7 -3708 9.6 PRDM1 POLR2A USF1 ZFHX2 RCOR1 ZNF366 JUND JUN ATF2 GLIS1 RNU6-157P MIR3120 MIR214 MIR199A2 GC01M172225 GC01M172219 DNM3OS DNM3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR214 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR214 Gene

Genomic Locations for MIR214 Gene
chr1:172,138,798-172,138,907
(GRCh38/hg38)
Size:
110 bases
Orientation:
Minus strand
chr1:172,107,938-172,108,047
(GRCh37/hg19)
Size:
110 bases
Orientation:
Minus strand

Genomic View for MIR214 Gene

Genes around MIR214 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR214 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR214 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR214 Gene

Proteins for MIR214 Gene

Post-translational modifications for MIR214 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR214 Gene

Domains & Families for MIR214 Gene

Gene Families for MIR214 Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR214: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR214 Gene

Function for MIR214 Gene

Gene Ontology (GO) - Molecular Function for MIR214 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 24011070
genes like me logo Genes that share ontologies with MIR214: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR214 Gene

Localization for MIR214 Gene

Gene Ontology (GO) - Cellular Components for MIR214 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 24158985
GO:0035068 micro-ribonucleoprotein complex IEA --
GO:0048471 perinuclear region of cytoplasm IDA 24158985
genes like me logo Genes that share ontologies with MIR214: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR214 Gene

Pathways & Interactions for MIR214 Gene

PathCards logo

SuperPathways for MIR214 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR214: view

Pathways by source for MIR214 Gene

1 KEGG pathway for MIR214 Gene

Interacting Proteins for MIR214 Gene

Gene Ontology (GO) - Biological Process for MIR214 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation IDA 25656649
GO:0010593 negative regulation of lamellipodium assembly ISS --
GO:0010629 negative regulation of gene expression IDA 27144530
GO:0016525 negative regulation of angiogenesis ISS --
GO:0030336 negative regulation of cell migration IDA 25656649
genes like me logo Genes that share ontologies with MIR214: view

No data available for SIGNOR curated interactions for MIR214 Gene

Drugs & Compounds for MIR214 Gene

No Compound Related Data Available

Transcripts for MIR214 Gene

mRNA/cDNA for MIR214 Gene

(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(3) RNA Central transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR214 Gene

No ASD Table

Relevant External Links for MIR214 Gene

GeneLoc Exon Structure for
MIR214
ECgene alternative splicing isoforms for
MIR214

Expression for MIR214 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR214 Gene

mRNA differential expression in normal tissues according to GTEx for MIR214 Gene

This gene is overexpressed in Spleen (x6.0) and Ovary (x5.4).

NURSA nuclear receptor signaling pathways regulating expression of MIR214 Gene:

MIR214
genes like me logo Genes that share expression patterns with MIR214: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR214 Gene

Orthologs for MIR214 Gene

Evolution for MIR214 Gene

ENSEMBL:
Gene Tree for MIR214 (if available)
TreeFam:
Gene Tree for MIR214 (if available)

No data available for Orthologs for MIR214 Gene

Paralogs for MIR214 Gene

No data available for Paralogs for MIR214 Gene

Variants for MIR214 Gene

Sequence variations from dbSNP and Humsavar for MIR214 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000948893 -- 172,138,488(-) C/ downstream_transcript_variant
rs1004077920 -- 172,139,829(-) T/C upstream_transcript_variant
rs1004091046 -- 172,139,423(-) G/A upstream_transcript_variant
rs1004238140 -- 172,140,473(-) C/T upstream_transcript_variant
rs1005309344 -- 172,139,585(-) G/T upstream_transcript_variant

Additional Variant Information for MIR214 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR214

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR214 Gene

Disorders for MIR214 Gene

MalaCards: The human disease database

(20) MalaCards diseases for MIR214 Gene - From: miR2Disease and GeneCards

Disorder Aliases PubMed IDs
cervical cancer
  • cervical cancer, somatic
ovarian cancer
  • ovarian cancer, somatic
intrahepatic cholangiocarcinoma
  • cholangiocarcinoma
facioscapulohumeral muscular dystrophy 1
  • fmd
vascular disease
  • vascular tissue disease
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR214

genes like me logo Genes that share disorders with MIR214: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR214 Gene

Publications for MIR214 Gene

  1. miR-214 targets ATF4 to inhibit bone formation. (PMID: 23223004) Wang X … Li Y (Nature medicine 2013) 2 3 58
  2. LncRNA KCNQ1OT1 promoted BMP2 expression to regulate osteogenic differentiation by sponging miRNA-214. (PMID: 30703347) Wang CG … Zhong D (Experimental and molecular pathology 2019) 3 58
  3. MiR-214 sensitizes human colon cancer cells to 5-FU by targeting Hsp27. (PMID: 30915129) Yang Y … Ma ZH (Cellular & molecular biology letters 2019) 3 58
  4. Downregulation of miRNA-214 in cancer-associated fibroblasts contributes to migration and invasion of gastric cancer cells through targeting FGF9 and inducing EMT. (PMID: 30646925) Wang R … Wang L (Journal of experimental & clinical cancer research : CR 2019) 3 58
  5. Long noncoding RNA MIR31HG is activated by SP1 and promotes cell migration and invasion by sponging miR-214 in NSCLC. (PMID: 30659947) Dandan W … Xuedong L (Gene 2019) 3 58

Products for MIR214 Gene

Sources for MIR214 Gene

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