Aliases for MIR214 Gene
Subcategory (RNA class) for MIR214 Gene
miRNA
Quality Score for this RNA gene is
18.2
External Ids for MIR214 Gene
- HGNC: 31591
- Entrez Gene: 406996
- Ensembl: ENSG00000283844
- OMIM: 610721
- miRBase: hsa-mir-214
ORGUL Members for MIR214 Gene
Previous HGNC Symbols for MIR214 Gene
- MIRN214
Previous GeneCards Identifiers for MIR214 Gene
- GC01M170375
- GC01M172180
- GC01M172182
- GC01M172188
- GC01M172192
- GC01M172198
- GC01M172195
- GC01M172191
- GC01M172204
- GC01M172208
Summaries for MIR214 Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR214 Gene
MIR214 (MicroRNA 214) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR214 include Cervical Cancer and Ovarian Cancer. Among its related pathways are MicroRNAs in cancer.
fRNAdb sequence ontologies for MIR214 Gene
-
nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.
Additional gene information for MIR214 Gene
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR214 Gene
Genomics for MIR214 Gene
GeneHancer (GH) Regulatory Elements for MIR214 Gene
Promoters and enhancers for MIR214 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH01J171434 | Enhancer | 1.1 | FANTOM5 Ensembl ENCODE | 5 | +703.9 | 703909 | 2.2 | JUN MAX CEBPB CEBPG EP300 GABPA GTF3C2 ATF4 JUND DIDO1 | PRRC2C METTL13 FMO4 MIR214 CYCSP53 GC01M171420 | |
| GH01J172137 | Promoter/Enhancer | 1.7 | UCNEbase Ensembl ENCODE dbSUPER | 0.7 | -3.7 | -3708 | 9.6 | USF1 TAF1 JUN ZNF398 ATF2 ZFHX2 JUND ZNF366 POLR2A GLIS1 | RNU6-157P DNM3OS MIR199A2 MIR214 MIR3120 DNM3 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around MIR214 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for MIR214 Gene
Genomic Locations for MIR214 Gene
- chr1:172,138,798-172,138,907
- (GRCh38/hg38)
- Size:
- 110 bases
- Orientation:
- Minus strand
- chr1:172,107,938-172,108,047
- (GRCh37/hg19)
- Size:
- 110 bases
- Orientation:
- Minus strand
Genomic View for MIR214 Gene
Genes around MIR214 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q24.3 by Entrez Gene
- 1q24.3 by HGNC
- 1q24.3 by Ensembl
MIR214 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR214 Gene
ORGUL Member Location for MIR214 Gene
Proteins for MIR214 Gene
Post-translational modifications for MIR214 Gene
No Post-translational modifications
Antibody Products
- Search GeneTex for Antibodies for MIR214
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR214
- Origene Custom Protein Services for MIR214
- Search GeneTex for Proteins for MIR214
No data available for DME Specific Peptides for MIR214 Gene
Domains & Families for MIR214 Gene
Gene Families for MIR214 Gene
- HGNC:
Graphical View of Domain Structure for InterPro Entry
No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR214 Gene
Function for MIR214 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 24011070 |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR214
-
CRISPR Products
- Browse CRISPR knockouts for MIR214
- Applied Biological Materials CRISPR for MIR214
-
Vectors and viruses for KO, Activation, Repression, and more
miRNA Products
Inhibitory RNA Products
Clone Products
- GenScript: Custom all cDNA clones Services for MIR214
- VectorBuilder custom plasmid, inducible vectors for MIR214
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR214
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MIR214
- Applied Biological Materials Clones for MIR214
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR214 Gene
Localization for MIR214 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | 24158985 |
| GO:0048471 | perinuclear region of cytoplasm | IDA | 24158985 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR214 Gene
Pathways & Interactions for MIR214 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | MicroRNAs in cancer | ||
Pathways by source for MIR214 Gene
1 KEGG pathway for MIR214 Gene
Interacting Proteins for MIR214 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008285 | negative regulation of cell proliferation | IDA | 25656649 |
| GO:0010593 | negative regulation of lamellipodium assembly | ISS | -- |
| GO:0016525 | negative regulation of angiogenesis | ISS | -- |
| GO:0030336 | negative regulation of cell migration | IDA | 25656649 |
| GO:0030837 | negative regulation of actin filament polymerization | ISS | -- |
No data available for SIGNOR curated interactions for MIR214 Gene
Transcripts for MIR214 Gene
fRNAdb Secondary structures for MIR214 Gene
mRNA/cDNA for MIR214 Gene
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000385214 110 bps (uc021pev.3)
- (3) RNA Central transcripts :
CRISPR Products
- Browse CRISPR knockouts for MIR214
- Applied Biological Materials CRISPR for MIR214
-
Vectors and viruses for KO, Activation, Repression, and more
miRNA Products
Inhibitory RNA Products
Clone Products
- GenScript: Custom all cDNA clones Services for MIR214
- VectorBuilder custom plasmid, inducible vectors for MIR214
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR214
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MIR214
- Applied Biological Materials Clones for MIR214
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for MIR214 Gene
mRNA differential expression in normal tissues according to GTEx for MIR214 Gene
This gene is overexpressed in Spleen (x6.0) and Ovary (x5.4).
NURSA nuclear receptor signaling pathways regulating expression of MIR214 Gene:
MIR214Primer Products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR214 Gene
Orthologs for MIR214 Gene
No data available for Orthologs for MIR214 Gene
Paralogs for MIR214 Gene
No data available for Paralogs for MIR214 Gene
Variants for MIR214 Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000948893 | -- | 172,138,488(-) | C/ | downstream_transcript_variant | |
| rs1004077920 | -- | 172,139,829(-) | T/C | upstream_transcript_variant | |
| rs1004091046 | -- | 172,139,423(-) | G/A | upstream_transcript_variant | |
| rs1004238140 | -- | 172,140,473(-) | C/T | upstream_transcript_variant | |
| rs1005309344 | -- | 172,139,585(-) | G/T | upstream_transcript_variant |
Additional Variant Information for MIR214 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR214
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR214 Gene
Disorders for MIR214 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cervical cancer |
|
|
| ovarian cancer |
|
|
| intrahepatic cholangiocarcinoma |
|
|
| dermatomyositis |
|
|
| vascular disease |
|
Search MIR214 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MIR214
No data available for UniProtKB/Swiss-Prot and Genatlas for MIR214 Gene
Publications for MIR214 Gene
- Hypoxia-induced activation of Twist/miR-214/E-cadherin axis promotes renal tubular epithelial cell mesenchymal transition and renal fibrosis. (PMID: 29277613) Liu M … Sun S (Biochemical and biophysical research communications 2018) 3 58
- Sulforaphane inhibits cancer stem-like cell properties and cisplatin resistance through miR-214-mediated downregulation of c-MYC in non-small cell lung cancer. (PMID: 28076844) Li QQ … Xiao GH (Oncotarget 2017) 3 58
- miR-214-5p Targets ROCK1 and Suppresses Proliferation and Invasion of Human Osteosarcoma Cells. (PMID: 28081735) Zhang M … Yin R (Oncology research 2017) 3 58
- The MicroRNA-199a/214 Cluster Targets E-Cadherin and Claudin-2 and Promotes High Glucose-Induced Peritoneal Fibrosis. (PMID: 28428333) Che M … Wang H (Journal of the American Society of Nephrology : JASN 2017) 3 58
- Long Non-Coding RNA KCNQ1OT1 Promotes Cataractogenesis via miR-214 and Activation of the Caspase-1 Pathway. (PMID: 28535504) Jin X … Zhang H (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017) 3 58
Products for MIR214 Gene
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- Browse R&D Systems for biochemical assays
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- Browse Primary Antibodies
- Browse Proteins and Enzymes
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- Browse cDNA Clones
- Browse Cell Culture Products
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- Custom Assay Services
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Custom all cDNA clones Services for MIR214
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR214
- VectorBuilder custom plasmid, inducible vectors for MIR214
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR214
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MIR214
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for MIR214
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for MIR214
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MIR214
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Sources for MIR214 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt