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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...
Aliases for MIR214 Gene
Subcategory (RNA class) for MIR214 Gene
miRNA
Number of RNA Genes sources:
6 / 17
Aliases for MIR214 Gene
External Ids for MIR214 Gene
- HGNC: 31591
- Entrez Gene: 406996
- Ensembl: ENSG00000283844
- OMIM: 610721
- miRBase: hsa-mir-214
Previous HGNC Symbols for MIR214 Gene
- MIRN214
Previous GeneCards Identifiers for MIR214 Gene
- GC01M170375
- GC01M172180
- GC01M172182
- GC01M172188
- GC01M172192
- GC01M172198
- GC01M172215
- GC01M172218
- GC01M172219
- GC01M172229
- GC01M172195
- GC01M172191
- GC01M172204
- GC01M172208
- GC01M172211
- GC01M172214
Summaries for MIR214 Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR214 Gene
MIR214 (MicroRNA 214) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR214 include Cervical Cancer and Ovarian Cancer. Among its related pathways are MicroRNAs in cancer.
Rfam classification for MIR214 Gene
-
microRNA mir-214
Additional gene information for MIR214 Gene
- HGNC(31591)
- Entrez Gene(406996)
- Ensembl(ENSG00000283844)
- OMIM(610721)
- Open Targets Platform(ENSG00000283844)
- Search for MIR214 at DataMed
- Search for MIR214 at HumanCyc
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR214 Gene
Genomics for MIR214 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MIR214 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH01J171434 | Enhancer | 0.8 | FANTOM5 ENCODE | 5 | +703.9 | 703909 | 2.2 | ATF7 SCRT2 CEBPB JUND NFE2 JUN FOS GABPA MAX NFIC | PRRC2C FMO4 MIR214 lnc-MYOC-4 RNU6-290P RF00026-083 | |
| GH01J172681 | Enhancer | 0.9 | Ensembl ENCODE dbSUPER | 4.3 | -543.2 | -543193 | 3.4 | TEAD4 ZNF512 NFE2 ZNF316 MAFG MAFK NFE2L2 MAFF BACH1 FOXA3 | RNU6-693P FASLG C1orf105 MIR214 RF00017-398 TNFSF18 | |
| GH01J172137 | Promoter/Enhancer | 2.3 | UCNEbase EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER | 0.7 | -3.7 | -3708 | 9.6 | PRDM1 JUND CEBPB USF1 ZFHX2 RCOR1 ZNF366 YY1 JUN GLIS1 | DNM3OS RNU6-157P MIR199A2 MIR214 MIR3120 C1orf105 DNM3 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MIR214 on the GeneHancer Hub at the UCSC Golden Path
Genomic Locations for MIR214 Gene
Genomic Locations for MIR214 Gene
- chr1:172,138,798-172,138,907
- (GRCh38/hg38)
- Size:
- 110 bases
- Orientation:
- Minus strand
- chr1:172,107,938-172,108,047
- (GRCh37/hg19)
- Size:
- 110 bases
- Orientation:
- Minus strand
Genomic View for MIR214 Gene
Genes around MIR214 on UCSC Golden Path with GeneCards custom track
MIR214 in the GeneCards ncRNA compendium hub on the UCSC Golden Path
- Cytogenetic band:
-
- 1q24.3 by HGNC
- 1q24.3 by Entrez Gene
- 1q24.3 by Ensembl
MIR214 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR214 Gene
Proteins for MIR214 Gene
Post-translational modifications for MIR214 Gene
No Post-translational modifications
Antibody Products
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR214
- Origene Custom Protein Services for MIR214
No data available for DME Specific Peptides for MIR214 Gene
Domains & Families for MIR214 Gene
No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR214 Gene
Function for MIR214 Gene
Phenotypes From GWAS Catalog for MIR214 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 24011070 |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MIR214 - Select products 50% OFF >
- * MIR214 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Browse CRISPR knockouts for MIR214
miRNA Products
Inhibitory RNA Products
Clone Products
- Applied Biological Materials (abm): Clones for MIR214 - Select products 50% OFF >
- * MIR214 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Addgene plasmids for MIR214
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR214 Gene
Localization for MIR214 Gene
| Compartment | Confidence |
|---|---|
| extracellular | 3 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| cytosol | 2 |
| peroxisome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | 24158985 |
| GO:0048471 | perinuclear region of cytoplasm | IDA | 24158985 |
| GO:1903561 | extracellular vesicle | HDA | 28798470 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR214 Gene
Pathways & Interactions for MIR214 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | MicroRNAs in cancer | ||
Pathways by source for MIR214 Gene
1 KEGG pathway for MIR214 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008285 | negative regulation of cell proliferation | IDA | 25656649 |
| GO:0010593 | negative regulation of lamellipodium assembly | ISS | -- |
| GO:0010629 | negative regulation of gene expression | IDA | 27144530 |
| GO:0016525 | negative regulation of angiogenesis | ISS | -- |
| GO:0030336 | negative regulation of cell migration | IDA | 25656649 |
No data available for Interacting Proteins and SIGNOR curated interactions for MIR214 Gene
Transcripts for MIR214 Gene
Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR214 Gene
| RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
|---|---|---|---|---|
| URS0000160683_9606 | precursor_RNA | 110 | 6 |
HGNC: 31591, RefSeq: NR_029627, Ensembl: ENST00000385214 (view in UCSC) , miRBase: MI0000290, Rfam: RF00660, |
| URS00002C11C3_9606 | miRNA | 22 | 6 |
RefSeq: NR_029627, LncBase: hsa-miR-214-3p, miRBase: MIMAT0000271, MirGeneDB: Hsa-Mir-214-v1_3p, TarBase: hsa-miR-214-3p, ENA: FJ623959.1:5999..6020:ncRNA, HB859647.1:1..22:misc_RNA, LM378911.1:1..22:ncRNA, LM608359.1:71..92:ncRNA, |
| URS00004DAA89_9606 | miRNA | 22 | 6 |
RefSeq: NR_029627, LncBase: hsa-miR-214-5p, miRBase: MIMAT0004564, MirGeneDB: Hsa-Mir-214-v1_5p, TarBase: hsa-miR-214-5p, ENA: FJ623959.1:5958..5979:ncRNA, LM380243.1:1..22:ncRNA, LM608359.1:30..51:ncRNA, |
| URS0000EFC831_9606 | precursor_RNA | 64 | 1 |
MirGeneDB: Hsa-Mir-214-v1, Hsa-Mir-214-v2, |
| URS000042BD45_9606 | miRNA | 23 | 1 |
MirGeneDB: Hsa-Mir-214-v2_3p, |
MIR214 in the GeneCards ncRNA compendium hub on the UCSC Golden Path
Additional transcripts not in RNAcentral for MIR214 Gene
- 2 NCBI additional mRNA sequence :
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MIR214 - Select products 50% OFF >
- * MIR214 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Browse CRISPR knockouts for MIR214
miRNA Products
Inhibitory RNA Products
Clone Products
- Applied Biological Materials (abm): Clones for MIR214 - Select products 50% OFF >
- * MIR214 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Addgene plasmids for MIR214
Relevant External Links for MIR214 Gene
- GeneLoc Exon Structure for
- MIR214
Expression for MIR214 Gene
mRNA differential expression in normal tissues according to GTEx for MIR214 Gene
This gene is overexpressed in Spleen (x6.0) and Ovary (x5.4).
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR214
Evidence on tissue expression from TISSUES for MIR214 Gene
- Muscle(2.4)
- Heart(2.4)
- Blood(2.4)
- Liver(2.3)
- Nervous system(2.1)
- Lymph node(2.1)
- Intestine(2)
- Kidney(2)
- Bone(2)
Primer Products
-
OriGene qPCR primer pairs for MIR214
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR214 Gene
Orthologs for MIR214 Gene
No data available for Orthologs for MIR214 Gene
Paralogs for MIR214 Gene
No data available for Paralogs for MIR214 Gene
Variants for MIR214 Gene
Additional Variant Information for MIR214 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR214
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR214 Gene
Disorders for MIR214 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cervical cancer |
|
|
| ovarian cancer |
|
|
| ovarian serous carcinoma |
|
|
| intrahepatic cholangiocarcinoma |
|
|
| vascular disease |
|
Search MIR214 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MIR214
No data available for UniProtKB/Swiss-Prot and Genatlas for MIR214 Gene
Publications for MIR214 Gene
- miR-214 targets ATF4 to inhibit bone formation. (PMID: 23223004) Wang X … Li Y (Nature medicine 2013) 2 3
- MicroRNA-214-3p modified tetrahedral framework nucleic acids target survivin to induce tumour cell apoptosis. (PMID: 31642557) Li S … Cai X (Cell proliferation 2020) 3
- LncRNA NEAT1 sponges miR-214 to regulate M2 macrophage polarization by regulation of B7-H3 in multiple myeloma. (PMID: 31731055) Gao Y … Chen FP (Molecular immunology 2020) 3
- miR-214 down-regulates MKK3 and suppresses malignant phenotypes of cervical cancer cells. (PMID: 31634561) Peng R … Hu Z (Gene 2020) 3
- lncRNA TINCR sponges miR-214-5p to upregulate ROCK1 in hepatocellular carcinoma. (PMID: 31900116) Hu M … Ye L (BMC medical genetics 2020) 3
ExternalLinks
Products for MIR214 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR214
- Origene Custom Protein Services for MIR214
- Browse OriGene Inhibitory RNA Products For MIR214
- OriGene qPCR primer pairs for MIR214
- Browse CRISPR knockouts for MIR214
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MIR214
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Addgene plasmids for MIR214
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for MIR214
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for MIR214
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MIR214
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for MIR214
Sources for MIR214 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB