microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR212 Gene

Subcategory (RNA class) for MIR212 Gene

miRNA

Number of RNA Genes sources:

5 / 14

Aliases for MIR212 Gene

  • MicroRNA 212 2 3 5
  • Hsa-MiR-212-3p 166 177
  • Hsa-MiR-212-5p 166 177
  • MIMAT0000269 51
  • MIMAT0022695 51
  • Hsa-Mir-212 3
  • MI0000288 51
  • Mir-212 3
  • MIRN212 3
  • RF00662 172
  • MIR212 2

External Ids for MIR212 Gene

Previous HGNC Symbols for MIR212 Gene

  • MIRN212

Previous GeneCards Identifiers for MIR212 Gene

  • GC17M001928
  • GC17M001931
  • GC17M001954
  • GC17M001959
  • GC17M001962

Summaries for MIR212 Gene

Entrez Gene Summary for MIR212 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR212 Gene

MIR212 (MicroRNA 212) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR212 include Leiomyoma, Uterine and Pituitary Adenoma. Among its related pathways are Parkinsons Disease Pathway.

Rfam classification for MIR212 Gene

Additional gene information for MIR212 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR212 Gene

Genomics for MIR212 Gene

GeneHancer (GH) Regulatory Elements for MIR212 Gene

Promoters and enhancers for MIR212 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J002049 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 -0.2 -176 3.1 EP300 SIN3A MYC USF1 PHF8 ZFX ZIC2 REST POLR2A ZBTB10 MIR212 MIR132 lnc-HIC1-3 RTN4RL1 TSR1 PITPNA SGSM2 SLC43A2 SMG6 RF00017-2214
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR212 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR212 Gene

Genomic Locations for MIR212 Gene
chr17:2,050,271-2,050,380
(GRCh38/hg38)
Size:
110 bases
Orientation:
Minus strand
chr17:1,953,565-1,953,674
(GRCh37/hg19)
Size:
110 bases
Orientation:
Minus strand

Genomic View for MIR212 Gene

Genes around MIR212 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR212 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR212 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR212 Gene

Proteins for MIR212 Gene

Post-translational modifications for MIR212 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR212 Gene

Domains & Families for MIR212 Gene

Gene Families for MIR212 Gene

genes like me logo Genes that share domains with MIR212: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR212 Gene

Function for MIR212 Gene

Gene Ontology (GO) - Molecular Function for MIR212 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 22880819
genes like me logo Genes that share ontologies with MIR212: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR212 Gene

Localization for MIR212 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR212 gene
Compartment Confidence
plasma membrane 2
extracellular 2
cytoskeleton 2
nucleus 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MIR212 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR212: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR212 Gene

Pathways & Interactions for MIR212 Gene

PathCards logo

SuperPathways for MIR212 Gene

SuperPathway Contained pathways
1 Parkinsons Disease Pathway
genes like me logo Genes that share pathways with MIR212: view

Pathways by source for MIR212 Gene

1 BioSystems pathway for MIR212 Gene
;

Gene Ontology (GO) - Biological Process for MIR212 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007179 transforming growth factor beta receptor signaling pathway IMP 25217442
GO:0010628 positive regulation of gene expression IDA 25217442
GO:0010629 negative regulation of gene expression IDA 25217442
GO:0016525 negative regulation of angiogenesis IDA 25217442
GO:0033137 negative regulation of peptidyl-serine phosphorylation IDA 28089352
genes like me logo Genes that share ontologies with MIR212: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR212 Gene

Drugs & Compounds for MIR212 Gene

No Compound Related Data Available

Transcripts for MIR212 Gene

mRNA/cDNA for MIR212 Gene

4 RNACentral transcripts :
1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
3 miRBase transcripts :
6 ENA transcripts :
2 LncBase transcripts :
1 Rfam transcripts :
2 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR212 Gene

No ASD Table

Relevant External Links for MIR212 Gene

GeneLoc Exon Structure for
MIR212

Expression for MIR212 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR212 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR212

genes like me logo Genes that share expression patterns with MIR212: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR212 Gene

Orthologs for MIR212 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR212 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-212 31
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-212 31
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir212 31
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-212 31
  • 95 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-212 31
  • 70 (a)
OneToMany
CU459076.1 31
  • 69 (a)
OneToMany
BX663516.1 31
  • 69 (a)
OneToMany
Species where no ortholog for MIR212 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR212 Gene

ENSEMBL:
Gene Tree for MIR212 (if available)
TreeFam:
Gene Tree for MIR212 (if available)

Paralogs for MIR212 Gene

No data available for Paralogs for MIR212 Gene

Variants for MIR212 Gene

Additional dbSNP identifiers (rs#s) for MIR212 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR212 Gene

Variant ID Type Subtype PubMed ID
dgv1403n106 CNV deletion 24896259
esv33884 CNV gain 17666407
nsv1070376 CNV deletion 25765185
nsv574216 CNV gain 21841781
nsv827857 CNV gain 20364138
nsv952103 CNV deletion 24416366

Additional Variant Information for MIR212 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR212

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR212 Gene

Disorders for MIR212 Gene

MalaCards: The human disease database

(19) MalaCards diseases for MIR212 Gene - From: miR2Disease, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR212

genes like me logo Genes that share disorders with MIR212: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR212 Gene

Publications for MIR212 Gene

  1. circ-Sirt1 controls NF-κB activation via sequence-specific interaction and enhancement of SIRT1 expression by binding to miR-132/212 in vascular smooth muscle cells. (PMID: 30820544) Kong P … Han M (Nucleic acids research 2019) 3 54
  2. hsa-miR-212 modulates the radiosensitivity of glioma cells by targeting BRCA1. (PMID: 29286157) He X … Fan S (Oncology reports 2018) 3 54
  3. MicroRNA‑212 inhibits the proliferation and invasion of human renal cell carcinoma by targeting FOXA1. (PMID: 29115609) Tong Z … Wang L (Molecular medicine reports 2018) 3 54
  4. LncRNA TUG1 promotes cell proliferation and suppresses apoptosis in osteosarcoma by regulating miR-212-3p/FOXA1 axis. (PMID: 29793327) Xie C … Cao Y (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018) 3 54
  5. MiR-212 Attenuates MPP⁺-Induced Neuronal Damage by Targeting KLF4 in SH-SY5Y Cells. (PMID: 29611404) Song Y … Chen X (Yonsei medical journal 2018) 3 54

Products for MIR212 Gene

Sources for MIR212 Gene