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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR211 (MicroRNA 211) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR211 include Melanoma and Ovarian Cancer.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH15J031079 | Enhancer | 0.9 | FANTOM5 ENCODE | 0.4 | -16.5 | -16515 | 4.8 | HNRNPL TEAD4 FOXA1 ZIC2 ESR1 POLR2A NFIC REST VEZF1 JUN | MTMR10 CHRNA7 lnc-MTMR10-1 MIR211 TRPM1 | |
GH15J031091 | Enhancer | 0.9 | Ensembl ENCODE | 0.3 | -27.0 | -26995 | 1.9 | GATAD2A SOX13 RCOR2 RXRB REST CEBPA TCF7 SP1 JUND ESR1 | lnc-MTMR10-1 TRPM1 MTMR10 FAN1 ENSG00000270055 MIR211 | |
GH15J031061 | Enhancer | 0.4 | CraniofacialAtlas | 0.7 | +2.9 | 2944 | 0.4 | RUNX3 JUNB BATF | MIR211 piR-41838-011 MTMR10 TRPM1 | |
GH15J031089 | Enhancer | 0.7 | ENCODE | 0.4 | -24.4 | -24411 | 0.2 | GATAD2A RXRB IRF2 SP1 CEBPA SOX13 TCF7 ZNF205 TEAD1 KDM6A | MTMR10 TRPM1 FAN1 lnc-MTMR10-1 MIR211 | |
GH15J031062 | Enhancer | 0.3 | Ensembl | 0.7 | +2.2 | 2242 | 1 | RUNX3 BATF | GOLGA8R MIR211 piR-41838-011 MTMR10 TRPM1 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS00001A3555_9606 | miRNA | 22 | 6 |
RefSeq: NR_029624, LncBase: hsa-miR-211-5p, miRBase: MIMAT0000268, MirGeneDB: Hsa-Mir-204-P2_5p, TarBase: hsa-miR-211-5p, ENA: HB859629.1:1..22:misc_RNA, LM378908.1:1..22:ncRNA, LM608356.1:26..47:ncRNA, |
URS000075B6A0_9606 | precursor_RNA | 110 | 5 |
HGNC: 31588, RefSeq: NR_029624, Ensembl: ENST00000384969 (view in UCSC) , miRBase: MI0000287, |
URS0000044FD7_9606 | miRNA | 21 | 4 |
RefSeq: NR_029624, miRBase: MIMAT0022694, MirGeneDB: Hsa-Mir-204-P2_3p, |
URS000064CB21_9606 | precursor_RNA | 102 | 1 |
Rfam: RF00646, |
URS0000EFE683_9606 | precursor_RNA | 59 | 1 |
MirGeneDB: Hsa-Mir-204-P2, |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-211 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | cfa-mir-211 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | bta-mir-211 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | mdo-mir-204 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Mir211 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | oan-mir-204 31 31 |
|
OneToMany | |
Chicken (Gallus gallus) |
Aves | gga-mir-204-2 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | aca-mir-204a-1 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | CABZ01083725.1 31 |
|
OneToMany | |
dre-mir-204-2 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv2534n100 | CNV | loss | 25217958 |
dgv4428n54 | CNV | loss | 21841781 |
esv2761861 | CNV | loss | 21179565 |
esv33507 | CNV | loss | 17666407 |
nsv456746 | CNV | loss | 19166990 |
nsv520825 | CNV | loss | 19592680 |
nsv568767 | CNV | loss | 21841781 |
Disorder | Aliases | PubMed IDs |
---|---|---|
melanoma |
|
|
ovarian cancer |
|
|
intestinal atresia |
|
|
chromosome 15q13.3 deletion syndrome |
|
|
microphthalmia |
|
|