microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR211 Gene

Subcategory (RNA class) for MIR211 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR211 Gene

  • MicroRNA 211 2 3 5
  • Hsa-MiR-211-5p 163 173
  • Hsa-Mir-211 2 3
  • MIR211 2 5
  • Hsa-Mir-204-P2 178
  • MIMAT0000268 50
  • MIMAT0022694 50
  • MI0000287 50
  • MIRN211 3
  • Mir-211 3
  • RF00646 168

External Ids for MIR211 Gene

Previous HGNC Symbols for MIR211 Gene

  • MIRN211

Previous GeneCards Identifiers for MIR211 Gene

  • GC15M029147
  • GC15M031357

Summaries for MIR211 Gene

Entrez Gene Summary for MIR211 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR211 Gene

MIR211 (MicroRNA 211) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR211 include Melanoma and Ovarian Cancer.

Rfam classification for MIR211 Gene

Additional gene information for MIR211 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR211 Gene

Genomics for MIR211 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR211 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J031079 Enhancer 0.9 FANTOM5 ENCODE 0.4 -16.5 -16515 4.8 HNRNPL TEAD4 FOXA1 ZIC2 ESR1 POLR2A NFIC REST VEZF1 JUN MTMR10 CHRNA7 lnc-MTMR10-1 MIR211 TRPM1
GH15J031091 Enhancer 0.9 Ensembl ENCODE 0.3 -27.0 -26995 1.9 GATAD2A SOX13 RCOR2 RXRB REST CEBPA TCF7 SP1 JUND ESR1 lnc-MTMR10-1 TRPM1 MTMR10 FAN1 ENSG00000270055 MIR211
GH15J031061 Enhancer 0.4 CraniofacialAtlas 0.7 +2.9 2944 0.4 RUNX3 JUNB BATF MIR211 piR-41838-011 MTMR10 TRPM1
GH15J031089 Enhancer 0.7 ENCODE 0.4 -24.4 -24411 0.2 GATAD2A RXRB IRF2 SP1 CEBPA SOX13 TCF7 ZNF205 TEAD1 KDM6A MTMR10 TRPM1 FAN1 lnc-MTMR10-1 MIR211
GH15J031062 Enhancer 0.3 Ensembl 0.7 +2.2 2242 1 RUNX3 BATF GOLGA8R MIR211 piR-41838-011 MTMR10 TRPM1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR211 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR211 Gene

Genomic Locations for MIR211 Gene
chr15:31,065,032-31,065,142
(GRCh38/hg38)
Size:
111 bases
Orientation:
Minus strand
chr15:31,357,235-31,357,344
(GRCh37/hg19)
Size:
110 bases
Orientation:
Minus strand

Genomic View for MIR211 Gene

Genes around MIR211 on UCSC Golden Path with GeneCards custom track
MIR211 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR211 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR211 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR211 Gene

Proteins for MIR211 Gene

Post-translational modifications for MIR211 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR211 Gene

Domains & Families for MIR211 Gene

Gene Families for MIR211 Gene

genes like me logo Genes that share domains with MIR211: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR211 Gene

Function for MIR211 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR211 Gene

Localization for MIR211 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR211 gene
Compartment Confidence
extracellular 2
cytoskeleton 2
nucleus 2
plasma membrane 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR211 Gene

Pathways & Interactions for MIR211 Gene

PathCards logo

SuperPathways for MIR211 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR211 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR211: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR211 Gene

Drugs & Compounds for MIR211 Gene

No Compound Related Data Available

Transcripts for MIR211 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR211 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00001A3555_9606 miRNA 22 6

RefSeq: NR_029624,

LncBase: hsa-miR-211-5p,

miRBase: MIMAT0000268,

MirGeneDB: Hsa-Mir-204-P2_5p,

TarBase: hsa-miR-211-5p,

ENA: HB859629.1:1..22:misc_RNA, LM378908.1:1..22:ncRNA, LM608356.1:26..47:ncRNA,

URS000075B6A0_9606 precursor_RNA 110 5

HGNC: 31588,

RefSeq: NR_029624,

Ensembl: ENST00000384969 (view in UCSC) ,

miRBase: MI0000287,

ENA: LM608356.1:1..110:precursor_RNA,

URS0000044FD7_9606 miRNA 21 4

RefSeq: NR_029624,

miRBase: MIMAT0022694,

MirGeneDB: Hsa-Mir-204-P2_3p,

ENA: LM383002.1:1..21:ncRNA, LM608356.1:63..83:ncRNA,

URS000064CB21_9606 precursor_RNA 102 1

Rfam: RF00646,

URS0000EFE683_9606 precursor_RNA 59 1

MirGeneDB: Hsa-Mir-204-P2,

MIR211 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR211 Gene

2 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR211 Gene

No ASD Table

Relevant External Links for MIR211 Gene

GeneLoc Exon Structure for
MIR211

Expression for MIR211 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR211 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR211

genes like me logo Genes that share expression patterns with MIR211: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR211 Gene

Orthologs for MIR211 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR211 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-211 31
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-211 31
  • 94 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-211 31
  • 89 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-204 31
  • 80 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir211 31
  • 76 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-204 31 31
  • 64 (a)
OneToMany
Chicken
(Gallus gallus)
Aves gga-mir-204-2 31
  • 73 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-204a-1 31
  • 80 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii CABZ01083725.1 31
  • 77 (a)
OneToMany
dre-mir-204-2 31
  • 56 (a)
OneToMany
Species where no ortholog for MIR211 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR211 Gene

ENSEMBL:
Gene Tree for MIR211 (if available)
TreeFam:
Gene Tree for MIR211 (if available)

Paralogs for MIR211 Gene

No data available for Paralogs for MIR211 Gene

Variants for MIR211 Gene

Additional dbSNP identifiers (rs#s) for MIR211 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR211 Gene

Variant ID Type Subtype PubMed ID
dgv2534n100 CNV loss 25217958
dgv4428n54 CNV loss 21841781
esv2761861 CNV loss 21179565
esv33507 CNV loss 17666407
nsv456746 CNV loss 19166990
nsv520825 CNV loss 19592680
nsv568767 CNV loss 21841781

Additional Variant Information for MIR211 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR211

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR211 Gene

Disorders for MIR211 Gene

MalaCards: The human disease database

(5) MalaCards diseases for MIR211 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
melanoma
  • malignant melanoma
ovarian cancer
  • ovarian cancer, somatic
intestinal atresia
chromosome 15q13.3 deletion syndrome
  • chromosome 15q13.3 microdeletion syndrome
microphthalmia
  • microphthalmos
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR211

genes like me logo Genes that share disorders with MIR211: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR211 Gene

Publications for MIR211 Gene

  1. microRNA-211 promotes proliferation, migration, and invasion ability of oral squamous cell carcinoma cells via targeting the bridging integrator 1 protein. (PMID: 30260023) Zheng J … Liu L (Journal of cellular biochemistry 2019) 3
  2. LncRNA DGCR5 regulates the non-small cell lung cancer cell growth, migration, and invasion through regulating miR-211-5p/EPHB6 axis. (PMID: 31241800) Kang M … Liu X (BioFactors (Oxford, England) 2019) 3
  3. microRNA-211 regulates cell proliferation, apoptosis and migration/invasion in human osteosarcoma via targeting EZRIN. (PMID: 31333725) Pei Y … Xie B (Cellular & molecular biology letters 2019) 3
  4. LncRNA MCM3AP-AS1 promotes proliferation and invasion through regulating miR-211-5p/SPARC axis in papillary thyroid cancer. (PMID: 31030335) Liang M … He G (Endocrine 2019) 3
  5. Long noncoding RNA MEG3 is a tumor suppressor in choriocarcinoma by upregulation of microRNA-211. (PMID: 31124134) Ji L … Li X (Journal of cellular physiology 2019) 3

Products for MIR211 Gene

Sources for MIR211 Gene