microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR210 Gene

Subcategory (RNA class) for MIR210 Gene

miRNA

Number of RNA Genes sources:

5 / 14

Aliases for MIR210 Gene

  • MicroRNA 210 2 3 5
  • Hsa-MiR-210-3p 166 177
  • Hsa-MiR-210-5p 166
  • MIMAT0026475 51
  • MIMAT0000267 51
  • Hsa-Mir-210 3
  • MI0000286 51
  • Mir-210 3
  • MIRN210 3
  • RF00679 172
  • MIR210 2

External Ids for MIR210 Gene

Previous HGNC Symbols for MIR210 Gene

  • MIRN210

Previous GeneCards Identifiers for MIR210 Gene

  • GC11M000561
  • GC11M000570
  • GC11M000575
  • GC11M000582
  • GC11M000581
  • GC11M000585
  • GC11M000605
  • GC11M000610
  • GC11M000569
  • GC11M000589
  • GC11M000591
  • GC11M000593
  • GC11M000595
  • GC11M000597
  • GC11M000599
  • GC11M000601
  • GC11M000578

Summaries for MIR210 Gene

Entrez Gene Summary for MIR210 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR210 Gene

MIR210 (MicroRNA 210) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR210 include Cardiovascular System Disease and Heart Disease. Among its related pathways are miRNAs involved in DNA damage response and DNA Damage Response.

Rfam classification for MIR210 Gene

Additional gene information for MIR210 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR210 Gene

Genomics for MIR210 Gene

GeneHancer (GH) Regulatory Elements for MIR210 Gene

Promoters and enhancers for MIR210 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J000566 Promoter/Enhancer 1.8 Ensembl ENCODE CraniofacialAtlas 500.7 -1.2 -1153 5 HNRNPK ZBTB40 EP300 SIN3A NRF1 POLR2G SP1 PHF8 JUND SIX5 MIR210 MIR210HG HRAS TMEM80 LRRC56 PHRF1 RNH1 ENSG00000270105 lnc-PHRF1-1
GH11J000775 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 4.9 -209.1 -209133 3.9 HNRNPK SIN3A NRF1 POLR2G USF1 PHF8 ZFX ZIC2 POLR2A ZBTB10 GATD1 LOC171391 lnc-CEND1-2 ENSG00000255108 TALDO1 TMEM80 MIR210 lnc-CEND1-3
GH11J000559 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 0.4 +5.3 5283 7.5 SIN3A TCF12 POLR2G SP1 GTF2E2 PHF8 TEAD4 FOS ZFX ZIC2 LMNTD2 RASSF7 NONHSAG007323.2 TMEM80 SNORA52 TSPAN4 RNH1 RPLP2 PHRF1 ENSG00000255237
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR210 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR210 Gene

Genomic Locations for MIR210 Gene
chr11:568,089-568,198
(GRCh38/hg38)
Size:
110 bases
Orientation:
Minus strand
chr11:568,089-568,198
(GRCh37/hg19)
Size:
110 bases
Orientation:
Minus strand

Genomic View for MIR210 Gene

Genes around MIR210 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR210 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR210 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR210 Gene

Proteins for MIR210 Gene

Post-translational modifications for MIR210 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR210 Gene

Domains & Families for MIR210 Gene

Gene Families for MIR210 Gene

HGNC:
genes like me logo Genes that share domains with MIR210: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR210 Gene

Function for MIR210 Gene

Phenotypes From GWAS Catalog for MIR210 Gene

Gene Ontology (GO) - Molecular Function for MIR210 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 18417479
genes like me logo Genes that share ontologies with MIR210: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR210 Gene

Localization for MIR210 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR210 gene
Compartment Confidence
extracellular 3
plasma membrane 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endosome 2
cytosol 2
peroxisome 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MIR210 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 18766170
genes like me logo Genes that share ontologies with MIR210: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR210 Gene

Pathways & Interactions for MIR210 Gene

genes like me logo Genes that share pathways with MIR210: view

Pathways by source for MIR210 Gene

;

Gene Ontology (GO) - Biological Process for MIR210 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010977 negative regulation of neuron projection development ISS --
GO:0030335 positive regulation of cell migration IMP 23322395
GO:0035148 tube formation IMP 23322395
GO:0035195 gene silencing by miRNA IMP 19826008
GO:0035278 miRNA mediated inhibition of translation IDA 18417479
genes like me logo Genes that share ontologies with MIR210: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR210 Gene

Drugs & Compounds for MIR210 Gene

No Compound Related Data Available

Transcripts for MIR210 Gene

mRNA/cDNA for MIR210 Gene

6 RNACentral transcripts :
1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
3 miRBase transcripts :
7 ENA transcripts :
2 LncBase transcripts :
1 Rfam transcripts :
1 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR210 Gene

No ASD Table

Relevant External Links for MIR210 Gene

GeneLoc Exon Structure for
MIR210

Expression for MIR210 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR210 Gene

mRNA differential expression in normal tissues according to GTEx for MIR210 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x4.4) and Skin - Sun Exposed (Lower leg) (x4.1).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR210

genes like me logo Genes that share expression patterns with MIR210: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR210 Gene

Orthologs for MIR210 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR210 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-210 31
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-210 31
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-210 31
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir210 31
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-210 31
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 31
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-210 31
  • 72 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-210 31
  • 68 (a)
OneToOne
Species where no ortholog for MIR210 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR210 Gene

ENSEMBL:
Gene Tree for MIR210 (if available)
TreeFam:
Gene Tree for MIR210 (if available)

Paralogs for MIR210 Gene

No data available for Paralogs for MIR210 Gene

Variants for MIR210 Gene

Additional dbSNP identifiers (rs#s) for MIR210 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR210 Gene

Variant ID Type Subtype PubMed ID
dgv1522n54 CNV loss 21841781
dgv1523n54 CNV gain 21841781
dgv182e199 CNV deletion 23128226
dgv564n106 OTHER inversion 24896259
esv2759794 CNV loss 17122850
nsv1039558 CNV gain 25217958
nsv1053964 CNV gain 25217958
nsv1077764 OTHER inversion 25765185
nsv1159791 CNV deletion 26073780
nsv467634 CNV loss 19166990
nsv467635 CNV loss 19166990
nsv469923 CNV loss 18288195
nsv469924 CNV gain 18288195
nsv518824 CNV loss 19592680
nsv527327 CNV loss 19592680
nsv528415 CNV loss 19592680
nsv552854 CNV loss 21841781
nsv552856 CNV gain 21841781
nsv951270 CNV deletion 24416366

Additional Variant Information for MIR210 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR210

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR210 Gene

Disorders for MIR210 Gene

MalaCards: The human disease database

(53) MalaCards diseases for MIR210 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
cardiovascular system disease
  • disease of subdivision of hemolymphoid system
heart disease
  • congenital heart disease
squamous cell carcinoma, head and neck
  • hnscc
myocardial infarction
  • myocardial infarction, susceptibility to
acute promyelocytic leukemia
  • apl
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR210

genes like me logo Genes that share disorders with MIR210: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR210 Gene

Publications for MIR210 Gene

  1. Negative regulation of Hif1a expression and TH17 differentiation by the hypoxia-regulated microRNA miR-210. (PMID: 24608041) Wang H … Weiss A (Nature immunology 2014) 2 3 54
  2. The effect and mechanism of miR-210 in down-regulating the autophagy of lung cancer cells. (PMID: 30573163) Ju S … Zhao J (Pathology, research and practice 2019) 3 54
  3. Contribution of regulatory T cells to immune tolerance and association of microRNA‑210 and Foxp3 in preeclampsia. (PMID: 30569125) Chen J … Wang C (Molecular medicine reports 2019) 3 54
  4. Role of miRNA-210, miRNA-21 and miRNA-126 as diagnostic biomarkers in colorectal carcinoma: impact of HIF-1α-VEGF signaling pathway. (PMID: 30357530) Sabry D … El-Deek HEM (Molecular and cellular biochemistry 2019) 3 54
  5. Plasma Level of MicroRNAs, MiR-107, MiR-194 and MiR-210 as Potential Biomarkers for Diagnosis Intestinal-Type Gastric Cancer in Human (PMID: 31127902) Parvaee P … Mondanizadeh M (Asian Pacific journal of cancer prevention : APJCP 2019) 3 54

Products for MIR210 Gene

Sources for MIR210 Gene