microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR21 Gene

RNA type for MIR21 Gene

miRNA

Aliases for MIR21 Gene

External Ids for MIR21 Gene

Previous HGNC Symbols for MIR21 Gene

  • MIRN21

Previous GeneCards Identifiers for MIR21 Gene

  • GC17P055276
  • GC17P057918
  • GC17P059708

Summaries for MIR21 Gene

Entrez Gene Summary for MIR21 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

CIViC Summary for MIR21 Gene

GeneCards Summary for MIR21 Gene

MIR21 (MicroRNA 21) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR21 include Oral Squamous Cell Carcinoma and Glioma. Among its related pathways are Proteoglycans in cancer and Nanoparticle triggered autophagic cell death.

Gene Wiki entry for MIR21 Gene

Rfam classification for MIR21 Gene

Additional gene information for MIR21 Gene

No data available for UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary and piRNA Summary for MIR21 Gene

Genomics for MIR21 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR21 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR21 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR21 Gene

Latest Assembly
chr17:59,841,262-59,841,342
(GRCh38/hg38)
Size:
81 bases
Orientation:
Plus strand

Previous Assembly
chr17:57,918,627-57,918,698
(GRCh37/hg19 by Entrez Gene)
Size:
72 bases
Orientation:
Plus strand

Genomic View for MIR21 Gene

Genes around MIR21 on UCSC Golden Path with GeneCards custom track
MIR21 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR21 Gene

Proteins for MIR21 Gene

Post-translational modifications for MIR21 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR21 Gene

Domains & Families for MIR21 Gene

Gene Families for MIR21 Gene

HGNC:
genes like me logo Genes that share domains with MIR21: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR21 Gene

Function for MIR21 Gene

Phenotypes From GWAS Catalog for MIR21 Gene

Gene Ontology (GO) - Molecular Function for MIR21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003730 mRNA 3'-UTR binding IDA 21376256
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IMP 18372920
genes like me logo Genes that share ontologies with MIR21: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR21 Gene

Localization for MIR21 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR21 gene
Compartment Confidence
extracellular 2
nucleus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MIR21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
GO:0005737 cytoplasm IDA 23657402
GO:0070062 extracellular exosome IDA 28159509
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIR21: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR21 Gene

Pathways & Interactions for MIR21 Gene

genes like me logo Genes that share pathways with MIR21: view

Pathways by source for MIR21 Gene

2 KEGG pathways for MIR21 Gene

Gene Ontology (GO) - Biological Process for MIR21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001568 blood vessel development ISS 28270521
GO:0001819 positive regulation of cytokine production IDA 30106099
GO:0001934 positive regulation of protein phosphorylation ISS --
GO:0001937 negative regulation of endothelial cell proliferation IDA 21347332
GO:0001960 negative regulation of cytokine-mediated signaling pathway IDA 30106099
genes like me logo Genes that share ontologies with MIR21: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR21 Gene

Drugs & Compounds for MIR21 Gene

No Compound Related Data Available

Transcripts for MIR21 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR21 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS00000AF93C_9606 pre_miRNA 72 5

RefSeq: NR_029493,

Ensembl: ENST00000362134 (view in UCSC) ,

miRBase: MI0000077,

Rfam: RF00658,

ENA: LM608166.1:1..72:precursor_RNA,

URS000039ED8D_9606 miRNA 22 5

RefSeq: NR_029493,

LncBase: hsa-miR-21-5p,

miRBase: MIMAT0000076,

TarBase: hsa-miR-21-5p,

ENA: AJ421741.1:1..22:misc_RNA, BK006524.1:3344..3365:ncRNA, HB859646.1:1..22:misc_RNA, LM378763.1:1..22:ncRNA, LM608166.1:8..29:ncRNA,

URS000009262D_9606 miRNA 21 5

RefSeq: NR_029493,

LncBase: hsa-miR-21-3p,

miRBase: MIMAT0004494,

TarBase: hsa-miR-21-3p,

ENA: LM380173.1:1..21:ncRNA, LM608166.1:46..66:ncRNA,

URS00004AF1CF_9606 pre_miRNA 81 1

ENA: AF480557.1:1..81:misc_RNA,

URS0000EFE31F_9606 precursor_RNA 61 1

MirGeneDB: Hsa-Mir-21,

MIR21 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR21 Gene

7 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR21 Gene

No ASD Table

Relevant External Links for MIR21 Gene

GeneLoc Exon Structure for
MIR21

Expression for MIR21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR21 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR21

Evidence on tissue expression from TISSUES for MIR21 Gene

  • Blood(2.8)
  • Heart(2.6)
  • Liver(2.5)
  • Muscle(2.5)
  • Intestine(2.5)
  • Kidney(2.4)
  • Lymph node(2.4)
  • Nervous system(2.4)
  • Skin(2.4)
  • Urine(2.3)
  • Lung(2.2)
  • Pancreas(2.2)
  • Saliva(2.2)
  • Bone marrow(2.2)
  • Spleen(2.1)
  • Stomach(2)
genes like me logo Genes that share expression patterns with MIR21: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR21 Gene

Orthologs for MIR21 Gene

Evolution for MIR21 Gene

ENSEMBL:
Gene Tree for MIR21 (if available)
TreeFam:
Gene Tree for MIR21 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR21

No data available for Orthologs for MIR21 Gene

Paralogs for MIR21 Gene

No data available for Paralogs for MIR21 Gene

Variants for MIR21 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR21 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Additional Variant Information for MIR21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR21
Leiden Open Variation Database (LOVD)
MIR21

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR21 Gene

Disorders for MIR21 Gene

MalaCards: The human disease database

(203) MalaCards diseases for MIR21 Gene - From: MID, LNC, COP, and GCD

Disorder Aliases PubMed IDs
oral squamous cell carcinoma
  • mouth squamous cell carcinoma
glioma
larynx cancer
  • laryngeal carcinoma
tongue squamous cell carcinoma
  • squamous cell carcinoma of tongue
cholesteatoma of middle ear
  • cholesteatoma
- elite association - COSMIC cancer census association via MalaCards
Search MIR21 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MIR21

genes like me logo Genes that share disorders with MIR21: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR21 Gene

Publications for MIR21 Gene

  1. Combined detection of serum exosomal miR-21 and HOTAIR as diagnostic and prognostic biomarkers for laryngeal squamous cell carcinoma. (PMID: 25099764) Wang J … Tian L (Medical oncology (Northwood, London, England) 2014) 3 72
  2. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 40
  3. MicroRNA-21 is induced early in pancreatic ductal adenocarcinoma precursor lesions. (PMID: 20093556) du Rieu MC … Cordelier P (Clinical chemistry 2010) 3 72
  4. MiR-21 indicates poor prognosis in tongue squamous cell carcinomas as an apoptosis inhibitor. (PMID: 19509158) Li J … Song E (Clinical cancer research : an official journal of the American Association for Cancer Research 2009) 3 72
  5. MiR-21 is an EGFR-regulated anti-apoptotic factor in lung cancer in never-smokers. (PMID: 19597153) Seike M … Harris CC (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 72

Products for MIR21 Gene

Sources for MIR21 Gene