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Aliases for MIR21 Gene

Subcategory (RNA class) for MIR21 Gene

miRNA

Quality Score for this RNA gene is

13

Aliases for MIR21 Gene

  • MicroRNA 21 2 3 5
  • Hsa-Mir-21 3
  • MiRNA21 3
  • MiR-21 3
  • MIRN21 3

External Ids for MIR21 Gene

Previous HGNC Symbols for MIR21 Gene

  • MIRN21

Previous GeneCards Identifiers for MIR21 Gene

  • GC17P055276
  • GC17P057918
  • GC17P059708

Summaries for MIR21 Gene

Entrez Gene Summary for MIR21 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR21 Gene

MIR21 (MicroRNA 21) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR21 include Oral Squamous Cell Carcinoma and Glioma. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and MicroRNAs in cancer.

Gene Wiki entry for MIR21 Gene

Additional gene information for MIR21 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR21 Gene

Genomics for MIR21 Gene

GeneHancer (GH) Regulatory Elements for MIR21 Gene

Promoters and enhancers for MIR21 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J059824 Promoter/Enhancer 2.8 VISTA FANTOM5 Ensembl ENCODE dbSUPER 650.7 +1.6 1620 36.2 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 MIR21 GC17M059843 GC17M059842 GC17M059841 GC17P059845 GC17P059844 GC17P059843 GC17P059842 PPM1D TUBD1
GH17J059781 Enhancer 2 VISTA FANTOM5 Ensembl ENCODE dbSUPER 12.8 -53.6 -53592 11.9 CLOCK MLX ZFP64 YBX1 FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 RPS6KB1 TUBD1 HEATR6 PPM1D RNFT1-DT SKA2 LOC100996660 MIR21 RNU6-450P TRIM37
GH17J059705 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.6 -133.4 -133393 5.2 CLOCK MLX FEZF1 DMAP1 YY1 SLC30A9 E2F8 SP3 NFYC GLIS1 VMP1 PTRH2 PPM1D TUBD1 RPS6KB1 HEATR6 RNFT1 SKA2 NDUFB8P2 RNFT1-DT
GH17J059751 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12.6 -79.8 -79782 20.4 HDGF PKNOX1 CLOCK FOXA2 MLX ARID4B NEUROD1 SIN3A YBX1 FEZF1 RPS6KB1 TUBD1 NDUFB8P2 PPM1D RNFT1-DT ENSG00000275860 ENSG00000224738 MIR21 RNU6-450P HEATR6
GH17J059725 Enhancer 1.1 Ensembl ENCODE 10.9 -115.5 -115521 1.5 HDGF FOXA2 ARID4B YY1 ZNF121 RXRA REST PPARG ZNF592 KAT8 GC17M059723 TUBD1 RPS6KB1 MIR21 RNU6-450P HEATR6 VMP1 PTRH2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR21 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR21 Gene

Genomic Locations for MIR21 Gene
chr17:59,841,266-59,841,337
(GRCh38/hg38)
Size:
72 bases
Orientation:
Plus strand
chr17:57,918,627-57,918,698
(GRCh37/hg19)
Size:
72 bases
Orientation:
Plus strand

Genomic View for MIR21 Gene

Genes around MIR21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR21 Gene

Proteins for MIR21 Gene

Post-translational modifications for MIR21 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR21 Gene

Domains & Families for MIR21 Gene

Gene Families for MIR21 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR21: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR21 Gene

Function for MIR21 Gene

Phenotypes From GWAS Catalog for MIR21 Gene

Gene Ontology (GO) - Molecular Function for MIR21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003730 mRNA 3-UTR binding IDA 21376256
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IMP 18372920
genes like me logo Genes that share ontologies with MIR21: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR21 Gene

Localization for MIR21 Gene

Gene Ontology (GO) - Cellular Components for MIR21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
GO:0005737 cytoplasm IDA 23657402
GO:0070062 extracellular exosome IDA 28159509
genes like me logo Genes that share ontologies with MIR21: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR21 Gene

Pathways & Interactions for MIR21 Gene

genes like me logo Genes that share pathways with MIR21: view

Pathways by source for MIR21 Gene

2 KEGG pathways for MIR21 Gene

Interacting Proteins for MIR21 Gene

Gene Ontology (GO) - Biological Process for MIR21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation ISS --
GO:0001937 negative regulation of endothelial cell proliferation IDA 21347332
GO:0007179 transforming growth factor beta receptor signaling pathway ISS --
GO:0007566 embryo implantation NAS 18556655
GO:0008284 positive regulation of cell proliferation IMP 16762633
genes like me logo Genes that share ontologies with MIR21: view

No data available for SIGNOR curated interactions for MIR21 Gene

Drugs & Compounds for MIR21 Gene

No Compound Related Data Available

Transcripts for MIR21 Gene

mRNA/cDNA for MIR21 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(3) RNA Central transcripts :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR21 Gene

No ASD Table

Relevant External Links for MIR21 Gene

GeneLoc Exon Structure for
MIR21
ECgene alternative splicing isoforms for
MIR21

Expression for MIR21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR21 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR21 Gene:

MIR21
genes like me logo Genes that share expression patterns with MIR21: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR21 Gene

Orthologs for MIR21 Gene

Evolution for MIR21 Gene

ENSEMBL:
Gene Tree for MIR21 (if available)
TreeFam:
Gene Tree for MIR21 (if available)

No data available for Orthologs for MIR21 Gene

Paralogs for MIR21 Gene

No data available for Paralogs for MIR21 Gene

Variants for MIR21 Gene

Sequence variations from dbSNP and Humsavar for MIR21 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000220885 -- 59,840,566(+) T/C upstream_transcript_variant
rs1003071912 -- 59,840,891(+) C/T upstream_transcript_variant
rs1003528503 -- 59,841,239(+) C/T upstream_transcript_variant
rs1004420391 -- 59,841,371(+) A/G downstream_transcript_variant
rs1004802057 -- 59,839,516(+) C/T upstream_transcript_variant

Additional Variant Information for MIR21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR21

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR21 Gene

Disorders for MIR21 Gene

MalaCards: The human disease database

(50) MalaCards diseases for MIR21 Gene - From: miR2Disease and GeneCards

Disorder Aliases PubMed IDs
oral squamous cell carcinoma
  • mouth squamous cell carcinoma
glioma
glioblastoma multiforme
  • adult glioblastoma multiforme
tongue squamous cell carcinoma
  • carcinoma, squamous cell
larynx cancer
  • laryngeal benign neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search MIR21 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MIR21

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR21: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR21 Gene

Publications for MIR21 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 44 58
  2. Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J … Zhao H (International journal of cancer 2009) 3 44 58
  3. Ibrutinib targets microRNA-21 in multiple myeloma cells by inhibiting NF-κB and STAT3. (PMID: 29320977) Ma J … Zhao H (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2018) 3 58
  4. The CADM2/Akt pathway is involved in the inhibitory effect of miR-21-5p downregulation on proliferation and apoptosis in esophageal squamous cell carcinoma cells. (PMID: 29680210) Li X … Zhao H (Chemico-biological interactions 2018) 3 58
  5. Gold nanoparticles superlattices assembly for electrochemical biosensor detection of microRNA-21. (PMID: 28826000) Tian L … Wang Y (Biosensors & bioelectronics 2018) 3 58

Products for MIR21 Gene

Sources for MIR21 Gene

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