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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR21 (MicroRNA 21) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR21 include Oral Squamous Cell Carcinoma and Glioma. Among its related pathways are Proteoglycans in cancer and Nanoparticle triggered autophagic cell death.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003730 | mRNA 3'-UTR binding | IDA | 21376256 |
GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IMP | 18372920 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | IDA | 26646931 |
GO:0005737 | cytoplasm | IDA | 23657402 |
GO:0070062 | extracellular exosome | IDA | 28159509 |
GO:1903561 | extracellular vesicle | HDA | 28798470 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | MicroRNAs in cancer | ||
2 | Proteoglycans in cancer | ||
3 | Alzheimers Disease | ||
4 | Nanoparticle triggered autophagic cell death |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001934 | positive regulation of protein phosphorylation | ISS | -- |
GO:0001937 | negative regulation of endothelial cell proliferation | IDA | 21347332 |
GO:0001960 | negative regulation of cytokine-mediated signaling pathway | IDA | 30106099 |
GO:0007179 | transforming growth factor beta receptor signaling pathway | ISS | -- |
GO:0007566 | embryo implantation | NAS | 18556655 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS00000AF93C_9606 | precursor_RNA | 72 | 6 |
HGNC: 31586, RefSeq: NR_029493, Ensembl: ENST00000362134 (view in UCSC) , miRBase: MI0000077, Rfam: RF00658, |
URS000039ED8D_9606 | miRNA | 22 | 5 |
RefSeq: NR_029493, LncBase: hsa-miR-21-5p, miRBase: MIMAT0000076, TarBase: hsa-miR-21-5p, ENA: AJ421741.1:1..22:misc_RNA, BK006524.1:3344..3365:ncRNA, HB859646.1:1..22:misc_RNA, LM378763.1:1..22:ncRNA, LM608166.1:8..29:ncRNA, |
URS000009262D_9606 | miRNA | 21 | 5 |
RefSeq: NR_029493, LncBase: hsa-miR-21-3p, miRBase: MIMAT0004494, TarBase: hsa-miR-21-3p, |
URS000018AA08_9606 | precursor_RNA | 3433 | 1 |
ENA: AY699265.1:1..3463:ncRNA, |
URS00004AF1CF_9606 | misc_RNA | 81 | 1 |
Disorder | Aliases | PubMed IDs |
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oral squamous cell carcinoma |
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glioma |
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larynx cancer |
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tongue squamous cell carcinoma |
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cholesteatoma of middle ear |
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