microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR20B Gene

Subcategory (RNA class) for MIR20B Gene

miRNA

Number of RNA Genes sources:

5 / 14

Aliases for MIR20B Gene

  • MicroRNA 20b 2 3 5
  • Hsa-MiR-20b-3p 166 177
  • Hsa-MiR-20b-5p 166 177
  • MIMAT0004752 51
  • MIMAT0001413 51
  • Hsa-Mir-20b 3
  • MI0001519 51
  • Mir-20b 3
  • MIRN20B 3
  • RF00051 172
  • MIR20B 2

External Ids for MIR20B Gene

Previous HGNC Symbols for MIR20B Gene

  • MIRN20B

Previous GeneCards Identifiers for MIR20B Gene

  • GC0XM133153
  • GC0XM133160
  • GC0XM133307
  • GC0XM133312
  • GC0XM133316
  • GC0XM133320
  • GC0XM133325
  • GC0XM133329
  • GC0XM133333
  • GC0XM133337
  • GC0XM133340
  • GC0XM133351
  • GC0XM133375
  • GC0XM134173
  • GC0XM134178
  • GC0XM134223
  • GC0XM134231
  • GC0XM134237
  • GC0XM134183
  • GC0XM134190
  • GC0XM134196
  • GC0XM134202
  • GC0XM134208
  • GC0XM134217

Summaries for MIR20B Gene

Entrez Gene Summary for MIR20B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR20B Gene

MIR20B (MicroRNA 20b) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR20B include T-Cell Leukemia and Multiple Sclerosis. Among its related pathways are Parkinsons Disease Pathway.

Rfam classification for MIR20B Gene

  • mir-17 microRNA precursor family

Additional gene information for MIR20B Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR20B Gene

Genomics for MIR20B Gene

GeneHancer (GH) Regulatory Elements for MIR20B Gene

Promoters and enhancers for MIR20B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ134169 Enhancer 0.2 Ensembl 500.7 0.0 -17 0.2 AF480556 MIR18B MIR19B2 MIR20B MIR363 MIR92A2 MIR106A ENSG00000283638
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR20B on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR20B Gene

Genomic Locations for MIR20B Gene
chrX:134,169,802-134,169,884
(GRCh38/hg38)
Size:
83 bases
Orientation:
Minus strand
chrX:133,303,839-133,303,907
(GRCh37/hg19)
Size:
69 bases
Orientation:
Minus strand

Genomic View for MIR20B Gene

Genes around MIR20B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR20B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR20B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR20B Gene

Proteins for MIR20B Gene

Post-translational modifications for MIR20B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR20B Gene

Domains & Families for MIR20B Gene

Gene Families for MIR20B Gene

genes like me logo Genes that share domains with MIR20B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR20B Gene

Function for MIR20B Gene

Gene Ontology (GO) - Molecular Function for MIR20B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 17205120
genes like me logo Genes that share ontologies with MIR20B: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR20B Gene

Localization for MIR20B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR20B gene
Compartment Confidence
extracellular 1
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MIR20B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR20B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR20B Gene

Pathways & Interactions for MIR20B Gene

PathCards logo

SuperPathways for MIR20B Gene

SuperPathway Contained pathways
1 Parkinsons Disease Pathway
genes like me logo Genes that share pathways with MIR20B: view

Pathways by source for MIR20B Gene

1 BioSystems pathway for MIR20B Gene
;

Gene Ontology (GO) - Biological Process for MIR20B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016525 negative regulation of angiogenesis IDA 24048733
GO:0035195 gene silencing by miRNA IDA 17205120
GO:0071356 cellular response to tumor necrosis factor IDA 28595801
GO:1905563 negative regulation of vascular endothelial cell proliferation IMP 28595801
GO:2000774 positive regulation of cellular senescence IMP 28595801
genes like me logo Genes that share ontologies with MIR20B: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR20B Gene

Drugs & Compounds for MIR20B Gene

No Compound Related Data Available

Transcripts for MIR20B Gene

mRNA/cDNA for MIR20B Gene

4 RNACentral transcripts :
1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
3 miRBase transcripts :
6 ENA transcripts :
2 LncBase transcripts :
1 Rfam transcripts :
2 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR20B Gene

No ASD Table

Relevant External Links for MIR20B Gene

GeneLoc Exon Structure for
MIR20B

Expression for MIR20B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR20B

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR20B Gene

Orthologs for MIR20B Gene

Evolution for MIR20B Gene

ENSEMBL:
Gene Tree for MIR20B (if available)
TreeFam:
Gene Tree for MIR20B (if available)

No data available for Orthologs for MIR20B Gene

Paralogs for MIR20B Gene

No data available for Paralogs for MIR20B Gene

Variants for MIR20B Gene

Additional dbSNP identifiers (rs#s) for MIR20B Gene

Additional Variant Information for MIR20B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR20B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR20B Gene

Disorders for MIR20B Gene

MalaCards: The human disease database

(8) MalaCards diseases for MIR20B Gene - From: miR2Disease and DISEASES

Disorder Aliases PubMed IDs
t-cell leukemia
  • leukemia, t-cell, chronic
multiple sclerosis
  • multiple sclerosis, susceptibility to
kidney cancer
  • renal cell carcinoma
schizophrenia
  • sczd
uterine anomalies
  • uterine disease
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR20B

genes like me logo Genes that share disorders with MIR20B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR20B Gene

Publications for MIR20B Gene

  1. Genome-wide identification of microRNAs regulating the human prion protein. (PMID: 30451334) Pease D … Aguzzi A (Brain pathology (Zurich, Switzerland) 2019) 3 54
  2. Lnc-TALC promotes O6-methylguanine-DNA methyltransferase expression via regulating the c-Met pathway by competitively binding with miR-20b-3p. (PMID: 31053733) Wu P … Jiang C (Nature communications 2019) 3 54
  3. Elevated miR-20b-5p expression in peripheral blood mononuclear cells: A novel, independent molecular biomarker of favorable prognosis in chronic lymphocytic leukemia. (PMID: 29715621) Papageorgiou SG … Pappa V (Leukemia research 2018) 3 54
  4. MicroRNA-20b-5p inhibits platelet-derived growth factor-induced proliferation of human fetal airway smooth muscle cells by targeting signal transducer and activator of transcription 3. (PMID: 29549727) Tang J … Luo L (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018) 3 54
  5. miR-20b reduces 5-FU resistance by suppressing the ADAM9/EGFR signaling pathway in colon cancer. (PMID: 27878272) Fu Q … Xie J (Oncology reports 2017) 3 54

Products for MIR20B Gene

Sources for MIR20B Gene