microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR20A Gene

Subcategory (RNA class) for MIR20A Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR20A Gene

  • MicroRNA 20a 2 3 5
  • Hsa-MiR-20a-5p 163 173
  • Hsa-MiR-20a-3p 163 173
  • Hsa-Mir-20a 2 3
  • Hsa-Mir-20 2 3
  • MIR20A 2 5
  • Putative MicroRNA 17 Host Gene Protein 3
  • Putative MicroRNA Host Gene 1 Protein 3
  • Hsa-Mir-17-P3a 178
  • MIMAT0000075 50
  • MIMAT0004493 50
  • MicroRNA 20 2
  • MI0000076 50
  • C13orf25 3
  • MiRNA20A 3
  • MIR17HG 3
  • MIRN20A 3
  • Mir-20a 3
  • RF00051 168
  • MIRHG1 3
  • MIRN20 3
  • MiR-20 3
  • MIR20 3
  • MIRH1 3

External Ids for MIR20A Gene

Previous HGNC Symbols for MIR20A Gene

  • MIRN20
  • MIRN20A

Previous GeneCards Identifiers for MIR20A Gene

  • GC13P090872
  • GC13P090880
  • GC13P092016
  • GC13P092024
  • GC13P092031
  • GC13P092039
  • GC13P092048
  • GC13P092058
  • GC13P092067
  • GC13P092077
  • GC13P092086
  • GC13P092001
  • GC13P091353
  • GC13P091358
  • GC13P091409
  • GC13P091412
  • GC13P091416
  • GC13P091427
  • GC13P091364
  • GC13P091375
  • GC13P091382
  • GC13P091389
  • GC13P091395
  • GC13P091403

Summaries for MIR20A Gene

Entrez Gene Summary for MIR20A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR20A Gene

MIR20A (MicroRNA 20a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR20A include B-Cell Lymphoma and Pulmonary Hypertension. Among its related pathways are Parkinsons Disease Pathway and DNA Damage Response.

Rfam classification for MIR20A Gene

  • mir-17 microRNA precursor family

Additional gene information for MIR20A Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR20A Gene

Genomics for MIR20A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR20A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J091346 Promoter/Enhancer 1.8 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.7 -2.1 -2059 5.2 GATAD2A CTCF TFE3 POLR2A BACH1 TARDBP FOXA1 LARP7 PRDM1 ZNF143 MIR17 MIR17HG MIR18A MIR19A piR-37523 GPC5 AB372624 MIR19B1 MIR20A MIR92A1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR20A on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR20A Gene

Genomic Locations for MIR20A Gene
chr13:91,351,060-91,351,140
(GRCh38/hg38)
Size:
81 bases
Orientation:
Plus strand
chr13:92,000,074-92,006,833
(GRCh37/hg19)
Size:
6,760 bases
Orientation:
Plus strand

Genomic View for MIR20A Gene

Genes around MIR20A on UCSC Golden Path with GeneCards custom track
MIR20A in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR20A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR20A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR20A Gene

Proteins for MIR20A Gene

Post-translational modifications for MIR20A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR20A Gene

Domains & Families for MIR20A Gene

Gene Families for MIR20A Gene

genes like me logo Genes that share domains with MIR20A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR20A Gene

Function for MIR20A Gene

Gene Ontology (GO) - Molecular Function for MIR20A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000993 RNA polymerase II complex binding IDA 25336585
GO:0003730 mRNA 3'-UTR binding IDA 22785209
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IMP 19390056
genes like me logo Genes that share ontologies with MIR20A: view

Animal Model Products

CRISPR Products

miRNA for MIR20A Gene

miRTarBase miRNAs that target MIR20A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIR20A Gene

Localization for MIR20A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR20A gene
Compartment Confidence
extracellular 1
cytoskeleton 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MIR20A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 18766170
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIR20A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR20A Gene

Pathways & Interactions for MIR20A Gene

genes like me logo Genes that share pathways with MIR20A: view

Pathways by source for MIR20A Gene

1 KEGG pathway for MIR20A Gene

Gene Ontology (GO) - Biological Process for MIR20A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003151 outflow tract morphogenesis ISS --
GO:0006469 negative regulation of protein kinase activity IDA 25447536
GO:0010611 NOT regulation of cardiac muscle hypertrophy ISS --
GO:0010629 negative regulation of gene expression IMP 22450430
GO:0010667 negative regulation of cardiac muscle cell apoptotic process ISS --
genes like me logo Genes that share ontologies with MIR20A: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR20A Gene

Drugs & Compounds for MIR20A Gene

No Compound Related Data Available

Transcripts for MIR20A Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR20A Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS0000574A2C_9606 miRNA 23 6

RefSeq: NR_029492,

LncBase: hsa-miR-20a-5p,

miRBase: MIMAT0000075,

MirGeneDB: Hsa-Mir-17-P3a_5p,

TarBase: hsa-miR-20a-5p,

ENA: LM378762.1:1..23:ncRNA, LM608165.1:8..30:ncRNA,

URS0000507C9B_9606 precursor_RNA 71 5

HGNC: 31577,

RefSeq: NR_029492,

Ensembl: ENST00000362279 (view in UCSC) ,

miRBase: MI0000076,

ENA: LM608165.1:1..71:precursor_RNA,

URS0000042E1F_9606 miRNA 22 5

RefSeq: NR_029492,

LncBase: hsa-miR-20a-3p,

miRBase: MIMAT0004493,

TarBase: hsa-miR-20a-3p,

ENA: LM380172.1:1..22:ncRNA, LM608165.1:44..65:ncRNA,

URS000062FB36_9606 precursor_RNA 81 1

Rfam: RF00051,

URS0000EFC36D_9606 precursor_RNA 60 1

MirGeneDB: Hsa-Mir-17-P3a,

MIR20A in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR20A Gene

3 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR20A Gene

No ASD Table

Relevant External Links for MIR20A Gene

GeneLoc Exon Structure for
MIR20A

Expression for MIR20A Gene

Evidence on tissue expression from TISSUES for MIR20A Gene

  • Blood(2.6)
  • Intestine(2.3)
  • Heart(2.3)
  • Liver(2.2)
  • Nervous system(2.2)
  • Muscle(2.2)
  • Lymph node(2.2)
  • Skin(2.1)
  • Kidney(2.1)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR20A Gene

Orthologs for MIR20A Gene

Evolution for MIR20A Gene

ENSEMBL:
Gene Tree for MIR20A (if available)
TreeFam:
Gene Tree for MIR20A (if available)

No data available for Orthologs for MIR20A Gene

Paralogs for MIR20A Gene

No data available for Paralogs for MIR20A Gene

Variants for MIR20A Gene

Additional dbSNP identifiers (rs#s) for MIR20A Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR20A Gene

Variant ID Type Subtype PubMed ID
nsv832679 CNV gain 17160897

Additional Variant Information for MIR20A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR20A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR20A Gene

Disorders for MIR20A Gene

MalaCards: The human disease database

(63) MalaCards diseases for MIR20A Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
b-cell lymphoma
  • b-cell lymphocytic neoplasm
pulmonary hypertension
  • primary pulmonary hypertension
leukemia, chronic myeloid
  • cml
gastric cancer
  • gastric cancer, somatic
prostate cancer
  • prostate cancer, somatic
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR20A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR20A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR20A Gene

Publications for MIR20A Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 41
  2. Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J … Zhao H (International journal of cancer 2009) 3 41
  3. Mir20a/106a-WTX axis regulates RhoGDIa/CDC42 signaling and colon cancer progression. (PMID: 30631060) Zhu GF … Zhang QL (Nature communications 2019) 3
  4. hsa-miR-20a-5p attenuates allergic inflammation in HMC-1 cells by targeting HDAC4. (PMID: 30684894) Lu Y … Liu P (Molecular immunology 2019) 3
  5. Expression Profile of microRNAs in Hypertrophic Cardiomyopathy and Effects of microRNA-20 in Inducing Cardiomyocyte Hypertrophy Through Regulating Gene MFN2. (PMID: 31295012) Sun D … Wen S (DNA and cell biology 2019) 3

Products for MIR20A Gene

Sources for MIR20A Gene