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Aliases for MIR208B Gene

Subcategory (RNA class) for MIR208B Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR208B Gene

  • MicroRNA 208b 2 3 5
  • Hsa-Mir-208b 3
  • Mir-208b 3
  • MIRN208B 3

External Ids for MIR208B Gene

Previous HGNC Symbols for MIR208B Gene

  • MIRN208B

Previous GeneCards Identifiers for MIR208B Gene

  • GC14M022959
  • GC14M023887

Summaries for MIR208B Gene

Entrez Gene Summary for MIR208B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR208B Gene

MIR208B (MicroRNA 208b) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR208B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR208B Gene

Genomics for MIR208B Gene

GeneHancer (GH) Regulatory Elements for MIR208B Gene

Promoters and enhancers for MIR208B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I023284 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10 +132.3 132312 3.4 HDGF PKNOX1 CLOCK FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 HOMEZ PIR53909 ACIN1 PRMT5 IPO4 THTPA TSSK4 NGDN PABPN1 PRMT5-AS1
GH14I023442 Enhancer 1.3 VISTA FANTOM5 ENCODE dbSUPER 11.4 -25.2 -25190 1.9 ZNF341 IKZF1 PHB2 E4F1 MYH6 MIR208B CMTM5 IL25 SLC22A17 MIR208A MYH7 NGDN
GH14I023378 Enhancer 1.1 VISTA ENCODE 11 +38.0 38023 3.2 ELF3 RB1 NFIB ARID4B KLF17 ZNF76 ZNF2 KLF5 ZNF48 ZSCAN9 MYH6 SLC22A17 MIR208B PPP1R3E BCL2L2 HOMEZ DHRS4-AS1 CMTM5 MIR208A
GH14I023279 Enhancer 1.1 ENCODE dbSUPER 10 +137.5 137476 2.1 HDGF PKNOX1 ATF1 ARNT TCF12 ZNF766 CBX5 GATA2 FOS ATF7 PABPN1 CMTM5 MIR208B ACIN1 ZFHX2-AS1 ZFHX2 HOMEZ PIR53909 HMGN2P1
GH14I023453 Enhancer 0.9 ENCODE 10.8 -36.3 -36323 1.8 FOXA2 MLX ARNT ARID4B BRCA1 SLC30A9 TCF12 ZNF766 NCOA1 MIER2 MYH6 MIR208B SLC22A17 MIR208A ZFHX2-AS1 ZFHX2 BCL2L2 CMTM5 IL25 HOMEZ
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR208B on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR208B Gene

Genomic Locations for MIR208B Gene
chr14:23,417,987-23,418,063
(GRCh38/hg38)
Size:
77 bases
Orientation:
Minus strand
chr14:23,887,196-23,887,272
(GRCh37/hg19)

Genomic View for MIR208B Gene

Genes around MIR208B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR208B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR208B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR208B Gene

ORGUL Member Location for MIR208B Gene

ORGUL Member Location for MIR208B gene

Proteins for MIR208B Gene

Post-translational modifications for MIR208B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR208B Gene

Domains & Families for MIR208B Gene

Gene Families for MIR208B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR208B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR208B Gene

Function for MIR208B Gene

Gene Ontology (GO) - Molecular Function for MIR208B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 19726871
genes like me logo Genes that share ontologies with MIR208B: view

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR208B Gene

Localization for MIR208B Gene

Gene Ontology (GO) - Cellular Components for MIR208B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with MIR208B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR208B Gene

Pathways & Interactions for MIR208B Gene

SuperPathways for MIR208B Gene

No Data Available

Interacting Proteins for MIR208B Gene

Gene Ontology (GO) - Biological Process for MIR208B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0014883 transition between fast and slow fiber ISS --
GO:0035195 gene silencing by miRNA IDA 19726871
genes like me logo Genes that share ontologies with MIR208B: view

No data available for Pathways by source and SIGNOR curated interactions for MIR208B Gene

Drugs & Compounds for MIR208B Gene

No Compound Related Data Available

Transcripts for MIR208B Gene

mRNA/cDNA for MIR208B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR208B Gene

No ASD Table

Relevant External Links for MIR208B Gene

GeneLoc Exon Structure for
MIR208B
ECgene alternative splicing isoforms for
MIR208B

Expression for MIR208B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR208B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR208B Gene:

MIR208B
genes like me logo Genes that share expression patterns with MIR208B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR208B Gene

Orthologs for MIR208B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR208B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-208b 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-208b 34
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir208b 34
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-208b 34
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-208b 34
  • 91 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-736 34
  • 70 (a)
OneToOne
Species where no ortholog for MIR208B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR208B Gene

ENSEMBL:
Gene Tree for MIR208B (if available)
TreeFam:
Gene Tree for MIR208B (if available)

Paralogs for MIR208B Gene

No data available for Paralogs for MIR208B Gene

Variants for MIR208B Gene

Sequence variations from dbSNP and Humsavar for MIR208B Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1060501434 uncertain-significance, Hypertrophic cardiomyopathy, not specified 23,419,593(-) A/T upstream_transcript_variant
rs137918672 likely-benign, Hypertrophic cardiomyopathy 23,419,547(-) C/A/G/T upstream_transcript_variant
rs141764279 likely-benign, uncertain-significance, not specified, Primary familial hypertrophic cardiomyopathy, Hypertrophic cardiomyopathy, Cardiovascular phenotype 23,418,398(-) G/A/T upstream_transcript_variant
rs142469226 likely-benign, Hypertrophic cardiomyopathy 23,418,314(-) G/A upstream_transcript_variant
rs144420313 benign, conflicting-interpretations-of-pathogenicity, likely-benign, not specified, Hypertrophic cardiomyopathy, Dilated Cardiomyopathy, Dominant, Myopathy, distal, 1, Left ventricular noncompaction cardiomyopathy, Scapuloperoneal myopathy, Myosin storage myopathy 23,419,231(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR208B Gene

Variant ID Type Subtype PubMed ID
esv2748480 CNV deletion 23290073
esv3584149 CNV gain 25503493
nsv456166 CNV gain 19166990
nsv470623 CNV gain 18288195
nsv564041 CNV gain 21841781

Additional Variant Information for MIR208B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR208B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR208B Gene

Disorders for MIR208B Gene

Additional Disease Information for MIR208B

No disorders were found for MIR208B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR208B Gene

Publications for MIR208B Gene

  1. MicroRNA-208b inhibits human osteosarcoma progression by targeting ROR2. (PMID: 28618961) Jiang Z … Fang J (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 58
  2. Circulating miR-208b: A Potentially Sensitive and Reliable Biomarker for the Diagnosis and Prognosis of Acute Myocardial Infarction. (PMID: 28164501) Liu X … Han Z (Clinical laboratory 2017) 3 58
  3. Circulation of miR-26a, miR-191, and miR-208b in plasma of patients with acute myocardial infarction. (PMID: 26712201) Bilal M … Khan MA (JPMA. The Journal of the Pakistan Medical Association 2016) 3 58
  4. Hepatitis-C-virus-induced microRNAs dampen interferon-mediated antiviral signaling. (PMID: 27841874) Jarret A … Savan R (Nature medicine 2016) 3 58
  5. miR-208b upregulation interferes with calcium handling in HL-1 atrial myocytes: Implications in human chronic atrial fibrillation. (PMID: 27545043) Cañón S … Bernad A (Journal of molecular and cellular cardiology 2016) 3 58

Products for MIR208B Gene

Sources for MIR208B Gene

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