microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR206 Gene

Subcategory (RNA class) for MIR206 Gene

miRNA

Number of RNA Genes sources:

5 / 17

Aliases for MIR206 Gene

  • MicroRNA 206 2 3 5
  • Hsa-Mir-206 2 3
  • MIR206 2 5
  • Hsa-Mir-1-P3 178
  • MIMAT0000462 50
  • Hsa-MiR-206 173
  • MI0000490 50
  • MiRNA206 3
  • MIRN206 3
  • Mir-206 3
  • RF00103 168

External Ids for MIR206 Gene

Previous HGNC Symbols for MIR206 Gene

  • MIRN206

Previous GeneCards Identifiers for MIR206 Gene

  • GC06P052120
  • GC06P052009

Summaries for MIR206 Gene

Entrez Gene Summary for MIR206 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. Disruption of the encoded miRNA has been implicated in multiple skeletal muscle disorders, including amyotrophic lateral sclerosis (ALS) and Duchenne muscular dystrophy (DMD), as well as in several cancers. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Aug 2017]

GeneCards Summary for MIR206 Gene

MIR206 (MicroRNA 206) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR206 include Rhabdomyosarcoma and Schizophrenia. Among its related pathways are MicroRNAs in cancer and Glial Cell Differentiation.

Rfam classification for MIR206 Gene

  • mir-1 microRNA precursor family

Additional gene information for MIR206 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR206 Gene

Genomics for MIR206 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR206 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J052639 Enhancer 1 Ensembl CraniofacialAtlas 9.1 +497.3 497322 3.7 LEF1 SOX13 IKZF1 NFKBIZ RCOR2 JUND MTA1 IRF2 HDAC1 GABPA TRAM2 TRAM2-AS1 EFHC1 CILK1 MIR206 ENSG00000216775 piR-59928-125 piR-45471-530 TMEM14A
GH06J052263 Enhancer 0.9 Ensembl ENCODE 10.1 +119.7 119693 0.7 CTCF ZNF143 RXRB REST RAD21 TRIM22 ZNF561 POLR2A BCLAF1 SMC3 LINCMD1 MIR133B PKHD1 IL17A MIR206 lnc-MCM3-1 IL17F piR-43046 MCM3
GH06J052116 Enhancer 0.7 Ensembl ENCODE dbSUPER 11 -27.8 -27831 0.9 FEZF1 GLIS1 MIR133B LINCMD1 PKHD1 MIR206 piR-46002-484 IL17A
GH06J052234 Enhancer 0.7 Ensembl 10.2 +90.1 90051 0.8 CTCF IKZF1 REST RAD21 TRIM22 ZNF600 ZNF10 ZXDB RUNX3 OSR2 HSALNG0050600 IL17A LINCMD1 MIR133B MIR206 PKHD1 IL17F lnc-IL17A-1
GH06J052271 Enhancer 0.8 Ensembl ENCODE 9.3 +127.7 127685 1.5 POLR2A FOXA2 ZBTB25 JUND STAT1 FOSL2 THAP11 RARA JUN FOS SLC25A20P1 IL17F EFHC1 PAQR8 LINCMD1 MIR133B MIR206 piR-43046 MCM3 lnc-MCM3-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR206 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR206 Gene

Genomic Locations for MIR206 Gene
chr6:52,144,349-52,144,434
(GRCh38/hg38)
Size:
86 bases
Orientation:
Plus strand
chr6:52,009,147-52,009,232
(GRCh37/hg19)
Size:
86 bases
Orientation:
Plus strand

Genomic View for MIR206 Gene

Genes around MIR206 on UCSC Golden Path with GeneCards custom track
MIR206 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR206 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR206 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR206 Gene

Proteins for MIR206 Gene

Post-translational modifications for MIR206 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR206 Gene

Domains & Families for MIR206 Gene

Gene Families for MIR206 Gene

genes like me logo Genes that share domains with MIR206: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR206 Gene

Function for MIR206 Gene

Phenotypes From GWAS Catalog for MIR206 Gene

Gene Ontology (GO) - Molecular Function for MIR206 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003730 mRNA 3'-UTR binding IDA 28342807
GO:0005515 protein binding IPI 31507089
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 20388878
genes like me logo Genes that share ontologies with MIR206: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR206 Gene

Localization for MIR206 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR206 gene
Compartment Confidence
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 2
cytosol 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MIR206 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016442 RISC complex IGI 31507089
genes like me logo Genes that share ontologies with MIR206: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR206 Gene

Pathways & Interactions for MIR206 Gene

PathCards logo

SuperPathways for MIR206 Gene

genes like me logo Genes that share pathways with MIR206: view

Pathways by source for MIR206 Gene

1 BioSystems pathway for MIR206 Gene
1 KEGG pathway for MIR206 Gene

Gene Ontology (GO) - Biological Process for MIR206 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010455 positive regulation of cell fate commitment ISS --
GO:0010629 negative regulation of gene expression IDA 28342807
GO:0010831 positive regulation of myotube differentiation ISS --
GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling IMP 26175229
GO:0032731 positive regulation of interleukin-1 beta production IDA 27277332
genes like me logo Genes that share ontologies with MIR206: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR206 Gene

Drugs & Compounds for MIR206 Gene

No Compound Related Data Available

Transcripts for MIR206 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR206 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS0000389B41_9606 precursor_RNA 86 5

HGNC: 31584,

RefSeq: NR_029713,

Ensembl: ENST00000384872 (view in UCSC) ,

miRBase: MI0000490,

ENA: LM608529.1:1..86:precursor_RNA,

URS000034B6F5_9606 miRNA 22 5

RefSeq: NR_029713,

miRBase: MIMAT0000462,

MirGeneDB: Hsa-Mir-1-P3_3p,

TarBase: hsa-miR-206,

ENA: LM379080.1:1..22:ncRNA, LM608529.1:53..74:ncRNA,

URS0000640912_9606 precursor_RNA 76 1

Rfam: RF00103,

URS0000EFC81B_9606 precursor_RNA 61 1

MirGeneDB: Hsa-Mir-1-P3,

URS0000D50206_9606 miRNA 23 1

MirGeneDB: Hsa-Mir-1-P3_5p,

MIR206 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR206 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR206 Gene

No ASD Table

Relevant External Links for MIR206 Gene

GeneLoc Exon Structure for
MIR206

Expression for MIR206 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR206 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR206

Evidence on tissue expression from TISSUES for MIR206 Gene

  • Muscle(2.8)
  • Heart(2.3)
  • Blood(2.2)
  • Nervous system(2.2)
  • Liver(2)
genes like me logo Genes that share expression patterns with MIR206: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR206 Gene

Orthologs for MIR206 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR206 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-206 31
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-206 31
  • 97 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-206 31
  • 95 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-206 31
  • 92 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir206 31
  • 84 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-206 31
  • 61 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-206 31
  • 88 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-206 31
  • 86 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-206-1 31
  • 63 (a)
OneToMany
dre-mir-206-2 31
  • 60 (a)
OneToMany
Species where no ortholog for MIR206 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR206 Gene

ENSEMBL:
Gene Tree for MIR206 (if available)
TreeFam:
Gene Tree for MIR206 (if available)

Paralogs for MIR206 Gene

No data available for Paralogs for MIR206 Gene

Variants for MIR206 Gene

Additional dbSNP identifiers (rs#s) for MIR206 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR206 Gene

Variant ID Type Subtype PubMed ID
nsv522645 CNV gain 19592680
nsv830662 CNV gain 17160897

Additional Variant Information for MIR206 Gene

Human Gene Mutation Database (HGMD)
MIR206
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR206

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR206 Gene

Disorders for MIR206 Gene

MalaCards: The human disease database

(10) MalaCards diseases for MIR206 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
rhabdomyosarcoma
schizophrenia
  • sczd
breast cancer
  • breast lobular carcinoma
lymphoplasmacytic lymphoma
  • waldenstrom macroglobulinemia
diabetes mellitus, noninsulin-dependent
  • niddm
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR206

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR206: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR206 Gene

Publications for MIR206 Gene

  1. MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia. (PMID: 20347265) Xu Y … Liu P (Schizophrenia research 2010) 3 41
  2. Roles of N-terminal Annexin A2 phosphorylation sites and miR-206 in colonic adenocarcinoma. (PMID: 32376265) Xiao L … Hou Y (Life sciences 2020) 3
  3. MicroRNA-206 predicts raised fetal growth retardation risk through the interaction with vascular endothelial growth factor in pregnancies. (PMID: 32049790) Li Y … Liu J (Medicine 2020) 3
  4. Reciprocal regulation of miR-206 and IL-6/STAT3 pathway mediates IL6-induced gefitinib resistance in EGFR-mutant lung cancer cells. (PMID: 31507089) Yang Y … Zhang T (Journal of cellular and molecular medicine 2019) 3
  5. LINC00707 contributes to hepatocellular carcinoma progression via sponging miR-206 to increase CDK14. (PMID: 30488589) Tu J … Ji J (Journal of cellular physiology 2019) 3

Products for MIR206 Gene

Sources for MIR206 Gene