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Aliases for MIR206 Gene

Subcategory (RNA class) for MIR206 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR206 Gene

  • MicroRNA 206 2 3 5
  • Hsa-Mir-206 3
  • MiRNA206 3
  • Mir-206 3
  • MIRN206 3

External Ids for MIR206 Gene

ORGUL Members for MIR206 Gene

Previous HGNC Symbols for MIR206 Gene

  • MIRN206

Previous GeneCards Identifiers for MIR206 Gene

  • GC06P052120
  • GC06P052009

Summaries for MIR206 Gene

Entrez Gene Summary for MIR206 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. Disruption of the encoded miRNA has been implicated in multiple skeletal muscle disorders, including amyotrophic lateral sclerosis (ALS) and Duchenne muscular dystrophy (DMD), as well as in several cancers. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Aug 2017]

GeneCards Summary for MIR206 Gene

MIR206 (MicroRNA 206) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR206 include Muscle Disorders and Epithelioid Sarcoma. Among its related pathways are miRs in Muscle Cell Differentiation and Glial Cell Differentiation.

Additional gene information for MIR206 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR206 Gene

Genomics for MIR206 Gene

GeneHancer (GH) Regulatory Elements for MIR206 Gene

Promoters and enhancers for MIR206 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I052263 Enhancer 0.7 ENCODE 10.1 +119.6 119569 0.2 CTCF RB1 ZNF48 RAD21 RFX5 SMC3 ZNF143 NR2F6 BCLAF1 CHD2 LINCMD1 MIR133B PKHD1 MIR206 IL17A PIR36045 SLC25A20P1
GH06I052116 Enhancer 0.6 ENCODE dbSUPER 11 -27.8 -27831 0.9 GLIS1 FEZF1 LINCMD1 MIR133B PKHD1 MIR206 GC06P052124
GH06I052101 Enhancer 0.6 ENCODE dbSUPER 10.9 -41.3 -41274 3.8 CTCF KLF1 CREB1 LINCMD1 MIR133B MIR206 IL17A IL17F SLC25A20P1 GC06P052124 PKHD1
GH06I052076 Enhancer 0.6 ENCODE 9.7 -66.7 -66694 2.2 NR2F2 YY1 SP1 JUND GLIS1 POU5F1 ZBTB33 HNF4A MIR206 PKHD1 GC06P052010
GH06I052271 Enhancer 0.6 ENCODE 9.3 +127.6 127606 1.4 ELF3 STAT1 FOXA2 FOXA3 JUN KAT8 JUND ZGPAT POLR2A CREB1 IL17F SLC25A20P1 EFHC1 PAQR8 LINCMD1 MIR133B MIR206 PIR36045 MCM3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR206 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR206 Gene

Genomic Locations for MIR206 Gene
chr6:52,144,349-52,144,434
(GRCh38/hg38)
Size:
86 bases
Orientation:
Plus strand
chr6:52,009,147-52,009,232
(GRCh37/hg19)

Genomic View for MIR206 Gene

Genes around MIR206 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR206 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR206 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR206 Gene

Proteins for MIR206 Gene

Post-translational modifications for MIR206 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR206 Gene

Domains & Families for MIR206 Gene

Gene Families for MIR206 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR206: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR206 Gene

Function for MIR206 Gene

Gene Ontology (GO) - Molecular Function for MIR206 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 20388878
genes like me logo Genes that share ontologies with MIR206: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR206 Gene

Localization for MIR206 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR206 Gene

Pathways & Interactions for MIR206 Gene

genes like me logo Genes that share pathways with MIR206: view

Pathways by source for MIR206 Gene

2 BioSystems pathways for MIR206 Gene
1 KEGG pathway for MIR206 Gene

Interacting Proteins for MIR206 Gene

Gene Ontology (GO) - Biological Process for MIR206 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010455 positive regulation of cell fate commitment ISS --
GO:0010831 positive regulation of myotube differentiation ISS --
GO:0035195 gene silencing by miRNA IDA 20388878
genes like me logo Genes that share ontologies with MIR206: view

No data available for SIGNOR curated interactions for MIR206 Gene

Drugs & Compounds for MIR206 Gene

No Compound Related Data Available

Transcripts for MIR206 Gene

mRNA/cDNA for MIR206 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR206 Gene

No ASD Table

Relevant External Links for MIR206 Gene

GeneLoc Exon Structure for
MIR206
ECgene alternative splicing isoforms for
MIR206

Expression for MIR206 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR206 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR206 Gene:

MIR206
genes like me logo Genes that share expression patterns with MIR206: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR206 Gene

Orthologs for MIR206 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR206 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-206 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-206 34
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-206 34
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-206 34
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir206 34
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-206 34
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-206 34
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-206 34
  • 86 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-206-1 34
  • 63 (a)
OneToMany
dre-mir-206-2 34
  • 60 (a)
OneToMany
Species where no ortholog for MIR206 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR206 Gene

ENSEMBL:
Gene Tree for MIR206 (if available)
TreeFam:
Gene Tree for MIR206 (if available)

Paralogs for MIR206 Gene

No data available for Paralogs for MIR206 Gene

Variants for MIR206 Gene

Sequence variations from dbSNP and Humsavar for MIR206 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000320950 -- 52,142,350(+) A/G upstream_transcript_variant
rs1001297727 -- 52,143,564(+) C/G upstream_transcript_variant
rs1002298903 -- 52,144,806(+) A/G downstream_transcript_variant
rs1004344881 -- 52,144,595(+) G/A downstream_transcript_variant
rs1005193881 -- 52,143,167(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR206 Gene

Variant ID Type Subtype PubMed ID
nsv522645 CNV gain 19592680
nsv830662 CNV gain 17160897

Additional Variant Information for MIR206 Gene

Human Gene Mutation Database (HGMD)
MIR206
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR206

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR206 Gene

Disorders for MIR206 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MIR206 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
muscle disorders
  • myopathy
epithelioid sarcoma
  • epithelioid cell sarcoma
myotonic disease
  • myotonic disorders
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR206

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR206: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR206 Gene

Publications for MIR206 Gene

  1. MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia. (PMID: 20347265) Xu Y … Liu P (Schizophrenia research 2010) 3 44 58
  2. MRTF-A-miR-206-WDR1 form feedback loop to regulate breast cancer cell migration. (PMID: 28822708) Xiang Y … Zhang TC (Experimental cell research 2017) 3 58
  3. Amphiregulin enhances VEGF-A production in human chondrosarcoma cells and promotes angiogenesis by inhibiting miR-206 via FAK/c-Src/PKCδ pathway. (PMID: 27826039) Wang CQ … Tang CH (Cancer letters 2017) 3 58
  4. Serum miRNAs miR-206, 143-3p and 374b-5p as potential biomarkers for amyotrophic lateral sclerosis (ALS). (PMID: 28454844) Waller R … Kirby J (Neurobiology of aging 2017) 3 58
  5. Myocardin inhibited the gap protein connexin 43 via promoted miR-206 to regulate vascular smooth muscle cell phenotypic switch. (PMID: 28342807) Li H … Zhang TC (Gene 2017) 3 58

Products for MIR206 Gene

Sources for MIR206 Gene

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