microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR205 Gene

Subcategory (RNA class) for MIR205 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR205 Gene

  • MicroRNA 205 2 3 5
  • Hsa-MiR-205-5p 163 173
  • Hsa-Mir-205 2 3
  • MIR205 2 5
  • Hsa-Mir-205-P1 178
  • Hsa-MiR-205-3p 173
  • MIMAT0000266 50
  • MIMAT0009197 50
  • MI0000285 50
  • MIRN205 3
  • Mir-205 3
  • RF00656 168

External Ids for MIR205 Gene

Previous HGNC Symbols for MIR205 Gene

  • MIRN205

Previous GeneCards Identifiers for MIR205 Gene

  • GC01P207673
  • GC01P209605

Summaries for MIR205 Gene

Entrez Gene Summary for MIR205 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR205 Gene

MIR205 (MicroRNA 205) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR205 include Squamous Cell Carcinoma and Melanoma. Among its related pathways are MicroRNAs in cancer.

Rfam classification for MIR205 Gene

Additional gene information for MIR205 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR205 Gene

Genomics for MIR205 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR205 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR205 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR205 Gene

Genomic Locations for MIR205 Gene
chr1:209,432,133-209,432,242
(GRCh38/hg38)
Size:
110 bases
Orientation:
Plus strand
chr1:209,605,478-209,605,587
(GRCh37/hg19)
Size:
110 bases
Orientation:
Plus strand

Genomic View for MIR205 Gene

Genes around MIR205 on UCSC Golden Path with GeneCards custom track
MIR205 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR205 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR205 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR205 Gene

Proteins for MIR205 Gene

Post-translational modifications for MIR205 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR205 Gene

Domains & Families for MIR205 Gene

Gene Families for MIR205 Gene

HGNC:
genes like me logo Genes that share domains with MIR205: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR205 Gene

Function for MIR205 Gene

Phenotypes From GWAS Catalog for MIR205 Gene

Gene Ontology (GO) - Molecular Function for MIR205 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IGI 19665999
genes like me logo Genes that share ontologies with MIR205: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR205 Gene

Localization for MIR205 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR205 gene
Compartment Confidence
extracellular 1
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MIR205 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR205: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR205 Gene

Pathways & Interactions for MIR205 Gene

PathCards logo

SuperPathways for MIR205 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR205: view

Pathways by source for MIR205 Gene

1 KEGG pathway for MIR205 Gene

Gene Ontology (GO) - Biological Process for MIR205 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:0035278 miRNA mediated inhibition of translation IDA 19665999
GO:0048261 negative regulation of receptor-mediated endocytosis IC 26781079
GO:0050728 negative regulation of inflammatory response IC 29548280
GO:0090272 negative regulation of fibroblast growth factor production IMP 27362808
genes like me logo Genes that share ontologies with MIR205: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR205 Gene

Drugs & Compounds for MIR205 Gene

No Compound Related Data Available

Transcripts for MIR205 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR205 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS0000016914_9606 precursor_RNA 110 5

HGNC: 31583,

RefSeq: NR_029622,

Ensembl: ENST00000384891 (view in UCSC) ,

miRBase: MI0000285,

ENA: LM608354.1:1..110:precursor_RNA,

URS0000446722_9606 miRNA 22 5

RefSeq: NR_029622,

LncBase: hsa-miR-205-5p,

miRBase: MIMAT0000266,

TarBase: hsa-miR-205-5p,

ENA: LM378906.1:1..22:ncRNA, LM608354.1:34..55:ncRNA,

URS000038727B_9606 miRNA 21 4

RefSeq: NR_029622,

miRBase: MIMAT0009197,

TarBase: hsa-miR-205-3p,

ENA: FM956499.1:1..21:ncRNA, LM381140.1:1..21:ncRNA, LM608354.1:71..91:ncRNA,

URS0000700573_9606 precursor_RNA 102 1

Rfam: RF00656,

URS0000EFE833_9606 precursor_RNA 60 1

MirGeneDB: Hsa-Mir-205-P1,

MIR205 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR205 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR205 Gene

No ASD Table

Relevant External Links for MIR205 Gene

GeneLoc Exon Structure for
MIR205

Expression for MIR205 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR205

Evidence on tissue expression from TISSUES for MIR205 Gene

  • Blood(2.3)
  • Skin(2.2)
  • Lymph node(2.2)
  • Intestine(2.1)
  • Urine(2.1)
  • Liver(2)
  • Kidney(2)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR205 Gene

Orthologs for MIR205 Gene

Evolution for MIR205 Gene

ENSEMBL:
Gene Tree for MIR205 (if available)
TreeFam:
Gene Tree for MIR205 (if available)

No data available for Orthologs for MIR205 Gene

Paralogs for MIR205 Gene

No data available for Paralogs for MIR205 Gene

Variants for MIR205 Gene

Additional dbSNP identifiers (rs#s) for MIR205 Gene

Additional Variant Information for MIR205 Gene

Human Gene Mutation Database (HGMD)
MIR205
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR205

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR205 Gene

Disorders for MIR205 Gene

MalaCards: The human disease database

(40) MalaCards diseases for MIR205 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
squamous cell carcinoma
  • epidermoid carcinoma
melanoma
  • malignant melanoma
squamous cell carcinoma, head and neck
  • hnscc
prostate cancer
  • prostate cancer, somatic
lung cancer
  • adenocarcinoma of lung
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR205

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with MIR205: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR205 Gene

Publications for MIR205 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 41
  2. The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. (PMID: 18376396) Gregory PA … Goodall GJ (Nature cell biology 2008) 2 3
  3. Prognostic Role of microRNA-205 in Human Gynecological Cancer: A Meta-Analysis of Fourteen Studies. (PMID: 32354230) Wu Z … Ye Q (DNA and cell biology 2020) 3
  4. microRNA-205 and microRNA-338-3p Reduces Cell Apoptosis in Prostate Carcinoma Tissue and LNCaP Prostate Carcinoma Cells by Directly Targeting the B-Cell Lymphoma 2 (Bcl-2) Gene. (PMID: 30741252) Zhang X … Zhang J (Medical science monitor : international medical journal of experimental and clinical research 2019) 3
  5. Downregulation of microRNA-205 inhibits cell invasion and angiogenesis of cervical cancer through TSLC1-mediated Akt signaling pathway. (PMID: 31049956) Zhang F … Xie BB (Journal of cellular physiology 2019) 3

Products for MIR205 Gene

Sources for MIR205 Gene