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Aliases for MIR205 Gene

Subcategory (RNA class) for MIR205 Gene

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Quality Score for this RNA gene is

3

Aliases for MIR205 Gene

  • MicroRNA 205 2 3 5
  • Hsa-Mir-205 3
  • Mir-205 3
  • MIRN205 3

External Ids for MIR205 Gene

ORGUL Members for MIR205 Gene

Previous HGNC Symbols for MIR205 Gene

  • MIRN205

Previous GeneCards Identifiers for MIR205 Gene

  • GC01P207673
  • GC01P209605

Summaries for MIR205 Gene

Entrez Gene Summary for MIR205 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR205 Gene

MIR205 (MicroRNA 205) is an RNA Gene, and is affiliated with the undefined RNA class. Diseases associated with MIR205 include Hereditary Hemorrhagic Telangiectasia. Among its related pathways are MicroRNAs in cancer.

Additional gene information for MIR205 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR205 Gene

Genomics for MIR205 Gene

GeneHancer (GH) Regulatory Elements for MIR205 Gene

Promoters and enhancers for MIR205 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I209427 Enhancer 1.1 Ensembl ENCODE dbSUPER 550.8 -0.6 -580 8.8 CTCF ATF1 TEAD4 TAL1 MCM2 RAD21 RFX5 CTBP1 GATA3 POLR2A MIR205 MIR205HG
GH01I209644 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.3 +220.9 220861 16.6 HDGF FOXA2 PKNOX1 SMAD1 ARNT FEZF1 IRF4 YY1 ZNF766 FOS LAMB3 G0S2 HSD11B1 LOC101930114 CAMK1G ENSG00000224260 MIR205 MIR205HG IRF6 TRAF3IP3
GH01I209396 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 12 -33.5 -33489 4 FOXA2 MAX ZIC2 RFX5 YY1 ZNF316 ELK1 NFE2 FOSL2 MAFK MIR205 MIR205HG TFDP1P LAMB3 LINC01698
GH01I209354 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 11.7 -76.3 -76346 3.5 CTCF STAT1 ZNF654 ZNF680 TRIM22 RAD21 RFX5 GATA3 POLR2A KLF16 MIR205HG MIR205 TFDP1P ENSG00000224260 IRF6 LINC01698 LAMB3 LINC01696
GH01I209366 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 11.1 -63.1 -63088 5.1 JUND GATA3 ZNF316 POLR2A FOSL2 FOS MAFK LINC01698 LAMB3 MIR205HG MIR205 ENSG00000224260 IRF6 HSD11B1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR205 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR205 Gene

Genomic Locations for MIR205 Gene
chr1:209,432,133-209,432,242
(GRCh38/hg38)
Size:
110 bases
Orientation:
Plus strand
chr1:209,605,478-209,605,587
(GRCh37/hg19)

Genomic View for MIR205 Gene

Genes around MIR205 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR205 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR205 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR205 Gene

Proteins for MIR205 Gene

Post-translational modifications for MIR205 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR205 Gene

Domains & Families for MIR205 Gene

Gene Families for MIR205 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR205: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR205 Gene

Function for MIR205 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR205 Gene

Localization for MIR205 Gene

Gene Ontology (GO) - Cellular Components for MIR205 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR205: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR205 Gene

Pathways & Interactions for MIR205 Gene

SuperPathways for MIR205 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR205: view

Pathways by source for MIR205 Gene

1 KEGG pathway for MIR205 Gene

Interacting Proteins for MIR205 Gene

Gene Ontology (GO) - Biological Process for MIR205 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903847 regulation of aorta morphogenesis ISS --
GO:1904685 positive regulation of metalloendopeptidase activity ISS --
genes like me logo Genes that share ontologies with MIR205: view

No data available for SIGNOR curated interactions for MIR205 Gene

Drugs & Compounds for MIR205 Gene

No Compound Related Data Available

Transcripts for MIR205 Gene

mRNA/cDNA for MIR205 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR205 Gene

No ASD Table

Relevant External Links for MIR205 Gene

GeneLoc Exon Structure for
MIR205
ECgene alternative splicing isoforms for
MIR205

Expression for MIR205 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR205 Gene:

MIR205
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR205 Gene

Orthologs for MIR205 Gene

Evolution for MIR205 Gene

ENSEMBL:
Gene Tree for MIR205 (if available)
TreeFam:
Gene Tree for MIR205 (if available)

No data available for Orthologs for MIR205 Gene

Paralogs for MIR205 Gene

No data available for Paralogs for MIR205 Gene

Variants for MIR205 Gene

Sequence variations from dbSNP and Humsavar for MIR205 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1001075229 -- 209,430,785(+) G/A upstream_transcript_variant
rs1002415223 -- 209,430,855(+) G/A upstream_transcript_variant
rs1002743799 -- 209,430,383(+) G/A upstream_transcript_variant
rs1003678424 -- 209,432,153(+) T/C non_coding_transcript_variant
rs1007085936 -- 209,430,513(+) A/G upstream_transcript_variant

Additional Variant Information for MIR205 Gene

Human Gene Mutation Database (HGMD)
MIR205
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR205

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR205 Gene

Disorders for MIR205 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR205 Gene - From: HGMD and GeneCards

Disorder Aliases PubMed IDs
hereditary hemorrhagic telangiectasia
  • osler hemorrhagic telangiectasia syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR205

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR205: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR205 Gene

Publications for MIR205 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 44 58
  2. MicroRNA-205 Mediates Proteinase-Activated Receptor 2 (PAR2) -Promoted Cancer Cell Migration. (PMID: 28990808) Yang X … Wang H (Cancer investigation 2017) 3 58
  3. LncRNA GAS5 suppresses the tumorigenesis of cervical cancer by downregulating miR-196a and miR-205. (PMID: 28671039) Yang W … Jiang L (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 58
  4. MiR-205 serves as a prognostic factor and suppresses proliferation and invasion by targeting insulin-like growth factor receptor 1 in human cervical cancer. (PMID: 28651495) Pang H … Yue X (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 58
  5. Chemosensitization and inhibition of pancreatic cancer stem cell proliferation by overexpression of microRNA-205. (PMID: 28536008) Chaudhary AK … Mahato RI (Cancer letters 2017) 3 58

Products for MIR205 Gene

Sources for MIR205 Gene

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