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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR203B (MicroRNA 203b) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH14J104115 | Promoter/Enhancer | 1.2 | Ensembl ENCODE dbSUPER | 600.7 | +0.6 | 568 | 2.1 | TARDBP FOXA1 EZH2 ZFX ESRRA POLR2A KLF4 ELK1 MBD2 SIN3A | MIR203A MIR203B lnc-KIF26A-1 KIF26A ASPG | |
GH14J104118 | Enhancer | 0.4 | Ensembl dbSUPER | 600.7 | -0.9 | -898 | 0.4 | EZH2 | MIR203A MIR203B ASPG KIF26A ENSG00000258748 | |
GH14J104119 | Enhancer | 0.4 | Ensembl dbSUPER | 0.7 | -2.4 | -2398 | 0.2 | MNT | MIR203B ENSG00000258748 KIF26A ASPG | |
GH14J104136 | Promoter | 0.7 | Ensembl | 0.4 | -18.8 | -18798 | 0.2 | EZH2 KLF7 ZBTB10 ZBTB26 ZFHX2 ZNF335 CTCF ZBTB7A ZBTB8A | ENSG00000258748 LOC105370708 KIF26A MIR203B ASPG | |
GH14J104134 | Enhancer | 0.7 | ENCODE | 0.4 | -17.8 | -17757 | 1.2 | CTCF EZH2 ZNF600 RBAK RAD21 ZNF524 KLF7 ZBTB10 ZBTB48 ZBTB17 | ENSG00000258748 LOC105370708 KIF26A MIR203B ASPG |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | MicroRNAs in cancer |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0035195 | gene silencing by miRNA | IEA | -- |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000075A5EE_9606 | precursor_RNA | 86 | 4 |
HGNC: 41811, RefSeq: NR_039859, Ensembl: ENST00000636080 (view in UCSC) , miRBase: MI0017343, |
URS00004A26B5_9606 | miRNA | 23 | 3 |
RefSeq: NR_039859, miRBase: MIMAT0019814, ENA: FR772784.1:1..23:ncRNA, |
URS00005ED615_9606 | miRNA | 22 | 3 |
RefSeq: NR_039859, miRBase: MIMAT0019813, ENA: FR772785.1:1..22:ncRNA, |
No disorders were found for MIR203B Gene.