Free for academic non-profit institutions. Other users need a Commercial license

MIR203B Gene(RNA Gene)

MicroRNA 203b

GCID:
GC14M104118
GIFtS:
11
Genes Participants
UDN Logo

Aliases for MIR203B Gene

Subcategory (RNA class) for MIR203B Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR203B Gene

  • MicroRNA 203b 2 3 5
  • MicroRNA 3545 2 3
  • Hsa-Mir-203b 3
  • Hsa-Mir-3545 3
  • MIR3545 3

External Ids for MIR203B Gene

ORGUL Members for MIR203B Gene

Previous HGNC Symbols for MIR203B Gene

  • MIR3545

Previous GeneCards Identifiers for MIR203B Gene

  • GC14M104588

Summaries for MIR203B Gene

Entrez Gene Summary for MIR203B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR203B Gene

MIR203B (MicroRNA 203b) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

Additional gene information for MIR203B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR203B Gene

Genomics for MIR203B Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for MIR203B Gene

Promoters and enhancers for MIR203B Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH14I104115 Enhancer 1.1 Ensembl ENCODE dbSUPER 550.8 +0.4 408 2.7 GTF2F1 CTCF ESRRA KLF1 SUZ12 SIN3A RFX5 E2F1 GATA3 ELK1 GC14P104120 MIR203A MIR203B GC14P104113
GH14I104134 Enhancer 0.7 ENCODE 0.4 -17.8 -17757 1.2 CTCF ZNF777 RAD21 ZNF335 ZFHX2 GLIS2 RBAK POLR2A ZBTB48 KLF7 ENSG00000258748 LOC105370708 MIR203B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR203B on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR203B Gene

Genomic Locations for MIR203B Gene
chr14:104,117,418-104,117,503
(GRCh38/hg38)
Size:
86 bases
Orientation:
Minus strand
chr14:104,583,755-104,583,840
(GRCh37/hg19)

Genomic View for MIR203B Gene

Genes around MIR203B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR203B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR203B Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR203B Gene

ORGUL Member Location for MIR203B Gene

ORGUL Member Location for MIR203B gene

Proteins for MIR203B Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIR203B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR203B Gene

Domains & Families for MIR203B Gene

Gene Families for MIR203B Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR203B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR203B Gene

Function for MIR203B Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR203B Gene

Localization for MIR203B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR203B Gene

Pathways & Interactions for MIR203B Gene

SuperPathways for MIR203B Gene

PathCards logo More details on SuperPathways for MIR203B
SuperPathway Contained pathways
1 MicroRNAs in cancer
MicroRNAs in cancer
-
genes like me logo Genes that share pathways with MIR203B: view

Pathways by source for MIR203B Gene

1 KEGG pathway for MIR203B Gene

Interacting Proteins for MIR203B Gene

Gene Ontology (GO) - Biological Process for MIR203B Gene

None

No data available for SIGNOR curated interactions for MIR203B Gene

Drugs & Compounds for MIR203B Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIR203B Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MIR203B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR203B Gene

No ASD Table

Relevant External Links for MIR203B Gene

GeneLoc Exon Structure for
MIR203B
ECgene alternative splicing isoforms for
MIR203B

Expression for MIR203B Gene

Products:

  1. Primer

NURSA nuclear receptor signaling pathways regulating expression of MIR203B Gene:

MIR203B
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR203B Gene

Orthologs for MIR203B Gene

Evolution for MIR203B Gene

ENSEMBL:
Gene Tree for MIR203B (if available)
TreeFam:
Gene Tree for MIR203B (if available)

No data available for Orthologs for MIR203B Gene

Paralogs for MIR203B Gene

No data available for Paralogs for MIR203B Gene

Variants for MIR203B Gene

Sequence variations from dbSNP and Humsavar for MIR203B Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000547842 -- 104,117,991(-) C/T upstream_transcript_variant
rs1001562153 -- 104,118,212(-) T/A upstream_transcript_variant
rs1006192963 -- 104,117,572(-) C/T upstream_transcript_variant
rs1006225359 -- 104,117,872(-) T/C upstream_transcript_variant
rs1006355502 -- 104,118,404(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR203B Gene

Variant ID Type Subtype PubMed ID
esv3635614 CNV gain 21293372
nsv1050479 CNV gain 25217958
nsv1054574 CNV loss 25217958
nsv470674 CNV loss 18288195
nsv519605 CNV loss 19592680
nsv566029 CNV loss 21841781
nsv566030 CNV gain 21841781
nsv827072 CNV gain 20364138
nsv952262 CNV deletion 24416366

Additional Variant Information for MIR203B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR203B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR203B Gene

Disorders for MIR203B Gene

Additional Disease Information for MIR203B

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MIR203B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR203B Gene

Publications for MIR203B Gene

  1. Suppression of Oral Carcinoma Oncogenic Activity by microRNA-203 via Down-regulation of SEMA6A. (PMID: 28982852) Lim HS … Kim DK (Anticancer research 2017) 3 58
  2. Upregulation of miR-203 and miR-210 affect growth and differentiation of keratinocytes after exposure to sulfur mustard in normoxia and hypoxia. (PMID: 26383628) Deppe J … Ries C (Toxicology letters 2016) 3 58
  3. Downregulation of Potential Tumor Suppressor miR-203a by Promoter Methylation Contributes to the Invasiveness of Gastric Cardia Adenocarcinoma. (PMID: 27791400) Liu W … Guo W (Cancer investigation 2016) 3 58
  4. miR-203 inhibition of renal cancer cell proliferation, migration and invasion by targeting of FGF2. (PMID: 25890121) Xu M … Da J (Diagnostic pathology 2015) 3 58
  5. Ectopic expressed miR-203 contributes to chronic obstructive pulmonary disease via targeting TAK1 and PIK3CA. (PMID: 26617776) Shi L … Ma Z (International journal of clinical and experimental pathology 2015) 3 58

Products for MIR203B Gene

Sources for MIR203B Gene

Content
Loading form....