microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR203B Gene

Subcategory (RNA class) for MIR203B Gene

miRNA

Number of RNA Genes sources:

2 / 17

Aliases for MIR203B Gene

  • MicroRNA 203b 2 3 5
  • MicroRNA 3545 2 3
  • Hsa-Mir-3545 2 3
  • MIR203B 2 5
  • Hsa-Mir-203b 3
  • MIMAT0019814 50
  • MIMAT0019813 50
  • MI0017343 50
  • MIR3545 3

External Ids for MIR203B Gene

Previous HGNC Symbols for MIR203B Gene

  • MIR3545

Previous GeneCards Identifiers for MIR203B Gene

  • GC14M104588

Summaries for MIR203B Gene

Entrez Gene Summary for MIR203B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR203B Gene

MIR203B (MicroRNA 203b) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

Rfam classification for MIR203B Gene

Additional gene information for MIR203B Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR203B Gene

Genomics for MIR203B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR203B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J104115 Promoter/Enhancer 1.2 Ensembl ENCODE dbSUPER 600.7 +0.6 568 2.1 TARDBP FOXA1 EZH2 ZFX ESRRA POLR2A KLF4 ELK1 MBD2 SIN3A MIR203A MIR203B lnc-KIF26A-1 KIF26A ASPG
GH14J104118 Enhancer 0.4 Ensembl dbSUPER 600.7 -0.9 -898 0.4 EZH2 MIR203A MIR203B ASPG KIF26A ENSG00000258748
GH14J104119 Enhancer 0.4 Ensembl dbSUPER 0.7 -2.4 -2398 0.2 MNT MIR203B ENSG00000258748 KIF26A ASPG
GH14J104136 Promoter 0.7 Ensembl 0.4 -18.8 -18798 0.2 EZH2 KLF7 ZBTB10 ZBTB26 ZFHX2 ZNF335 CTCF ZBTB7A ZBTB8A ENSG00000258748 LOC105370708 KIF26A MIR203B ASPG
GH14J104134 Enhancer 0.7 ENCODE 0.4 -17.8 -17757 1.2 CTCF EZH2 ZNF600 RBAK RAD21 ZNF524 KLF7 ZBTB10 ZBTB48 ZBTB17 ENSG00000258748 LOC105370708 KIF26A MIR203B ASPG
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR203B on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR203B Gene

Genomic Locations for MIR203B Gene
chr14:104,117,418-104,117,503
(GRCh38/hg38)
Size:
86 bases
Orientation:
Minus strand
chr14:104,583,755-104,583,840
(GRCh37/hg19)
Size:
86 bases
Orientation:
Minus strand

Genomic View for MIR203B Gene

Genes around MIR203B on UCSC Golden Path with GeneCards custom track
MIR203B in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR203B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR203B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR203B Gene

Proteins for MIR203B Gene

Post-translational modifications for MIR203B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR203B Gene

Domains & Families for MIR203B Gene

Gene Families for MIR203B Gene

genes like me logo Genes that share domains with MIR203B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR203B Gene

Function for MIR203B Gene

Phenotypes From GWAS Catalog for MIR203B Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR203B Gene

Localization for MIR203B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR203B Gene

Pathways & Interactions for MIR203B Gene

PathCards logo

SuperPathways for MIR203B Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR203B: view

Pathways by source for MIR203B Gene

1 KEGG pathway for MIR203B Gene

Gene Ontology (GO) - Biological Process for MIR203B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR203B: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR203B Gene

Drugs & Compounds for MIR203B Gene

No Compound Related Data Available

Transcripts for MIR203B Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR203B Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075A5EE_9606 precursor_RNA 86 4

HGNC: 41811,

RefSeq: NR_039859,

Ensembl: ENST00000636080 (view in UCSC) ,

miRBase: MI0017343,

URS00004A26B5_9606 miRNA 23 3

RefSeq: NR_039859,

miRBase: MIMAT0019814,

ENA: FR772784.1:1..23:ncRNA,

URS00005ED615_9606 miRNA 22 3

RefSeq: NR_039859,

miRBase: MIMAT0019813,

ENA: FR772785.1:1..22:ncRNA,

MIR203B in the GeneCards ncRNA compendium hub on the UCSC Golden Path

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR203B Gene

No ASD Table

Relevant External Links for MIR203B Gene

GeneLoc Exon Structure for
MIR203B

No data available for mRNA/cDNA for MIR203B Gene

Expression for MIR203B Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR203B Gene

Orthologs for MIR203B Gene

Evolution for MIR203B Gene

ENSEMBL:
Gene Tree for MIR203B (if available)
TreeFam:
Gene Tree for MIR203B (if available)

No data available for Orthologs for MIR203B Gene

Paralogs for MIR203B Gene

No data available for Paralogs for MIR203B Gene

Variants for MIR203B Gene

Additional dbSNP identifiers (rs#s) for MIR203B Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR203B Gene

Variant ID Type Subtype PubMed ID
esv3635614 CNV gain 21293372
nsv1050479 CNV gain 25217958
nsv1054574 CNV loss 25217958
nsv470674 CNV loss 18288195
nsv519605 CNV loss 19592680
nsv566029 CNV loss 21841781
nsv566030 CNV gain 21841781
nsv827072 CNV gain 20364138
nsv952262 CNV deletion 24416366

Additional Variant Information for MIR203B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR203B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR203B Gene

Disorders for MIR203B Gene

Additional Disease Information for MIR203B

No disorders were found for MIR203B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR203B Gene

Publications for MIR203B Gene

  1. Long noncoding RNA B3GALT5-AS1 suppresses colon cancer liver metastasis via repressing microRNA-203. (PMID: 30530918) Wang L … He Y (Aging 2018) 3
  2. MicroRNA-203 Increases Cell Radiosensitivity via Directly Targeting Bmi-1 in Hepatocellular Carcinoma. (PMID: 29906128) Shao Y … Jiang J (Molecular pharmaceutics 2018) 3
  3. MicroRNA-203 inhibits invasion and induces apoptosis of laryngeal cancer cells via targeting LASP1. (PMID: 30338803) Tan J … Yu LS (European review for medical and pharmacological sciences 2018) 3
  4. Suppression of Oral Carcinoma Oncogenic Activity by microRNA-203 via Down-regulation of SEMA6A. (PMID: 28982852) Lim HS … Kim DK (Anticancer research 2017) 3
  5. Upregulation of miR-203 and miR-210 affect growth and differentiation of keratinocytes after exposure to sulfur mustard in normoxia and hypoxia. (PMID: 26383628) Deppe J … Ries C (Toxicology letters 2016) 3

Products for MIR203B Gene

Sources for MIR203B Gene