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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...
Aliases for MIR203B Gene
Subcategory (RNA class) for MIR203B Gene
miRNA
Number of RNA Genes sources:
2 / 17
Aliases for MIR203B Gene
External Ids for MIR203B Gene
- HGNC: 41811
- Entrez Gene: 100616173
- Ensembl: ENSG00000283165
- miRBase: hsa-mir-203b
Previous HGNC Symbols for MIR203B Gene
- MIR3545
Previous GeneCards Identifiers for MIR203B Gene
- GC14M104588
Summaries for MIR203B Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR203B Gene
MIR203B (MicroRNA 203b) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.
Rfam classification for MIR203B Gene
-
microRNA mir-203
Additional gene information for MIR203B Gene
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR203B Gene
Genomics for MIR203B Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MIR203B Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH14J104115 | Promoter/Enhancer | 1.2 | Ensembl ENCODE dbSUPER | 600.7 | +0.6 | 568 | 2.1 | TARDBP FOXA1 EZH2 ZFX ESRRA POLR2A KLF4 ELK1 MBD2 SIN3A | MIR203A MIR203B lnc-KIF26A-1 KIF26A ASPG | |
| GH14J104118 | Enhancer | 0.4 | Ensembl dbSUPER | 600.7 | -0.9 | -898 | 0.4 | EZH2 | MIR203A MIR203B ASPG KIF26A ENSG00000258748 | |
| GH14J104119 | Enhancer | 0.4 | Ensembl dbSUPER | 0.7 | -2.4 | -2398 | 0.2 | MNT | MIR203B ENSG00000258748 KIF26A ASPG | |
| GH14J104136 | Promoter | 0.7 | Ensembl | 0.4 | -18.8 | -18798 | 0.2 | EZH2 KLF7 ZBTB10 ZBTB26 ZFHX2 ZNF335 CTCF ZBTB7A ZBTB8A | ENSG00000258748 LOC105370708 KIF26A MIR203B ASPG | |
| GH14J104134 | Enhancer | 0.7 | ENCODE | 0.4 | -17.8 | -17757 | 1.2 | CTCF EZH2 ZNF600 RBAK RAD21 ZNF524 KLF7 ZBTB10 ZBTB48 ZBTB17 | ENSG00000258748 LOC105370708 KIF26A MIR203B ASPG |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MIR203B on the GeneHancer Hub at the UCSC Golden Path
Genomic Locations for MIR203B Gene
Genomic Locations for MIR203B Gene
- chr14:104,117,418-104,117,503
- (GRCh38/hg38)
- Size:
- 86 bases
- Orientation:
- Minus strand
- chr14:104,583,755-104,583,840
- (GRCh37/hg19)
- Size:
- 86 bases
- Orientation:
- Minus strand
Genomic View for MIR203B Gene
Genes around MIR203B on UCSC Golden Path with GeneCards custom track
MIR203B in the GeneCards ncRNA compendium hub on the UCSC Golden Path
- Cytogenetic band:
-
- 14q32.33 by HGNC
- 14q32.33 by Entrez Gene
- 14q32.33 by Ensembl
MIR203B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR203B Gene
Proteins for MIR203B Gene
Post-translational modifications for MIR203B Gene
No Post-translational modifications
Antibody Products
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR203B
- Origene Custom Protein Services for MIR203B
No data available for DME Specific Peptides for MIR203B Gene
Domains & Families for MIR203B Gene
Gene Families for MIR203B Gene
- HGNC:
No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR203B Gene
Function for MIR203B Gene
Phenotypes From GWAS Catalog for MIR203B Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MIR203B - Select products 50% OFF >
- * MIR203B CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Browse CRISPR knockouts for MIR203B
miRNA Products
Inhibitory RNA Products
Clone Products
- Applied Biological Materials (abm): Clones for MIR203B - Select products 50% OFF >
- * MIR203B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR203B Gene
Localization for MIR203B Gene
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR203B Gene
Pathways & Interactions for MIR203B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | MicroRNAs in cancer | ||
Pathways by source for MIR203B Gene
1 KEGG pathway for MIR203B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0035195 | gene silencing by miRNA | IEA | -- |
No data available for Interacting Proteins and SIGNOR curated interactions for MIR203B Gene
Transcripts for MIR203B Gene
Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR203B Gene
| RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
|---|---|---|---|---|
| URS000075A5EE_9606 | precursor_RNA | 86 | 4 |
HGNC: 41811, RefSeq: NR_039859, Ensembl: ENST00000636080 (view in UCSC) , miRBase: MI0017343, |
| URS00004A26B5_9606 | miRNA | 23 | 3 |
RefSeq: NR_039859, miRBase: MIMAT0019814, ENA: FR772784.1:1..23:ncRNA, |
| URS00005ED615_9606 | miRNA | 22 | 3 |
RefSeq: NR_039859, miRBase: MIMAT0019813, ENA: FR772785.1:1..22:ncRNA, |
MIR203B in the GeneCards ncRNA compendium hub on the UCSC Golden Path
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MIR203B - Select products 50% OFF >
- * MIR203B CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Browse CRISPR knockouts for MIR203B
miRNA Products
Inhibitory RNA Products
Clone Products
- Applied Biological Materials (abm): Clones for MIR203B - Select products 50% OFF >
- * MIR203B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
Relevant External Links for MIR203B Gene
- GeneLoc Exon Structure for
- MIR203B
No data available for mRNA/cDNA for MIR203B Gene
Expression for MIR203B Gene
No Expression Related Data Available
Primer Products
-
OriGene qPCR primer pairs for MIR203B
Gene Expression Assay Products
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR203B Gene
Orthologs for MIR203B Gene
No data available for Orthologs for MIR203B Gene
Paralogs for MIR203B Gene
No data available for Paralogs for MIR203B Gene
Variants for MIR203B Gene
Additional Variant Information for MIR203B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR203B
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR203B Gene
Disorders for MIR203B Gene
Additional Disease Information for MIR203B
No disorders were found for MIR203B Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR203B Gene
Publications for MIR203B Gene
- Long noncoding RNA B3GALT5-AS1 suppresses colon cancer liver metastasis via repressing microRNA-203. (PMID: 30530918) Wang L … He Y (Aging 2018) 3
- MicroRNA-203 Increases Cell Radiosensitivity via Directly Targeting Bmi-1 in Hepatocellular Carcinoma. (PMID: 29906128) Shao Y … Jiang J (Molecular pharmaceutics 2018) 3
- MicroRNA-203 inhibits invasion and induces apoptosis of laryngeal cancer cells via targeting LASP1. (PMID: 30338803) Tan J … Yu LS (European review for medical and pharmacological sciences 2018) 3
- Suppression of Oral Carcinoma Oncogenic Activity by microRNA-203 via Down-regulation of SEMA6A. (PMID: 28982852) Lim HS … Kim DK (Anticancer research 2017) 3
- Upregulation of miR-203 and miR-210 affect growth and differentiation of keratinocytes after exposure to sulfur mustard in normoxia and hypoxia. (PMID: 26383628) Deppe J … Ries C (Toxicology letters 2016) 3
ExternalLinks
Products for MIR203B Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR203B
- Origene Custom Protein Services for MIR203B
- Browse OriGene Inhibitory RNA Products For MIR203B
- OriGene qPCR primer pairs for MIR203B
- Browse CRISPR knockouts for MIR203B
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MIR203B
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for MIR203B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for MIR203B
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MIR203B
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for MIR203B
Sources for MIR203B Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB