microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR203A Gene

Subcategory (RNA class) for MIR203A Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR203A Gene

  • MicroRNA 203a 2 3 5
  • Hsa-MiR-203a-3p 163 173
  • MicroRNA 203 2 3
  • Hsa-Mir-203 2 3
  • MIR203A 2 5
  • Hsa-Mir-203-V2 178
  • Hsa-Mir-203-V1 178
  • Hsa-Mir-203a 3
  • MIMAT0031890 50
  • MIMAT0000264 50
  • MI0000283 50
  • MiRNA203 3
  • Mir-203a 3
  • MIRN203 3
  • MiR-203 3
  • RF00696 168
  • MIR203 3

External Ids for MIR203A Gene

Previous HGNC Symbols for MIR203A Gene

  • MIRN203
  • MIR203

Previous GeneCards Identifiers for MIR203A Gene

  • GC14P104585
  • GC14P104119
  • GC14P104199
  • GC14P104331

Summaries for MIR203A Gene

Entrez Gene Summary for MIR203A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR203A Gene

MIR203A (MicroRNA 203a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR203A include Psoriasis and Skin Disease. Among its related pathways are DNA Damage Response and Cell Differentiation - Index.

Rfam classification for MIR203A Gene

Additional gene information for MIR203A Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR203A Gene

Genomics for MIR203A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR203A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J104115 Promoter/Enhancer 1.2 Ensembl ENCODE dbSUPER 600.7 -0.5 -470 2.1 TARDBP FOXA1 EZH2 ZFX ESRRA POLR2A KLF4 ELK1 MBD2 SIN3A MIR203A MIR203B lnc-KIF26A-1 KIF26A ASPG
GH14J104118 Enhancer 0.4 Ensembl dbSUPER 600.7 +1.0 996 0.4 EZH2 MIR203A MIR203B ASPG KIF26A ENSG00000258748
GH14J104147 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 12.1 +31.1 31096 6.6 CTCF ZNF629 KDM1A ZIC2 PATZ1 ZNF600 ZNF341 KLF9 ZNF211 SP2 KIF26A MIR203A C14orf180 ATP5MPL KLC1 ASPG lnc-ASPG-3
GH14J104137 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 5.3 +21.8 21759 3.8 CTCF KDM1A ZNF692 TARDBP ZNF143 ZIC2 PATZ1 REST RAD21 ZNF501 ENSG00000258748 LOC105370708 KIF26A ASPG MIR203A ATP5MPL lnc-ASPG-3 C14orf180
GH14J104122 Enhancer 0.4 Ensembl 5.3 +5.3 5296 0.6 ZNF512 ZNF366 ZNF791 ENSG00000202275 ENSG00000269940 XRCC3 MIR203A MIR203B ENSG00000258748 KIF26A ASPG
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR203A on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR203A Gene

Genomic Locations for MIR203A Gene
chr14:104,117,405-104,117,514
(GRCh38/hg38)
Size:
110 bases
Orientation:
Plus strand
chr14:104,583,742-104,583,851
(GRCh37/hg19)
Size:
110 bases
Orientation:
Plus strand

Genomic View for MIR203A Gene

Genes around MIR203A on UCSC Golden Path with GeneCards custom track
MIR203A in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR203A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR203A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR203A Gene

Proteins for MIR203A Gene

Post-translational modifications for MIR203A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR203A Gene

Domains & Families for MIR203A Gene

Gene Families for MIR203A Gene

genes like me logo Genes that share domains with MIR203A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR203A Gene

Function for MIR203A Gene

Phenotypes From GWAS Catalog for MIR203A Gene

Gene Ontology (GO) - Molecular Function for MIR203A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 22917968
genes like me logo Genes that share ontologies with MIR203A: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR203A Gene

Localization for MIR203A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR203A Gene

Pathways & Interactions for MIR203A Gene

genes like me logo Genes that share pathways with MIR203A: view

Pathways by source for MIR203A Gene

Gene Ontology (GO) - Biological Process for MIR203A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:0045415 negative regulation of interleukin-8 biosynthetic process IDA 23608026
GO:1900016 negative regulation of cytokine production involved in inflammatory response IGI 23608026
GO:2000483 negative regulation of interleukin-8 secretion IDA 23608026
genes like me logo Genes that share ontologies with MIR203A: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR203A Gene

Drugs & Compounds for MIR203A Gene

No Compound Related Data Available

Transcripts for MIR203A Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR203A Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00004DA9DB_9606 miRNA 22 6

RefSeq: NR_029620,

LncBase: hsa-miR-203a-3p,

miRBase: MIMAT0000264,

MirGeneDB: Hsa-Mir-203-v1_3p,

TarBase: hsa-miR-203a-3p,

ENA: LM378904.1:1..22:ncRNA, LM608352.1:65..86:ncRNA,

URS000075ACBD_9606 precursor_RNA 110 5

HGNC: 31581,

RefSeq: NR_029620,

Ensembl: ENST00000384836 (view in UCSC) ,

miRBase: MI0000283,

ENA: LM608352.1:1..110:precursor_RNA,

URS0000770B9E_9606 miRNA 25 3

RefSeq: NR_029620,

miRBase: MIMAT0031890,

ENA: LM383304.1:1..25:ncRNA, LM608352.1:27..51:ncRNA,

URS00002CBE8B_9606 precursor_RNA 80 1

Rfam: RF00696,

URS0000EFDA6A_9606 precursor_RNA 61 1

MirGeneDB: Hsa-Mir-203-v1, Hsa-Mir-203-v2,

MIR203A in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR203A Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR203A Gene

No ASD Table

Relevant External Links for MIR203A Gene

GeneLoc Exon Structure for
MIR203A

Expression for MIR203A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR203A Gene

mRNA differential expression in normal tissues according to GTEx for MIR203A Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x17.6), Skin - Not Sun Exposed (Suprapubic) (x17.1), and Esophagus - Mucosa (x11.8).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR203A

genes like me logo Genes that share expression patterns with MIR203A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR203A Gene

Orthologs for MIR203A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR203A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-203 31
  • 99 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-203 31
  • 95 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir203 31
  • 95 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-203 31
  • 81 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 73 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-203 31
  • 77 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-203 31
  • 82 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-203b 31
  • 72 (a)
OneToMany
dre-mir-203a 31
  • 71 (a)
OneToMany
Species where no ortholog for MIR203A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR203A Gene

ENSEMBL:
Gene Tree for MIR203A (if available)
TreeFam:
Gene Tree for MIR203A (if available)

Paralogs for MIR203A Gene

No data available for Paralogs for MIR203A Gene

Variants for MIR203A Gene

Additional dbSNP identifiers (rs#s) for MIR203A Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR203A Gene

Variant ID Type Subtype PubMed ID
esv3635614 CNV gain 21293372
nsv1050479 CNV gain 25217958
nsv1054574 CNV loss 25217958
nsv470674 CNV loss 18288195
nsv519605 CNV loss 19592680
nsv566029 CNV loss 21841781
nsv566030 CNV gain 21841781
nsv827072 CNV gain 20364138
nsv952262 CNV deletion 24416366

Additional Variant Information for MIR203A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR203A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR203A Gene

Disorders for MIR203A Gene

MalaCards: The human disease database

(19) MalaCards diseases for MIR203A Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
psoriasis
skin disease
  • genodermatosis
leukemia, chronic myeloid
  • cml
leukemia, acute lymphoblastic
  • all
gastric cancer
  • gastric cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with MIR203A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR203A Gene

Publications for MIR203A Gene

  1. SOX9/miR-203a axis drives PI3K/AKT signaling to promote esophageal cancer progression. (PMID: 31600529) Wang L … Li F (Cancer letters 2020) 3
  2. Proinflammatory cytokine TNFα promotes HPV-associated oral carcinogenesis by increasing cancer stemness. (PMID: 31911577) Hong HS … Shin KH (International journal of oral science 2020) 3
  3. Serine 195 phosphorylation in the RNA-binding protein Rbm38 increases p63 expression by modulating Rbm38's interaction with the Ago2-miR203 complex. (PMID: 30567739) Zhang Y … Chen X (The Journal of biological chemistry 2019) 3
  4. LncRNA CRNDE promotes hepatocellular carcinoma cell proliferation, invasion, and migration through regulating miR-203/ BCAT1 axis. (PMID: 30230527) Ji D … Liang H (Journal of cellular physiology 2019) 3
  5. Circular RNA circTADA2A promotes osteosarcoma progression and metastasis by sponging miR-203a-3p and regulating CREB3 expression. (PMID: 30940151) Wu Y … Fan S (Molecular cancer 2019) 3

Products for MIR203A Gene

Sources for MIR203A Gene