microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR202 Gene

RNA type for MIR202 Gene

miRNA

Aliases for MIR202 Gene

External Ids for MIR202 Gene

Previous HGNC Symbols for MIR202 Gene

  • MIRN202

Previous GeneCards Identifiers for MIR202 Gene

  • GC10M134912
  • GC10M135061

Summaries for MIR202 Gene

Entrez Gene Summary for MIR202 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR202 Gene

MIR202 (MicroRNA 202) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR202 include Hard Palate Cancer and Spermatogenic Failure, X-Linked, 1.

Rfam classification for MIR202 Gene

Additional gene information for MIR202 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR202 Gene

Genomics for MIR202 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR202 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J133245 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 250.7 +0.1 120 11.6 MYC NCOR1 ZNF592 ZNF223 NFIC ZIC2 HES1 BHLHE40 MNT NBN MIR202 MIR202HG TUBGCP2 SCART1 ENSG00000235245 ZNF511 VENTX PAOX ECHS1 KNDC1
GH10J133238 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 0.4 +12.1 12121 0.8 SP1 ZBTB7A KDM1A EZH2 VENTX MIR202 MIR202HG ADAM8
GH10J133240 Enhancer 0.5 ENCODE 0.4 +8.7 8668 1.4 ZIC2 SPI1 SCRT1 GLIS2 TCF12 MNT VENTX MIR202 MIR202HG ADAM8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR202 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR202 Gene

Latest Assembly
chr10:133,246,263-133,250,121
(GRCh38/hg38)
Size:
3,859 bases
Orientation:
Minus strand

Previous Assembly
chr10:135,061,015-135,061,124
(GRCh37/hg19 by Entrez Gene)
Size:
110 bases
Orientation:
Minus strand

Genomic View for MIR202 Gene

Genes around MIR202 on UCSC Golden Path with GeneCards custom track
MIR202 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR202 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR202 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR202 Gene

Proteins for MIR202 Gene

Post-translational modifications for MIR202 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR202 Gene

Domains & Families for MIR202 Gene

Gene Families for MIR202 Gene

HGNC:
genes like me logo Genes that share domains with MIR202: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR202 Gene

Function for MIR202 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR202 Gene

Localization for MIR202 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR202 gene
Compartment Confidence
extracellular 2
nucleus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endosome 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR202 Gene

Pathways & Interactions for MIR202 Gene

PathCards logo

SuperPathways for MIR202 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR202 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR202: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR202 Gene

Drugs & Compounds for MIR202 Gene

No Compound Related Data Available

Transcripts for MIR202 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR202 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS00003E24B2_9606 miRNA 20 5

RefSeq: NR_030170,

LncBase: hsa-miR-202-3p,

miRBase: MIMAT0002811,

TarBase: hsa-miR-202-3p,

ENA: LM379770.1:1..20:ncRNA, LM609461.1:64..83:ncRNA,

URS000075BC7D_9606 pre_miRNA 110 4

RefSeq: NR_030170,

Ensembl: ENST00000362219 (view in UCSC) ,

miRBase: MI0003130,

ENA: LM609461.1:1..110:precursor_RNA,

URS00003D8730_9606 miRNA 22 4

RefSeq: NR_030170,

miRBase: MIMAT0002810,

TarBase: hsa-miR-202-5p,

ENA: LM379769.1:1..22:ncRNA, LM609461.1:28..49:ncRNA,

URS0001BF374C_9606 pre_miRNA 1340 1

LncBook: HSALNT0170604,

URS0001BD85AE_9606 pre_miRNA 383 1

LncBook: HSALNT0170613,

MIR202 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR202 Gene

2 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR202 Gene

No ASD Table

Relevant External Links for MIR202 Gene

GeneLoc Exon Structure for
MIR202

Expression for MIR202 Gene

mRNA differential expression in normal tissues according to GTEx for MIR202 Gene

This gene is overexpressed in Testis (x29.0), Adrenal Gland (x16.8), and Ovary (x6.6).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR202

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR202 Gene

Orthologs for MIR202 Gene

Evolution for MIR202 Gene

ENSEMBL:
Gene Tree for MIR202 (if available)
TreeFam:
Gene Tree for MIR202 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR202

No data available for Orthologs for MIR202 Gene

Paralogs for MIR202 Gene

No data available for Paralogs for MIR202 Gene

Variants for MIR202 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR202 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR202 Gene

Variant ID Type Subtype PubMed ID
dgv2e196 CNV duplication 17116639
esv2759793 CNV gain+loss 17122850
esv2760107 CNV gain 21179565
esv3625030 CNV gain 21293372
esv3625035 CNV gain 21293372
nsv1159784 CNV deletion 26073780
nsv1159785 CNV deletion 26073780
nsv1159786 CNV deletion 26073780
nsv428243 CNV gain 18775914
nsv470980 CNV loss 18288195
nsv509381 CNV insertion 20534489
nsv516968 CNV loss 19592680
nsv528260 CNV loss 19592680
nsv552574 CNV gain 21841781
nsv832036 CNV loss 17160897
nsv832038 CNV gain+loss 17160897
nsv832039 CNV loss 17160897
nsv8750 CNV gain+loss 18304495
nsv952705 CNV deletion 24416366

Additional Variant Information for MIR202 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR202
Leiden Open Variation Database (LOVD)
MIR202

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR202 Gene

Disorders for MIR202 Gene

MalaCards: The human disease database

(20) MalaCards diseases for MIR202 Gene - From: MID, COP, and GCD

Disorder Aliases PubMed IDs
hard palate cancer
  • malignant neoplasm of hard palate
spermatogenic failure, x-linked, 1
  • spgfx1
varicose veins
  • varices
breast cancer
  • breast cancer, familial
prostate cancer
  • prostate cancer, somatic
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR202

genes like me logo Genes that share disorders with MIR202: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR202 Gene

Publications for MIR202 Gene

  1. Effect of miR-202-5p-mediated ATG7 on autophagy and apoptosis of degenerative nucleus pulposus cells. (PMID: 32016953) Chen J … Wang YJ (European review for medical and pharmacological sciences 2020) 3
  2. MiR-202-5p suppressed cell proliferation, migration and invasion in ovarian cancer via regulating HOXB2. (PMID: 32196576) Yu HY … Pan SS (European review for medical and pharmacological sciences 2020) 3
  3. LncRNA MALAT1 facilitates lung metastasis of osteosarcomas through miR-202 sponging. (PMID: 32728178) Zhang J … Li ZW (Scientific reports 2020) 3
  4. Retinal pigment epithelial cells secrete miR-202-5p-containing exosomes to protect against proliferative diabetic retinopathy. (PMID: 33007305) Gu S … Qiu L (Experimental eye research 2020) 3
  5. Blood microRNA 202-3p associates with the risk of essential hypertension by targeting soluble ST2. (PMID: 32338289) Li L … Wu F (Bioscience reports 2020) 3

Products for MIR202 Gene

Sources for MIR202 Gene