Aliases for MIR200C Gene
Subcategory (RNA class) for MIR200C Gene
miRNA
Quality Score for this RNA gene is
3
External Ids for MIR200C Gene
- HGNC: 31580
- Entrez Gene: 406985
- Ensembl: ENSG00000207713
- OMIM: 612092
- miRBase: hsa-mir-200c
Previous HGNC Symbols for MIR200C Gene
- MIRN200C
Previous GeneCards Identifiers for MIR200C Gene
- GC12P006971
- GC12P006974
- GC12P007072
- GC12P007027
- GC12P007176
- GC12P007219
- GC12P007270
- GC12P007325
- GC12P007369
- GC12P007414
Summaries for MIR200C Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR200C Gene
MIR200C (MicroRNA 200c) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are miRNA targets in ECM and membrane receptors and MicroRNAs in cancer.
Additional gene information for MIR200C Gene
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR200C Gene
Genomics for MIR200C Gene
GeneHancer (GH) Regulatory Elements for MIR200C Gene
Promoters and enhancers for MIR200C Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH12I006923 | Promoter/Enhancer | 2.5 | EPDnew FANTOM5 Ensembl ENCODE dbSUPER | 11.8 | -36.5 | -36548 | 6.8 | HDGF SMAD1 ARID4B SIN3A ZNF2 IRF4 YY1 ZNF213 ZNF143 FOS | ATN1 ZNF384 LRRC23 CHD4 ENSG00000219410 ENSG00000247853 SCARNA12 EMG1 PHB2 RPL13P5 | |
| GH12I006930 | Enhancer | 0.2 | dbSUPER | 11.8 | -32.6 | -32641 | 0.4 | MIR141 MIR200C MIR200CHG SCARNA12 EMG1 PHB2 SPSB2 RPL13P5 LRRC23 TPI1 | ||
| GH12I006940 | Promoter/Enhancer | 2.7 | EPDnew FANTOM5 Ensembl ENCODE dbSUPER | 0.4 | -10.0 | -10041 | 25.9 | CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 | PTPN6 C12orf57 ZNF384 ENSG00000219410 CHD4 ENSG00000247853 SPSB2 SCARNA12 ENSG00000256967 NCAPD2 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around MIR200C on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for MIR200C Gene
Genomic Locations for MIR200C Gene
- chr12:6,963,699-6,963,766
- (GRCh38/hg38)
- Size:
- 68 bases
- Orientation:
- Plus strand
- chr12:7,072,862-7,072,929
- (GRCh37/hg19)
Genomic View for MIR200C Gene
Genes around MIR200C on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12p13.31 by Ensembl
- 12p13.31 by Entrez Gene
- 12p13.31 by HGNC
MIR200C Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR200C Gene
Proteins for MIR200C Gene
Post-translational modifications for MIR200C Gene
No Post-translational modifications
Antibody Products
- Search GeneTex for Antibodies for MIR200C
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR200C
- Origene Custom Protein Services for MIR200C
- Search GeneTex for Proteins for MIR200C
No data available for DME Specific Peptides for MIR200C Gene
Domains & Families for MIR200C Gene
Gene Families for MIR200C Gene
- HGNC:
Graphical View of Domain Structure for InterPro Entry
No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR200C Gene
Function for MIR200C Gene
Phenotypes From GWAS Catalog for MIR200C Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 23765923 |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR200C
-
- Search ViGene Biosciences for MIR200C
CRISPR Products
- Browse CRISPR knockouts for MIR200C
- Applied Biological Materials CRISPR for MIR200C
-
Vectors and viruses for KO, Activation, Repression, and more
miRNA Products
- Search ViGene Biosciences for MIR200C
Inhibitory RNA Products
- Search ViGene Biosciences for MIR200C
Clone Products
- GenScript: Custom all cDNA clones Services for MIR200C
- VectorBuilder custom plasmid, inducible vectors for MIR200C
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR200C
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MIR200C
- Applied Biological Materials Clones for MIR200C
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR200C Gene
Localization for MIR200C Gene
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR200C Gene
Pathways & Interactions for MIR200C Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | MicroRNAs in cancer | ||
| 2 | miRNA targets in ECM and membrane receptors | ||
Pathways by source for MIR200C Gene
1 BioSystems pathway for MIR200C Gene
1 KEGG pathway for MIR200C Gene
Interacting Proteins for MIR200C Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0035195 | gene silencing by miRNA | IDA | 23765923 |
| GO:0045603 | positive regulation of endothelial cell differentiation | IDA | 23765923 |
| GO:1905562 | NOT regulation of vascular endothelial cell proliferation | IDA | 23765923 |
| GO:1905772 | positive regulation of mesodermal cell differentiation | IDA | 23765923 |
No data available for SIGNOR curated interactions for MIR200C Gene
Transcripts for MIR200C Gene
mRNA/cDNA for MIR200C Gene
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for MIR200C
- Applied Biological Materials CRISPR for MIR200C
-
Vectors and viruses for KO, Activation, Repression, and more
miRNA Products
- Search ViGene Biosciences for MIR200C
Inhibitory RNA Products
- Search ViGene Biosciences for MIR200C
Clone Products
- GenScript: Custom all cDNA clones Services for MIR200C
- VectorBuilder custom plasmid, inducible vectors for MIR200C
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR200C
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MIR200C
- Applied Biological Materials Clones for MIR200C
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for MIR200C Gene
NURSA nuclear receptor signaling pathways regulating expression of MIR200C Gene:
MIR200C
No Expression Related Data Available
Primer Products
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR200C Gene
Orthologs for MIR200C Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-200c 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | mdo-mir-200c 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | bta-mir-200c 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | cfa-mir-200c 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Mir200c 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | dre-mir-200c 34 |
|
OneToOne | |
| sea squirt (Ciona savignyi) |
Ascidiacea | csa-mir-141 34 |
|
OneToMany |
- Species where no ortholog for MIR200C was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for MIR200C Gene
No data available for Paralogs for MIR200C Gene
Variants for MIR200C Gene
| SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1001110105 | -- | 6,963,829(+) | C/A | downstream_transcript_variant | |
| rs1001273984 | -- | 6,964,080(+) | G/A | downstream_transcript_variant | |
| rs1001417130 | -- | 6,963,487(+) | C/A/T | upstream_transcript_variant | |
| rs1005625574 | -- | 6,963,031(+) | C/T | upstream_transcript_variant | |
| rs1005677858 | -- | 6,963,176(+) | G/T | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1035811 | CNV | gain | 25217958 |
| nsv1047373 | CNV | gain | 25217958 |
| nsv509453 | CNV | insertion | 20534489 |
Additional Variant Information for MIR200C Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR200C
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR200C Gene
Disorders for MIR200C Gene
Additional Disease Information for MIR200C
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for MIR200C Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR200C Gene
Publications for MIR200C Gene
- Long non-coding RNA LUCAT1 modulates methotrexate resistance in osteosarcoma via miR-200c/ABCB1 axis. (PMID: 29170124) Han Z … Shi L (Biochemical and biophysical research communications 2018) 3 58
- Garcinol downregulates Notch1 signaling via modulating miR-200c and suppresses oncogenic properties of PANC-1 cancer stem-like cells. (PMID: 26400206) Huang CC … Lee WH (Biotechnology and applied biochemistry 2017) 3 58
- The correlation between miR-200c and the severity of interstitial lung disease associated with different connective tissue diseases. (PMID: 27309544) Jiang Z … Li XP (Scandinavian journal of rheumatology 2017) 3 58
- Decreased expression of VLDLR is inversely correlated with miR-200c in human colorectal cancer. (PMID: 28112443) Kim BK … Yoon SK (Molecular carcinogenesis 2017) 3 58
- MicroRNA-200c plays an oncogenic role in nasopharyngeal carcinoma by targeting PTEN. (PMID: 28459373) Zhang ZZ … Zhang W (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 58
Products for MIR200C Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
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- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
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- Browse OriGene Antibodies
- Custom Antibody Services
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- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR200C
- Origene Custom Protein Services for MIR200C
- Browse OriGene Inhibitory RNA Products For MIR200C
- Browse OriGene qPCR primer pairs and template standards
- Browse CRISPR knockouts for MIR200C
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MIR200C
- GenScript: Custom all cDNA clones Services for MIR200C
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- Design optimal peptide antigens
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- Browse Antibodies at Cloud-Clone Corp.
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- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR200C
- VectorBuilder custom plasmid, inducible vectors for MIR200C
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR200C
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MIR200C
- Search GeneTex for Antibodies for MIR200C
- Search GeneTex for Proteins for MIR200C
Sources for MIR200C Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew