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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR200C (MicroRNA 200c) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR200C include Endometrial Cancer and Renal Cell Carcinoma, Nonpapillary. Among its related pathways are miRNA targets in ECM and membrane receptors and MicroRNAs in cancer.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH12J006923 | Promoter/Enhancer | 2.6 | EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER | 11.8 | -36.3 | -36327 | 7.3 | SP1 GATAD2A CTCF PRDM10 ZNF629 RFX1 IKZF1 ZNF692 POLR2A BACH1 | ATN1 HSALNG0088942 ZNF384 LRRC23 CHD4 ENSG00000219410 SPSB2 ENSG00000247853 SCARNA12 EMG1 | |
GH12J007004 | Enhancer | 0.5 | Ensembl | 11.6 | +43.6 | 43610 | 6.6 | ZNF600 SPI1 HNF4A RXRA PRDM10 MAFK HLF SP1 | RF00998-028 lnc-PHB2-5 EMG1 C1R C1RL PHB2 SCARNA12 MIR141 MIR200C MIR200CHG | |
GH12J006940 | Promoter/Enhancer | 2.7 | EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER | 0.4 | -10.0 | -10036 | 25.9 | ZNF221 ARHGAP35 CEBPG SP1 HNRNPL CREB1 GATAD2A CTCF TEAD4 PRDM10 | EMG1 PTPN6 MN309532 MIR200CHG C12orf57 ZNF384 ENSG00000219410 CHD4 ENSG00000247853 SPSB2 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003730 | mRNA 3'-UTR binding | IDA | 29778524 |
GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 23765923 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | MicroRNAs in cancer | ||
2 | miRNA targets in ECM and membrane receptors |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001818 | negative regulation of cytokine production | IDA | 27529418 |
GO:0010976 | positive regulation of neuron projection development | ISS | 28008308 |
GO:0030948 | negative regulation of vascular endothelial growth factor receptor signaling pathway | IMP | 24205206 |
GO:0034976 | response to endoplasmic reticulum stress | ISS | 28008308 |
GO:0035195 | gene silencing by miRNA | IDA,IEA | -- |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS0000192F9C_9606 | miRNA | 23 | 6 |
RefSeq: NR_029779, LncBase: hsa-miR-200c-3p, miRBase: MIMAT0000617, MirGeneDB: Hsa-Mir-8-P2b_3p, TarBase: hsa-miR-200c-3p, |
URS0000346F1C_9606 | miRNA | 22 | 6 |
RefSeq: NR_029779, LncBase: hsa-miR-200c-5p, miRBase: MIMAT0004657, MirGeneDB: Hsa-Mir-8-P2b_5p, TarBase: hsa-miR-200c-5p, |
URS0000171525_9606 | precursor_RNA | 68 | 5 |
HGNC: 31580, RefSeq: NR_029779, Ensembl: ENST00000384980 (view in UCSC) , miRBase: MI0000650, |
URS00006521EF_9606 | precursor_RNA | 78 | 1 |
Rfam: RF00241, |
URS0000EFE042_9606 | precursor_RNA | 63 | 1 |
MirGeneDB: Hsa-Mir-8-P2b, |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-200c 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | mdo-mir-200c 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | bta-mir-200c 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | cfa-mir-200c 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Mir200c 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | dre-mir-200c 31 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | csa-mir-141 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1035811 | CNV | gain | 25217958 |
nsv1047373 | CNV | gain | 25217958 |
nsv509453 | CNV | insertion | 20534489 |
Disorder | Aliases | PubMed IDs |
---|---|---|
endometrial cancer |
|
|
renal cell carcinoma, nonpapillary |
|
|
ovarian cancer |
|
|
gastric cancer |
|
|
lung cancer |
|