microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR200C Gene

RNA type for MIR200C Gene

miRNA

Aliases for MIR200C Gene

External Ids for MIR200C Gene

Previous HGNC Symbols for MIR200C Gene

  • MIRN200C

Previous GeneCards Identifiers for MIR200C Gene

  • GC12P006971
  • GC12P006974
  • GC12P007072
  • GC12P007027
  • GC12P007176
  • GC12P007585
  • GC12P007638
  • GC12P007691
  • GC12P007878
  • GC12P007219
  • GC12P007270
  • GC12P007325
  • GC12P007369
  • GC12P007414
  • GC12P007458
  • GC12P007501
  • GC12P007545
  • GC12P008229
  • GC12P009004

Summaries for MIR200C Gene

Entrez Gene Summary for MIR200C Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR200C Gene

MIR200C (MicroRNA 200c) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR200C include Endometrial Cancer and Renal Cell Carcinoma, Nonpapillary. Among its related pathways are MicroRNAs in cancer and miRNA targets in ECM and membrane receptors.

Rfam classification for MIR200C Gene

  • mir-8/mir-141/mir-200 microRNA precursor family

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR200C Gene

Genomics for MIR200C Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR200C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J006923 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.8 -36.3 -36327 7.3 BCLAF1 SP1 ZNF600 IKZF1 ZNF654 NCOR1 JUND CEBPA ZNF223 POLR2A ATN1 HSALNG0088942 MK280091 ZNF384 CHD4 ENSG00000219410 LRRC23 SPSB2 ENSG00000247853 SCARNA12
GH12J007004 Enhancer 0.5 Ensembl 11.6 +43.6 43610 6.6 ZNF600 RXRA PRDM10 SPI1 HNF4A MAFK HLF SP1 RF00998-028 lnc-PHB2-5 EMG1 C1R C1RL PHB2 SCARNA12 MIR141 MIR200C MIR200CHG
GH12J006940 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.4 -10.0 -10036 25.9 BCLAF1 SP1 ZNF654 ZNF207 NCOR1 MYC ZNF600 IKZF1 SSRP1 ZNF580 EMG1 PTPN6 MN309532 MIR200CHG C12orf57 ZNF384 ENSG00000219410 CHD4 ENSG00000247853 SPSB2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR200C on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR200C Gene

Latest Assembly
chr12:6,963,694-6,963,771
(GRCh38/hg38)
Size:
78 bases
Orientation:
Plus strand

Previous Assembly
chr12:7,072,862-7,072,929
(GRCh37/hg19 by Entrez Gene)
Size:
68 bases
Orientation:
Plus strand

chr12:7,072,862-7,072,929
(GRCh37/hg19 by Ensembl)
Size:
68 bases
Orientation:
Plus strand

Genomic View for MIR200C Gene

Genes around MIR200C on UCSC Golden Path with GeneCards custom track
MIR200C in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR200C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR200C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR200C Gene

Proteins for MIR200C Gene

Post-translational modifications for MIR200C Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR200C Gene

Domains & Families for MIR200C Gene

Gene Families for MIR200C Gene

genes like me logo Genes that share domains with MIR200C: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR200C Gene

Function for MIR200C Gene

Phenotypes From GWAS Catalog for MIR200C Gene

Gene Ontology (GO) - Molecular Function for MIR200C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003730 mRNA 3'-UTR binding IDA 29778524
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 23765923
genes like me logo Genes that share ontologies with MIR200C: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR200C Gene

Localization for MIR200C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR200C gene
Compartment Confidence
extracellular 3
cytoskeleton 3
plasma membrane 2
mitochondrion 2
nucleus 2
endosome 2
cytosol 2
peroxisome 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR200C Gene

Pathways & Interactions for MIR200C Gene

genes like me logo Genes that share pathways with MIR200C: view

Pathways by source for MIR200C Gene

1 BioSystems pathway for MIR200C Gene
1 KEGG pathway for MIR200C Gene

Gene Ontology (GO) - Biological Process for MIR200C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001818 negative regulation of cytokine production IDA 27529418
GO:0010976 positive regulation of neuron projection development ISS 28008308
GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway IMP 24205206
GO:0034976 response to endoplasmic reticulum stress ISS 28008308
GO:0035195 gene silencing by miRNA IDA,IEA --
genes like me logo Genes that share ontologies with MIR200C: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR200C Gene

Drugs & Compounds for MIR200C Gene

No Compound Related Data Available

Transcripts for MIR200C Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR200C Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS0000192F9C_9606 miRNA 23 6

RefSeq: NR_029779,

LncBase: hsa-miR-200c-3p,

miRBase: MIMAT0000617,

MirGeneDB: Hsa-Mir-8-P2b_3p,

TarBase: hsa-miR-200c-3p,

ENA: LM379140.1:1..23:ncRNA, LM608608.1:44..66:ncRNA,

URS0000346F1C_9606 miRNA 22 6

RefSeq: NR_029779,

LncBase: hsa-miR-200c-5p,

miRBase: MIMAT0004657,

MirGeneDB: Hsa-Mir-8-P2b_5p,

TarBase: hsa-miR-200c-5p,

ENA: LM380321.1:1..22:ncRNA, LM608608.1:5..26:ncRNA,

URS0000171525_9606 pre_miRNA 68 4

RefSeq: NR_029779,

Ensembl: ENST00000384980 (view in UCSC) ,

miRBase: MI0000650,

ENA: LM608608.1:1..68:precursor_RNA,

URS00006521EF_9606 pre_miRNA 78 1

Rfam: RF00241,

URS0001BC9AAB_9606 pre_miRNA 78 1

Rfam: RF00241,

MIR200C in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR200C Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR200C Gene

No ASD Table

Relevant External Links for MIR200C Gene

GeneLoc Exon Structure for
MIR200C

Expression for MIR200C Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR200C

Evidence on tissue expression from TISSUES for MIR200C Gene

  • Blood(2.1)
  • Intestine(2.1)
No Expression Related Data Available

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR200C Gene

Orthologs for MIR200C Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR200C Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-200c 30
  • 100 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-200c 30
  • 91 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-200c 30
  • 85 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-200c 30
  • 85 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir200c 30
  • 72 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-200c 30
  • 48 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea csa-mir-141 30
  • 44 (a)
OneToMany
Species where no ortholog for MIR200C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR200C Gene

ENSEMBL:
Gene Tree for MIR200C (if available)
TreeFam:
Gene Tree for MIR200C (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR200C

Paralogs for MIR200C Gene

No data available for Paralogs for MIR200C Gene

Variants for MIR200C Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR200C Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR200C Gene

Variant ID Type Subtype PubMed ID
nsv1035811 CNV gain 25217958
nsv1047373 CNV gain 25217958
nsv509453 CNV insertion 20534489

Additional Variant Information for MIR200C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR200C
Leiden Open Variation Database (LOVD)
MIR200C

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR200C Gene

Disorders for MIR200C Gene

MalaCards: The human disease database

(38) MalaCards diseases for MIR200C Gene - From: MID, COP, and GCD

Disorder Aliases PubMed IDs
endometrial cancer
  • endometrial cancer, familial
renal cell carcinoma, nonpapillary
  • rcc
ovarian cancer
  • ovarian cancer, somatic
gastric cancer
  • gastric cancer, somatic
lung cancer
  • lung cancer, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR200C

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with MIR200C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR200C Gene

Publications for MIR200C Gene

  1. Inflammatory Breast Carcinoma: Elevated microRNA miR-181b-5p and Reduced miR-200b-3p, miR-200c-3p, and miR-203a-3p Expression as Potential Biomarkers with Diagnostic Value. (PMID: 32708601) Fahim SA … Ibrahim SA (Biomolecules 2020) 3
  2. miR-200c/PAI-2 promotes the progression of triple negative breast cancer via M1/M2 polarization induction of macrophage. (PMID: 31801690) Meng Z … Zhang S (International immunopharmacology 2020) 3
  3. MiR-200c-3p suppression is associated with development of acquired resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors in EGFR mutant non-small cell lung cancer via a mediating epithelial-to-mesenchymal transition (EMT) process. (PMID: 32417760) Wang HY … Shih JY (Cancer biomarkers : section A of Disease markers 2020) 3
  4. Exosomal miR-200c suppresses chemoresistance of docetaxel in tongue squamous cell carcinoma by suppressing TUBB3 and PPP2R1B. (PMID: 32310826) Cui J … Ma J (Aging 2020) 3
  5. MiR-200c sensitizes Olaparib-resistant ovarian cancer cells by targeting Neuropilin 1. (PMID: 31898520) Vescarelli E … Ceccarelli S (Journal of experimental & clinical cancer research : CR 2020) 3

Products for MIR200C Gene

Sources for MIR200C Gene