Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR200C Gene

Subcategory (RNA class) for MIR200C Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR200C Gene

  • MicroRNA 200c 2 3 5
  • Hsa-Mir-200c 3
  • Mir-200c 3
  • MIRN200C 3

External Ids for MIR200C Gene

ORGUL Members for MIR200C Gene

Previous HGNC Symbols for MIR200C Gene

  • MIRN200C

Previous GeneCards Identifiers for MIR200C Gene

  • GC12P006971
  • GC12P006974
  • GC12P007072
  • GC12P007027
  • GC12P007176
  • GC12P007219
  • GC12P007270
  • GC12P007325
  • GC12P007369
  • GC12P007414

Summaries for MIR200C Gene

Entrez Gene Summary for MIR200C Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR200C Gene

MIR200C (MicroRNA 200c) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are miRNA targets in ECM and membrane receptors and MicroRNAs in cancer.

Additional gene information for MIR200C Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR200C Gene

Genomics for MIR200C Gene

GeneHancer (GH) Regulatory Elements for MIR200C Gene

Promoters and enhancers for MIR200C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I006923 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.8 -36.5 -36548 6.8 HDGF SMAD1 ARID4B SIN3A ZNF2 IRF4 YY1 ZNF213 ZNF143 FOS ATN1 ZNF384 LRRC23 CHD4 ENSG00000219410 ENSG00000247853 SCARNA12 EMG1 PHB2 RPL13P5
GH12I006930 Enhancer 0.2 dbSUPER 11.8 -32.6 -32641 0.4 MIR141 MIR200C MIR200CHG SCARNA12 EMG1 PHB2 SPSB2 RPL13P5 LRRC23 TPI1
GH12I006940 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 0.4 -10.0 -10041 25.9 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 PTPN6 C12orf57 ZNF384 ENSG00000219410 CHD4 ENSG00000247853 SPSB2 SCARNA12 ENSG00000256967 NCAPD2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR200C on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR200C Gene

Genomic Locations for MIR200C Gene
chr12:6,963,699-6,963,766
(GRCh38/hg38)
Size:
68 bases
Orientation:
Plus strand
chr12:7,072,862-7,072,929
(GRCh37/hg19)

Genomic View for MIR200C Gene

Genes around MIR200C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR200C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR200C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR200C Gene

Proteins for MIR200C Gene

Post-translational modifications for MIR200C Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR200C Gene

Domains & Families for MIR200C Gene

Gene Families for MIR200C Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR200C: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR200C Gene

Function for MIR200C Gene

Phenotypes From GWAS Catalog for MIR200C Gene

Gene Ontology (GO) - Molecular Function for MIR200C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 23765923
genes like me logo Genes that share ontologies with MIR200C: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR200C Gene

Localization for MIR200C Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR200C Gene

Pathways & Interactions for MIR200C Gene

genes like me logo Genes that share pathways with MIR200C: view

Pathways by source for MIR200C Gene

1 BioSystems pathway for MIR200C Gene
1 KEGG pathway for MIR200C Gene

Interacting Proteins for MIR200C Gene

Gene Ontology (GO) - Biological Process for MIR200C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA 23765923
GO:0045603 positive regulation of endothelial cell differentiation IDA 23765923
GO:1905562 NOT regulation of vascular endothelial cell proliferation IDA 23765923
GO:1905772 positive regulation of mesodermal cell differentiation IDA 23765923
genes like me logo Genes that share ontologies with MIR200C: view

No data available for SIGNOR curated interactions for MIR200C Gene

Drugs & Compounds for MIR200C Gene

No Compound Related Data Available

Transcripts for MIR200C Gene

mRNA/cDNA for MIR200C Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR200C Gene

No ASD Table

Relevant External Links for MIR200C Gene

GeneLoc Exon Structure for
MIR200C
ECgene alternative splicing isoforms for
MIR200C

Expression for MIR200C Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR200C Gene:

MIR200C
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR200C Gene

Orthologs for MIR200C Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR200C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-200c 34
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-200c 34
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-200c 34
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-200c 34
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir200c 34
  • 72 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-200c 34
  • 48 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-141 34
  • 44 (a)
OneToMany
Species where no ortholog for MIR200C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR200C Gene

ENSEMBL:
Gene Tree for MIR200C (if available)
TreeFam:
Gene Tree for MIR200C (if available)

Paralogs for MIR200C Gene

No data available for Paralogs for MIR200C Gene

Variants for MIR200C Gene

Sequence variations from dbSNP and Humsavar for MIR200C Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1001110105 -- 6,963,829(+) C/A downstream_transcript_variant
rs1001273984 -- 6,964,080(+) G/A downstream_transcript_variant
rs1001417130 -- 6,963,487(+) C/A/T upstream_transcript_variant
rs1005625574 -- 6,963,031(+) C/T upstream_transcript_variant
rs1005677858 -- 6,963,176(+) G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR200C Gene

Variant ID Type Subtype PubMed ID
nsv1035811 CNV gain 25217958
nsv1047373 CNV gain 25217958
nsv509453 CNV insertion 20534489

Additional Variant Information for MIR200C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR200C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR200C Gene

Disorders for MIR200C Gene

Additional Disease Information for MIR200C

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MIR200C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR200C Gene

Publications for MIR200C Gene

  1. Long non-coding RNA LUCAT1 modulates methotrexate resistance in osteosarcoma via miR-200c/ABCB1 axis. (PMID: 29170124) Han Z … Shi L (Biochemical and biophysical research communications 2018) 3 58
  2. Garcinol downregulates Notch1 signaling via modulating miR-200c and suppresses oncogenic properties of PANC-1 cancer stem-like cells. (PMID: 26400206) Huang CC … Lee WH (Biotechnology and applied biochemistry 2017) 3 58
  3. The correlation between miR-200c and the severity of interstitial lung disease associated with different connective tissue diseases. (PMID: 27309544) Jiang Z … Li XP (Scandinavian journal of rheumatology 2017) 3 58
  4. Decreased expression of VLDLR is inversely correlated with miR-200c in human colorectal cancer. (PMID: 28112443) Kim BK … Yoon SK (Molecular carcinogenesis 2017) 3 58
  5. MicroRNA-200c plays an oncogenic role in nasopharyngeal carcinoma by targeting PTEN. (PMID: 28459373) Zhang ZZ … Zhang W (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 58

Products for MIR200C Gene

Sources for MIR200C Gene

Content
Loading form....