microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR200B Gene

Subcategory (RNA class) for MIR200B Gene

miRNA

Quality Score for this RNA gene is

17

Aliases for MIR200B Gene

  • MicroRNA 200b 2 3 5
  • Hsa-MiR-200b-5p 168 179
  • Hsa-MiR-200b-3p 168 179
  • Hsa-Mir-200b 3
  • MIMAT0000318 53
  • MIMAT0004571 53
  • MI0000342 53
  • Mir-200b 3
  • MIRN200B 3
  • MIR200B 2
  • RF00241 174

External Ids for MIR200B Gene

Previous HGNC Symbols for MIR200B Gene

  • MIRN200B

Previous GeneCards Identifiers for MIR200B Gene

  • GC01P001100
  • GC01P001103
  • GC01P001106
  • GC01P001114
  • GC01P001127

Summaries for MIR200B Gene

Entrez Gene Summary for MIR200B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR200B Gene

MIR200B (MicroRNA 200b) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR200B include Cholangiocarcinoma and Hepatocellular Carcinoma. Among its related pathways are MicroRNAs in cancer and miRNA targets in ECM and membrane receptors.

Rfam classification for MIR200B Gene

  • mir-8/mir-141/mir-200 microRNA precursor family

Additional gene information for MIR200B Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR200B Gene

Genomics for MIR200B Gene

GeneHancer (GH) Regulatory Elements for MIR200B Gene

Promoters and enhancers for MIR200B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J001168 Enhancer 0.5 dbSUPER 750.6 +1.3 1274 0.6 HNF1A GLIS2 SOX13 GATAD2A SAP130 POLR2A ARID4B RARA ENSG00000272141 MIR200A MIR200B MIR429 RF00241
GH01J001109 Enhancer 0.8 ENCODE 11.7 -57.2 -57245 1.1 ZBTB40 SMARCE1 L3MBTL2 TEAD4 GTF2F1 SMARCA4 TRIM24 MTA1 IKZF1 DPF2 lnc-RNF223-4 piR-58273 LINC01786 UBE2J2 MIR200A MIR200B MIR429 PERM1 PLEKHN1 C1orf159
GH01J001189 Enhancer 0.5 FANTOM5 Ensembl 13.6 +22.3 22297 2 LARP7 SDF4 B3GALT6 MIR200A MIR200B MIR429 UBE2J2 LINC01786 C1QTNF12 TNFRSF18 ENSG00000237094
GH01J001108 Enhancer 0.5 Ensembl 11.7 -58.5 -58503 0.8 ZNF785 ZBTB5 ZNF146 YY2 ZNF558 piR-40348-001 lnc-RNF223-4 LINC01786 UBE2J2 MIR200A MIR200B MIR429 PERM1 PLEKHN1 C1orf159
GH01J001110 Enhancer 0.3 Ensembl 11.7 -56.2 -56203 0.2 MLLT1 ZBTB33 lnc-RNF223-4 piR-58273 LINC01786 UBE2J2 MIR200A MIR200B MIR429 PERM1 PLEKHN1 C1orf159
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR200B on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR200B Gene

Genomic Locations for MIR200B Gene
chr1:1,167,104-1,167,198
(GRCh38/hg38)
Size:
95 bases
Orientation:
Plus strand
chr1:1,102,484-1,102,578
(GRCh37/hg19)
Size:
95 bases
Orientation:
Plus strand

Genomic View for MIR200B Gene

Genes around MIR200B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR200B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR200B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR200B Gene

Proteins for MIR200B Gene

Post-translational modifications for MIR200B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR200B Gene

Domains & Families for MIR200B Gene

Gene Families for MIR200B Gene

genes like me logo Genes that share domains with MIR200B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR200B Gene

Function for MIR200B Gene

Phenotypes From GWAS Catalog for MIR200B Gene

Gene Ontology (GO) - Molecular Function for MIR200B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 21081489
genes like me logo Genes that share ontologies with MIR200B: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR200B Gene

Localization for MIR200B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR200B gene
Compartment Confidence
cytoskeleton 2
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MIR200B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016442 RISC complex IEA --
genes like me logo Genes that share ontologies with MIR200B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR200B Gene

Pathways & Interactions for MIR200B Gene

genes like me logo Genes that share pathways with MIR200B: view

Pathways by source for MIR200B Gene

1 BioSystems pathway for MIR200B Gene
1 KEGG pathway for MIR200B Gene

Gene Ontology (GO) - Biological Process for MIR200B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IMP 16762633
GO:0010629 negative regulation of gene expression IMP 21081489
GO:0010832 negative regulation of myotube differentiation ISS --
GO:0016525 negative regulation of angiogenesis IDA 21081489
GO:0035195 gene silencing by miRNA IMP 16762633
genes like me logo Genes that share ontologies with MIR200B: view

No data available for SIGNOR curated interactions for MIR200B Gene

Drugs & Compounds for MIR200B Gene

No Compound Related Data Available

Transcripts for MIR200B Gene

mRNA/cDNA for MIR200B Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(4) RNACentral transcripts :
(6) ENA transcripts :
(3) miRBase transcripts :
(2) TarBase transcripts :
(1) Rfam transcripts :
(2) LncBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR200B Gene

No ASD Table

Relevant External Links for MIR200B Gene

GeneLoc Exon Structure for
MIR200B
ECgene alternative splicing isoforms for
MIR200B

Expression for MIR200B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR200B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR200B Gene:

MIR200B
genes like me logo Genes that share expression patterns with MIR200B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR200B Gene

Orthologs for MIR200B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR200B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-200b 33
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir200b 33
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-200b 33
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-200b 33
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-200b 33
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-200b 33
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-200b 33
  • 70 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-200b 33
  • 72 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-141 33
  • 55 (a)
OneToMany
Species where no ortholog for MIR200B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR200B Gene

ENSEMBL:
Gene Tree for MIR200B (if available)
TreeFam:
Gene Tree for MIR200B (if available)

Paralogs for MIR200B Gene

No data available for Paralogs for MIR200B Gene

Variants for MIR200B Gene

Sequence variations from dbSNP and Humsavar for MIR200B Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000093724 -- 1,165,627(+) G/A upstream_transcript_variant
rs1001809323 -- 1,167,265(+) C/T downstream_transcript_variant
rs1002116517 -- 1,166,535(+) C/A upstream_transcript_variant
rs1002550980 -- 1,166,345(+) C/T upstream_transcript_variant
rs1004142633 -- 1,166,788(+) C/A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR200B Gene

Variant ID Type Subtype PubMed ID
dgv2n67 CNV gain 20364138
nsv1003578 CNV gain 25217958
nsv10161 CNV gain+loss 18304495
nsv1160644 CNV deletion 26073780
nsv1160772 CNV duplication 26073780
nsv428334 CNV gain 18775914
nsv469848 CNV gain 16826518
nsv470680 CNV loss 18288195
nsv482937 CNV loss 15286789
nsv509257 CNV insertion 20534489
nsv517709 CNV gain+loss 19592680
nsv544947 CNV loss 21841781
nsv544954 CNV loss 21841781
nsv950452 CNV deletion 24416366

Additional Variant Information for MIR200B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR200B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR200B Gene

Disorders for MIR200B Gene

MalaCards: The human disease database

(16) MalaCards diseases for MIR200B Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
cholangiocarcinoma
  • cca
hepatocellular carcinoma
  • hcc
ovarian cancer
  • ovarian cancer, somatic
prostate cancer
  • prostate cancer, somatic
lung cancer
  • adenocarcinoma of lung
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR200B

genes like me logo Genes that share disorders with MIR200B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR200B Gene

Publications for MIR200B Gene

  1. Long non-coding RNA ZEB1-AS1 regulates miR-200b/FSCN1 signaling and enhances migration and invasion induced by TGF-β1 in bladder cancer cells. (PMID: 30823924) Gao R … Bi J (Journal of experimental & clinical cancer research : CR 2019) 3 56
  2. MicroRNA-200b and -301 are associated with gemcitabine response as biomarkers in pancreatic carcinoma cells. (PMID: 30628651) Funamizu N … Manome Y (International journal of oncology 2019) 3 56
  3. Long non-coding RNA ZFAS1 regulates the malignant progression of gastric cancer via the microRNA-200b-3p/Wnt1 axis. (PMID: 30999814) Zhang F … Xu H (Bioscience, biotechnology, and biochemistry 2019) 3 56
  4. The role of the miR-200 family in epithelial-mesenchymal transition in colorectal cancer: a systematic review. (PMID: 29388209) O'Brien SJ … Galandiuk S (International journal of cancer 2018) 3 56
  5. DNA methylation regulated microRNAs in human cervical cancer. (PMID: 29077234) Varghese VK … Satyamoorthy K (Molecular carcinogenesis 2018) 3 56

Products for MIR200B Gene

Sources for MIR200B Gene