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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...
Aliases for MIR200B Gene
Subcategory (RNA class) for MIR200B Gene
miRNA
Number of RNA Genes sources:
6 / 17
Aliases for MIR200B Gene
External Ids for MIR200B Gene
- HGNC: 31579
- Entrez Gene: 406984
- Ensembl: ENSG00000207730
- OMIM: 612091
- miRBase: hsa-mir-200b
Previous HGNC Symbols for MIR200B Gene
- MIRN200B
Previous GeneCards Identifiers for MIR200B Gene
- GC01P001100
- GC01P001103
- GC01P001106
- GC01P001114
- GC01P001127
Summaries for MIR200B Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR200B Gene
MIR200B (MicroRNA 200b) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR200B include Cholangiocarcinoma and Ovarian Cancer. Among its related pathways are miRNA targets in ECM and membrane receptors and MicroRNAs in cancer.
Rfam classification for MIR200B Gene
-
mir-8/mir-141/mir-200 microRNA precursor family
Additional gene information for MIR200B Gene
- HGNC(31579)
- Entrez Gene(406984)
- Ensembl(ENSG00000207730)
- OMIM(612091)
- Open Targets Platform(ENSG00000207730)
- Search for MIR200B at DataMed
- Search for MIR200B at HumanCyc
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR200B Gene
Genomics for MIR200B Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MIR200B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MIR200B on the GeneHancer Hub at the UCSC Golden Path
Genomic Locations for MIR200B Gene
Genomic Locations for MIR200B Gene
- chr1:1,167,104-1,167,198
- (GRCh38/hg38)
- Size:
- 95 bases
- Orientation:
- Plus strand
- chr1:1,102,484-1,102,578
- (GRCh37/hg19)
- Size:
- 95 bases
- Orientation:
- Plus strand
Genomic View for MIR200B Gene
Genes around MIR200B on UCSC Golden Path with GeneCards custom track
MIR200B in the GeneCards ncRNA compendium hub on the UCSC Golden Path
- Cytogenetic band:
-
- 1p36.33 by HGNC
- 1p36.33 by Entrez Gene
- 1p36.33 by Ensembl
MIR200B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR200B Gene
Proteins for MIR200B Gene
Post-translational modifications for MIR200B Gene
No Post-translational modifications
Antibody Products
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR200B
- Origene Custom Protein Services for MIR200B
No data available for DME Specific Peptides for MIR200B Gene
Domains & Families for MIR200B Gene
Gene Families for MIR200B Gene
No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR200B Gene
Function for MIR200B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003730 | mRNA 3'-UTR binding | IDA | 29778524 |
| GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 21081489 |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MIR200B - Select products 50% OFF >
- * MIR200B CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Browse CRISPR knockouts for MIR200B
miRNA Products
Inhibitory RNA Products
Clone Products
- Applied Biological Materials (abm): Clones for MIR200B - Select products 50% OFF >
- * MIR200B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Addgene plasmids for MIR200B
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR200B Gene
Localization for MIR200B Gene
| Compartment | Confidence |
|---|---|
| extracellular | 3 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| cytosol | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR200B Gene
Pathways & Interactions for MIR200B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | MicroRNAs in cancer | ||
| 2 | miRNA targets in ECM and membrane receptors | ||
Pathways by source for MIR200B Gene
1 BioSystems pathway for MIR200B Gene
1 KEGG pathway for MIR200B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008284 | positive regulation of cell proliferation | IMP | 16762633 |
| GO:0010629 | negative regulation of gene expression | IMP | 21081489 |
| GO:0010832 | negative regulation of myotube differentiation | ISS | -- |
| GO:0016525 | negative regulation of angiogenesis | IDA | 21081489 |
| GO:0035195 | gene silencing by miRNA | IMP | 16762633 |
No data available for Interacting Proteins and SIGNOR curated interactions for MIR200B Gene
Transcripts for MIR200B Gene
Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR200B Gene
| RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
|---|---|---|---|---|
| URS000012A1DD_9606 | miRNA | 22 | 6 |
RefSeq: NR_029639, LncBase: hsa-miR-200b-5p, miRBase: MIMAT0004571, MirGeneDB: Hsa-Mir-8-P2a_5p, TarBase: hsa-miR-200b-5p, |
| URS000075C8DF_9606 | precursor_RNA | 95 | 5 |
HGNC: 31579, RefSeq: NR_029639, Ensembl: ENST00000384997 (view in UCSC) , miRBase: MI0000342, |
| URS000014D9C1_9606 | miRNA | 22 | 5 |
RefSeq: NR_029639, LncBase: hsa-miR-200b-3p, miRBase: MIMAT0000318, TarBase: hsa-miR-200b-3p, ENA: AJ535828.1:1..22:ncRNA, LM378951.1:1..22:ncRNA, LM608401.1:57..78:ncRNA, |
| URS0000650AFF_9606 | precursor_RNA | 74 | 1 |
Rfam: RF00241, |
| URS0000EFCEDB_9606 | precursor_RNA | 60 | 1 |
MirGeneDB: Hsa-Mir-8-P2a, |
MIR200B in the GeneCards ncRNA compendium hub on the UCSC Golden Path
Additional transcripts not in RNAcentral for MIR200B Gene
- 1 NCBI additional mRNA sequence :
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MIR200B - Select products 50% OFF >
- * MIR200B CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Browse CRISPR knockouts for MIR200B
miRNA Products
Inhibitory RNA Products
Clone Products
- Applied Biological Materials (abm): Clones for MIR200B - Select products 50% OFF >
- * MIR200B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Addgene plasmids for MIR200B
Relevant External Links for MIR200B Gene
- GeneLoc Exon Structure for
- MIR200B
Expression for MIR200B Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR200B
Evidence on tissue expression from TISSUES for MIR200B Gene
- Blood(2.3)
- Intestine(2.3)
- Liver(2.2)
- Kidney(2.2)
- Heart(2.1)
- Lymph node(2.1)
- Urine(2.1)
- Nervous system(2.1)
- Skin(2.1)
- Pancreas(2)
- Lung(2)
- Muscle(2)
Primer Products
-
OriGene qPCR primer pairs for MIR200B
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR200B Gene
Orthologs for MIR200B Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Cow (Bos Taurus) |
Mammalia | bta-mir-200b 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Mir200b 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | cfa-mir-200b 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | mdo-mir-200b 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | oan-mir-200b 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | gga-mir-200b 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | aca-mir-200b 31 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | dre-mir-200b 31 |
|
OneToOne | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | csa-mir-141 31 |
|
OneToMany |
- Species where no ortholog for MIR200B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Paralogs for MIR200B Gene
No data available for Paralogs for MIR200B Gene
Variants for MIR200B Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv2n67 | CNV | gain | 20364138 |
| nsv1003578 | CNV | gain | 25217958 |
| nsv10161 | CNV | gain+loss | 18304495 |
| nsv1160644 | CNV | deletion | 26073780 |
| nsv1160772 | CNV | duplication | 26073780 |
| nsv428334 | CNV | gain | 18775914 |
| nsv469848 | CNV | gain | 16826518 |
| nsv470680 | CNV | loss | 18288195 |
| nsv482937 | CNV | loss | 15286789 |
| nsv509257 | CNV | insertion | 20534489 |
| nsv517709 | CNV | gain+loss | 19592680 |
| nsv544947 | CNV | loss | 21841781 |
| nsv544954 | CNV | loss | 21841781 |
| nsv950452 | CNV | deletion | 24416366 |
Additional Variant Information for MIR200B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR200B
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR200B Gene
Disorders for MIR200B Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cholangiocarcinoma |
|
|
| ovarian cancer |
|
|
| prostate cancer |
|
|
| hepatocellular carcinoma |
|
|
| lung cancer |
|
Search MIR200B in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MIR200B
No data available for UniProtKB/Swiss-Prot and Genatlas for MIR200B Gene
Publications for MIR200B Gene
- Arrestin Domain Containing 3 Reverses Epithelial to Mesenchymal Transition and Chemo-Resistance of TNBC Cells by Up-Regulating Expression of miR-200b. (PMID: 31295851) Soung YH … Chung J (Cells 2019) 3
- MiR-200b-3p Functions as an Oncogene by Targeting ABCA1 in Lung Adenocarcinoma. (PMID: 31795847) Liu K … Zhao J (Technology in cancer research & treatment 2019) 3
- Long non-coding RNA CCAT2 acts as an oncogene in osteosarcoma through regulation of miR-200b/VEGF. (PMID: 31322006) Liu J … Li J (Artificial cells, nanomedicine, and biotechnology 2019) 3
- Knockdown of circDENND4C inhibits glycolysis, migration and invasion by up-regulating miR-200b/c in breast cancer under hypoxia. (PMID: 31488193) Ren S … Zhang Y (Journal of experimental & clinical cancer research : CR 2019) 3
- Autocrine TGF-β1/miR-200s/miR-221/DNMT3B regulatory loop maintains CAF status to fuel breast cancer cell proliferation. (PMID: 30851420) Tang X … Hou Y (Cancer letters 2019) 3
ExternalLinks
Products for MIR200B Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR200B
- Origene Custom Protein Services for MIR200B
- Browse OriGene Inhibitory RNA Products For MIR200B
- OriGene qPCR primer pairs for MIR200B
- Browse CRISPR knockouts for MIR200B
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MIR200B
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Addgene plasmids for MIR200B
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for MIR200B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for MIR200B
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MIR200B
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for MIR200B
Sources for MIR200B Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB