Free for academic non-profit institutions. Other users need a Commercial license
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR200B (MicroRNA 200b) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR200B include Cholangiocarcinoma and Ovarian Cancer. Among its related pathways are miRNA targets in ECM and membrane receptors and MicroRNAs in cancer.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003730 | mRNA 3'-UTR binding | IDA | 29778524 |
GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 21081489 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | MicroRNAs in cancer | ||
2 | miRNA targets in ECM and membrane receptors |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0008284 | positive regulation of cell proliferation | IMP | 16762633 |
GO:0010629 | negative regulation of gene expression | IMP | 21081489 |
GO:0010832 | negative regulation of myotube differentiation | ISS | -- |
GO:0016525 | negative regulation of angiogenesis | IDA | 21081489 |
GO:0035195 | gene silencing by miRNA | IMP | 16762633 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000012A1DD_9606 | miRNA | 22 | 6 |
RefSeq: NR_029639, LncBase: hsa-miR-200b-5p, miRBase: MIMAT0004571, MirGeneDB: Hsa-Mir-8-P2a_5p, TarBase: hsa-miR-200b-5p, |
URS000075C8DF_9606 | precursor_RNA | 95 | 5 |
HGNC: 31579, RefSeq: NR_029639, Ensembl: ENST00000384997 (view in UCSC) , miRBase: MI0000342, |
URS000014D9C1_9606 | miRNA | 22 | 5 |
RefSeq: NR_029639, LncBase: hsa-miR-200b-3p, miRBase: MIMAT0000318, TarBase: hsa-miR-200b-3p, ENA: AJ535828.1:1..22:ncRNA, LM378951.1:1..22:ncRNA, LM608401.1:57..78:ncRNA, |
URS0000650AFF_9606 | precursor_RNA | 74 | 1 |
Rfam: RF00241, |
URS0000EFCEDB_9606 | precursor_RNA | 60 | 1 |
MirGeneDB: Hsa-Mir-8-P2a, |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Cow (Bos Taurus) |
Mammalia | bta-mir-200b 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Mir200b 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | cfa-mir-200b 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | mdo-mir-200b 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | oan-mir-200b 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | gga-mir-200b 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | aca-mir-200b 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | dre-mir-200b 31 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | csa-mir-141 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv2n67 | CNV | gain | 20364138 |
nsv1003578 | CNV | gain | 25217958 |
nsv10161 | CNV | gain+loss | 18304495 |
nsv1160644 | CNV | deletion | 26073780 |
nsv1160772 | CNV | duplication | 26073780 |
nsv428334 | CNV | gain | 18775914 |
nsv469848 | CNV | gain | 16826518 |
nsv470680 | CNV | loss | 18288195 |
nsv482937 | CNV | loss | 15286789 |
nsv509257 | CNV | insertion | 20534489 |
nsv517709 | CNV | gain+loss | 19592680 |
nsv544947 | CNV | loss | 21841781 |
nsv544954 | CNV | loss | 21841781 |
nsv950452 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
cholangiocarcinoma |
|
|
ovarian cancer |
|
|
prostate cancer |
|
|
hepatocellular carcinoma |
|
|
lung cancer |
|