microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR200B Gene

RNA type for MIR200B Gene

miRNA

Aliases for MIR200B Gene

External Ids for MIR200B Gene

Previous HGNC Symbols for MIR200B Gene

  • MIRN200B

Previous GeneCards Identifiers for MIR200B Gene

  • GC01P001100
  • GC01P001103
  • GC01P001106
  • GC01P001114
  • GC01P001127

Summaries for MIR200B Gene

Entrez Gene Summary for MIR200B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR200B Gene

MIR200B (MicroRNA 200b) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR200B include Cholangiocarcinoma and Ovarian Cancer. Among its related pathways are MicroRNAs in cancer and miRNA targets in ECM and membrane receptors.

Rfam classification for MIR200B Gene

  • mir-8/mir-141/mir-200 microRNA precursor family

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR200B Gene

Genomics for MIR200B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR200B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J001168 Enhancer 0.5 dbSUPER 250.7 +1.3 1274 0.6 SAP130 RARA GABPB1 ARID4B HNF1A SOX13 HNRNPL GATAD2A GLIS2 MIR200A MIR200B MIR429 RF00241 TTLL10 ENSG00000272141 C1orf159
GH01J001109 Enhancer 0.8 ENCODE 11.7 -57.2 -57245 1.1 IKZF1 NCOR1 ZNF592 NFIC NONO REST NFATC3 NBN ZNF146 ATF1 HSALNG0000089 lnc-RNF223-4 piR-58273 LINC01786 UBE2J2 MIR200A MIR200B MIR429 PERM1 PLEKHN1
GH01J001189 Enhancer 0.6 FANTOM5 Ensembl 13.6 +22.2 22197 1.8 SPI1 LARP7 SDF4 B3GALT6 MIR200A MIR200B MIR429 LINC01786 UBE2J2 C1QTNF12 TNFRSF18 ENSG00000237094
GH01J001108 Enhancer 0.5 Ensembl 11.7 -58.5 -58503 0.8 ZBTB5 ZNF146 YY2 ZNF785 ZNF558 HSALNG0000089 lnc-RNF223-4 piR-40348-001 LINC01786 UBE2J2 MIR200A MIR200B MIR429 PERM1 PLEKHN1
GH01J001162 Promoter/Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.7 -2.8 -2753 5.5 KMT2B KDM6A SMAD4 SAP130 CUX1 RARA GABPB1 DMAP1 TEAD3 ZSCAN9 TTLL10 ENSG00000230092 SDF4 ENSG00000272141 MIR200B HSALNG0000102 C1orf159
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR200B on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR200B Gene

Latest Assembly
chr1:1,167,104-1,167,198
(GRCh38/hg38)
Size:
95 bases
Orientation:
Plus strand

Previous Assembly
chr1:1,102,484-1,102,578
(GRCh37/hg19 by Entrez Gene)
Size:
95 bases
Orientation:
Plus strand

chr1:1,102,484-1,102,578
(GRCh37/hg19 by Ensembl)
Size:
95 bases
Orientation:
Plus strand

Genomic View for MIR200B Gene

Genes around MIR200B on UCSC Golden Path with GeneCards custom track
MIR200B in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR200B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR200B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR200B Gene

Proteins for MIR200B Gene

Post-translational modifications for MIR200B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR200B Gene

Domains & Families for MIR200B Gene

Gene Families for MIR200B Gene

genes like me logo Genes that share domains with MIR200B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR200B Gene

Function for MIR200B Gene

Phenotypes From GWAS Catalog for MIR200B Gene

Gene Ontology (GO) - Molecular Function for MIR200B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003730 mRNA 3'-UTR binding IDA 29778524
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 21081489
genes like me logo Genes that share ontologies with MIR200B: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR200B Gene

Localization for MIR200B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR200B gene
Compartment Confidence
extracellular 3
plasma membrane 2
cytoskeleton 2
mitochondrion 2
nucleus 2
cytosol 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR200B Gene

Pathways & Interactions for MIR200B Gene

genes like me logo Genes that share pathways with MIR200B: view

Pathways by source for MIR200B Gene

1 BioSystems pathway for MIR200B Gene
1 KEGG pathway for MIR200B Gene

Gene Ontology (GO) - Biological Process for MIR200B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IMP 16762633
GO:0010629 negative regulation of gene expression IMP 21081489
GO:0010832 negative regulation of myotube differentiation ISS --
GO:0016525 negative regulation of angiogenesis IDA 21081489
GO:0035195 gene silencing by miRNA IMP 16762633
genes like me logo Genes that share ontologies with MIR200B: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR200B Gene

Drugs & Compounds for MIR200B Gene

No Compound Related Data Available

Transcripts for MIR200B Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR200B Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS000012A1DD_9606 miRNA 22 6

RefSeq: NR_029639,

LncBase: hsa-miR-200b-5p,

miRBase: MIMAT0004571,

MirGeneDB: Hsa-Mir-8-P2a_5p,

TarBase: hsa-miR-200b-5p,

ENA: LM380249.1:1..22:ncRNA, LM608401.1:21..42:ncRNA,

URS000014D9C1_9606 miRNA 22 5

RefSeq: NR_029639,

LncBase: hsa-miR-200b-3p,

miRBase: MIMAT0000318,

TarBase: hsa-miR-200b-3p,

ENA: AJ535828.1:1..22:ncRNA, LM378951.1:1..22:ncRNA, LM608401.1:57..78:ncRNA,

URS000075C8DF_9606 pre_miRNA 95 4

RefSeq: NR_029639,

Ensembl: ENST00000384997 (view in UCSC) ,

miRBase: MI0000342,

ENA: LM608401.1:1..95:precursor_RNA,

URS0000650AFF_9606 pre_miRNA 74 1

Rfam: RF00241,

URS0001BC7A87_9606 pre_miRNA 74 1

Rfam: RF00241,

MIR200B in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR200B Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR200B Gene

No ASD Table

Relevant External Links for MIR200B Gene

GeneLoc Exon Structure for
MIR200B

Expression for MIR200B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR200B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR200B

Evidence on tissue expression from TISSUES for MIR200B Gene

  • Blood(2.1)
  • Intestine(2)
genes like me logo Genes that share expression patterns with MIR200B: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR200B Gene

Orthologs for MIR200B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR200B Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
Mammalia bta-mir-200b 30
  • 97 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir200b 30
  • 92 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-200b 30
  • 85 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-200b 30
  • 84 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-200b 30
  • 62 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-200b 30
  • 67 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-200b 30
  • 70 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-200b 30
  • 72 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea csa-mir-141 30
  • 55 (a)
OneToMany
Species where no ortholog for MIR200B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR200B Gene

ENSEMBL:
Gene Tree for MIR200B (if available)
TreeFam:
Gene Tree for MIR200B (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR200B

Paralogs for MIR200B Gene

No data available for Paralogs for MIR200B Gene

Variants for MIR200B Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR200B Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR200B Gene

Variant ID Type Subtype PubMed ID
dgv2n67 CNV gain 20364138
nsv1003578 CNV gain 25217958
nsv10161 CNV gain+loss 18304495
nsv1160644 CNV deletion 26073780
nsv1160772 CNV duplication 26073780
nsv428334 CNV gain 18775914
nsv469848 CNV gain 16826518
nsv470680 CNV loss 18288195
nsv482937 CNV loss 15286789
nsv509257 CNV insertion 20534489
nsv517709 CNV gain+loss 19592680
nsv544947 CNV loss 21841781
nsv544954 CNV loss 21841781
nsv950452 CNV deletion 24416366

Additional Variant Information for MIR200B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR200B
Leiden Open Variation Database (LOVD)
MIR200B

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR200B Gene

Disorders for MIR200B Gene

MalaCards: The human disease database

(55) MalaCards diseases for MIR200B Gene - From: MID, COP, and GCD

Disorder Aliases PubMed IDs
cholangiocarcinoma
  • cholangiocarcinoma, susceptibility to
ovarian cancer
  • ovarian cancer, somatic
hepatocellular carcinoma
  • hcc
prostate cancer
  • prostate cancer, somatic
lung cancer
  • lung cancer, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR200B

genes like me logo Genes that share disorders with MIR200B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR200B Gene

Publications for MIR200B Gene

  1. A miR-200 microRNA cluster as prognostic marker in advanced ovarian cancer. (PMID: 19501389) Hu X … Wang X (Gynecologic oncology 2009) 3 72
  2. Involvement of human micro-RNA in growth and response to chemotherapy in human cholangiocarcinoma cell lines. (PMID: 16762633) Meng F … Patel T (Gastroenterology 2006) 3 72
  3. Evaluation of serum and gingival crevicular fluid microRNA-223, microRNA-203 and microRNA-200b expression in chronic periodontitis patients with and without diabetes type 2. (PMID: 33157494) Elazazy O … Abouzaid M (Archives of oral biology 2021) 3
  4. MicroRNA-200a Promotes Phagocytosis of Macrophages and Suppresses Cell Proliferation, Migration, and Invasion in Nasopharyngeal Carcinoma by Targeting CD47. (PMID: 32149101) Zhao Y … Li G (BioMed research international 2020) 3
  5. Decreased miR-200b-3p in cancer cells leads to angiogenesis in HCC by enhancing endothelial ERG expression. (PMID: 32591615) Moh-Moh-Aung A … Matsukawa A (Scientific reports 2020) 3

Products for MIR200B Gene

Sources for MIR200B Gene