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Aliases for MIR200A Gene

Subcategory (RNA class) for MIR200A Gene


Quality Score for this RNA gene is


Aliases for MIR200A Gene

  • MicroRNA 200a 2 3 5
  • Hsa-Mir-200a 3
  • Mir-200a 3
  • MIRN200A 3

External Ids for MIR200A Gene

ORGUL Members for MIR200A Gene

Previous HGNC Symbols for MIR200A Gene

  • MIRN200A

Previous GeneCards Identifiers for MIR200A Gene

  • GC01P001101
  • GC01P001104
  • GC01P001107
  • GC01P001115
  • GC01P001128
  • GC01P001169
  • GC01P001174
  • GC01P001202
  • GC01P001179
  • GC01P001182
  • GC01P001185
  • GC01P001191
  • GC01P001195
  • GC01P001198
  • GC01P001201

Summaries for MIR200A Gene

Entrez Gene Summary for MIR200A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR200A Gene

MIR200A (MicroRNA 200a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR200A include Meningioma, Radiation-Induced and Ovarian Cancer. Among its related pathways are Mesodermal Commitment Pathway and miRNA targets in ECM and membrane receptors.

Additional gene information for MIR200A Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR200A Gene

Genomics for MIR200A Gene

GeneHancer (GH) Regulatory Elements for MIR200A Gene

Promoters and enhancers for MIR200A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J001168 Enhancer 0.6 dbSUPER 600.7 +0.5 515 0.6 HNF1A GLIS2 SOX13 GATAD2A SAP130 POLR2A GABPB1 ARID4B RARA GC01P001208 GC01P001214 GC01P001216 GC01P001218 GC01P001219 GC01P001220 MIR200A MIR429 MIR200B ENSG00000272141
GH01J001109 Enhancer 1 Ensembl ENCODE 11.7 -58.0 -58002 1.1 ZNF148 GTF2F1 TRIM24 SMARCA4 MTA1 DPF2 IKZF1 ZNF512 ATF1 REST PIR52272 GC01P001113 GC01M001107 LINC01786 UBE2J2 MIR429 MIR200B MIR200A PERM1 PLEKHN1
GH01J001189 Enhancer 0.6 FANTOM5 Ensembl 13.6 +21.6 21638 2.2 LARP7 SDF4 B3GALT6 MIR200A MIR200B MIR429 UBE2J2 LINC01786 C1QTNF12 TNFRSF18 ENSG00000237094
GH01J001108 Enhancer 0.4 Ensembl 11.7 -59.3 -59262 0.4 ZBTB5 YY2 ZNF785 GC01M001107 LINC01786 UBE2J2 MIR200A MIR200B MIR429 PERM1 PLEKHN1 C1orf159 ENSG00000285812
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR200A on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR200A Gene

Genomic Locations for MIR200A Gene
90 bases
Plus strand
90 bases
Plus strand

Genomic View for MIR200A Gene

Genes around MIR200A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR200A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR200A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR200A Gene

Proteins for MIR200A Gene

Post-translational modifications for MIR200A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR200A Gene

Domains & Families for MIR200A Gene

Gene Families for MIR200A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR200A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR200A Gene

Function for MIR200A Gene

Gene Ontology (GO) - Molecular Function for MIR200A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 21698760
genes like me logo Genes that share ontologies with MIR200A: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR200A Gene

Localization for MIR200A Gene

Gene Ontology (GO) - Cellular Components for MIR200A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035068 micro-ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with MIR200A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR200A Gene

Pathways & Interactions for MIR200A Gene

genes like me logo Genes that share pathways with MIR200A: view

Pathways by source for MIR200A Gene

1 KEGG pathway for MIR200A Gene

Interacting Proteins for MIR200A Gene

Gene Ontology (GO) - Biological Process for MIR200A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IGI 28008308
GO:0043525 positive regulation of neuron apoptotic process ISS --
GO:0043536 positive regulation of blood vessel endothelial cell migration IMP 21698760
GO:1904646 cellular response to amyloid-beta ISS --
genes like me logo Genes that share ontologies with MIR200A: view

No data available for SIGNOR curated interactions for MIR200A Gene

Drugs & Compounds for MIR200A Gene

No Compound Related Data Available

Transcripts for MIR200A Gene

mRNA/cDNA for MIR200A Gene

(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(3) RNA Central transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR200A Gene

No ASD Table

Relevant External Links for MIR200A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR200A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR200A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR200A Gene:

genes like me logo Genes that share expression patterns with MIR200A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR200A Gene

Orthologs for MIR200A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR200A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-200a 35
  • 100 (a)
(Bos Taurus)
Mammalia bta-mir-200a 35
  • 93 (a)
(Mus musculus)
Mammalia Mir200a 35
  • 92 (a)
(Canis familiaris)
Mammalia cfa-mir-200a 35
  • 92 (a)
(Monodelphis domestica)
Mammalia mdo-mir-200a 35
  • 79 (a)
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-141 35
  • 56 (a)
Species where no ortholog for MIR200A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR200A Gene

Gene Tree for MIR200A (if available)
Gene Tree for MIR200A (if available)

Paralogs for MIR200A Gene

No data available for Paralogs for MIR200A Gene

Variants for MIR200A Gene

Sequence variations from dbSNP and Humsavar for MIR200A Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1001809323 -- 1,167,265(+) C/T upstream_transcript_variant
rs1002116517 -- 1,166,535(+) C/A upstream_transcript_variant
rs1002550980 -- 1,166,345(+) C/T upstream_transcript_variant
rs1003284241 -- 1,167,958(+) G/A/C downstream_transcript_variant
rs1003746029 -- 1,168,109(+) G/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR200A Gene

Variant ID Type Subtype PubMed ID
dgv2n67 CNV gain 20364138
nsv1003578 CNV gain 25217958
nsv10161 CNV gain+loss 18304495
nsv1160644 CNV deletion 26073780
nsv1160772 CNV duplication 26073780
nsv428334 CNV gain 18775914
nsv469848 CNV gain 16826518
nsv470680 CNV loss 18288195
nsv482937 CNV loss 15286789
nsv509257 CNV insertion 20534489
nsv517709 CNV gain+loss 19592680
nsv544947 CNV loss 21841781
nsv544954 CNV loss 21841781
nsv950452 CNV deletion 24416366

Additional Variant Information for MIR200A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR200A Gene

Disorders for MIR200A Gene

MalaCards: The human disease database

(14) MalaCards diseases for MIR200A Gene - From: miR2Disease and GeneCards

Disorder Aliases PubMed IDs
meningioma, radiation-induced
  • mnri
ovarian cancer
  • ovarian cancer, somatic
adamantinoma of long bones
  • long bone adamantinoma
breast cancer
  • breast tumor
lung cancer
  • adenocarcinoma of lung
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR200A

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR200A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR200A Gene

Publications for MIR200A Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 45 58
  2. Expression Levels of microRNAs miR-93 and miR-200a in Pancreatic Adenocarcinoma with Special Reference to Differentiation and Relapse-Free Survival. (PMID: 30537722) Karihtala P … Haapasaari KM (Oncology 2019) 3 58
  3. Plasma microRNAs Predict Chemoresistance in Patients With Metastatic Breast Cancer. (PMID: 30786836) Shao B … Li H (Technology in cancer research & treatment 2019) 3 58
  4. TP73-AS1 promotes breast cancer cell proliferation through miR-200a-mediated TFAM inhibition. (PMID: 28639399) Yao J … Zhou E (Journal of cellular biochemistry 2018) 3 58
  5. MiRNA-200a induce cell apoptosis in renal cell carcinoma by directly targeting SIRT1. (PMID: 28717923) Fu H … Zhang C (Molecular and cellular biochemistry 2018) 3 58

Products for MIR200A Gene

Sources for MIR200A Gene

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