microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR200A Gene

Subcategory (RNA class) for MIR200A Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR200A Gene

  • MicroRNA 200a 2 3 5
  • Hsa-MiR-200a-5p 163 173
  • Hsa-MiR-200a-3p 163 173
  • Hsa-Mir-200a 2 3
  • MIR200A 2 5
  • Hsa-Mir-8-P1a 178
  • MIMAT0000682 50
  • MIMAT0001620 50
  • MI0000737 50
  • MIRN200A 3
  • Mir-200a 3
  • RF00241 168

External Ids for MIR200A Gene

Previous HGNC Symbols for MIR200A Gene

  • MIRN200A

Previous GeneCards Identifiers for MIR200A Gene

  • GC01P001101
  • GC01P001104
  • GC01P001107
  • GC01P001115
  • GC01P001128
  • GC01P001169
  • GC01P001174
  • GC01P001202
  • GC01P001206
  • GC01P001238
  • GC01P001296
  • GC01P001179
  • GC01P001182
  • GC01P001185
  • GC01P001191
  • GC01P001195
  • GC01P001198
  • GC01P001201

Summaries for MIR200A Gene

Entrez Gene Summary for MIR200A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR200A Gene

MIR200A (MicroRNA 200a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR200A include Meningioma, Radiation-Induced and Ovarian Cancer. Among its related pathways are Mesodermal Commitment Pathway and miRNA targets in ECM and membrane receptors.

Rfam classification for MIR200A Gene

  • mir-8/mir-141/mir-200 microRNA precursor family

Additional gene information for MIR200A Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR200A Gene

Genomics for MIR200A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR200A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J001168 Enhancer 0.6 dbSUPER 600.7 +0.5 515 0.6 HNRNPL GATAD2A SOX13 SAP130 POLR2A GABPB1 RARA ARID4B HNF1A GLIS2 MIR200A MIR200B MIR429 RF00241 TTLL10 ENSG00000272141 C1orf159
GH01J001109 Enhancer 0.8 ENCODE 11.7 -58.0 -58004 1.1 ZNF512 LEF1 IKZF1 JUND MTA2 PKNOX1 MTA1 REST ZNF740 DPF2 lnc-RNF223-4 piR-58273 LINC01786 UBE2J2 MIR200A MIR200B MIR429 PERM1 PLEKHN1 C1orf159
GH01J001189 Enhancer 0.6 FANTOM5 Ensembl 13.6 +21.5 21538 2 SPI1 LARP7 SDF4 B3GALT6 MIR200A MIR200B MIR429 UBE2J2 LINC01786 C1QTNF12 TNFRSF18 ENSG00000237094
GH01J001108 Enhancer 0.5 Ensembl 11.7 -59.3 -59262 0.8 ZBTB5 ZNF146 YY2 ZNF785 ZNF558 lnc-RNF223-4 piR-40348-001 LINC01786 UBE2J2 MIR200A MIR200B MIR429 PERM1 PLEKHN1 C1orf159
GH01J001110 Enhancer 0.3 Ensembl 11.7 -57.0 -56962 0.2 ZBTB33 MLLT1 lnc-RNF223-4 piR-58273 LINC01786 UBE2J2 MIR200A MIR200B MIR429 PERM1 PLEKHN1 C1orf159
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR200A on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR200A Gene

Genomic Locations for MIR200A Gene
chr1:1,167,863-1,167,952
(GRCh38/hg38)
Size:
90 bases
Orientation:
Plus strand
chr1:1,103,243-1,103,332
(GRCh37/hg19)
Size:
90 bases
Orientation:
Plus strand

Genomic View for MIR200A Gene

Genes around MIR200A on UCSC Golden Path with GeneCards custom track
MIR200A in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR200A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR200A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR200A Gene

Proteins for MIR200A Gene

Post-translational modifications for MIR200A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR200A Gene

Domains & Families for MIR200A Gene

Gene Families for MIR200A Gene

genes like me logo Genes that share domains with MIR200A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR200A Gene

Function for MIR200A Gene

Gene Ontology (GO) - Molecular Function for MIR200A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 21698760
genes like me logo Genes that share ontologies with MIR200A: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR200A Gene

Localization for MIR200A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR200A gene
Compartment Confidence
extracellular 3
plasma membrane 2
cytoskeleton 2
mitochondrion 2
nucleus 2
cytosol 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR200A Gene

Pathways & Interactions for MIR200A Gene

genes like me logo Genes that share pathways with MIR200A: view

Pathways by source for MIR200A Gene

1 KEGG pathway for MIR200A Gene

Gene Ontology (GO) - Biological Process for MIR200A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IGI 28008308
GO:0043525 positive regulation of neuron apoptotic process ISS --
GO:0043536 positive regulation of blood vessel endothelial cell migration IMP 21698760
GO:1904646 cellular response to amyloid-beta ISS --
genes like me logo Genes that share ontologies with MIR200A: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR200A Gene

Drugs & Compounds for MIR200A Gene

No Compound Related Data Available

Transcripts for MIR200A Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR200A Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000023B77E_9606 miRNA 22 6

RefSeq: NR_029834,

LncBase: hsa-miR-200a-5p,

miRBase: MIMAT0001620,

MirGeneDB: Hsa-Mir-8-P1a_5p,

TarBase: hsa-miR-200a-5p,

ENA: LM379528.1:1..22:ncRNA, LM608664.1:16..37:ncRNA,

URS000075A884_9606 precursor_RNA 90 5

HGNC: 31578,

RefSeq: NR_029834,

Ensembl: ENST00000384875 (view in UCSC) ,

miRBase: MI0000737,

ENA: LM608664.1:1..90:precursor_RNA,

URS000008DA94_9606 miRNA 22 5

RefSeq: NR_029834,

LncBase: hsa-miR-200a-3p,

miRBase: MIMAT0000682,

TarBase: hsa-miR-200a-3p,

ENA: LM379202.1:1..22:ncRNA, LM608664.1:54..75:ncRNA,

URS00006E24A0_9606 precursor_RNA 77 1

Rfam: RF00241,

URS0000EFDBD3_9606 precursor_RNA 62 1

MirGeneDB: Hsa-Mir-8-P1a,

MIR200A in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR200A Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR200A Gene

No ASD Table

Relevant External Links for MIR200A Gene

GeneLoc Exon Structure for
MIR200A

Expression for MIR200A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR200A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR200A

Evidence on tissue expression from TISSUES for MIR200A Gene

  • Blood(2.3)
  • Liver(2.3)
  • Intestine(2.2)
  • Kidney(2.2)
  • Saliva(2.1)
  • Lymph node(2.1)
  • Nervous system(2.1)
  • Muscle(2.1)
  • Skin(2)
  • Urine(2)
  • Heart(2)
genes like me logo Genes that share expression patterns with MIR200A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR200A Gene

Orthologs for MIR200A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR200A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-200a 31
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-200a 31
  • 93 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-200a 31
  • 92 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir200a 31
  • 92 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-200a 31
  • 79 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea csa-mir-141 31
  • 56 (a)
OneToMany
Species where no ortholog for MIR200A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR200A Gene

ENSEMBL:
Gene Tree for MIR200A (if available)
TreeFam:
Gene Tree for MIR200A (if available)

Paralogs for MIR200A Gene

No data available for Paralogs for MIR200A Gene

Variants for MIR200A Gene

Additional dbSNP identifiers (rs#s) for MIR200A Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR200A Gene

Variant ID Type Subtype PubMed ID
dgv2n67 CNV gain 20364138
nsv1003578 CNV gain 25217958
nsv10161 CNV gain+loss 18304495
nsv1160644 CNV deletion 26073780
nsv1160772 CNV duplication 26073780
nsv428334 CNV gain 18775914
nsv469848 CNV gain 16826518
nsv470680 CNV loss 18288195
nsv482937 CNV loss 15286789
nsv509257 CNV insertion 20534489
nsv517709 CNV gain+loss 19592680
nsv544947 CNV loss 21841781
nsv544954 CNV loss 21841781
nsv950452 CNV deletion 24416366

Additional Variant Information for MIR200A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR200A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR200A Gene

Disorders for MIR200A Gene

MalaCards: The human disease database

(59) MalaCards diseases for MIR200A Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
meningioma, radiation-induced
  • mnri
ovarian cancer
  • ovarian cancer, somatic
lung cancer
  • adenocarcinoma of lung
breast cancer
  • breast lobular carcinoma
ovarian serous carcinoma
  • ovarian serous adenocarcinoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR200A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR200A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR200A Gene

Publications for MIR200A Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 41
  2. MicroRNA-200a suppresses prostate cancer progression through BRD4/AR signaling pathway. (PMID: 30784214) Guan H … Chen M (Cancer medicine 2019) 3
  3. FEN1 mediates miR-200a methylation and promotes breast cancer cell growth via MET and EGFR signaling. (PMID: 31266372) Zeng X … Che X (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019) 3
  4. MicroRNA-200a-3p accelerates the progression of osteoporosis by targeting glutaminase to inhibit osteogenic differentiation of bone marrow mesenchymal stem cells. (PMID: 31112871) Lv R … Zhou Q (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019) 3
  5. LncRNA H19 promotes lung cancer proliferation and metastasis by inhibiting miR-200a function. (PMID: 31187349) Zhao Y … Cai R (Molecular and cellular biochemistry 2019) 3

Products for MIR200A Gene

Sources for MIR200A Gene