microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR19B2 Gene

Subcategory (RNA class) for MIR19B2 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR19B2 Gene

  • MicroRNA 19b-2 2 3 5
  • Hsa-MiR-19b-2-5p 163 173
  • Hsa-MiR-19b-3p 163 173
  • Hsa-Mir-19b-2 2 3
  • MIR19B2 2 5
  • Hsa-Mir-19-P2b 178
  • MIMAT0004492 50
  • MIMAT0000074 50
  • MiR-19b-2 3
  • MI0000075 50
  • MIRN19B2 3
  • RF00245 168

External Ids for MIR19B2 Gene

Previous HGNC Symbols for MIR19B2 Gene

  • MIRN19B2

Previous GeneCards Identifiers for MIR19B2 Gene

  • GC0XM133152
  • GC0XM133159
  • GC0XM133306
  • GC0XM133311
  • GC0XM133315
  • GC0XM133319
  • GC0XM133324
  • GC0XM133328
  • GC0XM133332
  • GC0XM133336
  • GC0XM133338
  • GC0XM133349
  • GC0XM133373
  • GC0XM134172
  • GC0XM134177
  • GC0XM134222
  • GC0XM134228
  • GC0XM134236
  • GC0XM134216
  • GC0XM134182
  • GC0XM134189
  • GC0XM134195
  • GC0XM134201

Summaries for MIR19B2 Gene

Entrez Gene Summary for MIR19B2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR19B2 Gene

MIR19B2 (MicroRNA 19b-2) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR19B2 include T-Cell Lymphoblastic Leukemia/Lymphoma. Among its related pathways are Parkinsons Disease Pathway and MicroRNAs in cancer.

Rfam classification for MIR19B2 Gene

  • mir-19 microRNA precursor family

Additional gene information for MIR19B2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR19B2 Gene

Genomics for MIR19B2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR19B2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ134169 Enhancer 0.2 Ensembl 600.7 -0.1 -135 0.2 MIR106A MIR18B MIR19B2 MIR20B MIR363 MIR92A2 ENSG00000283638 CCDC160 GPC3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR19B2 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR19B2 Gene

Genomic Locations for MIR19B2 Gene
chrX:134,169,671-134,169,766
(GRCh38/hg38)
Size:
96 bases
Orientation:
Minus strand
chrX:133,303,701-133,303,797
(GRCh37/hg19)
Size:
97 bases
Orientation:
Minus strand

Genomic View for MIR19B2 Gene

Genes around MIR19B2 on UCSC Golden Path with GeneCards custom track
MIR19B2 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR19B2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR19B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR19B2 Gene

Proteins for MIR19B2 Gene

Post-translational modifications for MIR19B2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR19B2 Gene

Domains & Families for MIR19B2 Gene

Gene Families for MIR19B2 Gene

genes like me logo Genes that share domains with MIR19B2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR19B2 Gene

Function for MIR19B2 Gene

Gene Ontology (GO) - Molecular Function for MIR19B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IMP 22105995
genes like me logo Genes that share ontologies with MIR19B2: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR19B2 Gene

Localization for MIR19B2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR19B2 gene
Compartment Confidence
mitochondrion 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MIR19B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
GO:0048471 perinuclear region of cytoplasm ISS --
GO:0072562 blood microparticle IDA 24998411
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIR19B2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR19B2 Gene

Pathways & Interactions for MIR19B2 Gene

PathCards logo

SuperPathways for MIR19B2 Gene

genes like me logo Genes that share pathways with MIR19B2: view

Pathways by source for MIR19B2 Gene

1 BioSystems pathway for MIR19B2 Gene
1 KEGG pathway for MIR19B2 Gene

Gene Ontology (GO) - Biological Process for MIR19B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002862 negative regulation of inflammatory response to antigenic stimulus IDA 22105995
GO:0008284 positive regulation of cell proliferation ISS --
GO:0010629 negative regulation of gene expression IDA 25765596
GO:0010667 negative regulation of cardiac muscle cell apoptotic process ISS --
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle IDA 22197821
genes like me logo Genes that share ontologies with MIR19B2: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR19B2 Gene

Drugs & Compounds for MIR19B2 Gene

No Compound Related Data Available

Transcripts for MIR19B2 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR19B2 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000013D17D_9606 miRNA 23 6

RefSeq: NR_029490, NR_029491,

LncBase: hsa-miR-19b-3p,

miRBase: MIMAT0000074,

MirGeneDB: Hsa-Mir-19-P2a_3p, Hsa-Mir-19-P2b_3p,

TarBase: hsa-miR-19b-3p,

ENA: View 7 records in RNAcentral

URS0000204276_9606 precursor_RNA 96 5

HGNC: 31576,

RefSeq: NR_029491,

Ensembl: ENST00000385077 (view in UCSC) ,

miRBase: MI0000075,

ENA: LM608164.1:1..96:precursor_RNA,

URS000075D58E_9606 miRNA 22 5

RefSeq: NR_029491,

LncBase: hsa-miR-19b-2-5p,

miRBase: MIMAT0004492,

TarBase: hsa-miR-19b-2-5p,

ENA: LM608164.1:19..40:ncRNA,

URS00000D035D_9606 misc_RNA 81 1

ENA: AF480556.1:1..81:misc_RNA,

URS000070C945_9606 precursor_RNA 80 1

Rfam: RF00245,

MIR19B2 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR19B2 Gene

3 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR19B2 Gene

No ASD Table

Relevant External Links for MIR19B2 Gene

GeneLoc Exon Structure for
MIR19B2

Expression for MIR19B2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR19B2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR19B2

genes like me logo Genes that share expression patterns with MIR19B2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR19B2 Gene

Orthologs for MIR19B2 Gene

Evolution for MIR19B2 Gene

ENSEMBL:
Gene Tree for MIR19B2 (if available)
TreeFam:
Gene Tree for MIR19B2 (if available)

No data available for Orthologs for MIR19B2 Gene

Paralogs for MIR19B2 Gene

No data available for Paralogs for MIR19B2 Gene

Variants for MIR19B2 Gene

Additional dbSNP identifiers (rs#s) for MIR19B2 Gene

Additional Variant Information for MIR19B2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR19B2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR19B2 Gene

Disorders for MIR19B2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR19B2 Gene - From: miR2Disease

Disorder Aliases PubMed IDs
t-cell lymphoblastic leukemia/lymphoma
  • t-cell leukemia
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR19B2

genes like me logo Genes that share disorders with MIR19B2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR19B2 Gene

Publications for MIR19B2 Gene

  1. Acetylation of AGO2 promotes cancer progression by increasing oncogenic miR-19b biogenesis. (PMID: 30305728) Zhang H … Yu J (Oncogene 2019) 3
  2. MicroRNA (hsa-miR-19b-2-5p) targets key mitochondrial biogenesis genes-a bioinformatics analysis. (PMID: 29674166) Saini SK … Bamezai RNK (Mitochondrion 2018) 3
  3. MicroRNA-19b alleviates lipopolysaccharide-induced inflammatory injury in human intestinal cells by up-regulation of Runx3. (PMID: 30178853) Qiao CX … Zhao G (European review for medical and pharmacological sciences 2018) 3
  4. Mitochondria-targeted esculetin inhibits PAI-1 levels by modulating STAT3 activation and miR-19b via SIRT3: Role in acute coronary artery syndrome. (PMID: 28213977) Katta S … Kotamraju S (Journal of cellular physiology 2018) 3
  5. A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis. (PMID: 28431233) Treiber T … Meister G (Molecular cell 2017) 3

Products for MIR19B2 Gene

Sources for MIR19B2 Gene